• We demonstrate that human neutrophil α-defensins are potent inhibitors of LF. (pnas.org)
  • Here we tested the hypothesis that defensins, released from activated neutrophils onto the surface of biomaterials, might play a role in the deactivation of subsequent neutrophil populations. (asm.org)
  • Your search returned 2 avian beta-defensin 2 ELISA ELISA Kit across 1 supplier. (biocompare.com)
  • hsCRP ( with automated analyzer ) and a-defensins ( using ELISA ) were calculated for each sample. (sages.org)
  • MBS2602324 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Beta-Defensins 2 (DEFbeta2) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • Our Defensin alpha 5 Lysates can be used in a variety of model species. (novusbio.com)
  • More recently, however, β-defensins have also been identified in the heart of different species. (vin.com)
  • Both beta-defensins and their signaling molecules, Toll-Like Receptors, have been identified in the heart of various species. (vin.com)
  • Based on structural information on human β-defensin 2, we examine homologous defensins from various mammalian species for conserved functional physico-chemical characteristics. (biomedcentral.com)
  • According to published accounts, most species' genomes contain 15 to 50 defensins. (plantphysiol.org)
  • Modified Lubbock chronic wound biofilm formed by four bacterial species (Staphylococcus aureus, Streptococcus agalactiae, Pseudomonas aeruginosa, Enterococcus faecalis) was used for evaluation of honey and recombinant bee-derived defensin-1 antibiofilm efficacy. (blogspot.com)
  • Using a PCR approach, we described β-defensin sequences with two exons in three species of Colubridae snakes with high sequence similarity between them. (ovid.com)
  • Growing interest in beta-defensins steadily enhances our knowledge about various aspects of their gene location, expression patterns and the transcription factors involved in their regulation in vivo. (nih.gov)
  • High gene expression levels of α-defensin-3 and -4 have been detected in benign oral neoplasia, α-defensin-6 is considered to be a tumor marker for colon cancer. (mdpi.com)
  • Defensins are thought to be members of small gene families. (plantphysiol.org)
  • The promoter of the plant defensin gene PDF1.2 from Arabidopsis is systemically activated by. (deepdyve.com)
  • Herein, we assessed the association between single nucleotide polymorphisms (SNPs) in the canine β-defensin-1 ( CBD1 ) gene and the infection by L. infantum in two dog populations from Brazil (Sobral in Ceará State and São Raimundo Nonato in Piauí State) and one dog population from Italy. (biomedcentral.com)
  • The tissue distributions of the three antimicrobials, especially the two D. variabilis defensin isoforms, are markedly different, illustrating the immunocompetence of the many tissues that R. montanensis presumably invades once acquired by the tick. (pubmedcentralcanada.ca)
  • If so, the administration of extrinsic defensins or the stimulation of in vivo production of defensins would be appropriate therapeutic goals. (aappublications.org)
  • While this is the first identified mechanism of resistance to α-defensins in H. ducreyi, our in vivo data suggest that resistance to cathelicidin may be more important than defensin resistance to H. ducreyi pathogenesis. (iupui.edu)
  • Thus we demonstrate in vivo that β-defensins are essential for successful sperm maturation, and their disruption leads to alteration in intracellular calcium, inappropriate spontaneous acrosome reaction and profound male infertility. (prolekare.cz)
  • However, the physiological function of mammalian β-defensins in vivo has not been determined. (prolekare.cz)
  • Regarding their mode of antimicrobial action, most plant defensins interact with a specific microbial surface receptor, resulting in microbial cell death via e.g. induction of apoptosis. (kuleuven.be)
  • In a prior exploratory study investigating patients with exacerbation of chronic obstructive pulmonary disease (COPD), the investigators demonstrated a highly significant correlation between the expression level of Defensin-alpha 4 (DEFA4) mRNA in blood and the adrenal function assessed via low-dose ACTH tests. (clinicaltrials.gov)
  • β-defensins are structurally defined by the conserved cysteine-rich motif forming three disulphide bonds, which stabilize a β-sheet formation. (vin.com)
  • We expressed the defensin PaDef cDNA (pBME3) in the bovine endothelial cell line BVE-E6E7. (hindawi.com)
  • In the present work, a cDNA sequence encoding a new big defensin homologue was characterized from the scallop Argopecten purpuratus, namely ApBD1. (ovid.com)
  • This novel format of β-defensin, which induces mitochondrial-mediated apoptosis, may play an active role in EGFR-targeting cancer therapy. (chinaphar.com)
  • Pre-incubation of tachyzoites with human α-defensin-5 followed by exposure to a mouse embryonal cell line (NIH/3T3) significantly reduced T. gondii infection in these cells. (springer.com)
  • Thus, human α-defensin-5 is an innate immune molecule that causes severe toxocity to T. gondii and plays an important role in reducing cellular infection. (springer.com)
  • Like α-defensin-1, the PKC isoform-selective inhibitor Go6976 blocked HIV-1 infection in a dose-dependent manner. (jci.org)
  • Furthermore, kinetic studies and analysis of HIV-1 products indicated that α-defensin-1 and Go6976 blocked HIV-1 infection at similar stages in its life cycle, including nuclear import and transcription. (jci.org)
  • α-Defensin-1 inhibited HIV-1 infection following reverse transcription and integration. (jci.org)
  • Activated CD4 + T cells infected with HIV-1 HxB2 -pseudotyped replication-defective luciferase virus were treated with α-defensin-1 at 5 μg/ml, or with AZT at 5 μM ( A ) or L-731,988 at 10 μM ( B ), at different time points after infection. (jci.org)
  • 0.05, α-defensin-1-treated cells vs. nontreated controls at different time points, α-defensin-1-treated vs. AZT-treated cells at 9 and 16 hours after infection, α-defensin-1-treated vs. L-731,988-treated cells at 24 hours after infection. (jci.org)
  • Epithelial β-defensins constitute a rapidly mobilized local defense against microbial intruders at the epithelial and mucosal surfaces, and different studies have reported induction of epithelial β-defensins at sites of inflammation, injury, infection as well as other disease processes. (vin.com)
  • The expression of most β-defensins, including the human β-defensin 2 (HBD-2) and the mouse β-defensin 3 is induced or upregulated upon microbial infection. (biomedcentral.com)
  • and theta-defensins, which are expressed only in Old World monkeys, lesser apes and orangutans, are lectins with broad-spectrum antiviral efficacy. (nih.gov)
  • Theta defensins form a single beta hairpin structure and therefore also represent a distinct group. (wikipedia.org)
  • The structural and functional relationships between these three classes of alpha-defensins, beta-defensins, theta-defensins are discussed in this chapter. (asmscience.org)
  • Subsequent investigations confirmed relationships between scorpion toxins that block potassium channels and insect defensins in their three-dimensional structure and their disruption of membrane functions of invasive microbes. (wikipedia.org)
  • This structure differs from that of the plant alpha- and beta-thionins, but is analogous to scorpion toxins and insect defensins. (wikipedia.org)