Dedifferentiation of tumor cells. Medical search. Frequent questions

As suggested by stem classical cell biology, we assumed that the number of mutations in the CSC subpopulation should be lower and distinct compared to the differentiated tumor cells with higher proliferation. (nih.gov)
The de-differentiated cells are metabolically distinct from tumor-associated fibroblasts but exhibit comparable effects on tumor cell proliferation. (usda.gov)
Recent studies have shown that extracellular vesicles (EVs) can be exploited by tumors to assist in cancer cell growth, proliferation, migration, invasion and metastasis. (springer.com)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Sex steroid receptors (SSRs), which are involved in BC etiology and progression, promote BCSC proliferation, dedifferentiation and migration. (wjgnet.com)
Methods Cell proliferation was determined by CCK-8 assay when cell invasion was detected by transwell assay. (bvsalud.org)
When HIF-1α was efficiently knocked down in JEG3 cells, the proliferation rate was reduced by approximately 50% and the number of cells that migrated through the transwell insert was greatly decreased. (bvsalud.org)
Cell proliferation, migration, and invasion were partially recovered. (bvsalud.org)
While the tumor is often considered to arise from neuroendocrine proliferation or possibly dedifferentiation of an acinar carcinoma, the precise etiology remains uncertain. (karger.com)
Mechanistically, EBF2 uniformly activates Pparγ-expression in pancreatic cancer cells and limits cell proliferation, whereas oncogenic drivers are expressed differentially in the progenitor cell subsets. (amegroups.org)
The complex PDAC pathobiology is established predominantly through KRAS mutations and the associated cellular signaling that contributes to cell proliferation and dedifferentiation ( 5 , 6 ). (amegroups.org)
Moreover, the VEGFRs induce cellular processes that are common to many growth-factor receptors, including cell migration, survival and proliferation. (molecular-view.com)
VEGFR2 (vascular epithelial growth factor receptor 2, or KDR) is the receptor of VEGF (and its isoforms) which mediates normal endothelial cell survival, migration, and proliferation of blood vessels. (molecular-view.com)
For example, higher levels of the protein FOXM1 were associated with reduced cell differentiation and increased cell proliferation in breast and lung cancer. (mypharmacynews.com)
Myc is a highly pleiotropic transcription factor that governs cell expansion by coordinating diverse cellular processes, including proliferation, dedifferentiation, biosynthetic metabolism, cell growth, and angiogenesis ( Dang, 2012 ). (life-science-alliance.org)
Knockdown of nuclear PATZ1 by siRNA in an immortalized normal follicular epithelial cell line (Nthy-ori 3-1) altered cellular morphology and significantly increased cell proliferation, migration, and invasion. (oncotarget.com)
When PATZ1 was silenced in differentiated thyroid cancer (DTC) cell lines (TPC-1 and FTC-133), proliferation, cellular motility, and expression of uPA and MMPs were significantly increased. (oncotarget.com)
Forced expression of exogenous PATZ1 decreased proliferation, cellular motility, and the expression of uPA and MMPs in ATC cell lines (ACT-1 and FRO). (oncotarget.com)
Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. (jscimedcentral.com)
Hatten ME, Shelanski ML. Mouse cerebellar granule neurons arrest the proliferation of human and rodent astrocytoma cells in vitro. (jscimedcentral.com)
This study showed that combination therapy with Lira and Met could effectively reduce cell proliferation, induce apoptosis, and inhibit cell migration in the HUVECs. (ac.ir)
Role of metformin in suppressing 1, 2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation. (ac.ir)
Exenatide suppresses 1, 2-dimethylhydrazine-induced colon cancer in diabetic mice: Effect on tumor angiogenesis and cell proliferation. (ac.ir)
13. Wu X, Li S, Xue P, Li Y. Liraglutide, a glucagon-like peptide-1 receptor agonist, facilitates osteogenic proliferation and differentiation in MC3T3-E1 cells through phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), extracellular signal-related kinase (ERK)1/2, and cAMP/protein kinase A (PKA) signaling pathways involving β-catenin. (ac.ir)
Single nucleotide mutation of the BRAF V600E gene leads to increased activation of the MAP kinase cascade, resulting in proliferation and dedifferentiation. (generi-biotech.com)
Developmentally regulated EZH2 levels are one of the factors that can determine the higher order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control. (biomedcentral.com)
Development and homeostasis require the coordinate regulation of cell proliferation and differentiation. (biomedcentral.com)
Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. (biomedcentral.com)
They are endowed with GTP hydrolytic activity, mainly involved in cytoskeleton rearrangements and cell motility, but also involved in cell proliferation, transformation and differentiation [ 2 ]. (biomedcentral.com)

