CSIDLactase deficiencyLactose intoleranceMalabsorptionEnzymesDiarrheaDigestiveIntoleranceSIBOIsomaltase activityDisaccharidase deficienciesEnzyme deficiencyDeficientDisaccharidasesSacrosidaseSUCRAIDPancreasSymptomsGlucoseIsomaltoseSecondaryAbsenceMutationsVitaminIntestinesConsequencesActivityIncludeRareComplexPatientsFormPeopleResults
CSID15
- Congenital sucrase-isomaltase deficiency (CSID) is a genetic condition that affects a person's ability to digest certain sugars. (rareguru.com)
- What are the signs and symptoms of congenital sucrase-isomaltase deficiency (CSID)? (rareguru.com)
- How is congenital sucrase-isomaltase deficiency (CSID) diagnosed? (rareguru.com)
- How might congenital sucrase-isomaltase deficiency (CSID) be treated? (rareguru.com)
- The CSID Patient Community Support Yahoo Group is a community for patients and caregivers living with congenital sucrase isomaltase deficiency and for their families and friends. (rareguru.com)
- Sucraid ® (sacrosidase) Oral Solution is an enzyme replacement therapy for the treatment of genetically determined sucrase deficiency, which is part of Congenital Sucrase-Isomaltase Deficiency (CSID). (csiddiseaseinfo.com)
- Congenital sucrose-isomaltase deficiency (CSID) is a rare, genetic disease in which mutations in the sucrose-isomaltase (SI) gene cause digestion problems of sucrose resulting in diarrhea and abdominal pain. (clinicaltrialsgps.com)
- Children with chronic, idiopathic diarrhea or abdominal pain will have their sucrose-isomaltase gene assessed for a panel of known CSID mutations to determine the prevalence of these mutations in an enriched population and also determine functional deficiency using a breath test. (clinicaltrialsgps.com)
- Congenital sucrase-isomaltase deficiency (CSID), also called genetic sucrase-isomaltase deficiency (GSID), and sucrose intolerance, is a genetic, intestinal disorder that is caused by a reduction or absence of sucrase and isomaltase Explanations for GSID include: Mutations C1229Y and F1745C, which are present in the sucrase domain of SI, block SI path to anchor in the cell's aprical membrane but does not impact protein folding or isomaltase activity. (wikipedia.org)
- Carbohydrate intolerances with early onset and genetic cause include congenital sucrase-isomaltase deficiency (CSID), glucose-galactose malabsorption (GGM) and congenital lactase deficiency (CLD). (blueprintgenetics.com)
- Sacrosidase is used to treat sucrase deficiency that occurs in people with congenital sucrase-isomaltase deficiency (CSID). (everydayhealth.com)
- CSID is a genetic enzyme deficiency and sacrosidase will not cure this condition. (everydayhealth.com)
- The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). (umbc.edu)
- Background Enzyme replacement therapy with SUCRAID offers a pharmacologic alternative to sucrose free diets to treat symptoms in congenital sucrase-isomaltase deficiency (CSID). (bmj.com)
- Genetic variants causing loss of sucrase-isomaltase (SI) function result in malabsorption of sucrose and starch components and the condition congenital sucrase-isomaltase deficiency (CSID). (lu.se)
Lactase deficiency3
- Lactose - for lactose malabsorption (lactase deficiency). (abbottpathology.com.au)
- Acquired lactase deficiency (primary adult hypolactasia) is the most common form of carbohydrate intolerance. (msdmanuals.com)
- Due to the presence of lactose, this drug is not recommended in patients with galactose intolerance, Lapp lactase deficiency or Lapp malabsorption of glucose and galactose (rare hereditary diseases). (bilkova-apteka.co.uk)
Lactose intolerance2
- Certain conditions can result in digestive enzyme deficiencies, such as lactose intolerance and exocrine pancreatic insufficiency. (advancedfoodintolerancelabs.com)
- Lactose intolerance and lactase enzyme deficiency occurs primarily because of 3 major reasons. (drhoustonanderson.com)
Malabsorption7
- In addition, some affected infants may experience malnutrition, resulting from malabsorption of essential nutrients, and/or failure to thrive, resulting from nutritional deficiencies. (rareguru.com)
