Decreases integrin alpha4beta1. Medical search. Frequent questions

Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)

Snake disintegrins inhibit the binding of ligands to integrin receptors. (embl.de)

The CrkL-induced increase in cell adhesion was blocked by antibodies against VLA-4 (alpha4beta1) and VLA-5 (alpha5beta1) but was observed without changes in surface expression levels of these integrins. (nbrp.jp)

The ex vivo expression of CNS-related integrins (α4β1 and α L subunit of LFA-1) and the gut-related integrin (α4β7) was assessed using flow cytometry on CD4 + and CD8 + T cells. (neurology.org)
An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (lookformedical.com)

Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)
A decrease in the level of tumor necrosis factor α and the expression of inducible nitric oxide synthase as well as a (possibly) preserved mitochondrial redox status have also been noted as a result of exogenous melatonin treatment (39). (ectrx.org)
RESULTS: Endothelial expression of E-selectin, VCAM-1, ALCAM, ICAM-1, VLA-4, and β4 integrin was markedly increased early in tumor seeding. (ox.ac.uk)

Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
Integrin mediated cellular adhesion is dynamic process that is both indicative of and influenced by cell status. (thno.org)
CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G. (nbrp.jp)
On the other hand, a dominant negative mutant of H-Ras or that of Raf-1 enhanced the basal and CrkL-induced cell adhesion and that of R-Ras modestly decreased the adhesion. (nbrp.jp)

Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)

Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
Integrin ligation via cell-to-cell and cell-to-matrix contacts transduces intracellular signaling events in a process called 'outside-in' signaling (Fig. 2 ). (thno.org)
Integrin receptors are involved in cell-cell and cell-extracellular matrix interactions, serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in thrombosis and haemostasis. (embl.de)

Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
The biodirectional nature of integrin mediated signaling allows both extra- and intracellular cues to regulate activation [ 4 ] (Fig. 1 ). (thno.org)
Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)
Intracellular signals that result in integrin activation are referred to as 'inside-out' signaling events. (thno.org)
The presence of manganese partially restored the binding of these T cells to VCAM-1 in vitro, suggesting that FTY interferes with integrin activation. (neurology.org)

Cytokine screening revealed overall decreased secretion levels of insulin-like growth factor binding protein 2 (IGFBP2), CD147 (basigin) and CD31 (PECAM-1) as well as elevated levels of interleukin 5 (IL-5) and interferon gamma (IFNγ) in response to checkpoint inhibitor treatment. (uni-luebeck.de)

Intracellular signaling events that converge on the cytoplasmic domain of integrin tails are also capable of activating the high affinity state. (thno.org)

Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. (thno.org)
Strikingly, the binding of α4β1 + , α4β7 + , and to a lesser extent of α L high T cells to VCAM-1, MAdCAM-1, and ICAM-1, respectively, was decreased at month 12 under FTY treatment. (neurology.org)

Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. (embl.de)

After 12 months, DMF induced a decreased frequency of α L high CD4 + T cells combined with reduced binding to ICAM-1. (neurology.org)
By contrast, with FTY, there was a doubling of the frequency of α4β1 + and α L high , but a decreased frequency of α4β7 + T cells. (neurology.org)

11. Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine. (nih.gov)

Thus, we have identified a novel signaling mechanism activating PKA in diabetes (downregulation of an inhibitory regulatory subunit) that leads to deficits of circulating EPCs and impaired vascular repair, which could be reversed by α4-integrin mutation. (nih.gov)

In an acute myeloid leukemia (AML) model, several identified compounds reduced cAMP efflux, appropriately modulated pathways that are responsive to cAMP elevation (cAMP-responsive element-binding protein phosphorylation, and deactivation of Very Late Antigen-4 integrin), and induced mitochondrial depolarization and caspase activation. (unm.edu)

13. Role of decreased production of interleukin-10 and interferon-gamma in spontaneous apoptosis of B-chronic lymphocytic leukemia lymphocytes in vitro. (nih.gov)
May play a role in membrane transport and/or integrin dependent signal transduction. (cusabio.com)
Here, we present clinical and experimental evidence to clarify the role of the integrin β-like 1 (ITGBL1) as a key contributor to bone metastasis of breast cancer. (aacrjournals.org)

CD47 expression is decreased on the surface of erythrocytes in obese subjects. (cusabio.com)