Deficiency fibrinogen. Medical search. Frequent questions

Congenital fibrinogen deficiency (CFD) can result in bleeding complications, with the severity of symptoms coinciding with the extent of the fibrinogen deficiency. (riastap.com)
Learn About Congenital Fibrinogen Deficiency . (riastap.com)
RIASTAP is indicated for the treatment of acute bleeding episodes in pediatric and adult patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia. (riastap.com)
Fibryga ® receives marketing authorization for congenital fibrinogen deficiency in 16 EU countries, the US and Canada. (octapharma.com)
The 2011 launch of the clinical trial to investigate the use of our high-purity human fibrinogen concentrate in congenital fibrinogen deficiency was the start of a clinical development programme in a very rare disease. (octapharma.com)
This approval extends the original 2017 marketing authorisation for Octapharma's high-purity human fibrinogen concentrate for use in congenital fibrinogen deficiency. (octapharma.com)

Our human fibrinogen concentrates receive European label extension to treat acquired fibrinogen deficiency. (octapharma.com)
Today, scientific progress allows us to produce high-purity human fibrinogen concentrate to treat acquired fibrinogen deficiency (AFD). (octapharma.com)

Haemophilias together with von Willebrand disease represent the great majority of hereditary bleeding disorders (95-97%) and only about 3-5% are rare coagulation factor deficiencies. (hemofilia.fi)
In these, bleeding symptoms are generally milder than in haemophilia and vary between different coagulation factor deficiencies and patients. (hemofilia.fi)
The results suggested that, at our institution, most of the post-operative bleeding complications can be attributed to platelet dysfunction or low fibrinogen levels/activity (manifested as low TEG maximum amplitude) rather than coagulation factor deficiencies or inadequate protamine (which would manifest by prolonged R time on TEG). (pcics.org)

Pasmant E, Dumont B, Lacapere JJ, Dautzenberg MD, Bezeaud A. A severe neonatal presentation of factor II deficiency. (medscape.com)
Other factor deficiencies are more rare but can include factor V, factor VII, factor X, factor XI, and fibrinogen. (emoryhealthcare.org)
Hemophilia A is an X-linked, recessive disorder caused by deficiency of functional plasma clotting factor VIII (FVIII), which may be inherited or arise from spontaneous mutation. (medscape.com)
Fibrinogen, also known as factor I, is a naturally occurring blood plasma glycoprotein. (octapharma.com)
Here evidence implicating omega-3 (n-3) fatty acid deficiency in the pathoaetiology of CHD and MDD is reviewed, and the hypothesis that n-3 fatty acid deficiency is a preventable risk factor for CHD comorbidity in MDD patients is evaluated. (hindawi.com)
A rapidly emerging body of evidence suggests that membrane omega-3 (n-3) fatty acid deficiency is a preventable risk factor for both CHD [ 18 ] and MDD [ 19 ]. (hindawi.com)
To evaluate the hypothesis that n-3 fatty acid deficiency is a risk factor for CHD morbidity and mortality in MDD, it is important to consider that the age at onset for unipolar and bipolar depression peaks in young adulthood (15-19 years) [ 24 , 25 ], whereas CHD mortality peaks substantially later (75-84 years) [ 26 ]. (hindawi.com)
Mutations in the F10 -coding gene can cause factor X (FX) deficiency, leading to abnormal coagulation activity and severe tendency for hemorrhage. (karger.com)
It is the deficiency of factor VIII or IX in the intrinsic pathway that causes hemophilia. (pediatriconcall.com)
There are two types of hemophilia - Hemophilia A and Hemophilia B. Hemophilia A results from deficiency or abnormality of factor VIII. (pediatriconcall.com)
Hemophilia B results from deficiency or abnormality of factor IX. (pediatriconcall.com)
factor one, FI) are due to the deficiency or functional defect of the coagulation factor, or the combination of both. (hemofilia.fi)
factor two, FII) deficiency are a tendency for skin and mucosal bleeds, such as bruising, nose bleeds and heavy menstruation. (hemofilia.fi)
This is in line with the results of previous studies associating vitamin D deficiency with increased levels of the pro-inflammatory chemical interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-10 (IL-10). (naturalnews.com)
Cryo may be used to treat bleeding due to Hemophilia A (factor VIII (8) deficiency) or von Willebrand disease when appropriate factor concentrates are not available and/or desmopressin (DDAVP) is contraindicated or ineffective. (medscape.com)
We previously demonstrated that factor XI (FXI) deficiency in mice reduced the atherosclerotic plaque area in coronary sinuses and the aortic arch. (spandidos-publications.com)
Delaying surgery may be indicated if: Parturients with a history of extensive mucosal bleeding (due to platelet dysfunction) and prolonged bleeding (due to factor VIII deficiency) after surgery. (renalandurologynews.com)
These gene mutations are inherited in a different manner, depending on the specific type of Factor I deficiency. (yycnewcentrallibrary.com)
Also known as coagulation factor I, fibrinogen is relevant for the initiation and propagation of building a firm blood clot. (octapharmausa.com)
Acquired factor X deficiency is a rare diagnosis, especially without the association of other co-existing conditions such as amyloidosis. (mdpi.com)
Factor I (1) or fibrinogen deficiency is an inherited bleeding disorder caused when a person's body does not produce any or enough of a protein in the blood (fibrinogen) that plays an important role in blood clotting or the fibrinogen doesn't work properly. (hfq.org.au)
Explains the causes of Factor I deficiency, its symptoms, diagnosis and treatment. (hfq.org.au)
What are rare clotting factor deficiencies? (hfq.org.au)
There are often multiple factor deficiencies contributing to the problem which are concurrent to the liver disease. (wagwalking.com)
Congenital factor XIII (FXIII) deficiency, originally recognized by Duckert in 1960, is a rare autosomal recessive disease usually associated with a severe bleeding diathesis. (medscape.com)
Although acquired factor XIII deficiency has been described in association with hepatic failure, inflammatory bowel disease, and myeloid leukemia, the only significant association with bleeding in children is the inherited deficiency. (medscape.com)
Inherited factor XIII deficiency is usually due to mutations in the gene encoding the catalytic A subunit, located on chromosome 6. (medscape.com)
Because the clinical bleeding is severe in most patients with hereditary factor XIII deficiency, the diagnosis is made at an early age, often during infancy. (medscape.com)
Recurrent miscarriage may be a feature of some congenital factor (eg, factor XIII) and fibrinogen deficiencies. (medscape.com)