- The absence or severe reduction in sucrase and isomaltase activity in the brush-border membrane of the small intestine is responsible for malabsorption of dietary disaccharides and starch. (mhmedical.com)
- Sucrose - for sucrose malabsorption (sucrase-isomaltase deficiency). (abbottpathology.com.au)
- allergy to fructose, sucrase / isomaltase deficiency, glucose-galactose malabsorption. (behealthis.com)
- Individuals with inherited issues like fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase deficiency should avoid this medication. (medino.com)
- The drug contains sucrose, it is not recommended for people with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency. (theeurostore24.com)
- Its use is not recommended in patients with fructose intolerance, a symdrome malabsorption of glucose and galactose or sucrase / isomaltase (rare hereditary diseases). (bilkova-apteka.co.uk)
Enzymes8
- In order to examine the consequences of CD26/DPP IV deficiency on the activity of other enzymes, CD26 deficient mice were investigated. (srce.hr)
- Other enzymes are sucrase (breaks down sucrose), maltase (breaks down maltase), and lactase( breaks down lactose). (advancedfoodintolerancelabs.com)
- This family includes the following closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), lysosomal acid alpha-glucosidase (GAA), neutral alpha-glucosidase C (GANC), the alpha subunit of neutral alpha-glucosidase AB (GANAB), and alpha-glucosidase II. (umbc.edu)
- This rare, genetic metabolic condition happens when someone is deficient in the enzymes sucrase and isomaltase. (pharexhealth.com)
- Lysosomal storage disorders are caused by a deficiency or absence of required enzymes. (conduent.com)
- The three major enzymes made by the brush border include sucrase-isomaltase, maltase-glucoamaltase and lactase. (drhoustonanderson.com)
- While a leaky gut is a big factor in autoimmunity, a deficiency in digestive and pancreatic enzymes, as well as gastric acid and bile salts shouldn't be overlooked. (naturalendocrinesolutions.com)
- The breakdown of food continues in the small intestine, as there are brush border enzymes, which includes maltase, lactase, and sucrase. (naturalendocrinesolutions.com)
Diarrhea2
- Some of the early warning signs of a digestive enzyme deficiency include stomach pain or cramps, bloating, diarrhea, gas, oily bowel movements, and unexplained weight loss. (pharexhealth.com)
- Infection may result in decreased intestinal absorption of sodium, glucose, and water, and decreased levels of intestinal lactase, alkaline phosphatase, and sucrase activity, and may lead to isotonic diarrhea. (cdc.gov)
Digestive3
- As I mentioned, the issue with digestive enzyme deficiencies depends on what's going on. (msholisticwellness.com)
- Other digestive enzyme deficiencies they noted were sucrase and maltase. (mediavillage.it)
- A study published in the journal Phytotherapy Research has found that extracts from pineapple guava ( Feijoa sellowiana ) may prevent digestive problems caused by a deficiency in disaccharidases and oxidative stress-related diseases. (nutrients.news)
Intolerance2
- A deficiency is responsible for sucrose intolerance. (wikipedia.org)
- Symptoms and signs of carbohydrate intolerance are similar in all disaccharidase deficiencies. (msdmanuals.com)
SIBO1
- Could your SIBO be from undiagnosed Genetic Sucrase Isomaltase Deficiency? (drcynthiarudert.com)
Isomaltase activity1
- Results showed that pineapple guava extract only increased lactase and sucrase?isomaltase activity in Caco?2 cells. (nutrients.news)
Disaccharidase deficiencies1
- According to Pierre Russo in Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas (2nd Edition, 2009), disaccharidase deficiencies are "often secondary, resulting from diffuse mucosal damage caused by infectious gastroenteritis, gluten-sensitive enteropathy, or other food allergies. (drhoustonanderson.com)
Enzyme deficiency2
- Is an Enzyme Deficiency Possible? (pharexhealth.com)
- So, an enzyme deficiency doesn't always cause the same symptoms. (msholisticwellness.com)
Deficient2
