Autologous peripheral blood stemHSCTHematopoietic stemMarrowDonorPBSCTRemissionTransplantChemotherapy FollowedLymphocytesMononuclear cellsRelapseUmbilicalTransplantsAllogeneic or autologousMobilizationPBSCRegimenPatients with relapsedCyclophosphamideMultiple myelomaHigh-doseDonorsApheresisUnderwentProgenitor cellImmature cellsPost-transplantationEtoposideRecipientsLymphomasCord bloodSolid tumorsTumorsRefractoryCountsCytomegalovirusPlateletEngraftmentTherapyPlateletsAcuteLymphoidPatient'sGraftUndergoneChildren with relapsedParkinson'sDiagnosisSurvivalImmunotherapy
Autologous peripheral blood stem4
- The patient had undergone autologous peripheral blood stem-cell transplantation to treat ovarian cancer. (medscape.com)
- Forty-two female patients (median age of 46 years) with breast cancer refractory to neoadjuvant chemotherapy received HDCT (cyclophosphamide, carmustine and thiotepa) supported by an autologous peripheral blood stem cells transplant. (elsevierpure.com)
- 1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
- The patient then underwent high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (auto-PBSCT). (elsevierpure.com)
HSCT26
- Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
- The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
- Chronic graft- versus -host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). (haematologica.org)
- Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for patients with non-malignant diseases as well as high-risk and refractory hematopoietic malignancies. (haematologica.org)
- There is a paucity of data examining the tolerance and outcome of hematopoietic stem cell transplantation (HSCT) for relapse after tositumomab/iodine-131 tositumomab. (cancernetwork.com)
- There is a paucity of data examining the tolerance andoutcome of hematopoietic stem cell transplantation (HSCT) for relapse aftertositumomab/iodine-131 tositumomab. (cancernetwork.com)
- The median time from tositumomab/iodine-131tositumomab therapy to HSCT was 554 days (range: 77-2,893 days). (cancernetwork.com)
- Five patients received autologous HSCT: threemarrow and two peripheral blood stem cells. (cancernetwork.com)
- In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia. (nih.gov)
- CMV infection is one of most frequent infectious complications in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). (cttjournal.com)
- We analyzed cytotoxic T-lymphocytes (CTLs) in peripheral blood of 39 patients on day +30 after allo-HSCT. (cttjournal.com)
- Figure 1 shows the number of CMV-specific T cells at the day +30 after allo-HSCT in patients with various modes of GVHD prophylaxis. (cttjournal.com)
- Patients with more "aggressive" GVHD prophylaxis regimens (based on the use of high doses of post-transplant cyclophosphamide, T-cell depletion) have less CMV-specific T cells at +30 days after allo-HSCT. (cttjournal.com)
- The "dot plot" shows the results of the study of CMV-specific T cells in one of the patients with T-depletion at +30 days after HSCT. (cttjournal.com)
- Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
- We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
- Patients with high pre-HSCT BAALC / ABL1 copy numbers were more likely to experience relapse within 100 days after HSCT. (oncotarget.com)
- Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)
- For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
- Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
- are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
- 3, the late phase (1100 days post-HSCT). (cdc.gov)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Hematopoietic stem1
- To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
Marrow42
- Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
- Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
- Characterize the time to recovery of normal bone marrow function after transplantation in these patients. (knowcancer.com)
- OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
- In autologous stem cell transplantation, stem cells are collected (or "harvested") from either the bone marrow , bloodstream (called a peripheral blood stem cell harvest), or sometimes a combination of both. (leukaemia.org.au)
- It is more common these days to collect bone marrow stem cells from the bloodstream. (leukaemia.org.au)
- Stem cells normally live in the bone marrow, but they can be encouraged to move out of the bone marrow and into the bloodstream. (leukaemia.org.au)
- G-CSF promotes the production of stem cells in the bone marrow which then leak out into your normal blood circulation in your veins. (leukaemia.org.au)
- Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
- From here the stem cells make their way to your bone marrow where they become re-established and start making new blood cells. (leukaemia.org.au)
- Bone marrow transplantation , 37 (10), 929-935. (elsevierpure.com)
