Decreases bone. Medical search. Frequent questions

This new, long-term follow-up of bone mineral density sheds significant new light on osteoporosis and bone research, and also changes our understanding of bone loss in older women," Professor Heikki Kröger from the University of Eastern Finland says. (uef.fi)
In conclusion, if controlled interventions will confirm our findings that an exercise-induced bone gain can be well maintained with decreased activity and that the maintenance of the bone gain is independent of the starting age of activity, exercise can be recommended for preventing osteoporosis and related fractures. (nih.gov)
Osteoporosis is a condition that affects bone density. (healthline.com)
Osteoporosis is a major health care problem that is characterized by a loss of bone mass that can lead to pain, immobility, and fragility fractures that, in turn, result in increased mortality ( WHO Scientific Group Meeting on Prevention and Management of Osteoporosis, 2004 ). (frontiersin.org)
To circumvent the slow progress of human osteoporosis and the manifold confounding factors associated with human studies, we here turned to a mouse model in order to compare various treadmill training regimens for their propensity to prevent osteoporosis-associated bone loss. (frontiersin.org)
Insufficient mineralization of the skeleton during growth leads to reduced peak bone mass and an increased risk of osteoporosis and fractures later in life. (gu.se)
Bone-targeting ZBTB16 overexpression had a therapeutic effect on the decreased bone density and remodeling capacity of Brd4 fl/fl Prx1 -cre mice and osteoporosis (OP) models. (nature.com)
Dysregulation of SE-mediated ZBTB16 expression leads to osteoporosis, and bone-targeting ZBTB16 overexpression is efficient in accelerating bone repair and treating osteoporosis. (nature.com)
Osteoporosis is a bone disease that occurs when the mass and density or formation and strength of bones are low. (medicalnewstoday.com)
The immune system may play a role in bone formation, and autoimmune disorders may increase a person's risk of developing osteoporosis. (medicalnewstoday.com)
Osteoporosis is a bone condition, not an autoimmune condition. (medicalnewstoday.com)
They noted that several autoimmune disorders, including rheumatoid arthritis, have a link to osteoporosis, due to inflammatory cells directly or indirectly affecting bone formation. (medicalnewstoday.com)
People assigned as female at birth generally have smaller bones with less mass, increasing the risk of osteoporosis. (medicalnewstoday.com)
People with slender, thin bones have an increased risk of osteoporosis. (medicalnewstoday.com)
They note that both autoantibodies and inflammation may contribute to bone formation and density changes, which can lead to osteoporosis. (medicalnewstoday.com)
Osteoporosis is a bone condition. (medicalnewstoday.com)
We hypothesized that the increased bone turnover in osteoporosis also is a major cause of vertebral fractures because of its adverse effects on the microarchitecture of the vertebrae and, thus, that normalization of bone turnover by antiresorptive drug therapy will decrease VFR substantially. (elsevierpure.com)
Riggs, BL, Melton, LJ & O'Fallon, WM 1996, ' Drug therapy for vertebral fractures in osteoporosis: Evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy ', Bone , vol. 18, no. 3 SUPPL. (elsevierpure.com)
The study examines how various dietary patterns, beyond the Mediterranean diet, influence osteoporosis and fracture risk in older adults, emphasizing the importance of both diet and exercise in bone health. (news-medical.net)
BACKGROUND: Prolia is a prescription medicine approved in June 2010 to treat postmenopausal women with osteoporosis at high risk for bone fracture. (medlineplus.gov)
Prolia was later approved to treat men with osteoporosis, glucocorticoid induced osteoporosis, bone loss in men receiving androgen deprivation therapy for prostate cancer and in women receiving aromatase inhibitor therapy for breast cancer. (medlineplus.gov)
end of menstrual periods) who have an increased risk for fractures (broken bones) or who cannot take or did not respond to other medication treatments for osteoporosis. (medlineplus.gov)
Osteolysis/osteoporosis, induced by multiple myeloma (MM), are characterized by severely imbalanced uncoupled bone remodelling due to increased osteoclastogenesis and suppressed osteoblast differentiation occurring close to MM cell infiltration. (unimore.it)
Iliac crest biopsies were taken from 34 patients with MM (52% of which displayed osteolytic bone lesions), 10 with monoclonal gammopathy of uncertain significance (MGUS) and 10 without haematological malignancies/osteoporosis/metabolic bone diseases. (unimore.it)
Follow along on our year-long guide to Osteoporosis, an exploration of the latest recommendations and research on diagnosis, treatment, and management of this bone disease that is the major cause of fractures in postmenopausal women and in older men. (medpagetoday.com)
Osteoporosis is caused by decreases in bone mineral density and bone mass, or changes in bone structure or strength. (medpagetoday.com)
IGF-binding protein-5 (IGFBP-5) is abundant in serum and bone during normal skeletal development, but levels decrease in osteoporosis. (westminster.ac.uk)
The decision to include assessments of bone density in the survey was based on the recognition of the growing problem of osteoporosis, or decreased bone mass. (cdc.gov)
The low bone mass that characterizes osteoporosis causes an increased susceptibility to spontaneous or a traumatic bone fracture. (cdc.gov)
Bone mass can decrease without symptoms for a significant period of time before fracture occurs, and since fracture is the main clinical sign of the disease, many clinicians and researchers limit the definitions of osteoporosis to the presence of an atraumatic fracture. (cdc.gov)
Estimates of low bone density derived from NHANES III data will offer unique information regarding bone loss and osteoporosis. (cdc.gov)
The osteoporosis component will also include assessment of risk factors for low bone mass and for falling, since both are related to the occurrence of osteoporotic hip fractures. (cdc.gov)
More than one half of persons 50 years and older are affected by osteoporosis, and an additional 34 million persons in the United States have an increased risk of osteoporosis because of low bone mass. (aafp.org)
The occurrence of fragility fractures and the finding of low bone mineral density (BMD) help to diagnose osteoporosis. (aafp.org)
There is good evidence to support treating persons with osteoporosis to prevent continued bone loss and reduce the risk of fracture. (aafp.org)
Risk is increased in women with lower body weight, and in those who smoke, have lost weight, have a family history of osteoporosis, have decreased physical activity, use alcohol or caffeine, and have low calcium and vitamin D intake. (aafp.org)
Questions for Neda Sarafrazi, Health Statistician and Lead Author of " Osteoporosis or Low Bone Mass in Older Adults: United States, 2017-2018 . (cdc.gov)
Osteoporosis is the most common bone disease characterized by weakening of bone tissue, bone structure and strength and may lead to increased risk of fractures. (cdc.gov)
Monitoring the prevalence of osteoporosis and low bone mass may inform public health programs that focus on reducing or preventing of osteoporosis and its consequences. (cdc.gov)
Do you have a 2017-2018 estimate of exactly how many Americans aged 50 and over have osteoporosis and low bone mass? (cdc.gov)
ABSTRACT To test the hypothesis that regional fat and not total body weight has a protective effect on bone mineral density (BMD) in postmenopausal women, a cross-sectional study was conducted during the period from March 2008 to June 2009 on 303 healthy postmenopausal women presenting to the osteoporosis unit for screening purposes. (who.int)