CSCs are enriched near macrophages, particularly near macrophage-containing intravasation sites called Tumor Microenvironment of Metastasis (TMEM) doorways. (nature.com)
Here, we report that adipocytes from tumor-invasive mammary fat undergo de-differentiation to fibroblast-like precursor cells during tumor progression and integrate into the tumor microenvironment. (usda.gov)
Collectively, the metabolic interplay between tumor cells and adipocytes induces adipocyte mesenchymal transition and contributes to reconfigure the stroma into a more tumor-friendly microenvironment. (usda.gov)
Cancer cells have proven efficient in educating fibroblasts, within their microenvironment, to secrete EVs as communicative vessels for mediating phenotypic changes in recipient cells. (springer.com)
Bobrie A, Krumeich S, Reyal F, Recchi C, Moita LF, Seabra MC, Ostrowski M, Théry C (2012) Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. (springer.com)
Through them, the cells modify their microenvironment and the behavior of neighboring cells. (frontiersin.org)
Various proinflammatory cytokines can be detected within the melanoma tumor microenvironment. (biomedcentral.com)
In the tumor microenvironment, IL32 expression is highly correlated with genes related to T cell infiltration, and also positively correlates with high AXL/low MITF dedifferentiated gene signature. (biomedcentral.com)
Expression of IL32 in human melanoma can be transcriptionally regulated in the context of a proinflammatory tumor microenvironment with either induced or constitutive IL32 expression strongly, but not invariably, correlating with a dedifferentiated genetic signature. (biomedcentral.com)
Advances in immunotherapy have shed greater focus on the role of tumor-infiltrating immune cells, which are vital components of the tumor immune microenvironment (TIME). (aging-us.com)
TP53 mutations are also associated with the infiltration of immune cells into the tumor microenvironment [ 10 - 12 ]. (aging-us.com)
by contributing to sustained chronic inflammation as a result of modulating the immune cells so that the tumor microenvironment is activated by invasion of immune suppressive regulatory T cells, and/or by mediating the release of inflammatory mediators by immune cells with no anti-tumor activity. (jscimedcentral.com)
The interplay between the gliomas, the tumor microenvironment and infiltrating immune cells can hold key information to how to utilize PD-L1/PD-1 directed immunotherapies to successfully treat GBM patients. (jscimedcentral.com)
This divergent effect might be dependent on the glioma subclass, expression levels of PD-L1 and PD-L1 regulatory molecules, but most importantly on the cell type that express PD-L1 in the tumor microenvironment. (jscimedcentral.com)
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. (jscimedcentral.com)
The tumor microenvironment and the interactions of CSCs with their niches also play an important role in the response to RT. (ugr.es)
This review provides a deep insight into the characteristics and radioresistance mechanisms of CSCs and into the role of CSCs and tumor microenvironment in both the primary tumor and metastasis in response to radiation, and the radiobiological principles related to the CSC response to RT. (ugr.es)
Therefore, while M2-like macrophages are pathogenic, additional cells in the cyst microenvironment, such as for example Compact disc8+ T cells and stromal cells, could be protecting (9). (baxkyardgardener.com)
miR-214 has been linked to inflammation signaling pathways and is found in cells in the tumor microenvironment (20C23). (baxkyardgardener.com)
A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. (biomedcentral.com)

BACKGROUND: Gestational choriocarcinoma (GC) is a highly malignant trophoblastic tumor that often develops from a complete hydatidiform mole (HM). (bvsalud.org)
Here, we investigated the mechanism by which NLRP7 controls these processes in malignant (JEG-3) and non-tumor (HTR8/SVneo) trophoblastic cells. (bvsalud.org)
Acinic cell carcinoma (ACC) makes up about 6.5% of all salivary gland neoplasms and roughly 18% of all malignant neoplasms of the salivary glands . (webpathology.com)
ACC is the most common malignant salivary gland tumor which may present with bilateral involvement . (webpathology.com)
Cholangiocarcinoma (CCA) is a highly malignant tumor originating from the intra- or extra-hepatic bile ducts that has shown increasing morbidity and mortality rates worldwide in the last few years [ 1 ]. (aging-us.com)
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor in humans. (cellimagelibrary.org)
Transduction by oncogenic lentiviral vectors of neural stem cells (NSCs), astrocytes, or even mature neurons in the brains of mice can give rise to malignant gliomas. (cellimagelibrary.org)
We propose that most differentiated cells in the CNS upon defined genetic alterations undergo dedifferentiation to generate a NSC or progenitor state to initiate and maintain the tumor progression, as well as to give rise to the heterogeneous populations observed in malignant gliomas. (cellimagelibrary.org)
Our study demonstrates that PATZ1 knockdown enhances malignant phenotype both in thyroid follicular epithelial cells and thyroid cancer cells, suggesting that PATZ1 functions as a tumor suppressor in thyroid follicular epithelial cells and is involved in the dedifferentiation of thyroid cancer. (oncotarget.com)
BRAF gene mutations are also associated with a number of tumors (malignant melanoma, non-Hodgkin's lymphoma, thyroid papillary carcinoma, non-small cell lung carcinoma and lung adenocarcinoma). (generi-biotech.com)
Notably, during de-differentiation or metabolic rewiring, certain malignant cancer cells acquire an intrinsic vulnerability to ferroptosis. (scientistlive.com)
Notably, some malignant cancer cells acquire intrinsic sensitivity to ferroptosis during dedifferentiation or metabolic remodeling. (medicaltrend.org)
Based on the similarities between the astrocytomas and their normal cell lineage, and the theory that the progression of transformation in malignant cells involves a de-differentiation to an earlier developmental state, the ability of astrocytomas to metabolise fatty acid in a similar manner known to occur in normal astrocytes from the developing brain was investigated. (ucl.ac.uk)
We found that INK4b and INK4a , but not ARF , are upregulated following the differentiation of haematopoietic progenitor cells, in ageing fibroblasts and in senescing malignant rhabdoid tumour cells. (biomedcentral.com)

Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
This gene is regarded as a potential tumor suppressor gene. (cancerindex.org)
The n/2 gene encodes the tumor suppressor called merlin. (ucf.edu)
We show that in the nephron BPGM is constitutively expressed, and up-regulated under conditions like acute kidney injury, clear cell renal carcinoma, or knock-out of the tumor suppressor von Hippel Lindau protein (VHL). (charite.de)
In thyroid cancer cell lines, PATZ1 functioned as a tumor suppressor regardless of p53 status. (oncotarget.com)
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. (jscimedcentral.com)
The INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. (biomedcentral.com)
The INK4b-ARF-INK4a tumor suppressor locus (Figure 1A ) plays a central role in controlling the equilibrium between progenitor cell renewal and cancer risk [ 1 - 8 ]. (biomedcentral.com)
Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer. (cdc.gov)

Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
Inducing de-differentiation by Xbp1s overexpression promotes tumor progression despite lower adiposity. (usda.gov)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
Using this vesicular delivery system, cancer cells can establish a new metastatic niche within distant sites, away from the primary tumor, thus favoring cancer progression. (springer.com)
Breast cancers can express vascular endothelial growth factor (VEGF), or VEGFR2 and increased VEGF expression in breast cancers is associated with tumor progression and increased risk of recurrence. (molecular-view.com)
The theory that cancer progression involves the acquisition by tumor cells of features similar to those of stem cells has gained strength in the scientific community. (mypharmacynews.com)
If we can identify the point at which tumor cells acquire the characteristics of stem cells, it will be possible to look for ways to interrupt the process and avoid progression of the disease. (mypharmacynews.com)
Overexpression of protein kinase FA/GSK-3α (a proline-directed protein kinase) correlates with human hepatoma dedifferentiation/progression. (connsante.com)
Association of protein kinase FA/GSK-3alpha (a proline-directed kinase and a regulator of protooncogenes) with human cervical carcinoma dedifferentiation/progression. (connsante.com)
Functional enrichment analysis of the DEGs in the high OSM-expressing CCA tissues showed that pathways related to tumor progression and immune response were significantly upregulated. (aging-us.com)
The plasticity of CSCs, a process highly dependent on the epithelial-mesenchymal transition (EMT) and associated to cell dedifferentiation, complicates the identification and eradication of CSCs and it might be involved in disease relapse and progression after irradiation. (ugr.es)

