AnatomyOrganismsPhenomena and Processes
Notophthalmus viridescensSalamandridaeExtremitiesRegenerationCell DedifferentiationTriturusAmbystoma mexicanumUrodelaAnimal FinsAmbystomaCell DifferentiationTurbellariaLimb BudsForelimbNotophthalmusTailPlanarians
Amphibian limb regenerationXenopusUrodeleRegenerationZebrafishAmputationMolecularTailWoundCellsGenesCellTypeFormSalamandersRegenerateRegrowVertebratesRegeneration occursAmputationsAdultNervesTissuesIntermediateMammalsNerveTissueFormationLostPromote
Amphibian limb regeneration1
Xenopus6
  • The upregulation of chaperone genes has been reported in other studies of regenerating newt and axolotl limbs, Xenopus stage 52 hindlimbs, and zebrafish fins. (atpasesignaling.com)
  • Interestingly, in Xenopus limb buds rendered regeneration deficient by heat shock induced expression of transgenic noggin, chaperone gene expression is not really maintained since it is in wild style buds. (atpasesignaling.com)
  • Xenopus tadpoles can regenerate their tails, limb buds and the lens of the eye, although the ability of the latter two organs to regenerate diminishes with advancing developmental stage. (biomedcentral.com)
  • Activation of this transgene blocks regeneration of the tail and limb of Xenopus tadpoles. (biomedcentral.com)
  • Gene over-expression analyses in Xenopus limb and tail regeneration have indicated that successful regeneration requires the re-activation of developmental FGF or BMP signalling pathways [ 8 - 12 ]. (biomedcentral.com)
  • We examined the bioelectric properties (resting potential gradients in the epidermis) of Xenopus laevis froglets undergoing hindlimb amputation and observed that the contralateral (undamaged) limb exhibits apparent depolarization signals immediately after the opposite hindlimb is amputated. (biologists.com)
Urodele2
  • Glial Growth Factor and nerve-dependent proliferation in the regeneration blastema of urodele amphibians. (wikipedia.org)
  • Beyond this, little is identified concerning the molecular mechanism of dedifferentiation from the regener ating urodele limb. (atpasesignaling.com)
Regeneration10
  • He investigated cellular interactions in the mammalian peripheral nervous system, and the mechanisms underlying limb regeneration in salamanders. (wikipedia.org)
  • His work on limb regeneration included studies on dedifferentiation, nerve dependence of regeneration, positional identity, senescent cells, and regeneration as an evolutionary variable. (wikipedia.org)
  • Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate.Science 330, 485-490 (2007). (wikipedia.org)
  • Nevertheless, 3 on the four transcription component genes used to reprogram mammalian grownup somatic cells to pluripo tency are upregulated all through blastema forma tion in regenerating newt limbs, as well as all through lens regeneration. (atpasesignaling.com)
  • Epimorphic regeneration is the process by which complete regeneration of a complex structure such as a limb occurs through production of a proliferating blastema. (biomedcentral.com)
  • Furthermore, the underlying mesenchyme remains rounded and does not expand to form a cone shaped blastema, a normal feature of successful regeneration. (biomedcentral.com)
  • While all vertebrates are capable of some types of tissue regeneration, most, including humans, have lost the ability to regenerate whole structures such as limbs ( epimorphic regeneration ), [ 1 ]. (biomedcentral.com)
  • We have used this line to show that BMP function is not only required for appendage regeneration but that it is specifically needed to generate a proliferating blastema while being dispensable for wound healing [ 12 ]. (biomedcentral.com)
  • This is an intermediate kind of regeneration without undergoing dedifferentiation. (pw.live)
  • Neurons release some trophic factors which may either act as stimulatory or as inhibitory factors in limb regeneration. (pw.live)
Zebrafish1
  • Using Affymetrix Gene Chip analysis, we have identified genes linked to regenerative success downstream of BMP signalling, including the BMP inhibitor Gremlin and the stress protein Hsp60 ( no blastema in zebrafish). (biomedcentral.com)
Amputation2
  • The wound epithelium of N1 transgenic hindlimb buds, which forms over the cut surface of the limb bud after amputation, does not transition normally into the distal thickened apical epithelial cap. (biomedcentral.com)
  • N1 transgenic hindlimbs, which do not regenerate, do not form an apical epithelial cap or cone shaped blastema following amputation. (biomedcentral.com)
Molecular1
  • The molecular characteri zation of blastema cell surface antigens and study of the regulation of dedifferentiation by transcription variables, microRNAs, polycomb proteins and chromatin modify ing enzymes is going to be essential for comprehending the mecha nism of dedifferentiation in regenerating amphibian limbs. (atpasesignaling.com)
Tail1
  • Both in limb and tail the progenator of mesenchyme is the blastema formed by dedifferentiation, their division is controlled by nerve and wound epidermis. (pw.live)
Wound1
  • Once the wound is healed, the cells of the stump must mobilise under the wound epidermis and begin the process of replacing lost tissues, by forming a proliferating blastema. (biomedcentral.com)
Cells3
  • Dedifferentiation Dedifferentiation happens in conjunction with the libera tion of cells from their tissue matrix by protease induced histolysis. (atpasesignaling.com)
  • Nuclear transplantation studies and ectopic grafting experi ments have proven that blastema cells are certainly not repro grammed to pluripotency. (atpasesignaling.com)
  • In sponges, archaeocytes perform this function, but other cells can also do so by undergoing dedifferentiation. (pw.live)
Genes1
  • reported the upregulation of two genes connected with combating cell strain in regenerating axolotl limbs at four dpa. (atpasesignaling.com)
Cell2
  • Newt myotubes re-enter the cell cycle by phosphorylation of the retinoblastoma protein. (wikipedia.org)