We found that LIGHT was overproduced by CD14+ monocytes, CD8+ T-cells and neutrophils of peripheral blood and bone marrow (BM) from MM-bone disease patients. (unifg.it)
This work studied the proliferation capacity of mesenchymal stem cells isolated from human bone marrow in function of donor's age. (foreverlabs.com)
In conclusion, this study showed an effect of donor's age on the proliferation capacity of mesenchymal stem cells isolated from bone marrow that was correlated to a decrease in clonogenicity. (foreverlabs.com)
Talquetamab-tgvs is used to treat multiple myeloma (a type of cancer of the bone marrow) that has returned or that did not respond to at least 4 other treatments. (medlineplus.gov)
Ganciclovir can decrease bone marrow function. (webmd.com)
Sternal bone marrow fat decreased. (foresight.org)
For example, it can cause bone marrow not to produce enough red blood cells, which can lead to anemia. (cdc.gov)
Benzene causes harmful effects on the bone marrow and can cause a decrease in red blood cells, leading to anemia. (cdc.gov)
Animal studies have shown low birth weights, delayed bone formation, and bone marrow damage when pregnant animals breathed benzene. (cdc.gov)
topenia and hypocellular bone marrow [ 2 ]. (who.int)
On examination, she was found to have induce or aggravate bone marrow hypopla- pallor. (who.int)
Bone marrow aspi- she delivered vaginally a healthy male baby rate and trephine biopsy were markedly weighing 2050 g with good Apgar scores. (who.int)
The etiology is uncertain, and the main complaint was of general weakness treatment of choice, bone marrow trans- and easy bruising. (who.int)
In vitro effects of benzene metabolites on mouse bone marrow stromal cells. (cdc.gov)
The effects of benzene (71432) metabolites on bone marrow stromal cells were investigated in-vitro. (cdc.gov)
Bone marrow cell suspensions were prepared from male B6C3F1-mice and cultured with hydroquinone (123319), benzoquinone (106514), catechol (120809), phenol (108952), and 1,2,4-benzenetriol (533733) at concentrations from 0.0000015 to formed in the presence of these metabolites was determined and compared with values from untreated stromal cell cultures. (cdc.gov)
Stromal cells exposed to metabolites at these same concentrations were also cultured simultaneously with fresh bone marrow cells in agar to measure the effect on the ability of stromal cells to support growth of granulocyte monocyte colony forming cells. (cdc.gov)
The authors conclude that benzene metabolites are toxic to mouse bone marrow stromal cells in-vitro. (cdc.gov)