The role of BCSCs in cancer formation, growth, invasiveness, therapy resistance and tumor recurrence is becoming increasingly clear. (wjgnet.com)
Introduction: Glioma stem cells isolated from human glioblastomas are resistant to radiation and cytotoxic chemotherapy and may drive tumor recurrence. (nih.gov)
To date, 5 years after surgery, the patient remains without evidence of tumor recurrence. (mdpi.com)
increased metastases, tumor recurrence, and even acquired resistance against the anti-CSC therapies developed in experimental models. (bmbreports.org)
Despite the technological advances in RT, which allow a more precise delivery of radiation while progressively minimizing the impact on normal tissues, issues like radioresistance and tumor recurrence remain important challenges. (ugr.es)
The Keratocystic Odontogenic Tumor (KOT) is a pathology classified as an odontogenic cyst and began to be considered an odontogenic tumor in 2005, because of the presence of intrinsic characteristics compatible with neoplasm, such as its high rate of recurrence and differentiated mechanism of growth. (bvsalud.org)
This entity, now designated as Keratocystic Odontogenic Tumor (KOT), received this denomination because of its aggressive behavior and high rates of recurrence, and began to be considered a true neoplasm 2 . (bvsalud.org)

Level of resistance to anti-tumor remedies can be a characteristic of tumor and CSCs and triggered by up-regulation of genetics accountable for medication efflux and DNA restoration[4]. (researchhunt.com)
TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses" presented b. (virginia.edu)
7. Eftekhari S, Montazeri H, Tarighi P. Synergistic anti-tumor effects of Liraglutide, a glucagon-like peptide-1 receptor agonist, along with Docetaxel on LNCaP prostate cancer cell line. (ac.ir)

Like EMTs, CATs are involved in the invasion of tumor cells into surrounding tissues, with amoeboid movement more likely to occur in soft extracellular matrix (ECM) and mesenchymal movement in stiff ECM. (wikipedia.org)
Result HIF-1α was shown to be strongly expressed in both clinical tumour tissues and cell lines in choriocarcinoma. (bvsalud.org)
Fixation to the surrounding tissues and facial paralysis are uncommon in the absence of transformation to high-grade tumor (de-differentiation). (webpathology.com)
Using immunohistochemistry in a well-characterized set of adenocarcinoma tissues, we showed down-regulation of epithelial markers (E-cadherin and cytokeratin 18) and up-regulation of mesenchymal markers (vimentin and α-smooth muscle actin) with concomitant transforming growth factor-β1 (TGF-β1) expression at the invasive margin compared with the central tumor. (aacrjournals.org)
These include the loss of proliferative control, enhanced cellular migration and invasion, extracellular matrix degradation, angiogenesis, lymphangiogenesis, and vascular invasion followed by the distant seeding of tumor cells in specific tissues, such as the liver or lung. (aacrjournals.org)
We identified 96 differentially expressed genes (DEGs), including 13 upregulated and 83 downregulated genes, in CCA tissues as regulatory T cells were significantly higher and the proportions of activated natural killer cells and monocytes were significantly lower in CCA tissues than the precancerous tissues. (aging-us.com)
CCA patients with a higher proportion of neutrophils and T-regulatory cells (Tregs) and lower proportion of CD8 + T cells in the tumor tissues are associated with poor prognosis [ 5 ]. (aging-us.com)
However, only limited types of tumor-infiltrating immune cells have been analyzed in CCA tissues and the mechanisms regulating the tumor infiltration of immune cells are poorly understood. (aging-us.com)
Recent studies demonstrate that somatic mutations in the tumor tissues influence immunotherapeutic response in several cancers [ 6 , 7 ]. (aging-us.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

In contrast, Akt-phosphorylation, β-catenin, and c-Myc are repressed in the cells, presumably inhibiting tumor growth. (amegroups.org)
icFSP1 exhibits a unique mechanism of action, which promotes ferroptosis in cancer cells by triggering the phase separation of FSP1, thereby inhibiting tumor growth. (medicaltrend.org)

Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. (nature.com)
CSCs display the slow-migratory, invadopod-rich phenotype that is the hallmark of disseminating tumor cells. (nature.com)
At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
CSCs have an enhanced ability to self-renew, which makes them uniquely capable of initiating and sustaining primary and metastatic tumor growth 3 . (nature.com)
The cancer stem cell model implies a hierarchical organization within breast tumors maintained by cancer stem-like cells (CSCs). (nih.gov)
Accordingly, CSCs are a subpopulation of cancer cells with capacity for self-renewal, differentiation and tumor initiation. (nih.gov)
In order to answer these questions, we undertook exome sequencing of CSCs from 12 breast cancer patients, along with paired primary tumor samples. (nih.gov)
Our analysis revealed that the majority of somatic mutations are shared between CSCs and bulk primary tumor, with similar frequencies in the two. (nih.gov)
The data presented here exclude the possibility that CSCs are only a phenotypic consequence of certain somatic mutations, that is a distinct and non-reversible population of cells. (nih.gov)
In addition, our results imply that CSCs must be a population of cells that can dynamically switch from differentiated tumor cells, and vice versa. (nih.gov)
This finding increases our understanding of CSC function in tumor heterogeneity and the importance of identifying drugs to counter de-differentiation rather than targeting CSCs. (nih.gov)
Cancer stem cells (CSCs) and poorly differentiated progenitor cells in pancreatic ductal adenocarcinoma (PDAC) exacerbate hierarchical tissue organization contributing to cell hyperproliferation and therapy resistance. (amegroups.org)
We isolated CSCs from low passage PDAC cell lines derived from human tumors and commercially available cell lines. (amegroups.org)
Expression of EBF2 in the PDX1 and E-cadherin-expressing and organoid forming pancreatic epithelial CSCs indeed induced ductal and acinar-like structural differentiation in vivo in tumors resulting in tumor suppression. (amegroups.org)
According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. (bmbreports.org)
CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. (bmbreports.org)
For the past 20 years, plenty of studies have suggested that only a small subpopulation of the cancer cells with tumor-initiating capability is the core origin of the tumorigenesis and the subset of cancer cells was named cancer stem cells (CSCs). (bmbreports.org)
As it can be inferred from its nomenclature, CSCs share several features of normal stem cells. (bmbreports.org)
The capability of CSCs to type tumors in immunodeficient rodents at extremely low cell quantities surrogates their high tumorigenic potential[2]. (researchhunt.com)
Nakashima and co-workers proven an boost of percentage of Compact disc24+/Compact disc44+ cells in gemcitabine-resistant BTC cells and demonstrated that genetics of the BRCA/Fanconi fix path was over-expressed right here, hence hooking up the noticed chemoresistance in these CSCs with a particular fix path[45]. (researchhunt.com)
In BTC, ABCG2 was proven to end up being over-expressed in BTC growth spheres and in Compact disc44+/Compact disc133+ cells, producing it a applicant for medicinal involvement in putative BTC CSCs[43,47,48]. (researchhunt.com)

