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Protocatechuate-3,4-DioxygenaseOrnithine DecarboxylaseHydroxybenzoatesCarboxy-LyasesGlutamate DecarboxylaseDopa DecarboxylaseHistidine DecarboxylaseParabensAdenosylmethionine DecarboxylaseVanillic AcidAdipatesOxygenasesUroporphyrinogen DecarboxylaseOrotidine-5'-Phosphate DecarboxylaseQuinic AcidCatecholsDecarboxylationTyrosine DecarboxylasePseudomonasPolyaminesEflornithineDioxygenasesPutrescineAromatic-L-Amino-Acid DecarboxylasesAcinetobacterBenzoatesBiodegradation, EnvironmentalGlycine Decarboxylase ComplexSpermidineGentisatesBenzoic AcidMolecular Sequence DataOrnithineOxidoreductases, O-DemethylatingPhthalic AcidsGallic AcidSphingomonasAmino Acid SequenceHydrocarbons, AromaticComamonas testosteroniGlycine Dehydrogenase (Decarboxylating)ComamonasDiaminesBenzaldehydesKineticsSpermineGenes, BacterialEnzyme InductionBrevibacteriumBase SequenceCatechol 1,2-DioxygenaseAcinetobacter calcoaceticusBiogenic PolyaminesGlycine Decarboxylase Complex H-ProteinChlorobenzoatesProteasome Endopeptidase ComplexCloning, MolecularMitoguazoneEscherichia coliBacterial ProteinsGene Expression Regulation, BacterialIsonicotinic AcidsSubstrate SpecificityEugenolCoumaric AcidsPseudomonas putidaMutationMethylmalonyl-CoA DecarboxylaseOxaloacetic AcidCoenzyme A-TransferasesStiff-Person SyndromeSequence Analysis, DNARNA, MessengerOperonCarboxylic Ester HydrolasesOxygen IsotopesAgmatineCell-Free SystemSpermidine SynthaseSequence Homology, Amino AcidRestriction MappingMolecular WeightDihydroxyphenylalanineSpectrophotometryThiamine PyrophosphateNitrobenzoatesUbiquitinProteolysisDNA, BacterialEnterobacterPyruvatesMultigene FamilyCulture MediaHydrogen-Ion ConcentrationPyridoxal PhosphateMitosporic FungiGene Expression Regulation, EnzymologicMultienzyme ComplexesCell LineSelenomonas
MainRoleCatecholPathwayInvolvesGenes
Main2
  • In order to analyse the annotation and the quality of our genome annotation, we looked at four main specific annotation types such as antibiotic resitance, restriction enzyme, metals (such as cadmium, copper and mercury), and other toxic compounds (such as phenol, nitrate, nitrite). (igem.org)
  • In the present work, we intended to perform the in vitro experiment for investigating the degradation of 17ß-estradiol, the main environmental estrogen, by human intestinal microflora Aspergillus niger RG13B1. (bvsalud.org)
Role2
  • Biodegradation is still an efficient tactics to remove environmental hormones, but human intestinal microbes remain to be elucidated in the role of their degradation. (bvsalud.org)
  • This study first illustrated the role of human gut microbe in 17ß-estradiol degradation and provided new insights into its degradation mechanism by A. niger RG13B1. (bvsalud.org)
Catechol4
  • The enzyme protocatechuate decarboxylase (EC 4.1.1.63) catalyzes the chemical reaction 3,4-dihydroxybenzoate ⇌ {\displaystyle \rightleftharpoons } catechol + CO2 This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. (wikipedia.org)
  • The systematic name of this enzyme class is 3,4-dihydroxybenzoate carboxy-lyase (catechol-forming). (wikipedia.org)
  • This series of steps is part of protocatechuate para-cleavage, link , or catechol degradation II, link . (lbl.gov)
  • This is part of a MetaCyc pathway for catechol degradation, link . (lbl.gov)
Pathway4
  • In order to improve our knowledge of the microbial paracetamol degradation pathway, we inoculated a bioreactor with sludge of a hospital WWTP (Pharmafilter, Delft, NL) and fed it with paracetamol as the sole carbon source. (biorxiv.org)
  • Comment: In the meta-cleavage pathway ( link ), the 4,5-dioxygenase ligAB splits protocatechuate to 4-carboxy-2-hydroxymuconate-6-semialdehyde. (lbl.gov)
  • In the ortho-cleavage pathway ( link ), the 3,4-oxygenase pcaHG cleaves the ring to 3-carboxy-cis,cis-muconate, a cycloisomerase forms 4-carboxymuconolactone (2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate), a decarboxylase forms 3-oxoadipate enol lactone ((4,5-dihydro-5-oxofuran-2-yl)-acetate), and a hydrolase forms 3-oxoadipate. (lbl.gov)
  • Comment: In MetaCyc pathway glutaryl-CoA degradation ( link ), glutaryl-CoA is oxidized to (E)-glutaconyl-CoA and oxidatively decarboxylated to crotonyl-CoA (both by the same enzyme), hydrated to 3-hydroxybutanoyl-CoA, oxidized to acetoacetyl-CoA, and cleaved to two acetyl-CoA. (lbl.gov)
Involves1
  • Comment: An aerobic route for degradation of 4-hydroxybenzoate involves 4-hydroxybenzoate 3-monooxygenase pobA, which forms protocatechuate (3,4-dihydroxybenzoate). (lbl.gov)
Genes2
  • This study presents the reassessment of earlier published data with reference to the article published in Environmental Microbiology entitled 'IncP-type plasmids carrying genes for antibiotic resistance or aromatic compound degradation are prevalent in sequenced Aromatoleum and Thauera strains' by Lo et al. (bvsalud.org)
  • However, the genes and corresponding proteins involved in microbial paracetamol degradation are still elusive. (biorxiv.org)