Testosterone helps produce and strengthen bone, so males with low testosterone, especially older men, may have lower bone volume and be more susceptible to bone fractures. (healthline.com)
The significant decrease in BMD and low levels of vitamin D documented in the present cohort, along with the risk for pathologic fractures reported in adult individuals with CS, testifies the requirement for a preventive treatment to alleviate evolutive complications resulting from dysregulated bone metabolism. (unicatt.it)
Radiographs show short, thick, ribbonlike long bones with multiple fractures and callus formation at all sites (ribs, long bones). (medscape.com)
It can lead to decreased bone strength and an increased risk of fractures. (medicalnewstoday.com)
The conventional belief is that osteopenia is the major cause of vertebral fractures and that drug therapy must induce a substantial increase in vertebral bone mineral density (BMD) before the vertebral fracture rate (VFR) is decreased. (elsevierpure.com)
Simple strategies to strengthen your bones, implemented by the whole community not just those at higher risk, could lead to a substantial decrease in hip fractures, a new Australian study suggests. (news-medical.net)
Since the proportion of persons over 65 years of age is projected to increase from 11 to 22 percent in the next 70 years, the extent of problems associated with hip fractures is not likely to decrease in the future. (cdc.gov)
However, not all osteoporotic individuals suffer atraumatic fractures, and the association between bone mass and fracture incidence has yet to be clearly defined. (cdc.gov)

Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. (ebi.ac.uk)
Prolia works by blocking a protein called RANK (receptor activator of nuclear factor kappa beta) and helps prevent bone cells called osteoclasts from breaking down bone in the body. (medlineplus.gov)
Increased Osteoblasts, and Decreased Osteoclasts. (tamu.edu)
Importantly, tibias from these mice had 37% more osteoblasts, 26% fewer osteoclasts as well as 36% and 40% higher mineral apposition and bone formation rates, respectively. (tamu.edu)
We conclude that GC-B-dependent bone formation is coupled to an early juvenile process that requires both increased osteoblasts and decreased osteoclasts. (tamu.edu)