- Among seven allogeneic transplants,three received matched related peripheral blood stem cells and four receivedmatched unrelated marrow (n = 3) or peripheral blood (n = 1) stem cells.Allogeneic recipients received tacrolimus and methotrexate for graft-vs-hostdisease prophylaxis. (cancernetwork.com)
- Bone marrow was stimulated with 300 microg filgrastim subcutaneously daily for 3 days. (cellsurgicalnetwork.com)
- Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow abnormality, either hypocellularity or tumor involvement. (shengsci.com)
- Bone marrow transplantation , 51 (12), 1599-1601. (johnshopkins.edu)
- This cancer usually originates in the bone marrow where blood production takes place. (ndtv.com)
- Before undergoing lymphodepletion, 9% blasts were detectable in bone marrow and 0.3% blasts were observed immediately before infusion of 50x106 BE-CAR7 cells. (ajmc.com)
- On day 27, the patient's bone marrow was hypocellular and in morphologic remission with undetectable minimal residual disease and she was discharged 52 days after stem-cell transplantation. (ajmc.com)
- Ongoing neutropenia and lymphopenia were challenges throughout the investigational period, and BE-CAR7 T cells were detected at serial time points in blood, marrow, and pleural fluid. (ajmc.com)
- Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
- Patients undergoing fludarabine therapy (purine analog) , bone marrow transplantation or peripheral blood stem cell transplantation. (utmb.edu)
- India's most trusted facility for bone marrow transplantation at the Apollo Cancer Centre at Teynampet, Chennai. (medtravelhelp.com)
- A bone marrow transplant is a process of transferring healthy bone marrow cells from a donor to a patient who has unhealthy bone marrow. (medtravelhelp.com)
- About a week or two before the bone marrow harvest is done, the patient (or the donor, for an Allogeneic transplantation) may have 1 to 2 units of blood taken. (medtravelhelp.com)
- Cord blood is rich in peripheral stem cells and can be used instead of bone marrow for transplantation. (medtravelhelp.com)
- The patient's own, or the donated bone marrow or peripheral stem cells or cord blood will then be given through the central line into a vein. (medtravelhelp.com)
- Bone marrow is the tissue found inside bones where blood cells are developed and stored. (medtravelhelp.com)
- The bone marrow cells that make other blood cells are called stem cells which are needed in a bone marrow transplant. (medtravelhelp.com)
- This is an important study, and ultimately, I think our goal is to overcome the use of chemotherapy and radiation, which can destroy healthy cells along with malignant ones," commented Catherine Bollard, MD, MBChB, a bone and marrow transplant specialist at George Washington University/Children's National Medical Health System, Washington, DC. (medscape.com)
- Because plasma cells in bone marrow (or occasionally in other sites) synthesize immunoglobulin L chains, which are deposited in various organs, the L chains must travel through the bloodstream. (medscape.com)
- Approximately 40% of patients have more than 10% plasma cells in the bone marrow. (medscape.com)
- Reticulated or immature platelet assays are useful for the differential diagnosis of thrombocytopenia and for monitoring bone marrow recovery after chemotherapy or stem cell transplantation and several other clinical entities. (ijsr.net)
- The concentration of retPLT in bone marrow is on the average 2?3 times higher than in peripheral blood, where they correlate with megakaryocyte numbers. (ijsr.net)
- G-CSF stimulates your bone marrow to produce a type of white blood cell, called neutrophils. (drugs.com)
- A transplantation of stem cells, from umbilical cord blood or from a peripheral stem cell or bone marrow donor, is appropriate for some boys with the disease, such as those with early symptoms and MRI abnormalities. (sunjournal.com)
- Bone marrow contains stem cells, which are immature cells that become blood cells. (medlineplus.gov)
- People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
- Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood. (medlineplus.gov)
- First, the donor is given 5 days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
- Equivalent numbers of patients in both cohorts received bone marrow or peripheral blood allogeneic or autologous stem cell transplantation (SCT). (elsevierpure.com)
- Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
- 15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)
Donor27
- Donor-T-cells were transduced with the replication-deficient retrovirus SFCMM-3, expressing HSV-TK and the truncated ΔLNGFR for selection of transduced cells. (frontiersin.org)
- Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
- Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