During clot formation, integrin αIIbβ3 binds to a protein called fibrinogen. (medlineplus.gov)
Attachment of integrin αIIbβ3 from adjacent platelets to the same fibrinogen protein helps platelets cluster together (platelet cohesion) to form a blood clot. (medlineplus.gov)
Fibrinogen deficiency may cause bleeding symptoms, whereas abnormal structure of the protein can result in either excessive bleeding or coagulation tendencies. (hemofilia.fi)
We hypothesized that cardiac dysfunction was responsible for the high perinatal lethality that we previously reported in fibrinogen-like protein 2 ( Fgl2) knockout (KO) mice. (mcmaster.ca)
Pupura fulminas is the result of severe (homozygous) Protein C or Protein S deficiency causing massive thromboembolic complications (a form disseminated intravascular coagulation) in newborns shortly after birth. (labtestsonline.org.uk)
They collected blood samples from the participants and evaluated the levels of 25-hydroxyvitamin D (25(OH)D), which is the major storage and circulating form of vitamin D in the body, and three inflammatory markers, namely C-reactive protein (CRP), fibrinogen, and white blood cells. (naturalnews.com)
Fibrinogen is a protein found in blood plasma which plays a vital role in blood clotting. (yycnewcentrallibrary.com)
Fibrinogen (feye-BRIN-oh jen) is a protein needed for blood to clot. (yycnewcentrallibrary.com)

[ 1 ] Dysfibrinogenemia is a qualitative defect in fibrinogen (type II) marked by functional abnormalities of fibrinogen who carry one abnormal allele that may result in either bleeding or thrombosis. (medscape.com)
For example, neoplasia (abnormal growth of tissues and cells), and inflammation of the liver will cause a reduction in the breaking down of blood clots, and a deficiency in the production of coagulation proteins. (wagwalking.com)

CSL Behring is proud to serve communities of people who have von Willebrand disease (VWD), hemophilia, primary immunodeficiency (PID), hereditary angioedema (HAE), fibrinogen deficiency, Alpha 1 antitrypsin deficiency, and other rare diseases. (cslbehring.de)