SGLT2i may alter renal tubular phosphate reabsorption and are associated with increased serum concentrations of phosphate, fibroblast growth factor-23 (FGF-23), parathyroid hormone (PTH), decreased 1,25-hydroxyvitamin D levels, as well as increased bone turnover. (lww.com)

In BMN-111 injected mice, tibial mRNAs for Rank ligand and osteoprotegrin were increased and decreased, respectively, whereas sclerostin mRNA was elevated 400-fold, consistent with increased osteoclast activity and decreased osteoblast activity. (tamu.edu)
Using a recently developed human osteoblastic cell line (hFOB/ER9) with high levels (approximately 4,000 per nucleus) of estrogen receptors and the characteristic phenotype of the mature osteoblast, we tested the hypothesis that estrogen decreases bone formation by inhibiting the action of the insulin-like growth factor (IGF) paracrine/autocrine system. (elsevierpure.com)

Physical exercise is considered to delay bone loss associated with post-menopausal estrogen deficiency in women. (frontiersin.org)
Estrogen therapy decreased the bone turnover rate to normal and eliminated the relationship between VFR and bone turnover, whereas the inverse relationship with vertebral BMD persisted. (elsevierpure.com)
Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4. (elsevierpure.com)
ICI 182,780, a pure anti-estrogen, completely blocked E2-mediated decreases in cell proliferation and increases in levels of IGFBP-4 mRNA and protein. (elsevierpure.com)
This action may mediate, at least in part, the decreases in bone formation that are observed after estrogen treatment in vivo. (elsevierpure.com)
Dive into the research topics of 'Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4. (elsevierpure.com)

While decreased bone mineralization has been documented in other RASopathies, such as neurofibromatosis type 1 and Noonan syndrome, systematic studies investigating bone mineral density (BMD) are lacking in CS. (unicatt.it)
Several diseases can result in disorders of bone mineralization, which can be defined as the process by which osteoid becomes calcified. (medscape.com)

It also increases blood glucose levels by reducing glucose uptake in muscle and adipose tissue, decreasing protein synthesis, and increasing the breakdown of fats into fatty acids. (wikipedia.org)
GC-B7E/7E mice that express a GC-B mutant that cannot be inactivated by dephosphorylation exhibit increased CNP-dependent GC-B activity, which increases bone length, as well as bone mass and strength. (tamu.edu)
Importantly, how GC-B increases bone mass is not known. (tamu.edu)

NHANES III will provide the first reference data on bone density from a nationally representative sample and will permit an examination of bone mineral density in black and Hispanic population subgroups, for whom prevalence of low bone mass is poorly defined. (cdc.gov)
27.3 kg/m2 and obese prevalence of low bone mass is higher ergy X-ray absorptiometry (DEXA). (who.int)

Results from a study published in the American Journal of Human Biology suggest that the COVID-19 pandemic has had negative effects on bone tissue-;including both bone mineral density in the forearm and total bone mineral content. (news-medical.net)
In addition, bone loss occurs at different rates in different types of bone, so it is possible for individuals to have bone loss in the spine, but normal bone density in the forearm. (cdc.gov)

To test the hypothesis that IGFBP-5 promotes the acquisition of bone mineral density (BMD), we generated transgenic (Tg) mice overexpressing Igfbp5 using a cytomegalovirus enhancer and β-actin promoter (CMV/βA). (westminster.ac.uk)

Through numerical simulations we demonstrate that our model can be used to explore theoretically many of the qualitative features of the role of osteocytes in bone biology as presented in recent literature. (ebi.ac.uk)
The aim of this study is to investigate the eventual involvement of osteocytes in bone remodelling alterations occurring in MM patients. (unimore.it)