- Determine the safety of LMB-2 immunotoxin-treated, selectively-depleted donor T cells, administered after allogeneic PBSCT, in these patients. (knowcancer.com)
- OUTLINE: This is a dose-escalation study of LMB-2 immunotoxin-treated, selectively-depleted donor T cells. (knowcancer.com)
- LMB-2 immunotoxin is added to the PBMCs in order to selectively deplete T cells from the donor PBMCs. (knowcancer.com)
- LMB-2 immunotoxin-treated, selectively-depleted donor T cells: Patients receive LMB-2 immunotoxin-treated, selectively-depleted donor T cells IV over 30-60 minutes on approximately day 28. (knowcancer.com)
- Cohorts of 3-6 patients receive escalating dose of LMB-2 immunotoxin-treated, selectively-depleted donor T cells until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
- In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
- 2 cGvHD is a multisystemic disorder that occurs due to foreign donor immune cells attacking the recipient's tissues. (haematologica.org)
- The team transduced healthy volunteer donor T cells using a lentivirus to express a CAR with specificity for CD7, which is expressed in T-cell ALL. (ajmc.com)
- Finally, patient 3 is a 15-year-old boy who first presented with mixed-phenotype acute leukemia in 2016 and underwent a first allogeneic stem cell transplantation from a matched unrelated donor. (ajmc.com)
- Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
- Apollo Cancer Centre is one of the few setups in India with facilities to search for a potential unrelated donor and offer transplantation. (medtravelhelp.com)
- On occasions when the patient does not have a good matched relative / unrelated donor, a partially matched, unrelated cord blood with adequate cell dose would be an option. (medtravelhelp.com)
- Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
- The donor had scheduled a trip to Sri Lanka, and was to return 3 days before the scheduled start of granulocyte-colony-stimulating factor, or G-CSF, application. (cdc.gov)
- The donor had returned from her trip 3 days before the start of G-CSF-injections without any signs of infection. (cdc.gov)
- Standard leukopheresis processing of blood from the donor was performed without problems. (cdc.gov)
- Granulocyte-colony stimulating factor (G-CSF)-mobilized, T cell-depleted haploidentical paternal stem cells were infused on day 0 together with cultured donor mesenchymal stem cells. (lu.se)
- If a donor's HLAs match well with a person who needs a transplant, the donor must give a new blood sample to confirm the match. (medlineplus.gov)
- Donor stem cells can be collected in two ways. (medlineplus.gov)
- Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
- During the collection, blood is removed from the donor through a line in a vein (IV). (medlineplus.gov)
- The red blood cells are returned to the donor through an IV in the other arm. (medlineplus.gov)
- On October 29, 2019, the patient underwent allogeneic peripheral blood stem cell transplantation from a full match (6/6) unrelated donor (man, blood type O, aged 37) (Fig. 1 a) at Nanfang Hospital, Southern Medical University. (biomedcentral.com)
- Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
PBSCT4
- In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
- Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
- Determine the feasibility and efficacy of a reduced-intensity conditioning regimen comprising alemtuzumab, fludarabine, melphalan, and thiotepa followed by allogeneic peripheral blood stem cell transplantation (PBSCT) in patients with hematologic malignancies. (knowcancer.com)
- A study by Dispenzieri et al showed that the absolute value of immunoglobulin free light chain (FLC) as a precursor protein of amyloid is prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation (PBSCT). (medscape.com)
Remission7
- These cells are collected in advance (while they are in remission ) and returned to the patient at a later stage. (leukaemia.org.au)
- Stem cells are usually collected when the patient's disease is in remission or their disease is in a more stable state. (leukaemia.org.au)
- He remains in complete remission 2 years after transplantation. (elsevierpure.com)
- The primary endpoint was complete remission (CR) or CR with partial haematological recovery of peripheral blood counts (CRh) within the first two cycles. (nih.gov)
- The child is normal with sustained remission on day +218 post stem cell transplant. (lvhn.org)
- The study reported by Dr Topp and colleagues enrolled 189 patients with Philadelphia chromosome-negative, primary refractory or relapsed disease (first relapse within 12 months of first remission, relapse within 12 months after allogeneic hemopoietic stem cell transplantation, or no response to or relapse after first salvage therapy or beyond). (medscape.com)
- Routine Imaging for Diffuse Large B-Cell Lymphoma in First Complete Remission Does Not Improve Post-Treatment Survival: A Danish-Swedish Population-Based Study. (lu.se)