Typical symptoms of FXIII deficiency include umbilical bleeding in newborns, a tendency for bruising, joint bleeds, and increased risk of sudden cerebral haemorrhage. (hemofilia.fi)
FXIII deficiency, an autosomal recessive disorder, is a rare but potentially life-threatening cause of a hemorrhagic diathesis. (medscape.com)
However, these tests cannot be used to screen for FXIII deficiency because the results would be within reference ranges in a patient with isolated severe FXIII deficiency. (medscape.com)
BACKGROUND: Characterization of inherited mild-FXIII deficiency is imprecise than its rare, inherited severe forms. (bvsalud.org)
OBJECTIVE: To assess the prevalence and burden of mild-FXIII deficiency among the apparently-healthy German-Caucasian population and to correlate it with genetic heterozygosity at FXIII and Fibrinogen gene loci. (bvsalud.org)
as well as to targeted re-sequencing of FXIII and Fibrinogen genes based on Next generation sequencing. (bvsalud.org)
To draw a contrast, a retrospective analysis was performed on a cohort of mild inherited FXIII deficiency patients referred to us. (bvsalud.org)
RESULTS: The prevalence of mild FXIII deficiency is high (â ¼0.8%) among the screened German-Caucasian population, as compared to its rare-severe forms. (bvsalud.org)
CONCLUSION: This extensive, population-based quasi-experimental approach revealed the burden of heterozygosity at FXIII and Fibrinogen gene loci to be causative towards the clinical manifestation of inherited mild-FXIII deficiency that results in ''unexplained bleeding'' upon provocation. (bvsalud.org)

[ 6 ] Therefore, disorders of fibrinogen may be associated with either a bleeding or a thrombotic predisposition. (medscape.com)

Cryo is used most commonly for replacement of fibrinogen in patients that are bleeding or at increased risk of bleeding. (medscape.com)
With fibryga® we have amended our bleeding management portfolio addressing the need for a fast and reliable control of bleeding by the replacement of fibrinogen. (octapharmausa.com)
fibryga® is a novel fibrinogen concentrate produced from pooled plasma providing fast reconstitution, high level of safety, purity, and functionality for the treatment of patients where fast and efficacious replacement of fibrinogen is needed. (octapharmausa.com)

Congenital abnormalities of fibrinogen are divided into two types: type I, or quantitative abnormalities (afibrinogenemia and hypofibrinogenemia), and type II, or qualitative abnormalities (dysfibrinogenemia and hypodysfibrinogenemia). (medscape.com)
Afibrinogenemia and hypofibrinogenemia are quantitative defects in fibrinogen (type I), which result from mutations that affect plasma fibrinogen concentration inherited on both chromosomal alleles and are frequently associated with a bleeding diathesis but occasionally a thrombotic event. (medscape.com)
Fibrinogen replacement may be indicated for hypofibrinogenemia or dysfibrinogenemia whether acquired or congenital. (medscape.com)
Hypofibrinogenemia is characterized by reduced amounts of immunoreactive fibrinogen. (nih.gov)

Thrombin time is more sensitive than PT or aPTT for quantitative and qualitative defects in fibrinogen. (medscape.com)
Clotting and immunological methods were used to determine activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time (TT), fibrinogen levels, FX activity, and FX antigen levels. (karger.com)

In the low-fibrinogen (below 411 mg/dL) postoperatively irradiated group, OS rates at 2 and 3 years were 86 and 83 %, and in the high-fibrinogen group 66 and 51 %, respectively. (springermedizin.at)
In the RT group with low fibrinogen levels, OS rates after 2 and 3 years were 74 and 53 %, and in the high-fibrinogen group 40 and 22 %, respectively. (springermedizin.at)
What does a high fibrinogen level mean? (yycnewcentrallibrary.com)
High fibrinogen is associated with higher rates of heart disease, blood vessel dysfunction, and stroke. (yycnewcentrallibrary.com)