To assess the relationship of VPA to bone mass and calcium metabolism in 40 adults with epilepsy on long-term VPA monotherapy, 40 age- and sex-matched epileptic patients taking phenytoin (PHT), and 40 healthy control subjects. (neurology.org)
Testosterone is a hormone that can affect appearance and sexual development, stimulate sperm production and sex drive , and help build muscle and bone mass. (healthline.com)
Males with low T may notice a decrease in muscle mass. (healthline.com)
Bone mass is aquired during childhood and adolescence, with peak bone mass reached between the ages of 20 and 30. (gu.se)
Inadequate nutrition can negatively impact bone mass and growth. (gu.se)
Figure 3, page 10 in the thesis: Bone mass throughout life. (gu.se)
It occurs when bone mineral density and mass decrease or when the structure or quality of bone changes. (medicalnewstoday.com)
Dual energy x-ray absorptiometry (DXA) is the gold standard for assessing bone mass and evaluating fracture risk. (news-medical.net)
This natural slowdown has triggered an interest in using synthetic human growth hormone (HGH) as a way to stave off some of the changes linked to aging, such as decreased muscle and bone mass. (mayoclinic.org)
A 2018 study put a group of overweight Italian women on a 12-week rebounding programme that saw 'significant improvements' in body composition - decreased waist circumferences, decreased fat mass, and increased lean and muscular mass. (acefitness.org)
A technique called dual-energy x-ray absorptiometry was used to perform measures of body composition, including bone mineral density (BMD) and fat mass. (sciencedaily.com)
In addition to its effects on bone mass, GH regulates muscle mass, muscular strength, body composition, lipid and carbohydrate metabolism, and cardiac function. (medscape.com)
Mineral apposition rates and trabecular bone mass were not elevated in response to BMN-111. (tamu.edu)
Because 9-week-old male GC-B7E/7E mice have increased bone mass but do not exhibit increased mineral apposition rates, we examined 4-week-old male GC-B7E/7E mice and found that these animals had increased serum osteocalcin, but not CTX. (tamu.edu)
The distribution of bone density at the hip that is collected in the survey will provide reference data for clinicians and researchers in assessing bone mass in individuals. (cdc.gov)
In the United States, there are 47.6 million people aged 50 years and over with low bone mass (30.7 million women and 16.9 million men). (cdc.gov)
Body mass index (BMI) was the disease may become larger in de- other drugs with known effect on bone calculated as weight (kg)/height (m)². (who.int)

Herein, we investigated whether LIGHT has a role in Multiple Myeloma (MM)-bone disease. (unifg.it)
Decreased osteocyte viability in multiple myeloma patients: osteolytic bone lesions, apoptosis and their potential role in bone remodeling alterations. (unimore.it)

Bone mineral density at the femoral neck bone in postmenopausal women decreased by an average of 10% during a 25-year follow-up, according to a new study from the University of Eastern Finland. (uef.fi)
Being the world's hitherto longest follow-up of changes in bone mineral density in postmenopausal women, the study shows that bone loss after menopause is significantly lower than has previously been assumed on the basis of earlier studies. (uef.fi)

Social isolation may negatively impact bone health, suggests a study conducted in mice being presented Sunday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill. (news-medical.net)

Bone loss and hypovitaminosis D are reported in patients taking antiepileptic drugs, but little is known about changes in bone and calcium metabolism from valproic acid (VPA). (neurology.org)
Blood and urine biomarkers of bone metabolism were also assessed. (unicatt.it)
Safety of SGLT2i with regard to bone and mineral metabolism. (lww.com)
Emerging evidence suggests that SGLT2i may also affect bone and mineral metabolism. (lww.com)
This review analyzes recent evidence on the safety of SGLT2i with respect to bone and mineral metabolism in people with CKD, and discusses potential underlying mechanisms and clinical implications. (lww.com)
Although SGLT2i are associated with abnormalities of bone and mineral metabolism, they have not been linked to a higher risk of fracture among patients with CKD. (lww.com)

In particular, the BMD findings in Paralympic athletes suggest increased density of cortical bone--the thick outer layer of bone, which responds to weight-bearing exercise. (sciencedaily.com)

