IdarubicinEtoposideAnthracyclineAnthracyclines doxorubicinHydrochlorideCardiotoxicityChemotherapyCytarabineDosesLiposomalMedicationsEnzymeDrugsDoseAcuteCancerTypesDoctorPatientsEpirubicinMitoxantroneCisplatinCerubidineToxicityAnthracyclinesReceive doxorubicinTrastuzumabExtravasationAntineoplasticSevereMedicationExamplesCumulativeDosageUptakeCardiomyopathySynthesisLiverPrecautionsIngredientsPowderVeinSide effects
Idarubicin1
- Anthracyclines, e. g. daunorubicin, doxorubicin, and idarubicin, consist of a tetracycline moiety linked via a glycosidic bond to a sugar residue, usually the aminosugar daunosamine. (lu.se)
Etoposide4
- I. To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/ carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the event-free survival (EFS) of patients with newly diagnosed stage 4 diffuse anaplastic Wilms tumor (DAWT) as compared to historical controls. (clinicaltrials.gov)
- To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the EFS of patients with standard-risk relapsed favorable histology Wilms tumor (SRrFHWT) as compared to historical controls. (clinicaltrials.gov)
- I. To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the overall survival (OS) of patients with newly diagnosed stage 4 DAWT as compared to historical controls. (clinicaltrials.gov)
- For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
Anthracycline2
- Daunorubicin is an antineoplastic anthracycline antibiotic with actions similar to those of doxorubicin. (e-lactancia.org)
- The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. (enzyme-database.org)
Anthracyclines doxorubicin1
- Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. (joplink.net)
Hydrochloride1
- The risk of developing secondary acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) is increased following treatment with doxorubicin hydrochloride. (medscape.com)
Cardiotoxicity1
- The cardioprotective effects of Nar are well documented in the healthy state, in myocardial infarction, and in daunorubicin-, doxorubicin-, and high-glucose-induced cardiotoxicity [ 2 , 12 - 17 ]. (hindawi.com)
Chemotherapy1
- Doxorubicin should only be given by health care professionals familiar with the use of chemotherapy medications used to treat cancer. (pharmasave.com)
Cytarabine12
- Daunorubicin and cytarabine lipid complex is different than other products containing these medications and should not be substituted for one another. (safemedication.com)
- Daunorubicin and cytarabine lipid complex slows or stops the growth of cancer cells in your body. (safemedication.com)
- Daunorubicin and cytarabine lipid complex comes as a powder to be mixed with liquid and injected intravenously (into a vein) by a doctor or nurse in a medical facility. (safemedication.com)
- tell your doctor and pharmacist if you are allergic to daunorubicin, cytarabine, any other medications, or any of the ingredients in daunorubicin and cytarabine lipid complex. (safemedication.com)
- Many other medications may also interact with daunorubicin and cytarabine lipid complex, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (safemedication.com)
- You or your partner should not become pregnant while you are receiving daunorubicin and cytarabine lipid complex. (safemedication.com)
- You should use birth control to prevent pregnancy in yourself or your partner during your treatment with daunorubicin and cytarabine lipid complex and for 6 months after your final dose. (safemedication.com)
- If you become pregnant while receiving daunorubicin and cytarabine lipid complex, call your doctor. (safemedication.com)
- Daunorubicin and cytarabine lipid complex may harm the fetus. (safemedication.com)
- You should not breastfeed during your treatment with daunorubicin and cytarabine lipid complex and for at least 2 weeks after your final dose. (safemedication.com)
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving daunorubicin and cytarabine lipid complex. (safemedication.com)
- Daunorubicin and cytarabine lipid complex may cause side effects. (safemedication.com)
Doses1
- In adults, the incidence of CHF was 3% at a cumulative doxorubicin dose of 400 mg/m 2 , 7% at a cumulative dose of 550 mg/m 2 , and 18% at cumulative doses higher than 700 mg/m 2 . (medscape.com)
Liposomal2
- Initial studies show it seems to work as well as liposomal doxorubicin and its main side effect is a low white blood cell count. (cancer.org)
- Liposomal formulations of daunorubicin and doxorubicin have been approved that appear to be somewhat less toxic to cardiac tissue. (wikidoc.org)
Medications3
- Doxorubicin is suitable for use in combination with other medications. (medicalnewstoday.com)
- The recommended dose of doxorubicin varies according to the specific condition being treated, the response to therapy, the other medications being used, and body size. (pharmasave.com)
- Daunorubicin is in a class of medications called anthracyclines. (safemedication.com)
Enzyme2
- apalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- enzalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
Drugs1
- These are particularly potent drugs, with doxorubicin used most commonly in veterinary medicine. (vin.com)
Dose1
- Each single-dose vial of sterile, lyophilized red powder, contains doxorubicin HCl 10 mg. (pharmasave.com)
Acute1
- Doctors prescribe daunorubicin for certain types of acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) . (medicalnewstoday.com)
Cancer1
- Doxorubicin prevents the growth of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction of cells. (pharmasave.com)
Types1
- doxorubicin decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
Doctor1
- If you miss an appointment to receive doxorubicin, contact your doctor as soon as possible to reschedule your appointment. (pharmasave.com)
Patients1
- Patients in the standard arm (surgery alone) will undergo large en- bloc curative intent surgery will be performed within 4 weeks following randomization. (who.int)
Epirubicin3