They express markers of less differentiated cone together with neuronal/ganglion cell markers with marked inter- and intra-tumor heterogeneity. (nih.gov)
Given the heterogeneity and complex etiology of the GBM and the origin of the tumor cells, it is not surprising that the environment that surrounds the tumors display wide varieties of responses. (jscimedcentral.com)
Tumor heterogeneity is responsible for the variation in the radiation response of the different tumor subpopulations. (ugr.es)

NLRP7 involvement in tumor cell growth and tolerance was further characterized in vivo using the metastatic mouse model of GC. (bvsalud.org)
Background Anti-programmed cell death protein 1 (PD-1) antibodies are now routinely administered for metastatic melanoma and for increasing numbers of other cancers, but still only a fraction of patients respond. (bmj.com)
Here, we investigated whether such reactive T cells can also be informative for clinical outcomes in metastatic melanoma under PD-1 immune-checkpoint blockade (ICB). (bmj.com)
VEGFR2 is often overexpressed in metastatic colorectal cancer and correlated with increased tumor size and dedifferentiation of cancer cells. (molecular-view.com)
Metastatic tumors, for example, had high stemness indices. (mypharmacynews.com)

In mammary gland development, Notch-dependent heterotypic signaling between resident tissue macrophages and mammary stem cells supports survival and function of the normal mammary stem cell 20 . (nature.com)
Liposarcoma is a lipogenic tumor of large deep-seated connective tissue spaces. (medscape.com)
In this paper, we discovered that certain fat cells change their identity when breast cancer spreads into the fat tissue. (usda.gov)
An evaluation of melanoma tissue from selected cases suggested a correlation between tumor-resident NY-ESO-1- and Melan-A-reactive T cells and disease control, supporting the notion of a therapy-associated sequestration of cells from the periphery to the tumor predominantly in those patients benefitting from ICB. (bmj.com)
According to this theory, tumor cells tend to "forget" the tissue from which they originated as the disease progresses, acquiring an undifferentiated phenotype associated with heightened aggressiveness and treatment resistance. (mypharmacynews.com)
In a study whose findings were published in the journal Cell on Thursday, May 5, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP-USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the body). (mypharmacynews.com)
Metabolic adaptations significantly contribute to tumor development and escape from tissue homeostatic defenses. (biomed.news)
Chemo-radio therapeutic outcomes are poor in CCA patients because the tumor is highly desmoplastic with fibrogenic connective tissue and immune cells such as T lymphocytes, natural killer (NK) cells and macrophages that infiltrate the tumor epithelium [ 4 ]. (aging-us.com)
Kingwell K. Neuro-oncology: Glioblastoma prognosis linked to neuronal PD-L1 expression in tumour-adjacent tissue. (jscimedcentral.com)
Anti-angiogenic effects of Metformin, an AMPK activator, on human umbilical vein endothelial cells and on granulation tissue in rat. (ac.ir)
Some tumors contain only mature adipose tissue, whereas others contain multivacuolated lipoblasts and may have areas resembling atypical lipomatous tumor (ALT) ( Am J Surg Pathol 2011;35:1177 ). (pathologyoutlines.com)
In fact, icFSP1 strongly inhibited tumour growth in vivo with distinct condensates of FSP1 in tumor tissue, thus proposing a new concept to combat tumours by promoting phase separation of FSP1 and ferroptosis. (scientistlive.com)
icFSP1 can strongly inhibit tumor growth in vivo, and there is obvious formation of FSP1 aggregates in tumor tissue. (medicaltrend.org)

Low DHT levels elicit apoptosis of prostate secretory luminal cells and epithelial atrophyluminal epithelial apoptosis, but the histologic response to 5ARI treatment is often heterogeneous and lower urinary tract symptoms often persist, requiring surgical intervention. (ghenry.info)
OUsing objective profiling with using the Visium spatial gene expression platform, we foundshowed that atrophied acini from 5ARI treated patients with decreased epithelial infolding and reduced lumen size were high in a club-cell gene signature in 5ARI treated patientshad increased club cell gene expression. (ghenry.info)
More than 95% of thyroid cancers are derived from thyroid follicular epithelial cells and are classified into differentiated thyroid cancer (DTC), including papillary and follicular thyroid cancer (PTC and FTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC). (oncotarget.com)
Others possess discovered that miR-192/194 inhibits cyst epithelial dedifferentiation (16). (baxkyardgardener.com)

Although the precise etiology of liposarcomas is not yet defined, the presumed origin likely involves terminal dedifferentiation of mesenchymal cellular components. (medscape.com)
The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells. (connsante.com)
Microarray analysis revealed that tumors of astrocytic and neuronal origin match the mesenchymal GBM subtype. (cellimagelibrary.org)
Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. (biomedcentral.com)
These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. (biomedcentral.com)