  • Hence it can be possible that LIN28 may perform a part from the selleckchem transcriptional regulation of nuclear reprogramming dur ing limb cell dedifferentiation. (atpasesignaling.com)
Type1
  • The pattern of depolarization matches that of the amputated limb and is correlated to the position and type of injury, revealing that information about damage is available to remote body tissues and is detectable non-invasively in vivo by monitoring the bioelectric state. (biologists.com)
Form2
  • involves dedifferentiation to form undifferentiated mass of tissue. (pw.live)
  • This is called as blastema or bud (callus in plant) which then redifferentiate to form the lost part controlled by neuronal and hormonal factors. (pw.live)
Salamanders4
  • Some lower order vertebrates such as salamanders and newts are able regrow severed limbs through a process called e pimorphic regeneration . (nih.gov)
  • Some lower order vertebrates such as salamanders and newts have the ability to regrow severed limbs through a process called epimorphic regeneration. (nih.gov)
  • He investigated cellular interactions in the mammalian peripheral nervous system, and the mechanisms underlying limb regeneration in salamanders. (wikipedia.org)
  • Urodele amphibians (eg, salamanders and newts) can regenerate complex tissues that are identical to the original in both appearance and function. (medrego.com)
Regenerate2
  • This initiative addresses an aspirational goal in the NICHD Strategic Plan titled ' advancing the ability to regenerate human limbs by using emerging technologies to activate the body's own growth pathways and processes' . (nih.gov)
  • The current state of the science suggests that focused investment in research on key aspects of epimorphic regeneration is necessary for developing strategies to regenerate limbs in higher vertebrates and mammals including humans. (nih.gov)
Regrow1
  • Aside from being used to generally describe any number of specific healing processes, regeneration also is a specific method of healing that is noted for its ability to regrow lost limbs, severed nerve connections, and other wounds that mammals cannot heal. (academickids.com)
Vertebrates3
  • The primary focus is on gaining insight into the body's own growth regulatory networks and processes that can be manipulated to promote limb regeneration in vertebrates including in mammals that might otherwise lack the capacity for regeneration. (nih.gov)
  • As a first step towards this goal, this announcement seeks to promote transformative basic research in animal models to identify key regulatory mechanisms that can be manipulated to drive limb regeneration in higher vertebrates (including in mammals) that might otherwise lack the capacity for regeneration. (nih.gov)
  • In summary, to directly address an aspirational goal of the NICHD Strategic Plan, the proposed initiative is primarily focused on gaining insight on the body's own growth pathways and processes that can be manipulated to promote limb regeneration in higher vertebrates (including mammals) that might otherwise lack the capacity for regeneration. (nih.gov)
Regeneration occurs1
  • Epimorphic regeneration occurs through the formation of a blastema, a process that includes dedifferentiation, trans-differentiation, migration of adult stem cells to the site of injury and other morphogenetic events that allow proper tissue growth and patterning. (nih.gov)
Amputations1
  • Additionally, an estimated 1.6 million people (2005 data) are living with limb injury or disease induced amputations and the number is expected to double by 2050. (nih.gov)
Adult2
  • Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate.Science 330, 485-490 (2007). (wikipedia.org)
  • The entire process takes around 3 month in the adult - and the limb becomes fully functional. (academickids.com)
Nerves1
  • This blastema then reforms into all the components of the missing limb: bone, muscle, nerves, and blood vessels. (medrego.com)
Tissues1
  • Regeneration is the ability to restore lost or damaged tissues, organs or limbs. (academickids.com)
Intermediate1
Mammals1
  • Unlike typical mammals, which heal wounds by forming a scar, these mice begin by forming a blastema, a structure associated with rapid cell growth and de-differentiation as seen in amphibians. (eurekalert.org)
Nerve3
  • His work on limb regeneration included studies on dedifferentiation, nerve dependence of regeneration, positional identity, senescent cells, and regeneration as an evolutionary variable. (wikipedia.org)
  • If the processes behind regeneration are fully understood, it is believed this would lead to better treatment for individuals with nerve injuries, broken backs, paralysis, and missing limbs. (academickids.com)
  • Both in limb and tail the progenator of mesenchyme is the blastema formed by dedifferentiation, their division is controlled by nerve and wound epidermis. (pw.live)
Tissue3
  • In another, injection of a solution of tissue taken from a newt's blastema into a rat's wound duplicated many of the elements of dedifferentiation. (academickids.com)
  • Much like a newt that has lost a limb, these mice will replace missing or damaged tissue with healthy tissue that lacks any sign of scarring," said the project's lead scientist Ellen Heber-Katz, Ph.D., a professor in Wistar's Molecular and Cellular Oncogenesis program. (eurekalert.org)
  • involves dedifferentiation to form undifferentiated mass of tissue. (pw.live)
Formation1
  • At the same time, pattern formation genes - such as Hox A and HoxD - are activated as they were when the limb was formed in the embryo. (academickids.com)
Lost2
  • 1 gene lost = 1 limb regained? (eurekalert.org)
  • This is called as blastema or bud (callus in plant) which then redifferentiate to form the lost part controlled by neuronal and hormonal factors. (pw.live)
Promote1
  • The purpose of this Funding Opportunity Announcement (FOA) is to promote transformative basic research on limb regeneration using animal models. (nih.gov)