In osteoporotic women treated with fluoride, VFR decreased as vertebral BMD increased, provided that patients with high (toxic) serum fluoride levels were not included in the comparison. (elsevierpure.com)

The net effect is an increase in the concentration of glucose in the blood, further complemented by a decrease in the sensitivity of peripheral tissue to insulin, thus preventing this tissue from taking the glucose from the blood. (wikipedia.org)

The aim was to exhibit whether a pedicle screw with proximal doubling of the threads (cortical thread) is ahead of a standard conventional threaded pedicle screw in vertebral bodies with low bone quality. (springer.com)
As evident from computer-generated three-dimensional graphic plots of data from osteoporotic women treated with placebo, VFR increased as bone turnover increased or as vertebral BMD decreased. (elsevierpure.com)
Over the range of values in the data set, increased vertebral BMD and decreased bone turnover had approximately equal effects in decreasing VFR. (elsevierpure.com)

however, none of the treadmill training regimens prevented ovariectomy induced bone loss. (frontiersin.org)

J Bone Miner Res. (uef.fi)

Skeletal dysplasias, also known as osteochondrodysplasias, are a heterogeneous group of heritable disorders characterized by abnormalities of cartilage and bone growth, resulting in abnormal shape and size of the skeleton and disproportion of the long bones, spine, and head. (medscape.com)
Contrary to popular opinion, research has shown exercising young horses in mindful moderation decreases the probability of lameness and improves the musculoskeletal development of bone, cartilage, tendons, and ligaments. (msucares.com)

As primary sources of osteoblasts, MSCs show osteogenic functions that are closely associated with bone homeostasis and development. (nature.com)
Histomorphometry revealed that although the bone formation rate and mineralizing surface at the periosteum decreased in Tg mice, they increased at the endosteum, suggesting opposing effects of IGFBP-5 on periosteal and endosteal osteoblasts (by altering proliferation or survival). (westminster.ac.uk)

The present data provide evidence that, similar to what is recently seen in NF1 and NS, bone homeostasis is impaired in CS. (unicatt.it)
In conclusion, our findings for the first time provide evidence for a role of LIGHT in MM-bone disease development. (unifg.it)
However, there is increasing evidence that osteocytes play important roles in the cycle of targeted bone remodeling, in serving as a significant source of RANKL to support osteoclastogenesis, and in secreting the bone formation inhibitor sclerostin. (ebi.ac.uk)
thus, this study provides the first in vivo evidence, by genetic manipulation, for IGF-independent actions of IGFBP-5 in bone function. (westminster.ac.uk)

In cultures of BM samples from patients with bone disease, LIGHT inhibited the formation of CFU-F and CFU-OB as well as the expression of osteoblastic markers including collagen-I, osteocalcin and bone sialoprotein-II. (unifg.it)
Several factors regulate bone formation, with nutrition being a crucial one," says Anna Svedlund, pediatrician at Queen Silvia Children's Hospital. (gu.se)
It also decreases bone formation. (wikipedia.org)
These changes in the immune system may directly affect bone density by altering bone formation. (medicalnewstoday.com)
Moreover, there is also increasing interest in sclerostin, an osteocyte-secreted bone formation inhibitor, and its role in regulating local response to changes in the bone microenvironment. (ebi.ac.uk)
Thus, both formation-stimulating and resorption-inhibiting drugs can substantially decrease VFR but do so by different mechanisms. (elsevierpure.com)
Studies have shown that IGFBP-5 stimulates markers of bone formation by potentiating IGF actions and by IGF-independent actions. (westminster.ac.uk)
At a concentration of 0.00005mol catechol decreased colony formation 40 percent, but greater concentrations had similar effects. (cdc.gov)