CATs are the least common transition type in invading tumor cells, although they are noted in melanoma explants. (wikipedia.org)
We previously showed that the presence of NY-ESO-1-reactive and/or Melan-A-reactive T cells in the blood correlated with prolonged overall survival (OS) of patients with melanoma with a heterogeneous treatment background. (bmj.com)
Methods Peripheral blood T cell stimulation by NY-ESO-1 and Melan-A overlapping peptide libraries was assessed before and during ICB in two independent cohorts of a total of 111 patients with stage IV melanoma. (bmj.com)
Interleukin 32 (IL32) is produced by T cells, NK cells and monocytes/macrophages, but also by a subset of melanoma cells. (biomedcentral.com)
We analyzed RNA sequencing data from 53 in-house established human melanoma cell lines and 479 melanoma tumors from The Cancer Genome Atlas dataset. (biomedcentral.com)
We also evaluated the impact of proinflammatory molecules TNFα and IFNγ on IL32 expression and dedifferentiation in melanoma cell lines in vitro. (biomedcentral.com)
A significant proportion of established human melanoma cell lines express IL32, with its expression being highly correlated with a dedifferentiation genetic signature (high AXL/low MITF). (biomedcentral.com)
Non IL32-expressing differentiated melanoma cell lines exposed to TNFα or IFNγ can be induced to express the three predominant isoforms (α, β, γ) of IL32. (biomedcentral.com)
However, the role of IL32 in human melanoma cells is less well understood. (biomedcentral.com)
The human melanoma cell lines were established from patient biopsies. (biomedcentral.com)
Melanoma cell lines were treated with 1000 IU/mL TNFα and 100 IU/mL IFNγ (PeproTech US, Rocky Hill, NJ) for the indicated time points. (biomedcentral.com)
Results revealed that hypoxia exposure upregulated Nodal expression and activated Nodal signaling in melanoma cancer cell A375, contributed to maintain stemness and promotes malignancy potential, including invasion, sphere formation and dacarbazine resistance. (cusabio.com)

But, when we change the metabolism of these cells, we can slow down the growth of the breast cancer cells in our animal study. (usda.gov)
Many physiological and pathophysiological conditions are attributed to the lack of oxygen, forcing cells to switch their energy metabolism and find a new balance between energy production and consumption. (charite.de)
In 2019, a team of researchers around Marcus Conrad, Director of the Institute of Metabolism and Cell Death at Helmholtz Munich, had already identified the first FSP1-specific inhibitor, known as iFSP1. (scientistlive.com)
To identify in vivo active ferroptosis inducers targeting FSP1, the team performed a screening campaign in cells, followed by DMPK ("drug metabolism and pharmacokinetics") validation studies. (scientistlive.com)
In order to develop effective FSP1 inhibitors in vivo, the research team screened about 10,000 small molecules and conducted DMPK (Drug Metabolism and Pharmacokinetics) verification studies, and finally discovered and determined a new in vivo effective The FSP1 inhibitor, icFSP1 , sensitizes many human cancer cells to ferroptosis and inhibits tumor growth in vivo. (medicaltrend.org)
In vitro and in vivo comparisons of astrocytomas with normal human astrocytes and normal brain revealed that certain characteristic aspects of the transformed cells' metabolism may be related to the normal metabolic features of their lineage. (ucl.ac.uk)

Fzd9 was significantly induced within 4 h of acute Myc activation in vivo, its expression was maintained as long as Myc activity was sustained, and rapidly decreased following Myc deactivation and tumor regression ( Lawlor et al, 2006 ). (life-science-alliance.org)
The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo. (jscimedcentral.com)
These efforts eventually led to the identification of icFSP1 as a novel class of compounds that sensitise many human cancer cells to ferroptosis and attenuate tumour growth in vivo. (scientistlive.com)
Furthermore, the conservation in vivo of the 1H-NMR astrocytoma profile seen in cell culture serves as a strong validation for the development of tumour-specific profiles based on cell culture extracts, where conditions can be carefully controlled and a large number of metabolites simultaneously investigated. (ucl.ac.uk)

In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
Overexpression of cellular activity and protein level of protein kinase FA/GSK-3α correlates with human thyroid tumor cell dedifferentiation. (connsante.com)
In some cancers, PD-L1 expression by tumor cells correlates with a good prognosis for the patient, whereas in glioblastoma many reports suggest that it is a bad prognostic marker. (jscimedcentral.com)

Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. (nature.com)
Furthermore, macrophages were shown to contribute to a niche that can support and maintain a breast CSC (BCSC) phenotype through heterotypic CD90/EphA4 signaling between macrophage and tumor cell 14 . (nature.com)
Gliomas promote immunosuppression through induction of B7-H1 expression in tumor-associated macrophages. (jscimedcentral.com)
Cysts are encircled by various kinds of immune system cells, including M2-like macrophages and cytotoxic T (Compact disc8+) and helper T (Compact disc4+) cells, aswell as cells of non-immune origin, such as for example interstitial/stromal cells (4). (baxkyardgardener.com)

ATC is believed to occur from a terminal dedifferentiation of previously undetected long-standing thyroid carcinoma (eg, papillary, follicular). (medscape.com)

The tumor phenotype in mice takes eight weeks to develop from the H-Ras and shp53 model. (genengnews.com)
However, the loss of NF1 and p53 takes up to seven months to develop the tumor phenotype. (genengnews.com)
The tumor phenotype is revealed when mice appear lethargic and have an enlarged head. (genengnews.com)
Schwannoma cells lose the characteristic bipolar, spindle morphology and assume a round fibroblast-like phenotype. (ucf.edu)
The analysis also identified molecules whose expression was associated with dedifferentiation (loss of differentiated phenotype) for some cancer types. (mypharmacynews.com)

Studies have also identified other contender genes and genomic disruptions in human pancreatic exocrine tumors classified patients into different subclasses based on tumor histotypes and cancer-specific chromosomal rearrangements ( 7 - 9 ). (amegroups.org)
Using the Myc-switchable pIns-MycER TAM ;RIP7-Bcl-x L β-cell tumor model in an unbiased reversible kinetic expression analysis, we previously identified genes required for maintenance of Myc-driven β-cell tumors. (life-science-alliance.org)
We found a relatively small subset of Myc target genes whose change in expression (whether induction or repression) was dependent upon sustained Myc activity, and that such changes were reversed by deactivation of Myc and consequent tumor regression. (life-science-alliance.org)
One of these candidate tumor maintenance genes was Fzd9 , a member of the "frizzled" gene family of Wnt receptors ( Lawlor et al, 2006 ). (life-science-alliance.org)
The spectrum of morphological atrophy changes in prostate acini from 5ARI treated patients ending with atrophy correlated with reduced androgen receptor signaling and increased expression of urethral club cell genes including LTF, PIGR, OLFM4, SCGB1A1 and SCGB3A1. (ghenry.info)