The ambitious goal of this programme was to show that our high-purity human fibrinogen concentrate is at least as effective as cryoprecipitate for AFD - and is a more practical and reliable alternative to it. (octapharma.com)
Eight years on, and after the detailed design, planning and conduct of clinical trials by a dedicated Octapharma team, our high-purity human fibrinogen concentrate has now been approved for use in AFD in 15 countries of the EU. (octapharma.com)
Members of the dedicated Octapharma human fibrinogen concentrate team. (octapharma.com)
After Octapharma's high-purity human fibrinogen concentrate obtained regulatory approval in the USA, Canada and the EU in 2017 for the treatment of very rare congenital fibrinogen deficiencies (with further approval obtained in Switzerland in 2018 for both acquired and congenital fibrinogen deficiencies), clinical initiatives continued with FORMA-05, the first new clinical study in AFD. (octapharma.com)
The FORMA-05 clinical study was a prospective, randomised, single-blind, controlled, non-inferiority study which compared the efficacy of Octapharma's high-purity human fibrinogen concentrate to that of cryoprecipitate during cytoreductive surgery to treat pseudomyxoma peritonei, a rare cancer that usually starts in the appendix. (octapharma.com)
In 2017, Octapharma started discussing another study using Octapharma's high-purity human fibrinogen concentrate in cardiac surgery with a group of Canadian physicians led by Dr Keyvan Karkouti in Toronto. (octapharma.com)

The most relevant observation was that plasma fibrinogen levels were significantly associated with a reduction of overall survival rates. (springermedizin.at)

RiaSTAP ® , Fibrinogen Concentrate (Human), is contraindicated in patients with known anaphylactic or severe systemic reactions to human plasma-derived products. (riastap.com)
The heterozygous variants p.Ser362Asn or p.Tyr384Ter indicate mild FX deficiency, but the compound heterozygous mutation of the two causes severe congenital FX deficiency and bleeding. (karger.com)
The symptoms vary, and severe deficiency is associated with a higher risk for severe bleeding, such as intracranial and joint bleeds. (hemofilia.fi)
In severe FX deficiency (FX level below 1%), joint and muscle bleeding and intracranial bleeds may also occur. (hemofilia.fi)
The product is indicated for the treatment of patients with congenital fibrinogen deficiencies, as well as patients experiencing severe bleeding related to acquire fibrinogen deficiency during surgical interventions and trauma. (octapharmausa.com)

ITGA2B or ITGB3 gene mutations result in a shortage (deficiency) of functional integrin αIIbβ3. (medlineplus.gov)
Therefore, identifying mutations in F10 is important for diagnosing congenital FX deficiency. (karger.com)
Genetic analysis of these two mutations may help characterize the bleeding tendency and confirm congenital FX deficiency. (karger.com)

However, these tests have a poor sensitivity to mild fibrinogen deficiency or dysfunction. (medscape.com)
We conclude that Fgl2 deficiency is not associated with obvious structural cardiac defects but is associated with a high incidence of neonatal death as well as contractile dysfunction and rhythm abnormalities during embryonic and postnatal development in mice. (mcmaster.ca)

Although the primary function of fibrinogen is in fibrin clot formation, it has a multitude of other functions, including nonsubstrate thrombin binding, platelet aggregation, and fibrinolysis. (medscape.com)
Exposure of its nonsubstrate thrombin-binding sites after fibrin clot formation promotes the antithrombotic properties of fibrinogen. (medscape.com)

A shortage (deficiency) of functional integrin αIIbβ3 prevents sufficient binding of fibrinogen or other proteins, impairing the formation of blood clots. (medlineplus.gov)
The Clauss fibrinogen assay is a quantitative, clot-based, functional assay. (yycnewcentrallibrary.com)

Fibrinogen and thrombotic disease. (springermedizin.at)

Elevated fibrinogen levels increase the risk of blood clots, which can, in turn, contribute to an increased risk of heart disease. (yycnewcentrallibrary.com)
When your fibrinogen is low, your body can't create blood clots and heal injuries. (yycnewcentrallibrary.com)

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice. (medscape.com)

Afibrinogenemia is characterized by the complete absence of immunoreactive fibrinogen. (nih.gov)

About RiaSTAP RiaSTAP is a lyophilized fibrinogen concentrate for reconstitution. (riastap.com)
With no other alternatives, AFD is treated with cryoprecipitate in many countries around the world and thus there is a high medical need for a fibrinogen concentrate approved in this indication. (octapharma.com)
The rationale for the FORMA-05 study was to investigate whether a fibrinogen concentrate is an effective alternative to cryoprecipitate in a model indication of AFD. (octapharma.com)
In many parts of the world, patients are still treated with cryoprecipitate, as a fibrinogen concentrate is not licensed for AFD. (octapharma.com)
Cryoprecipitate is less pure, contains several coagulation factors, and a higher volume is required than for fibrinogen concentrate. (octapharma.com)
Octapharma today announced that the Swiss Agency for Therapeutic Products, Swissmedic, granted marketing authorization to its new fibrinogen concentrate product fibryga® for the treatment of congenital and acquired fibrinogen deficiencies. (octapharmausa.com)
Fibryga® is a lyophilized fibrinogen concentrate for intravenous infusion, produced from pooled human plasma.The key features of the product are the purity, the unaltered functionality of fibrinogen, and a high level of pathogen safety. (octapharmausa.com)

