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  • Treg
  • Consequently, only wt, but not CD28-deficient, Treg were able to continuously suppress aGvHD and induce long-term survival of the recipient mice. (frontiersin.org)
  • Moreover, the delayed kinetics of aGvHD lethality after transplantation of iCD28KO Treg provides a novel animal model for similar disease courses found in patients after allo-HSCT. (frontiersin.org)
  • cytokines
  • In situations in which both CD4 + and CD8 + T cells can recognize host alloantigenic disparities, CD8 + T cells with CTL activity are thought to be driven to expand by CD4 + T cells that provide helper cytokines, which support CD8 + T cell growth. (jimmunol.org)
  • Therapies to treat inflammatory diseases include monoclonal antibodies that either neutralize inflammatory cytokines or their receptors. (wikipedia.org)
  • Inflammatory cytokines play a role in initiating the inflammatory response and to regulate the host defence against pathogens mediating the innate immune response. (wikipedia.org)
  • Dysregulation of proinflammatory cytokines have also been linked to depression and other neurological diseases. (wikipedia.org)
  • transplants
  • In a study designed to enhance the outcomes of vascular transplant through vascular endothelial cell gene therapy, the third generation of Lentivirus showed to be effective in the delivery of genes to moderate venous grafts and transplants in procedures like coronary artery bypass. (wikipedia.org)
  • Mice
  • Several types of immunodeficient mice can be used to establish PDX models: athymic nude mice, severely compromised immune deficient (SCID) mice, NOD-SCID mice, and recombination-activating gene 2 (Rag2)-knockout mice. (wikipedia.org)
  • In 1996 INSERM scientists from Strasbourg showed, in knockout mice that were deficient in both CD4 and LAG-3, that the two proteins were not functionally equivalent. (wikipedia.org)
  • recipients
  • To evaluate whether peripheral induction contributed to regulatory T-cell predominance, we adoptively transferred Tbx21 −/− T cells that consisted of fate mapping for FoxP3: recipients of flow-purified effector cells that were Foxp3 − and Tbx21 −/− had enhanced T-regulatory-cell predominance during autoimmune graft- versus -host disease. (haematologica.org)
  • pathologies
  • An abnormal metabolism or change in the expression of sulfatide has also been associated with various pathologies, including neuropathologies, such as metachromatic leukodystrophy, Alzheimer's disease, and Parkinson's disease. (wikipedia.org)
  • antibodies
  • The placenta does not block maternal IgG antibodies, which thereby may pass through the human placenta, providing immune protection to the fetus against infectious diseases. (wikipedia.org)
  • Other examples of insufficient immune tolerance in pregnancy are Rh disease and pre-eclampsia: Rh disease is caused by the mother producing antibodies (including IgG antibodies) against the Rhesus D antigen on her baby's red blood cells. (wikipedia.org)
  • coronary
  • Pseudoaneurysms can be caused by trauma that punctures the artery, such as knife and bullet wounds, as a result of percutaneous surgical procedures such as coronary angiography or arterial grafting, or use of an artery for injection. (wikipedia.org)
  • tumor
  • Unlike creating xenograft mouse models using existing cancer cell lines, there are no intermediate in vitro processing steps before implanting tumor fragments murine host to create a PDX. (wikipedia.org)
  • lysosomal storage
  • Metachromatic leukodystrophy (MLD, also called arylsulfatase A deficiency) is a lysosomal storage disease which is commonly listed in the family of leukodystrophies as well as among the sphingolipidoses as it affects the metabolism of sphingolipids. (wikipedia.org)
  • Accumulation of sulfatide can cause metachromatic leukodystrophy, a lysosomal storage disease and may be caused because of a defect in arylsulfatase A, leading to an inability to degrade sulfatide. (wikipedia.org)
  • inflammatory disease
  • Studies in other inflammatory disease models, however, have provided strong evidence that these two populations have nonredundant, complementary roles in maintaining immunological tolerance ( 15 , 16 ), indicating that Tregs are not a monolithic population, but constitute a heterogeneous population of cells with differing specificities and functions. (jimmunol.org)
  • protein
  • Adding rice, bananas, or pectin to the diet during diarrhea may be beneficial, but Duro and Duggan point out that the BRAT diet is not nutritionally complete and may be deficient in energy, fat, protein, fiber, vitamin A, vitamin B12, and calcium. (wikipedia.org)
  • Biomechanical analyses of the consequence of the deficiencies in the cytoskeletal proteins dystrophin (the protein deficient in Duchenne muscular dystrophy) and desmin in isolated muscle fibres and muscle cell cultures Biochemical investigations into the neurodegeneration using the wobbler mouse model for ALS. (wikipedia.org)
  • therapeutic
  • However, the immunosuppressive drugs and TCD hamper the therapeutic potential of allo-HCT, resulting in attenuated graft-vs.-leukemia (GVL) effect as well as increased vulnerability to infection. (frontiersin.org)
  • Therapy
  • To be effective in gene therapy, there must be insertion, alteration and/or removal of host cell genes. (wikipedia.org)
  • Therapy requires manipulation of the Lentivirus genes and structure for delivery of specific genes to alter the course of the disease. (wikipedia.org)
  • Certain diseases involving caspase-9 are treated with therapy by targeting this enzyme. (wikipedia.org)
  • cytokine
  • Due to its proinflammatory action, a proinflammatory cytokine tends to make the disease itself or the symptoms correlated to a disease worse by causing fever, inflammation, tissue destruction, and in some cases, even shock and death. (wikipedia.org)
  • deficiency
  • When the arylsulfatase A enzyme level is normal but the sulfatides are still high - meaning that they are not being broken down because the enzyme is not activated - the resulting disease is saposin B deficiency, which presents similar to MLD. (wikipedia.org)
  • hereditary
  • Aneurysms are a result of a weakened blood vessel wall, and may be a result of a hereditary condition or an acquired disease. (wikipedia.org)
  • inflammation
  • Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with inflammatory bowel disease. (mskcc.org)
  • model
  • In an experimental model using donor IL-23-deficient APC, reduction of gut damages was demonstrated along with marked reduction of circulating LPS ( 7 ). (frontiersin.org)
  • cell
  • ATOH1-deficient organoid culture demonstrated that IL-22 induced epithelial regeneration independently of the Paneth cell niche. (nih.gov)
  • By quantifying graft-vs-host disease alloresponses in vivo, we demonstrate that both CD4 + and CD8 + T cell-mediated alloresponses are regulated by 4-1BB/4-1BB ligand interactions to approximately the same extent. (jimmunol.org)
  • Within the viral genome are DNA sequences that code for specific enzymes effecting the incorporation of the viral DNA into the host cell genome. (wikipedia.org)
  • The viral DNA is then sent into the nucleus of the host cell where it is then incorporated into the host cell's genome with the help of the viral enzyme integrase. (wikipedia.org)
  • From there the host cell performs transcription and translation to create viral particles and assemble virions which then burst from the host cell when enough are made. (wikipedia.org)
  • Because the virus has been adapted to lose most of its genome, the virus becomes safer and more effective in transplanting the required genes into the host cell. (wikipedia.org)
  • occur
  • Without correct function, abnormal tissue development can occur leading to abnormal function, diseases and premature death. (wikipedia.org)