- Tell your doctor and pharmacist if you are taking or have ever received certain cancer chemotherapy medications such as daunorubicin (cerubidine), doxorubicin (Doxil), epirubicin (Ellence), mitoxantrone (Novantrone), cyclophosphamide (Cytoxan), or trastuzumab (Herceptin). (safemedication.com)
- Anthracyclines such as doxorubicin, daunorubicin, and epirubicin, are well known for their potential to cause elevations in left-ventricular ejection fraction, which may lead to heart failure and cardiotoxicity. (pharmacytimes.com)
- Tell your doctor and pharmacist if you are being treated with anthracycline medications for cancer such as daunorubicin (Cerubidine), doxorubicin (Doxil), epirubicin (Ellence), and idarubicin (Idamycin) at this time or within 7 months after receiving pertuzumab, trastuzumab, and hyaluronidase-zzxf injection. (prescriptiongiant.com)
Mitoxantrone1
- Patients who received more than one anthracycline prior to study entry should have each individual agent cumulative dose converted to doxorubicin equivalent and added together (eg, a patient who received cumulative dose of Daunorubicin at 200 mg/m2 and Mitoxantrone 48 mg/m2 has a total doxorubicin dose equivalent of 358.6 mg/m2 (200 mg/m2 x 0.833 + 48 mg/m2 x 4). (mycancergenome.org)
Cisplatin3
- The objective of our study was to determine whether BPA at low nanomolar concentrations opposes the action of doxorubicin, cisplatin, and vinblastine in the estrogen receptor-α (ERα)-positive T47D and the ERα-negative MDA-MB-468 breast cancer cells. (nih.gov)
- The aim of the study was to evaluate orally administered MGN-3 against gross pathological changes and weight loss produced by a single intraperitoneal dose of cisplatin or doxorubicin by daily oral dosing of 5 or 50 mg/kg MGN-3. (researchgate.net)
- Nausea is also more common with this group, although nausea has a higher risk with some, such as cisplatin, and then also with certain combinations, such as cyclophosphamide with doxorubicin. (buddiesforlife.co.za)
Cerubidine1
- Daunorubicin is available as a solution or a powder for injection in 20 and 50 mg vials [5 mg/mL] generically and under the brand name Cerubidine. (nih.gov)
Toxicity3
- While hepatotoxicity from daunorubicin may be rare, it is likely due to direct hepatic toxicity. (nih.gov)
- Toxicity from daunorubicin may occur, which may result in disease of the heart muscle or heart failure. (rxwiki.com)
- Cardiac toxicity: Doxorubicin, Daunorubicin, and Anthracyclins. (pharmacy180.com)
Anthracyclines3
- Daunorubicin is in a class of medications called anthracyclines. (nih.gov)
- Doxorubicin is in a class of medications called anthracyclines. (nih.gov)
- Daunorubicin belongs to a group of drugs called anthracyclines. (rxwiki.com)
Receive doxorubicin1
- Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive doxorubicin. (nih.gov)
Trastuzumab3
- Previous research indicates that up to 18% of patients have developed cardiac dysfunction while taking combination therapy with trastuzumab and doxorubicin, and 2% to 4% of patients may develop severe heart failure. (pharmacytimes.com)
- Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with Doxorubicin, taxanes, and trastuzumab. (pharmacytimes.com)
- trastuzumab, daunorubicin. (medscape.com)
Extravasation1
- Local extravasation of daunorubicin causes severe local tissue injury. (nih.gov)
Antineoplastic2
- However, high doses of daunorubicin given in combination with other antineoplastic agents have been linked to cases of sinusoidal obstruction syndrome, typically presenting with right upper quadrant pain 10 to 30 days after the infusion, followed by weight gain, ascites and liver test abnormalities. (nih.gov)
- Daunorubicin is used alone or in combination with other antineoplastic medications for the treatment of many types of cancer including cancers of the blood (e.g., leukemia), lymphosarcoma, reticulosarcoma, Wilm's tumour, and Ewing tumours. (medbroadcast.com)
Severe1
- Doxorubicin can cause a severe decrease in the number of blood cells in your bone marrow. (nih.gov)
Medication2
- Daunorubicin is a prescription medication used to treat certain types of blood cancer. (rxwiki.com)
- In the case of daunorubicin, there are no specific foods that you must exclude from your diet when receiving this medication. (rxwiki.com)
Examples1
- Examples are encapsulated form of doxorubicin and daunorubicin. (medkonect.com)
Cumulative1
- Daunorubicin: Should not be used in patients who have previously received the recommended maximum cumulative doses of doxorubicin or daunorubicin. (pediatriconcall.com)
Dosage1
- Myelosuppressive agents: Dosage reduction of daunorubicin may be required. (pediatriconcall.com)
Uptake1
- Zaleskis G, Garberytė S, Pavliukevičienė B, Valinčius G, Characiejus D, Mauricas M, Kraśko JA, Žilionytė K, Žvirblė M, Pašukonienė V. Doxorubicin uptake in ascitic lymphoma model: resistance or curability is governed by tumor cell density and prolonged drug retention. (jcancer.org)
Cardiomyopathy1
- Daunorubicin associated with decreased risk for cardiomyopathy compare to Doxorubicin. (nih.gov)
Synthesis1
Liver2
- In many instances, it is difficult to attribute the liver test abnormalities to daunorubicin, because of the exposure to other potentially hepatotoxic agents. (nih.gov)
- Daunorubicin is metabolized in the liver via microsomal enzymes and production of a toxic or immunogenic intermediate may trigger liver injury. (nih.gov)
Precautions1
- See the "Daunorubicin Precautions" section. (rxwiki.com)
Ingredients1
- Do not take daunorubicin if you are allergic to daunorubicin or to any of its ingredients. (rxwiki.com)
Powder1
- Doxorubicin comes as a solution (liquid) or as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. (nih.gov)
Vein2
- Daunorubicin is usually injected into a vein through a specially prepared site on your skin. (medbroadcast.com)
- Doxorubicin should be administered only into a vein. (nih.gov)
Side effects1
- Serious side effects have been reported with daunorubicin. (rxwiki.com)