Although this evidence was obtained from studies conducted largely in parallel in the fields of cardiology and psychiatry, the potential contribution of n-3 fatty acid deficiency to increased CHD morbidity and mortality in MDD has been postulated previously [ 22 , 23 ]. (hindawi.com)
Worldwide, vitamin K deficiency causes infant morbidity and mortality. (merckmanuals.com)

Symptoms that can be related to a clotting deficiency are listed here. (wagwalking.com)
Dogs typically display symptoms of liver-related clotting deficiency only as the liver is becoming progressively more diseased. (wagwalking.com)

The objective of this retrospective study was to clarify the potential prognostic significance of pre-therapeutic fibrinogen levels in head and neck squamous cell carcinoma (HNSCC) patients treated with curative intent by primary radiotherapy (RT) or with postoperative radiotherapy (PORT). (springermedizin.at)
We conclude from these results that elevated pre-therapeutic fibrinogen may serve as a biomarker associated with worsened prognosis in locally advanced head and neck cancer patients treated by either RT or surgery followed by adjuvant radiotherapy. (springermedizin.at)
Certain antibiotics (particularly some cephalosporins and other broad-spectrum antibiotics), salicylates, megadoses of vitamin E , and hepatic insufficiency increase risk of bleeding in patients with vitamin K deficiency. (merckmanuals.com)
In addition to rare congenital fibrinogen deficiencies, there are significant numbers of patients with bleeding complications in surgeries and trauma caused by acquired low levels of fibrinogen. (octapharmausa.com)
So far, there has been limited controlled clinical evidence to support rational treatment for patients with fibrinogen deficiency," Dr. Ashok Roy, Haemotologist at Basingstoke Hospital, UK, says. (octapharmausa.com)
The results from the study are extremely important to help clinicians understand the importance of fibrinogen replacement in massively bleeding patients. (octapharmausa.com)

Girolami A, Santarossa C, Cosi E, Ferrari S, Lombardi AM, Girolami B. Bleeding manifestations in heterozygotes with prothrombin deficiency or abnormalities vs. unaffected family members as observed during a long follow-up study. (medscape.com)

In the final step of the coagulation cascade, fibrinogen is converted to fibrin, with formation of a fibrin clot. (medscape.com)
The assay measures the ability of fibrinogen to form fibrin clot after being exposed to a high concentration of purified thrombin. (yycnewcentrallibrary.com)

Initial evaluation for VWD would be obtaining a basic hemostasis evaluation, including a CBC with platelet count, activated partial thromboplastin time (aPTT), prothrombin time, and fibrinogen levels. (renalandurologynews.com)

Recently, a team of scientists from institutes in London, Australia, and Brazil found that vitamin D deficiency leads to an increase in inflammatory markers . (naturalnews.com)
Levels of fibrinogen increase in inflammatory states as part of the acute-phase response. (yycnewcentrallibrary.com)

Fibrinogen is an acute phase reactant and thus elevated levels may be associated with inflammation. (yycnewcentrallibrary.com)
Furthermore, describing how vitamin D levels fluctuate month-to-month may provide a basis for implementing public health strategies to increase 25(OH)D levels when deficiency is most acute. (cdc.gov)

Vitamin K deficiency results from extremely inadequate intake or fat malabsorption. (merckmanuals.com)
Vitamin K deficiency decreases levels of prothrombin and other vitamin K-dependent coagulation factors, causing defective coagulation and, potentially, bleeding. (merckmanuals.com)
Vitamin K deficiency causes hemorrhagic disease of the newborn Blood loss , which usually occurs 1 to 7 days postpartum. (merckmanuals.com)
In healthy adults, dietary vitamin K deficiency is uncommon because vitamin K is widely distributed in green vegetables and the bacteria of the normal gut synthesize menaquinones. (merckmanuals.com)