Transplant7
- What is an autologous stem cell transplant? (leukaemia.org.au)
- It's important to realise that the processes involved in a stem cell transplant are often long and complex. (leukaemia.org.au)
- In the week leading up to your transplant you will be given a few days of very high-dose chemotherapy, and sometimes radiotherapy , to destroy your underlying disease. (leukaemia.org.au)
- In the week following the transplant, your blood counts drop dramatically. (leukaemia.org.au)
- Five days before the scheduled transplant day, or day minus 5, the recipient tested positive for Klebsiella pneumoniae infection of the central venous catheter. (cdc.gov)
- BK polyomavirus (BKPyV) is a member of the Polyomaviridae family, and it was first identified in 1971 by electron microscopy of the urine and uroepithelial cells of a renal transplant recipient [ 1 ]. (biomedcentral.com)
- Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
Chemotherapy Followed1
- Because there is no effective chemotherapeutic regimen for intrathoracic malignant neurogenic tumor, all three patients received high-dose chemotherapy followed by hematopoietic stem cell transplantation. (springeropen.com)
Lymphocytes4
- These results suggest that the exposure to environmental pollutants in utero affects genetic constitution of fetus and increases MN values in their body cells, which is detectable right after birth in peripheral blood lymphocytes. (go.jp)
- Recent studies have shown that soluble factors elaborated by human T lymphocytes enhance erythroid burst formation by human peripheral blood null cells. (shengsci.com)
- It is the cancer of the lymphatic system and the lymph nodes and particularly affects a type of white blood cells, called lymphocytes. (ndtv.com)
- Peripheral blood lymphocytes were analysed by flow cytometry, ELISA, and T-cell-receptor spectratyping before and after transplantation. (northwestern.edu)
Mononuclear cells3
- T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
- Peripheral blood mononuclear cells were obtained after admission by leukapheresis. (cellsurgicalnetwork.com)
- At least 6.5 x 10(8) [corrected] mononuclear cells/kg patient weight were collected from the peripheral blood of each patient, cyropreserved, and returned intravenously following CBV administration. (shengsci.com)
Relapse3
- CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
- Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). (shengsci.com)
- Patients who relapse after transplantation have a poor prognosis, with less than 15% long-term survival. (ajmc.com)
Umbilical6
- Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
- The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
- For umbilical cord blood harvest, the cord is clamped after delivery of the baby, and blood is drawn from the cord with a needle and collected in a sterile bag. (msdmanuals.com)
- This is the blood that is left behind in the placenta and the umbilical cord after the delivery of a baby. (medtravelhelp.com)
- peripheral blood, or placental/umbilical cord blood). (cdc.gov)
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Transplants2
- Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
- In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
Allogeneic or autologous1
- This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Mobilization4
- UDENYCA is not indicated for the mobilization of peripheral blood progenitor cells for hematopoietic stem cell transplantation. (drugs.com)
- Leukapheresis was scheduled to commence on day 4 of the mobilization regimen. (bvsalud.org)
- The stem cell mobilization result was poor. (cdc.gov)
- Before apheresis, the donor's blood count showed mild thrombocytopenia after G-CSF mobilization. (cdc.gov)
PBSC2
- Allogeneic peripheral blood stem cell (PBSC) transplantation: Patients undergo allogeneic PBSC transplantation on day 0. (knowcancer.com)
- The patient received peripheral blood stem cells (PBSC) and had successful engraftment with complete hematological recovery. (lvhn.org)
Regimen4
- In case of CD20-positive B cell lymphoid malignancies the ICE regimen is often combined today with rituximab. (wikipedia.org)
- All patients except two who received reduced intensity had severe mucositis.Reversible veno-occlusive disease of the liver also developed in two patients.There was one death from graft-vs-host disease and no regimen-related mortality.Engraftment was prompt, with a median recovery of absolute neutrophil count to ³ 500/µL of 12 days (range: 11-18 days). (cancernetwork.com)
- Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
- The preparative regimen included high-dose (131)I-MIBG on day -20, followed by fludarabine (Flu), thiotepa, and melphalan (Mel) from day -8 to -1. (lu.se)
Patients with relapsed2
