Decorin core protein. Medical search. Frequent questions

Fibromodulin is a 42kDa protein of a family of small interstitial leucine-rich repeat proteoglycans (SLRPs). (wikipedia.org)
To acquire a comprehensive understanding of the biological functions of the matrisome and its components, including proteoglycans and glycosaminoglycans (GAGs), in GBM tumorigenesis, and to identify potential biomarker candidates, we studied the alterations of GAGs, including heparan sulfate (HS) and chondroitin sulfate (CS), the core proteins of proteoglycans, and other glycosylated matrisomal proteins in GBM subtypes vs. control human brain tissue samples. (bu.edu)
Proteoglycans are comprised of a core protein and one or more covalently attached glycosaminoglycan (GAG) chains. (openbiochemistryjournal.com)
The major chondroitin sulfate (CS) and dermatan sulfate (DS) proteoglycans are aggrecan, versican, biglycan and decorin. (openbiochemistryjournal.com)
Proteoglycans are complex macromolecules comprised of a core protein and one or more covalently attached glycosaminoglycans (GAG) chains so that structurally they are both proteins and carbohydrates. (openbiochemistryjournal.com)
The spectrum of properties of proteoglycans is determined by both the core proteins and the GAG chains. (openbiochemistryjournal.com)
Proteoglycans-PG (e.g., aggrecan, decorin, biglycan, fibromodulin) share a common characteristic as proteins, since all core protein has special sugar side chains (glycosaminoglycan -GAG). (porcpotlas.hu)
HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)
Proteoglycans (PGs) are complex macromolecules composed of a core protein and covalently linked polysaccharide chain(s) which play a critical role in cell-cell and cell-matrix interactions. (oncotarget.com)
Decorin can be an associate of the tiny leucine-rich proteoglycan (SLRP) family members and is among the most abundant proteoglycans from the interstitial matrix. (imacst.com)
GAGs are usually covalently linked to protein cores to form proteoglycans. (phosphatases.com)

Decorin interacts with collagen via its protein core and influences collagen fibrillogenesis, thus regulating excessive bundle-like aggregation of collagen. (mattek.com)
As skin ages, there is lack of functional decorin, which results in disrupted collagen fibres and in a reduction in the tensile strength of the skin. (mattek.com)
Two tetrapeptide sequences have been identified as the specific binding sites of decorin to collagen fibrils. (mattek.com)
Like decorin, this synthetic tetrapeptide proved, through in vitro tests, to regulate collagen fibrillogenesis and to influence the diameter of collagen fibres, making them thinner and more uniform. (mattek.com)
We compared gene expression of collagen Type I, decorin, and versican including enzymes involved in their metabolism as matrix metalloproteases (MMP-2 and -9) and tissue inhibitory of metalloproteinase (TIMP-1 and -2) using real-time PCR, zymography and FACE analysis. (unisa.it)
We found greater gene expression of proteoglycan core protein decorin and versican, collagen Type I, MMPs and TIMPs in the tendon rupture. (unisa.it)
The two major proteins in the cartilage is collagen and proteoglycan. (porcpotlas.hu)
The primary ECM binding companions are fibrillar collagens (type I, II, III and VI) and decorin shows to are likely involved in the legislation of fibrillogenesis and stabilization of fibrils, and could become a central participant in collagen set up/turnover and therefore tissues homeostasis [8, 9]. (imacst.com)
Helping this, decorin knock-out in mice leads to unusual collagen fibril development and improved collagen degradation [10]. (imacst.com)
Furthermore to playing a job in collagen fibril development in the interstitial ECM, decorin sequesters multiple development factors, such as for example TGF-beta and antagonizes many associates from the receptor tyrosine kinase family members straight, like the epidermal development aspect receptor (EGFR) and insulin-like development aspect receptor I (IGF-IR) [7, 11C14]. (imacst.com)
Collagen is the most ubiquitous and abundant protein in humans. (amboss.com)
It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)
Anti-Collagen Type IV has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted specificities. (rockland.com)
Non-specific cross-reaction of anti-collagen antibodies with other human serum proteins or non-collagen extracellular matrix proteins is negligible. (rockland.com)

Structural diversity of leucine-rich repeat proteins. (embl.de)
The superfamily of leucine-rich repeat proteins can be subdivided into at least six subfamilies, characterised by different lengths and consensus sequences of the repeats. (embl.de)

It shares significant sequence homology with biglycan and decorin. (wikipedia.org)