- Although Sucraid ® provides replacement therapy for the deficient sucrase, it does not provide specific replacement therapy for the deficient isomaltase. (csiddiseaseinfo.com)
- The aim of this study was to determine the influence of age on intestinal brush-border disaccharidases (lactase, sucrase, and maltase), and alkaline phosphatase activity in CD26 deficient mice. (srce.hr)
Disaccharidases1
- Disaccharides are normally split into monosaccharides by disaccharidases (eg, lactase , maltase, isomaltase, sucrase [invertase]) located in the brush border of small-bowel enterocytes. (msdmanuals.com)
Sacrosidase1
- Sacrosidase is a yeast-based enzyme that replaces an enzyme called sucrase which is normally produced in the body. (everydayhealth.com)
SUCRAID2
- The effects of Sucraid ® have not been evaluated in patients with secondary (acquired) disaccharidase deficiency. (csiddiseaseinfo.com)
- Sucraid ® has not been tested to see if it works in patients with secondary (acquired) sucrase deficiency. (csidcares.org)
Pancreas1
- An increase in lipase levels can be measured as well as a deficiency, indicating acute inflammation of the pancreas, known as acute pancreatitis. (advancedfoodintolerancelabs.com)
Symptoms1
- Reversing non-congenital disaccharidase deficiency is something that can often be accomplished by paying careful attention to your symptoms and making necessary lifestyle changes. (drhoustonanderson.com)
Glucose1
- Do not use in the case of a deficiency of glucose-6-phosphate dehydrogenase. (theeurostore24.com)
Isomaltose1
- In order to predict isomaltose binding in sucrase-isomaltase structure, a model was produced by hand. (wikipedia.org)
Secondary1
- In infants, temporary secondary disaccharidase deficiency may complicate enteric infections or abdominal surgery. (msdmanuals.com)
Absence1
- Its absence is manifested by an inherited disease called sucrase-isomaltase deficiency. (bvsalud.org)
Mutations1
- Furthermore, a relationship between mutations in sucrase-isomaltase and chronic lymphocytic leukemia (CLL) has been identified. (wikipedia.org)
Vitamin3
- Do you have a vitamin B deficiency? (nutrients.news)
- Maxical Tablet is used to prevent & treat vitamin D and calcium deficiency in the elderly. (tabletwise.net)
- Maxical is also used to treat osteoporosis patients who are at risk of vitamin D and calcium deficiency. (tabletwise.net)
Intestines2
- In people who lack the sucrase enzyme, sugar can pass into the intestines where it can interact with bacteria. (everydayhealth.com)
- This deficiency may cause undigested food to go past your intestines and prevent your body from absorbing nutrients from food. (pharexhealth.com)
Consequences1
- The clinical consequences of sucrase-isomaltase deficiency. (apothekon.com)
Activity1
- Disaccharidase deficiency is defined as an enzyme activity of at least two standard deviations below the normal mean value. (mhmedical.com)
Include1
- Congenital enzyme deficiencies are rare and include deficiencies of lactase or sucrase-isomaltase. (msdmanuals.com)
Rare2
- Molybdenum cofactor deficiency (MoCD) is a rare genetic disorder that results from one of several single gene defects in the biosynthetic pathway of molybdenum cofactor. (conduent.com)
- Being born with disaccharidase deficiency is very rare. (drhoustonanderson.com)
Complex2
- By heterodimerizing the two subunits, the sucrase-isomaltase complex is formed. (wikipedia.org)
- Scientists have discovered the crystal structure for N-terminal human sucrase-isomaltase (ntSI) in apo form to 3.2 Å and in complex with the inhibitor kotalanol to 2.15 Å resolution. (wikipedia.org)
Patients1
- Connect with other caregivers and patients with Congenital sucrase-isomaltase deficiency and get the support you need. (rareguru.com)
Form1
- Congenital sucrase-isomaltase deficiency arising from a mutant form of sucrase-isomaltase that accumulates in the endoplasmic reticulum. (iberpymes.com)
People1
- Two people might experience deficiencies. (msholisticwellness.com)
Results1
- Sucrase-isomaltase's mechanism results in a net retention of configuration at the anomeric center. (wikipedia.org)