- New research in clustered regularly interspaced short palindromic repeats (CRISPR) technology suggests that base-edited T cells could be useful in patients with relapsed leukemia and could help anticipate the risks of immunotherapy -related complications. (ajmc.com)
- [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Cyclophosphamide4
- Topotecan (0.75mg/m 2) and cyclophosphamide (250mg/m 2) were administered IV on days 1-5. (authorea.com)
- Conclusions The recommended phase 2 doses and schedules for this combination are topotecan 0.75mg/m 2 IV days 1-5, cyclophosphamide 250mg/m 2 IV days 1-5, and cabozantinib 25mg/m 2 days 8-21. (authorea.com)
- We mobilised autologous haemopoietic stem cells with 2·0 g/m 2 cyclophosphamide and 10 μg/kg granulocyte colony stimulating factor daily, enriched with CD34-positive selection, and reinfused after immunosuppression with 200 mg/kg cyclophosphamide, 1 g methylprednisolone, and 90 mg/kg equine antithymocyte globulin. (northwestern.edu)
- Subsequently, chemotherapy consisting of cisplatin (25 mg/m 2 on days 1 to 5), cyclophosphamide (1,200 mg/m 2 on days 1 and 2), vincristine (1.5 mg/m 2 on day 1), and pirarubicin-doxorubicin (40 mg/m 2 on day 3) was administered. (springeropen.com)
Multiple myeloma5
- The 2 men had multiple myeloma and relapsed follicular non-Hodgkin lymphoma and had neutropenic fever 5 and 4 days post-SCT, respectively. (cdc.gov)
- Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
- Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy. (shengsci.com)
- Eighty-two patients with advanced multiple myeloma (MM) were enrolled in 2 sequential clinical studies of 1 or 2 courses of myeloablative therapy with stem cell support. (shengsci.com)
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
High-dose6
- Cycles are repeated every 14 days for 3 cycles, then high-dose chemotherapy with autologous stem-cell transplantation follows (if the patient is considered eligible for HDCT and ASCT). (wikipedia.org)
- Three days after starting high-dose therapy, he developed a fever, and a chest X-ray revealed pneumonia in the right lower lung. (elsevierpure.com)
- The Peripheral stem cells can even be frozen until the patient has had the high-dose treatment. (medtravelhelp.com)
- The remaining seven received high-dose chemotherapy and stem-cell infusion. (northwestern.edu)
- High-dose iodine-131-metaiodobenzylguanidine with haploidentical stem cell transplantation and posttransplant immunotherapy in children with relapsed/refractory neuroblastoma. (lu.se)
- We evaluated the feasibility and efficacy of using high-dose iodine-131-metaiodobenzylguanidine ((131)I-MIBG) followed by reduced-intensity conditioning (RIC) and transplantation of T cell-depleted haploidentical peripheral blood stem cells (designated haplo-SCT) to treat relapsing/refractory neuroblastoma (RRNB). (lu.se)
Donors9
- Transduced cells were transfused either after day +60 (matched donors) or on day +42 (haploidentical donors). (frontiersin.org)
- Effectiveness of single-dose 6 mg pegfilgrastim in mobilizing peripheral blood stem cells in allogeneic hematopoietic cell transplantation donors. (bvsalud.org)
- A single injection of 12 mg pegfilgrastim was used to mobilize peripheral blood progenitor cells (PBPCs) from healthy donors in some studies. (bvsalud.org)
- The purpose of this study was to determine if 6 mg of pegfilgrastim was effective and safe for mobilizing CD34+ cells in donors for allogeneic hematopoietic stem cell transplantation . (bvsalud.org)
- The 73.3% of donors mobilized with pegfilgrastim yielded >4 × 106 cells /kg CD34+ cells in a single apheresis procedure when compared to the 33.3% of donors mobilized with G-CSF (P (bvsalud.org)
- Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
- Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
- Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
- In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
Apheresis4
- Stem cells are collected from your bloodstream by passing all your blood through a special machine called a cell separator (or apheresis machine). (leukaemia.org.au)
- The apheresis machine draws blood from the body, spins the blood very quickly, collects the part that contains the blood stem cells , and returns the rest of the blood back to the body. (leukaemia.org.au)
- standard apheresis is done 4 to 6 days afterward. (msdmanuals.com)
- In the morning of the second day after apheresis, the platelet count dropped, procalcitonine level was elevated, C-reactive protein level was elevated, and a slight skin rash developed. (cdc.gov)
Underwent6
- The green color indicates patients who additionally underwent prophylactic infusion of the CD45RA- fraction at day 0. (cttjournal.com)
- He underwent lymphodepletion and received 1x106 BE-CAR7 T cells per kilogram. (ajmc.com)
- A third of these patients subsequently underwent allogeneic hemopoietic stem cell transplantation. (medscape.com)