The induction of the dedifferentiation occurs only when two hits occur in the same cell: either H-Ras overexpression and loss of p53 or loss of tumor suppressors NF1 and p53. (genengnews.com)
In contrast, promoting lipid-storage capacity in adipocytes through MitoNEET overexpression curbs tumor growth despite greater adiposity. (usda.gov)
In addition, HTR8/SVneo cells overexpressing NLRP7 were used to determine the impact of NLRP7 overexpression on non-tumor cells. (bvsalud.org)
Overexpression of glycogen synthase kinase-3 in ovarian carcinoma cells with acquired paclitaxel resistance. (connsante.com)

Here we show that cell differentiation suppresses tumor formation. (amegroups.org)
Metformin suppresses tumor angiogenesis and enhances the chemosensitivity of gemcitabine in a genetically engineered mouse model of pancreatic cancer. (ac.ir)

This study reveals a previously unrecognized function of EBF2 in regulating PDAC progenitor cell differentiation and tumor suppression. (amegroups.org)

This study was designed to examine the involvement of PATZ1 in carcinogenesis and dedifferentiation of thyroid cancer. (oncotarget.com)
Immunohistochemistry on clinical specimens indicated nuclear PATZ1 expression in all normal thyroid glands and adenomatous goiter, while nuclear PATZ1 expression decreased along with the dedifferentiation of thyroid cancer. (oncotarget.com)
Circulating cell-free DNA, SLC5A8 and SLC26A4 hypermethylation, BRAF(V600E): A non-invasive tool panel for early detection of thyroid cancer. (cdc.gov)

Prespecification and plasticity: shifting mechanisms of cell migration" (PDF). (wikipedia.org)
Although studies have identified unique transcription factors in the selection of normal pancreatic lineages, the cells of origin and molecular mechanisms arbitrating PDAC growth are poorly defined. (amegroups.org)
In this study, we used bioinformatics tools to analyze transcriptome data from cholangiocarcinoma (CCA) patients in multiple datasets (Sun Yat-sen University, TCGA and GSE32225 cohorts) to identify mechanisms that regulate tumor infiltration by immune cells and survival outcomes. (aging-us.com)

Collective cell migration Dedifferentiation Invasion (cancer) Krakhmal, N. V. (wikipedia.org)
The cell invasion rate was also significantly reduced. (bvsalud.org)
Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase‐9 activation through a calcium and protein kinase Cα‐dependent pathway: Phorbol‐12‐myristate‐13‐acetate‐induced/extracellular signal‐regulated kinase/activator protein‐1. (ac.ir)
Multivariate analysis demonstrated worse prognosis with age older than 70 years, white blood cell count of 10,000/μL or more, extrathyroidal invasion, and distant metastases at the time of diagnosis. (medscape.com)

Although once differentiated, cells typically do not change their migration mode, EMTs and CMTs are highly plastic with cells capable of interconverting between them depending on intracelluar regulatory signals and the surrounding ECM. (wikipedia.org)
Drug-based inhibition of CXCR4 using AMD3100 covered up migration and intrusion of BTC cells, and this impact was just visible in the Compact disc24+ CSC subpopulation[50]. (researchhunt.com)
Cells exhibit three distinct modes of migration when invading the 3 D environment. (biomedcentral.com)

In renal cells BPGM modulates glucose utilization, promotes scavenging of reactive oxygen species, as well as cell survival under stress. (charite.de)
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. (jscimedcentral.com)
Liraglutide promotes the angiogenic ability of human umbilical vein endothelial cells through the JAK2/STAT3 signaling pathway. (ac.ir)
The study found that phase separation of FSP1 promotes ferroptosis and led to the development of a new anticancer drug called icFSP1, which sensitizes cancer cells to ferroptosis. (medicaltrend.org)

They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)

The survival outcomes of CCA patients were associated with the TP53 gene mutation status, levels of Oncostatin M (OSM) expression, and the proportions of tumor-infiltrating immune cell types, including dendritic cells, monocytes, and T follicular helper cells. (aging-us.com)

Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D (2016) Extracellular vesicles in cancer: cell-to-cell mediators of metastasis. (springer.com)
The cone dedifferentiation in subtype 2 is associated with stemness features including low immune and interferon response, E2F and MYC/MYCN activation and a higher propensity for metastasis. (nih.gov)
Chemotherapy resistance or tumor metastasis is an important clinical problem in cancer treatment. (medicaltrend.org)

The authors explain in the article that NSD1 mutation has recently been linked in the scientific literature to the blocking of cellular differentiation and the promotion of oncogenesis in this type of tumor. (mypharmacynews.com)
Histologically, the lesions exhibit a lobular growth pattern and are composed of cellular nodules with the classic appearance of SFT, patternless distribution of both oval and spindle shaped cells with uniform spindled nuclei and scant cytoplasm in a variably collagenous stroma and branched, often thick walled, hemangiopericytoma-like vessels ( Ann Diagn Pathol 2018;34:142 ) admixed with adipocyte rich lobules ( Arch Pathol Lab Med 1999;123:941 ). (pathologyoutlines.com)
In this study, we investigated how higher-order chromatin structure modulates differential expression of the human INK4b-ARF-INK4a locus during progenitor cell differentiation, cellular ageing and senescence of cancer cells. (biomedcentral.com)
A cellular process that selectively eliminates cells with mutations from further development through short-range cell-cell interaction. (bvsalud.org)

Cells were transfected with the early B-cell factor-2 (EBF2) to activate progenitor cell differentiation and gauged the tumorigenic potentials of the derived cell subsets. (amegroups.org)
During progenitor cell differentiation and ageing, PcG silencer EZH2 attenuates, causing loss of PRC binding and transcriptional activation of INK4b and INK4a . (biomedcentral.com)

The second model known as hierarchic model state governments that a growth is normally, like solid areas, a hierarchically arranged heterogeneous cell conglomerate in which just a little subset of cells - the CSC - possess the capability to self-renew and to provide rise to little girl cells of several difference, whereas the bulk of cancers cells that form the bulk of the growth cannot obtain CSC features. (researchhunt.com)