High intake of vitamin D is recommended during nutritional treatment for anorexia nervosa, and it is crucial to monitor bone density both early on and in the long term. (gu.se)
The levels of vitamin D decreased in women with severe anorexia nervosa who were hospitalized for nutritional treatment. (gu.se)
Existing scientific data on the effects of vitamin K (VK) on bone health and elucidated the underlying mechanisms. (news-medical.net)
When Prolia is used in these patients, adequate calcium and vitamin D supplementation and frequent blood calcium monitoring, possibly more often than is already being conducted, may help decrease the likelihood or severity of these risks. (medlineplus.gov)

Short stems have been introduced partly to preserve bone in the proximal femur by a more physiological loading of the bone. (lu.se)

A reduction of osteocyte viability (OC-V) was shown in osteoporotic bone. (unimore.it)
Also, because bone density values overlap between normal and osteoporotic individuals, clear criteria for definitions of abnormality have not been established. (cdc.gov)

A logistic eficial effects on bone [2]. (who.int)

the increase of osteocyte death (apoptosis/degeneration) in relation to the presence of bone lesions may represent a triggering event to osteoclast recruitment. (unimore.it)

Here we develop a cell population model of bone remodeling that includes the role of osteocytes, sclerostin, and allows for the possibility of RANKL expression by osteocyte cell populations. (ebi.ac.uk)

It's also really beneficial internally, helping to build bone density and improve lymph flow which flushes the body of viruses, toxins, bacteria, waste and dead cells. (acefitness.org)
For highly trained Paralympic athletes with cerebral palsy, bone mineral density and other measures of body composition are similar to those of able-bodied adults of similar age, reports a new study. (sciencedaily.com)
For highly trained Paralympic athletes with cerebral palsy (CP), bone mineral density and other measures of body composition are similar to those of able-bodied adults of similar age, reports a study in the American Journal of Physical Medicine & Rehabilitation , the official journal of the Association of Academic Physiatrists. (sciencedaily.com)
With advancing age, in both men and women, the body produces decreasing amounts of testosterone over time. (rxlist.com)
While it helps to maintain sex drive, sperm production, pubic hair and body hair, testosterone is also responsible for maintaining muscles and bones. (rxlist.com)
Patients with growth hormone deficiency (GHD) typically have hyperlipidemia, increased body fat, premature atherosclerotic plaques, delayed bone maturation, and impaired cardiac function. (medscape.com)
Overweight indicates excess body weight for a given height from fat, muscle, bone, water or a combination of these factors, whereas obesity is defined as having excess body fat. (who.int)
All scans were performed by regression model was done for detec- more body fat have lower rates of bone trained physicians and analysed by the tion of the independent risk factors resorption (an independent predictor researcher. (who.int)
nificance of individual coefficients in the en, bone mineral status is much more Daily routine calibration was done model was assessed by the Hosmer- closely associated with total body fat using the standard phantom supplied Lemeshow test for goodness of fit and [4] and in a multivariate model total fat by the manufacturer. (who.int)

Patients who develop severe bone, joint and/or muscle pain at any time should contact their doctor. (merck.com)
Muscle and bone-strengthening exercises are also recommended. (newsweek.com)

LIGHT, a TNF superfamily member, is involved in T-cell homeostasis and erosive bone disease associated with rheumatoid arthritis. (unifg.it)
As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and development. (nature.com)

This prospective 5-year follow-up study of 64 adult female racquet sports players and 27 controls assessed the changes in the playing-to-nonplaying arm bone mineral content (BMC) differences to answer three questions: (1) Are training-induced bone gains lost with decreased training? (nih.gov)
The bone mineral content reaches a maximum value during the 30s and then declines beginning in the 40s in women. (active-seti.info)

Surprisingly, BMD decreased in a gender-dependent manner, with Tg male adults affected more severely than Tg females (31.3% vs. 19.2% reduction, respectively, compared with wild-type mice, assessed by dual energy x-ray absorptiometry). (westminster.ac.uk)

a bone resorption marker) associated with either drug significantly exceeded control values. (neurology.org)
Introduction: Previous bone density studies have generally shown bone resorption around both cemented and uncemented total hip arthroplasty (THA) stems. (lu.se)