In the ruptured area, we found increased core protein synthesis but without the normal glycosaminoglycan production. (unisa.it)
The amounts of decorin with both glycosaminoglycan (GAG) and N-linked oligosaccharides were decreased in the AS-C area compared to the AS-N area. (oatext.com)
PGs are characterized by a core protein to which sulphated glycosaminoglycan (GAG) and oligosaccharides are covalently attached as side chains [9]. (oatext.com)
It includes a one covalently attached N-terminal glycosaminoglycan (GAG) string, made up of either chondroitin or dermatan sulfate, and 12 leucine-rich tandem Ipfencarbazone repeats representing the proteins core [4C6]. (imacst.com)

2008). Moreover, data from this same study showed that, while relatively few SNPs were found among 10 different USA300 genomes, genes encoding cell envelope proteins more commonly exhibited high dN/dS ratios (57% of all genes with multiple nonsynonymous substitutions) (Kennedy et al. (dub-signal.com)
In Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, edn 2. (jmolbiochem.com)
5′-aza-dC and/or Trichostatin A resulted in transcriptional upregulation of the genes, suggesting that low expression of ECM components, proteoglycan core proteins and HS biosynthetic system is due to epigenetic suppression in type I cells. (oncotarget.com)
Setting aside sporadic mutations, every somatic cell in the body contains an identical genome with an identical complement of genes, each of which encodes a specific protein. (ernolaszlo.com)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)

Keratin ( / ˈ k ɛr ə t ɪ n / [1] [2] ) is one of a family of structural fibrous proteins also known as scleroproteins . (wikipedia.org)

IL23 aims degradative and known in different similar cellular collagens clock-wise as aciduria, Edition, protein and methionine. (evakoch.com)

Little attention, however, has been paid to glycosylation of the extracellular matrix components that constitute the majority of glycosylated protein mass and presumed biological properties. (escholarship.org)
solid course="kwd-title" Keywords: Decorin, Cathepsin-S, Extracellular matrix, Tumor, Idiopathic pulmonary fibrosis, Serum biomarker Background Idiopathic pulmonary fibrosis (IPF), persistent obstructive pulmonary disease (COPD) and lung tumor are lung pathologies that are seen as a excessive build up of extracellular matrix (ECM) resulting in loss of cells homeostasis and intensifying disease phenotype [1C3]. (imacst.com)

In vitro studies suggest that the multiple functions of decorin are related to both its core protein and its dermatan sulfate chain. (biomedcentral.com)
In addition, the B. burgdorferi surface lipoproteins TSA HDAC cost decorin-binding proteins A and B (DbpA and DbpB) recognize both decorin and dermatan sulfate [43, 51, 52]. (phosphatases.com)
The T/C-28a2 cell line was developed from human chondrocyte cells [69], which were shown to express fibronectin, decorin and dermatan sulfate [70, 71]. (phosphatases.com)

Fibromodulin is a protein that in humans is encoded by the FMOD gene. (wikipedia.org)

Sequence analyses of LRR proteins suggested the existence of several different subfamilies of LRRs. (embl.de)
In recentyears, a number of diverse plant proteins with low sequence similarity toBet v 1 was identified. (embl.de)

An additional adhesin, BBK32 (fibronectin binding protein) is a surface lipoprotein that can bind both fibronectin and GAGs to promote binding of B. burgdorferi to various mammalian cells [41, 53]. (phosphatases.com)

The medical data indicated that degradation of decorin by cathepsin-S can be an important area of the pathology of lung tumor and IPF. (imacst.com)
Elevated ECM redecorating and protease-mediated degradation of ECM protein is normally a well-documented and significant element of cancers pathology and lung fibrosis [1C3, 22]. (imacst.com)
We hypothesize that degradation of decorin may possess biomarker potential in these pathologies as degradation of decorin might inactivate and disrupt its anti-tumor and anti-fibrotic features. (imacst.com)

At least six families of LRR proteins, characterised by different lengths and consensus sequences of the repeats, have been identified. (embl.de)
Eleven-residue segments of the LRRs (LxxLxLxxN/CxL), corresponding to the beta-strand and adjacent loop regions, are conserved in LRR proteins, whereas the remaining parts of the repeats (herein termed variable) may be very different. (embl.de)
Furthermore, the difference in the packing explains why the repeats from different subfamilies never occur simultaneously in the same protein. (embl.de)
The approach used for the prediction of the leucine-rich repeat protein structures can be applied to other proteins containing internal repeats of about 20 to 30 residue in length. (embl.de)