It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)
A main factor related to radioresistance is the presence of cancer stem cells (CSC) inside tumors, which are responsible for metastases, relapses, RT failure, and a poor prognosis in cancer patients. (ugr.es)

To develop the methodology, the group analyzed the molecular profiles of human embryonic stem cells and compared them with data for 12,000 samples of 33 different tumor types held by The Cancer Genome Atlas (TCGA ), a US public database. (mypharmacynews.com)

Recently, we have demonstrated that NLRP7 is highly expressed in GC tumor cells and contributes to their tumorigenesis. (bvsalud.org)
Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors. (jscimedcentral.com)
However, whether an additional stem cell population contributes to injury-induced SCs, and how plastic SC fate is during the regeneration process, have remained controversial issues. (silverchair.com)

Prognosis is poor when cancer is advanced or hepatic synthetic function is poor, but for small tumors that are confined to the liver, ablative therapies are palliative and surgical resection or liver transplantation is sometimes curative. (msdmanuals.com)

The immunosuppressive effect of CsA is mainly attributed to inhibition of calcineurin phosphatase activity, consequently favoring the inactive phosphorylated form of nuclear factor of activated T-cells (NFAT). (charite.de)
The research team further studied the potential mechanism of icFSP1 on FSP1, and the results showed that, unlike the previously discovered inhibitor iFSP1, icFSP1 does not competitively inhibit the activity of FSP1 enzymes, but induces the relocation and aggregation of FSP1 from the cell membrane to the cell , synergizes with glutathione peroxidase 4 (GPX4) inhibition. (medicaltrend.org)

The recognition of these two subtypes, one maintaining a cone-differentiated state, and the other, more aggressive, associated with cone dedifferentiation and expression of neuronal markers, opens up important biological and clinical perspectives for retinoblastomas. (nih.gov)

the 5-year patient survival is about 8% ( 1 ) due to the late-stage disease diagnosis, tangible tumor resistance to therapy ( 2 ) and aberrant post-treatment tumor relapse ( 3 ). (amegroups.org)
Cancer cells with healthy mitochondria and high SRC exhibit greater metabolic flexibility and higher resistance to GLUT1 inhibitors. (biomed.news)
Reflection of the medication efflux pump ABCG2 is normally another system of cells to gain healing level of resistance and also an set up CSC gun[46]. (researchhunt.com)
In October 2019, the Marcus Conrad team of Helmholtz Munich Research Center in Germany published a paper in Nature [1] , which identified FSP1 as a new type of potent ferroptosis inhibitor independent of glutathione , through the production of coenzyme Q10 Antioxidant forms of (CoQ) promote cancer cell resistance to ferroptosis. (medicaltrend.org)

however, the tumor growth rate was significantly reduced. (amegroups.org)
Tumor cells closer to 1 were more similar to stem cells and significantly more aggressive than tumor cells closer to 0," Malta said. (mypharmacynews.com)
Moreover, the ratio of nuclear PATZ1 positive tumors was significantly decreased in ATC irrespective of p53 status. (oncotarget.com)

These transformed cells possess different metabolic states, act differently, and help the cancer cells grow. (usda.gov)
Based the dual action of OA in metabolic regulation and mitochondrial dynamics, further results revealed that mitochondrial functional status and spare respiratory capacity (SRC) of cancer cells had a close correlation with mitochondrial metabolic plasticity, and played important roles in the susceptibility to cancer therapy aiming at glucose restriction. (biomed.news)
Thus, inhibiting mitochondrial fusion breaks mitochondrial metabolic plasticity and increases cancer cell susceptibility to glucose restriction therapy. (biomed.news)

Prognosis depends on the stage, histologic subtype or grade, anatomic location of the tumor, tumor size, and the overall treatment regimen used. (medscape.com)
PD-L1 expression by neurons nearby tumors indicates better prognosis in glioblastoma patients. (jscimedcentral.com)

Cell Rep 19, no. 11 (June 13, 2017): 2304-18. (duke.edu)
Cell Rep. 2017 Jun 13;19(11):2304-2318. (duke.edu)

This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)
The tumor cells display a variety of growth patterns such as solid, follicular, microcystic , and papillary cystic . (webpathology.com)
Suppression of proline-directed protein kinase F(A) expression inhibits the growth of human chronic myeloid leukaemia cells. (connsante.com)
Suppression of proline-directed protein kinase F(A) systemically inhibits the growth of human acute leukemia cells. (connsante.com)
Besides these two primary versions, a third feasible beginning of CSC is normally talked about in the reading, specifically de-differentiation of currently dedicated cells - a trend that was noticed in different growth organizations and that is definitely most likely to play a part in biliary system tumor (BTC) as talked about later on in this content[7-10]. (researchhunt.com)
cancer cells lack the presence of Lefty, thus leading to uncontrolled tumor growth. (cusabio.com)
Issazadeh-Navikas S. Alerting the immune system via stromal cells is central to the prevention of tumor growth. (jscimedcentral.com)
Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. (duke.edu)

Three distinct subgroups based on clinicopathologic and cytogenetic features have been identified: well-differentiated/dedifferentiated, myxoid/round-cell, and pleomorphic. (medscape.com)
Toshitaka Nakamura, lead author of the study, further explains that "icFSP1-induced FSP1 condensations require distinct structural components and N-terminal myristoylation" as demonstrated by using recombinant FSP1 proteins as well as different cell lines and tumor samples. (scientistlive.com)

Current Opinion in Cell Biology. (wikipedia.org)
Keep up with the Node 'Lab meeting' posts as the platform regularly highlights development and stem cell biology labs from across the globe and showcases research and researchers from the community. (silverchair.com)

Dinorah Friedmann-Morvinski, a post-doctoral fellow in Inder Verma's lab at the Salk Institute, has shown how tumors originated from mature neurons dedifferentiate into glioma stem-like progenitor cells. (genengnews.com)

Differential tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA /GSK-3α in well and poorly differentiated human prostate carcinoma cells. (connsante.com)