Osteocytes seem to regulate bone remodelling by different manners including apoptosis. (unimore.it)

Inadequate anchoring of pedicle screws in vertebrae with poor bone quality is a major problem in spine surgery. (springer.com)
Compared to a conventional pedicle screw, the use of a cortical threaded pedicle screw promises superior fatigue load in vertebrae with reduced bone quality. (springer.com)
Radiographs demonstrate thin flattened vertebrae, short ribs, small sacrosciatic notch, extremely short long tubular bones, and markedly short and curved femora (telephone receiver-like appearance). (medscape.com)

Published in Journal of Bone and Mineral Research , the present findings are from the 25-year follow-up. (uef.fi)
During the 1950s and 1970s, many new bone dysplasias were identified based on clinical manifestations, radiographic findings, inheritance patterns, and morphology of the growth plate. (medscape.com)
The new findings in highly trained young adults with CP help in understanding how bone and other physiological systems adapt to exercise training. (sciencedaily.com)

There were also surprisingly few risk factors affecting bone mineral density. (uef.fi)
However, another study found only a nonsignificant decrease in risk for colorectal cancer among people following a vegetarian diet. (healthline.com)
Clinical trials have not demonstrated an increased risk of bone fracture associated with SGLT2i use among patients with CKD with or without diabetes mellitus. (lww.com)
This medication helps control CMV retinitis and decrease the risk of blindness.Valganciclovir is not a cure for CMV disease. (webmd.com)

QRM, Moehrendorf, Germany) to enable subsequent determination of the apparent volumetric bone mineral density (vBMD) in terms of mg calcium hydrogen carbonate per cm 3 . (springer.com)

However, anorexia nervosa patients had lower bone density compared to a control group of healthy young women. (gu.se)
Patients should not stop Prolia treatment without first consulting your health care professional, as stopping may worsen your bone condition. (medlineplus.gov)

Elevated cGMP stimulates long bone growth, and inactivating mutations in CNP or GC-B reduce cGMP, which causes dwarfism. (tamu.edu)

In the simultaneous culture system, stromal cell exposure to hydroquinone and benzoquinone produced dose dependent decreases in granulocyte monocyte colonies. (cdc.gov)

We also observed no negative impacts on their growth or bone density during 24 months of MAD treatment. (gu.se)

High-velocity strides cause the bone to become stronger, and when horses are kept in stalls and undergo training that does not include amounts of high-impact exercise, bones lose strength very quickly. (msucares.com)
Instead, it develops due to decreasing bone density and strength. (medicalnewstoday.com)

Radiographs demonstrate boomeranglike triangular or oval form of the long bones (humeri), absent radii, markedly delayed ossification of phalanges, short femora, and absent fibulae. (medscape.com)

Anatomy53

Organisms3

Diseases27

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Psychiatry and Psychology1

Phenomena and Processes19

Technology, Industry, Agriculture4

Health Care2

Osteoporosis41

Marrow18

Fractures8

Osteoclasts5

Increased bone turnover1

Osteoblast2

Estrogen6

Mineralization2

Increases3

Prevalence of low bone mass2

Density in the forearm2

Hypothesis1

Osteocytes in bone2

Mass17

Multiple Myeloma2

Postmenopausal Women2

Negatively impact bone1

Metabolism6

Cortical bone1

Serum1

Insulin1

Vertebral3

Induced bone loss1

Miner Res1

Cartilage2

Osteoblasts2

Evidence4

Formation8

Vitamin4

Femur1

Osteoporotic2

Effects on bone1

Osteoclast1

Sclerostin1

Body9

Muscle2

Homeostasis2

Mineral content2

Mice1

Resorption2

Regulate bone1

Vertebrae3

Findings3

Risk4

Calcium1

Patients2

Stimulates1

Dependent1

Impacts1

Strength2

Long bones1