- Patients underwent dose-intense immune suppression and autologous haemopoietic stem-cell (CD34) infusion. (northwestern.edu)
- Results: Nine patients underwent stem-cell mobilisation but two were excluded before transplantation because of infection. (northwestern.edu)
- After transplantation, the patient tested positive for recurrent blood cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections, and on March 31, 2020, he underwent lung lavage because of bilateral pneumonia. (biomedcentral.com)
Progenitor cell1
- Enhancement of human erythroid progenitor cell growth by media conditioned by a human t-lymphocyte line. (shengsci.com)
Immature cells2
- Pegfilgrastim is a leukocyte growth factor that works by binding to a receptor on immature cells called hematopoietic cells, which can develop into any type of blood cell. (drugs.com)
- Stem cells are immature cells that produce blood cells. (epnet.com)
Post-transplantation2
- After completion of study treatment, patients are followed weekly for 100 days post-transplantation and then periodically for survival. (knowcancer.com)
- At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)
Etoposide1
Recipients2
- The majority of stem cell recipients rely on indwelling central venous catheters situated in superior vena cava or right atrium. (lvhn.org)
- The high numbers of leukocytes remaining in a unit of pRBCs during the storage process can fragment, deteriorate, and release cytokines, and they have been implicated as a cause of reactions to a current and subsequent blood transfusions in some transfusion recipients. (utmb.edu)
Lymphomas2
- CD19 is a protein expressed on the surface of B-cell-derived ALLs and non-Hodgkin's lymphomas. (medscape.com)
- Real world data on prognostic factors and treatment in peripheral T-cell lymphomas: a study from the Swedish Lymphoma Registry. (lu.se)
Cord blood3
- Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
- One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
- The positive result came too late to save cord blood. (sunjournal.com)
Solid tumors1
- Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Tumors1
- Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
Refractory1
- The drug was recently approved by the US Food and Drug Administration for patients with Philadelphia chromosome-negative precursor B-cell ALL who have relapsed or who were refractory to previous treatment. (medscape.com)
Counts3
- Two-platform method was used to calculate absolute CMV (NLV/TPR)-specific CD3+CD8+ cell counts in peripheral blood. (cttjournal.com)
- BE-CAR7 were detected in peripheral blood during a period in which the patient had very low absolute lymphocyte subset counts. (ajmc.com)
- A total of 11 plasma ex- nisolone daily, with advice to get her blood change sessions were carried out over a counts tested at regular intervals. (who.int)
Cytomegalovirus1
- Functionality of HSV-TK gene expressing T-cells was shown by loss of bcr-able gene expression as well as by control of cytomegalovirus-reactivation. (frontiersin.org)
Platelet4
- The patient also had cytopenia from day 0 onward and was dependent on blood and platelet support. (ajmc.com)
- Her temperature increased, the platelet count dropped on day 0 to the day after. (cdc.gov)
- Median time to an absolute neutrophil count higher than 0·5x10 9 /L and nontransfused platelet count higher than 20x10 9 /L was 9 days (range 8-11) and 11 days (10-13), respectively. (northwestern.edu)
- She was initially given supportive treat- is more common in developing countries, ment with platelet and packed-cell transfu- as a result of rapid industrialization and ad- sions, antibiotics and prednisolone. (who.int)
Engraftment1
- Ninety subjects (73%) were discharged just after engraftment was reached on day +12 (10-14). (nature.com)
Therapy12
- She had neutropenic fever on day 13 of induction therapy. (cdc.gov)
- The best response after surgery, HDCT, and radiation therapy was assessed 60 days after transplantation. (elsevierpure.com)
- Radiation therapy: It utilizes high-energy rays to destroy cancer cells. (ndtv.com)
- Targeted therapy: This therapy uses drugs that target only cancer cells without harming normal cells and is most commonly used to treat leukaemia. (ndtv.com)
- The patients with "aggressive" GVHD prophylaxis are the most likely candidates for cell therapy. (cttjournal.com)
- The use of base editing to generate universal, off-the-shelf CAR T cells is a promising approach for relapsed leukemia, with potential implications for the future of gene therapy. (ajmc.com)
- Large doses of chemotherapy and/or radiation therapy are then applied to kill the cancer cells. (epnet.com)
- Patients received an oral rinse, consisting of iseganan 9 mg or placebo, to be swished/swallowed six times daily, starting with stomatotoxic therapy and continuing up to 21 days. (elsevierpure.com)