The study focuses on "stemness," defined as the potential for self-renewal and differentiation from the cell of origin, and on "stemness indices" developed during postdoctoral research conducted by Tathiane Malta as part of a project supported by FAPESP and with Houtan Noushmehr, a professor in FMRP-USP's Genetics Department, as principal investigator. (mypharmacynews.com)

2. Viallard C, Larrivée B. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. (ac.ir)

Current knowledge about the most aggressive forms of BC points to the role of specific cells with stem properties located within BC, the so-called "BC stem cells" (BCSCs). (wjgnet.com)
Gestational choriocarcinoma of the ovary is an exceptionally rare and highly aggressive tumor. (bvsalud.org)
This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. (biomedcentral.com)

Treatment efficacy may depend on the presence of glioma stem cells, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype. (nih.gov)
Serial neurosphere culture, multi-lineage differentiation, and orthotopic transplantation were used to assess whether these mutations induced de-differentiation of cortical astrocytes into glioma stem cells. (nih.gov)
Conclusion: A defined set of core signaling pathway mutations induces de-differentiation of cortical murine astrocytes into glioma stem cells. (nih.gov)
Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. (jscimedcentral.com)

On the other hand, removing Compact disc8+ T cells from an ADPKD mouse model or excluding stroma from in vitro PKD organoid ethnicities aggravates cyst development (9, 10). (baxkyardgardener.com)

Here we show that gliomas can originate from differentiated cells in the central nervous system (CNS), including cortical neurons. (cellimagelibrary.org)

Here we show that the brown adipose differentiation gene, EBF2, activates differentiation-associated signals in the cancer progenitor cells in culture and CSC transplantation models. (amegroups.org)
In order to study the transcriptional regulation of IL32 in these cell lines, we cloned up to 10.5 kb of the 5′ upstream region of the human IL32 gene into a luciferase reporter vector. (biomedcentral.com)
In the case of head and neck squamous cell carcinoma, for example, high stemness indices correlated with mutations in the gene NSD1. (mypharmacynews.com)
Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. (life-science-alliance.org)
Using a extensive gene KLF4 antibody evaluation array, Leelawat et al[50] likened the appearance profile of Compact disc24+ and Compact disc24- BTC cells and discovered improved appearance of CXCR4 in the Compact disc24+ subpopulation. (researchhunt.com)
Biodistribution (BD) studies are critical components when assessing the preclinical safety evaluation of cell and gene therapy molecules. (generi-biotech.com)

Cell survival, dedifferentiation, camouflage, and aggressiveness were compared between normal JEG-3 cells or knockdown for NLRP7, JEG-3 Sh NLRP7. (bvsalud.org)
Liu Q , Lan T , Song Y , Cai J , Yu X , Chen W , . Oncostatin M expression and TP53 mutation status regulate tumor-infiltration of immune cells and survival outcomes in cholangiocarcinoma. (aging-us.com)
Our study demonstrates that OSM expression and TP53 mutation status regulate the tumor infiltration by immune cells and survival outcomes in CCA. (aging-us.com)
Prostate luminal cells within atrophied acini also adapted to low DHT conditions by increasing NF-κB signaling and anti-apoptotic BCL2 expression, which may explain their survival. (ghenry.info)

The miR-214 host transcript is usually expressed in stromal cells in the developing kidney and in cells surrounding kidney cysts. (baxkyardgardener.com)

It harbors few genetic alterations other than the initiating RB1 inactivation and corresponds to differentiated tumors expressing mature cone markers. (nih.gov)
By contrast, subtype 2 tumors harbor frequent recurrent genetic alterations including MYCN-amplification. (nih.gov)

The degree and complexity of the interplay among the many cells in the market and the root pathogenic or protecting molecular signals aren't completely known. (baxkyardgardener.com)

These cells can be isolated through the phenotypic markers CD44+/CD24-, expression of ALDH1 and an ability to form nonadherent, multicellular spheres in vitro. (nih.gov)
Using nanoString GeoMx digital spatial profiling, we confirmed that histologically atrophied acini with expressing SCGB3A1 expression displayed higher levels of club cell markers compared to histologically normal, NKX3-1 expressing+ regions that retained prostate identity. (ghenry.info)
All the tumors, irrespective of the site of lentiviral vector injection (the initiating population), shared common features of high expression of stem or progenitor markers and low expression of differentiation markers. (cellimagelibrary.org)

Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis. (cancerindex.org)
It is well known that during the development of multicellular organisms, there are a variety of predetermined and precisely controlled programmed cell death , such as apoptosis (Apoptosis) , programmed necrosis (Necroptosis) , cell death (Pyroptosis) , and iron Death (Ferroptosis) , etc. (medicaltrend.org)

We developed an in vitro model ofNF2 using ad-ere ( ad-Cre) viral mediated deletion of nj2 exon 2 in primary mouse Schwann cells. (ucf.edu)
A panel of esophageal cell lines was examined for the ability of TGF-β1 to induce EMT in vitro . (aacrjournals.org)
Moreover, hypoxia or osmotic stress up-regulate BPGM in kidney cells in vitro. (charite.de)

Anatomy34

Organisms15

Diseases69

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes46

Disciplines and Occupations1

Information Science4

Health Care4

Proliferation29

Microenvironment20

Malignant14

Suppressor9

Progression11

Recurrence7

Anti-tumor3

Tissues10

Inhibiting tumor growth2

CSCs22

Heterogeneity3

Metastatic5

Tissue13

Epithelial4

Mesenchymal6

Melanoma12

Metabolism6

Vivo4

Correlates3

Macrophages4

Terminal dedifferentiation1

Phenotype5

Genes5

Overexpression4

Suppresses tumor2

Differentiation and tumor1

Thyroid3

Mechanisms3

Invasion4

Migration3

Promotes4

Fibroblasts1

Dendritic cells1

Metastasis3

Cellular4

Progenitor cell differentiation2

Cancers1

Poor prognosis2

Different tumor1

Contributes3

Therapies1

Inhibition2

Neuronal1

Resistance4

Significantly3

Metabolic3

Prognosis2

20172

Growth8

Distinct2

Biology2

Mature neurons1

Poorly differentiated1

Self-renewal1

Angiogenesis1

Aggressive3

Glioma4

Cyst1

Gliomas1

Gene6

Survival4

Stromal cells1

Genetic alterations2

Interplay1

Markers3

Apoptosis2

Vitro3