The conversion of soluble fibrinogen to insoluble fibrin. (medscape.com)

The authors of the study observed that people exhibiting low serum levels of 25(OH)D had increased concentrations of CRPs, fibrinogen, and white blood cells. (naturalnews.com)
Fibrinogen levels drop as a result of traumatic injuries and blood loss, liver disease, leukemia, certain medications, or genetic disorders. (yycnewcentrallibrary.com)
A consistent body of observational evidence links elevated levels of fibrinogen with cardiovascular risk. (yycnewcentrallibrary.com)
Levels of fibrinogen in the blood can be detected with the use of a blood test which can also be used to look at levels of other clotting agents and substances in the blood. (yycnewcentrallibrary.com)
Low levels of fibrinogen are associated with bleeding most commonly secondary to liver disease or Disseminated Intravascular Coagulation (DIC). (yycnewcentrallibrary.com)

Liver disease often means there will be a deficiency in clotting proteins as a result. (wagwalking.com)
All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). (bvsalud.org)

Overall, this study shows that vitamin D deficiency is potentially involved in the development of chronic inflammatory diseases, suggesting that this vitamin has anti-inflammatory potential. (naturalnews.com)

Integrin α-x/β 2 recognizes the sequence g-p-r in fibrinogen α-chain. (lu.se)
Integrin α-m/β-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. (lu.se)

What is fibrinogen antigen nephelometry? (yycnewcentrallibrary.com)
The Fibrinogen Antigen, Nephelometry test contains 1 test with 1 biomarker. (yycnewcentrallibrary.com)

Fibrinogen is a 340-kD glycoprotein that is synthesized in the liver and circulates in plasma at a concentration of 2-4 g/L, with a half-life of 4 days. (medscape.com)

But it also became an early step in one of the most audacious clinical programmes which Octapharma has conducted, targeting acquired fibrinogen deficiency (AFD). (octapharma.com)

In vitro and clinical data indicate that the clot strength in FIBTEM increases in a fibrinogen concentration-dependent manner independent of platelet count. (wikipedia.org)
Decreased concentration of fibrinogen in the blood. (nih.gov)
RÉSUMÉ Les polymorphismes du gène du facteur VII peuvent contribuer à l'élévation de la concentration en activité coagulante du facteur VII (FVIIc) qui a été associée au risque cardio-vasculaire. (who.int)
Les sujets ayant un génotype R/R avaient une concentration en FVIIc significativement plus élevée que les sujets hétérozy- gotes et homozygotes porteurs de l'allèle Q353 (96,36 vs 59,52). (who.int)
La concentration en FVIIc avec le polymor- phisme d'insertion de 10 pb n'était pas significativement différente. (who.int)

vi) APP transgenic mice with apolipoprotein E (ApoE) deficiency had increased atherosclerosis and vascular inflammation ( 16 ). (spandidos-publications.com)
Why fibrinogen is high in inflammation? (yycnewcentrallibrary.com)

Pharmacokinetic analyses in fibrinogen-KO and FcRn-KO mice were performed to evaluate the effect of albumin and fibrinogen on in-vivo half-life of rFIX-LXa-FXIIIB. (bvsalud.org)

Fibrinogen deficiency is caused by a mutation (change) on the FGA, FGB or FGG gene all of which play a role in causing blood to clot. (yycnewcentrallibrary.com)

Anatomy4

Organisms2

Diseases45

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes27

Information Science3

Health Care1

Congenital fibrinogen deficiency6

Treat acquired fibrinogen deficiency2

Coagulation factor deficiencies3

Factor29

Protein8

Abnormal2

Hereditary1

FXIII9

Disorders of fibrinogen1

Replacement of fibrinogen3

Hypofibrinogenemia4

Thrombin time2

High-fibrinogen4

Human fibrinogen6

Plasma fibrinogen1

Severe5

Mutations3

Dysfunction2

Clot formation2

Functional2

Thrombotic1

Blood clots2

Hemorrhage1

Afibrinogenemia1

Concentrate7

Morbidity and morta2

Symptoms2

Patients6

Abnormalities1

Fibrin clot2

Prothrombin time1

Increase in inflammatory2

Acute2

Vitamin K deficien4

Soluble1

Levels5

Proteins2

Inflammatory1

Integrin2

Antigen2

Glycoprotein1

Octapharma1

Concentration5

Inflammation2

Albumin1

Mutation1