Core proteins determine the cellular location and serve as scaffolds for the GAG chains and the highly ionic chains determine physical properties of tissues and bind factors including growth factors and apolipoproteins. (openbiochemistryjournal.com)
Because of its different ECM proteins binding companions and its own legislation of cell cell and development differentiation, decorin continues to be called as the guardian in the matrix [7] spotting the importance of decorin in tissues homeostasis. (imacst.com)
Furthermore, decreased decorin inside the tumor stroma is normally an unhealthy prognostic aspect of invasive breasts-, lung- and gentle tissues cancers aswell such as myeloma [5, 16C18]. (imacst.com)
Fibrosis is normally seen as a an elevated and disorganized deposition of ECM protein resulting in lack of tissues and body organ function. (imacst.com)
As decorin can be an inhibitor of TGF-beta, many studies have looked into the decorins potential to stop the fibrotic response and decorin shows to reduce tissues fibrosis in kidney and lung in multiple disease versions [19C21]. (imacst.com)
ECM consists of proteins and polysaccharides distributed in many different tissues of the body. (biomedcentral.com)

Decorins capability to modulate several indication transduction pathways provides trained with a valid popularity within cancers and several research have uncovered decorin being a Ipfencarbazone tumor repressor which counteracts tumorigenic and angiogenic development [15]. (imacst.com)
In addition, proteomic profile confirmed that a set of proteins, related to tumor aggressiveness, were positively affected by targeted nanoparticles. (dovepress.com)

The concave face and the adjacent loops are the most common protein interaction surfaces on LRR proteins. (embl.de)
The obvious benefit of this method is that the low sample requirement allows detection of SH2 binding in samples which are difficult to analyze using traditional protein interaction assays. (biomedcentral.com)

RESULTS: Structural comparisons ofrepresentative members of already known protein families structurallyrelated to Bet v 1 with all entries of the Protein Data Bank yielded 47structures with non-identical sequences. (embl.de)
A distance-based phylogenetic treeyielded a classification into 11 subfamilies, nine exclusively containingplant sequences and two subfamilies of bacterial proteins. (embl.de)
These sequences were engineered to generate new tetrapeptides with improved affinity that would present a decorin-like activity. (mattek.com)
A focused library of several candidates was synthesized containing only tetrapeptides that mimicked the binding sequences of decorin. (mattek.com)
Banerjee-Basu S & Baxevanis AD 2002 Predictive Methods Using Protein Sequences. (jmolbiochem.com)

There is a great interest in studying phosphotyrosine dependent protein-protein interactions in tyrosine kinase pathways that play a critical role in many aspects of cellular function. (biomedcentral.com)
An important consequence of reversible phosphorylation of tyrosine residues on proteins is the creation of binding sites for phosphotyrosine recognizing domains such as Src homology 2 (SH2) and phosphotyrosine binding (PTB) domains [ 1 , 2 ]. (biomedcentral.com)
SH2 profiling is a unique proteomic method in which interactions between an array of SH2 domains and protein samples are quantitatively analyzed, thereby defining the functional output of tyrosine phosphorylation. (biomedcentral.com)

These main PG groups are further classified into families according to their gene homology, core protein properties, size, and modular composition. (hindawi.com)

Extending the study, we here characterized other SLRPs of proline/arginine-rich end leucine-rich repeat protein (PRELP), decorin, and biglycan in AS valves. (oatext.com)

The protein has three globular domains, and between the second and third domain expands the long linear protein line covered by negatively charged sugar side chains. (porcpotlas.hu)
Its core protein consists of two globular domains G1 and G3 present in the N-terminus and C-terminus, respectively, plus a central aspect that may carry variable quantity of GAG chains. (translateinthetownships.com)

It can have up to four N-linked keratan sulfate chains attached to the core protein within the leucine-rich region. (wikipedia.org)
PGs, molecules which consist of a protein core that is covalently modified with GAG chains, are distributed both to the ECM "proper" associated with the cell membrane as well as located to intracellular compartment. (hindawi.com)

Lipid uptake occurs through caveolae, plasma membrane invaginations formed by caveolins (CAV) and caveolae-associated protein 1 (CAVIN1). (aacrjournals.org)
Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). (thermofisher.com)
It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. (thermofisher.com)

2015. 1,3-dinitrobenzene induces age-and region-specific oxidation to mitochondria -related proteins in brain. (umich.edu)

Proteomics study identified 88 high stringent differentially expressed proteins comparing the three treatment groups with controls. (dovepress.com)

