• In 1971, patients diagnosed with beta-methylcrotonylglycinuria, a carboxylase deficiency, were clinically responsive to supplemental biotin treatment. (medscape.com)
  • Patients with ATIII deficiency requiring anticoagulant therapy with heparin will need higher doses of heparin. (wikipedia.org)
  • Multiple carboxylase deficiency (MCD) is one of many metabolic disorders that occur in the absence of the coenzyme activity of biotin. (medscape.com)
  • Biotin deficiency can result in behavioral disorders, lack of coordination, learning disabilities and seizures. (wikipedia.org)
  • Antithrombin III deficiency (abbreviated ATIII deficiency) is a deficiency of antithrombin III. (wikipedia.org)
  • A 2004 case study from Metametrix detailed the effects of biotin deficiency, including aggression, cognitive delay, and reduced immune function. (wikipedia.org)
  • In biotinidase deficiency, biotin-dependent enzymes are affected, namely the 4 human carboxylases: acetyl-CoA carboxylase, propionyl-CoA carboxylase, β-methylcrotonyl-CoA carboxylase, and pyruvate CoA carboxylase. (medscape.com)
  • Neonatal-onset multiple carboxylase deficiency most likely results from holocarboxylase synthetase deficiency (another biotin-responsive metabolic abnormality). (medscape.com)
  • Acquired factor X deficiency in light-chain (AL) amyloidosis is rare and associated with advanced disease. (medscape.com)
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