- Especially during and after steroid pulse therapy or immunosuppressive therapy for graft versus host diseases, BKPyV load in blood/urine needs to be regularly measured, and the immunosuppressive intensity should be adjusted properly after the BKPyV reactivation diagnosis. (biomedcentral.com)
- This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
- A study by Tang et al determined that long-term TKI therapy may reduce the abundance of leukemic stem cells in select patients. (medscape.com)
- The lesions remitted after five days of gargling with the mucositis mouthwash and two sessions of low-level laser therapy on the lesions. (bvsalud.org)
Platelets2
- During this time you will be more at risk of infections (due to the lack of infection-fighting white blood cells ) and bleeding (due to a lack of platelets ). (leukaemia.org.au)
- Red blood cells do not provide viable platelets, nor do they provide clinically significant amounts of coagulation factors. (utmb.edu)
Acute7
- [ 1 ] Acute GVHD describes a distinctive syndrome of dermatitis (see the image below), hepatitis, and enteritis developing within 100 days after allogeneic hematopoietic cell transplantation (HCT). (medscape.com)
- Diarrhea in acute GHVD is green, mucoid, watery, and mixed with exfoliated cells forming fecal casts. (medscape.com)
- Blinatumomab is a bispecific T-cell engager antibody construct targeting CD19, an antigen consistently expressed on B-lineage acute lymphoblastic leukaemia cells. (nih.gov)
- Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation. (shengsci.com)
- Most children with T-cell acute lymphoblastic leukemia (ALL) can be treated with standard chemotherapy regimens, but patients with induction failure or elevated minimal residual disease after consolidation generally receive allogeneic stem-cell transplantation. (ajmc.com)
- Patients who benefit most from the transfusion of RBCs include those with chronic anemia resulting from kidney failure or gastrointestinal bleeding, and those with acute blood loss resulting from surgery or trauma. (utmb.edu)
- High risk of acute pulmonary toxicity with both myeloablative and non-myeloablative total body irradiation-based conditioning for allogeneic stem cell transplantation. (dukecancerinstitute.org)
Lymphoid1
- In addition to allogeneic HCT, procedures associated with high risk of GVHD include transplantation of solid organs containing lymphoid tissue and transfusion of unirradiated blood products. (medscape.com)
Patient's2
- They are used to replace stem cells that have been damaged by high doses of chemotherapy , used to treat the patient's underlying disease. (leukaemia.org.au)
- The isolated cells (2.5-7.5×10(5)) were resuspended in 300 microL of the patient's cerebrospinal fluid, and implanted in motor cortexes using a Hamilton syringe. (cellsurgicalnetwork.com)
Graft4
- The investigators then used base editing to inactivate 3 genes encoding CD52 and CD7 receptors and the b chain of the ab T-cell receptor to evade lymphodepleting serotherapy, CAR7 T-cell fratricide, and graft-versus-host disease, respectively. (ajmc.com)
- Analysis of immunologic recovery showed fast reappearance of potentially immunocompetent natural killer (NK) and T cells, which might have acted as effector cells responsible for the graft-versus-tumor (GVT) effect. (lu.se)
- One patient rejected the graft, was rescued with autologous backup, and died of progressive disease 5 months after transplantation. (lu.se)
- Both patients had consistent infectious pneumonia and graft-versus-host disease after stem cell transplantation. (biomedcentral.com)
Undergone1
- We recently observed 3 cases of L. trevisanii bacteremia in patients who had recently undergone peripheral blood stem cell transplantation (SCT. (cdc.gov)
Children with relapsed1
Parkinson's1
- By linking together basic and clinical research, we aim to clarify cellular mechanisms of regeneration following damage to the brain and develop new therapeutic strategies to restore function in this organ (primarily in stroke and Parkinson's disease) by transplantation of stem cells or reprogrammed cells and optimization of endogenous repair mechanisms. (lu.se)
Diagnosis1
- Patient 2 was a 13-year-old boy with a diagnosis of cortical T-cell ALL 3 years prior to study enrollment, who had relapsed while receiving maintenance treatment. (ajmc.com)
Survival1
- Absolute lymphocyte count recovery at day 15 (ALC-15) after autologous stem cell transplantation seems to be a powerful prognostic indicator for overall survival and progression-free survival. (medscape.com)
Immunotherapy2
- Immunotherapy: In this treatment option, the immune system is activated to kill only specific cancer cells. (ndtv.com)
- For these patients, cellular immunotherapy could help achieve deep leukemic clearance, although chimeric antigen receptor (CAR) T-cell strategies against T-cell cancers have been difficult. (ajmc.com)