A decorin fragment was identified in individual knee articular Ipfencarbazone cartilage using previously. (imacst.com)

Aravind L & Koonin EV 1999 Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches. (jmolbiochem.com)

Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. (thermofisher.com)

PG is attached to a long sugar molecule (hyaluronic acid), secured by the link protein. (porcpotlas.hu)

Summary Cathepsin-S degraded decorin could possibly be quantified in serum Ipfencarbazone using the DCN-CS competitive ELISA. (imacst.com)

We also report distinct protein, peptide, and glycopeptide features for GBM subtypes comparisons. (bu.edu)
It was found that the final model of biglycan resembles in structure its template protein bearing a set of distinct parallel β-sheet structure patterns. (jmolbiochem.com)

Moreover, it was recently shown that decorin has antiangiogenic activities [19], although it evokes mitochondrial autophagy (mitophagy) in breast carcinoma cells [20]. (translateinthetownships.com)
Red blood cells infected with the malaria parasite Plasmodium falciparum display a protein, VAR2CSA, which can recognize and bind CSA molecules present on placental cells and in placental blood spaces. (elifesciences.org)
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)

Natural metabolic pathways are dynamically regulated at the transcriptional, translational, and protein levels. (rpi.edu)

By examining changes in various proteins involved in the wound healing response at the cellular level, Segars hopes to understand why the corneas of diabetic patients fail to heal effectively. (bu.edu)
Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. (thermofisher.com)

To accomplish this, the transcriptional unit is preceded by regulatory elements, such as promoters and enhancers, that modulate production of its protein encoding transcript ( Figure 1.2 ). (ernolaszlo.com)

Glucosamine is an aminosugar, and is an important factor in the synthesis of different lipids, proteins and the glucosaminoglycans (GAG). (porcpotlas.hu)
The Core director Dr. Remmer has 24 years of experience directing a Proteomics & Peptide Synthesis Core. (umich.edu)
With the histone of synthesis, the signaling glutamate is to introduce released well nuclear after protein. (evakoch.com)

Therefore, a substitute for decorin would make up for the non-functional decorin that is present as we age. (mattek.com)

with us one can be cytosol proteins, " badenova( 2009) is four primary photoreceptors, the most non-crossover-generating of which chloroplasts release, phosphorylated, and ready ataxia bacterial to a cascade of challenging glycoprotein GTPases. (evakoch.com)

CONCLUSION: The ubiquitous distribution of Bet v 1-relatedproteins among all superkingdoms suggests that a Bet v 1-like protein wasalready present in the last universal common ancestor. (embl.de)

Overall comparison of the model of biglycan to the recently determined x-ray structure of the same protein returns a very low Root Mean Square Deviation (RMSD), which confirms the viability of the model and its reliability as a platform for the study biglycan interactions. (jmolbiochem.com)

Zymography analysis, reflecting expression of enzymatic activity, confirmed the gene expression data at protein level. (unisa.it)
It is important to have a fundamental understanding of how information flows from gene to protein to understand the role of epigenetics in aging. (ernolaszlo.com)

There are 178812 LRR_TYP domains in 76927 proteins in SMART's nrdb database. (embl.de)

They account for the majority of proteins in the ECM , which makes them the most abundant proteins in the human body. (amboss.com)

The complete taxonomic breakdown of all proteins with LRR_TYP domain is also avaliable . (embl.de)

In this study, we aimed to identify and classify all Betv 1-related structures from the Protein Data Bank and all Bet v 1-relatedsequences from the Uniprot database. (embl.de)
Laskowski RA, Rullmannn JA, MacArthur MW, Kaptein R & Thornton JM 1996 AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. (jmolbiochem.com)

Proteoglycans11

Collagen14

Leucine-rich repeat pro2

Biglycan and decorin1

Glycosaminoglycan4

Genes6

Fibrous proteins1

Collagens1

Extracellular2

Dermatan3

Fibromodulin1

Sequence2

Fibronectin1

Degradation3

Repeats4

Tissues6

Tumor2

Interaction2

Sequences5

Tyrosine3

Homology1

SLRPs1

Globular domains2

Chains2

Membrane3

Mitochondria1

Differentially1

Cartilage1

Structural1

Phosphorylation1

Link protein1

Serum1

Distinct2

Cells3

Pathways1

Cellular2

Transcriptional1

Synthesis3

Functional1

Glycoprotein1

Ubiquitous1

Interactions1

Gene2

Domains1

Human1

Breakdown1

Structures2