• Oral dosing of rats with SCN-, before acute ischemia-reperfusion injury (30 min occlusion, 24 h or 4 week recovery), significantly reduced the infarct size as a percentage of the total reperfused area (54% versus 74%), and increased the salvageable area (46% versus 26%) as determined by MRI imaging. (ku.dk)
  • Indeed, berberine reduced lipopolysaccharide-induced injury in intestine, ischemia-reperfusion-induced tight junction injury, and polymicrobial sepsis-induced damage to intestinal mucosal barrier in rats. (usda.gov)
  • Experimental stroke (transient focal cerebral ischemia) was induced by a 2-hour middle cerebral artery occlusion (MCAO) with the use of a suture inserting into the lumen of the internal carotid artery (ICA) in male Wistar rats. (banglajol.info)
  • APC reduces the pulmonary endothelial cell injury and hypotension in rats administered endotoxin (ET) by inhibiting TNF-α production through inhibition of its transcription. (eurekaselect.com)
  • Furthermore, APC reduces the ischemia / reperfusion-induced renal injury and the stress-induced gastric mucosal injury in rats. (eurekaselect.com)
  • Furthermore, APC reduced the spinal cord injury induced by compression-trauma or ischemia / reperfusion by inhibiting TNF-α production in rats, suggesting that APC may be a potential therapeutic agent for spinal cord injury in which only limited therapeutic measures are currently available. (eurekaselect.com)
  • We then established the rat ischemia-reperfusion injury (IR) model and transplanted the iPSC-derived RPCs into the injured rats in combination with the hydrogel. (biomedcentral.com)
  • Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. (phypha.ir)
  • Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
  • The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)
  • Adeno-associated viral (AAV)-NRP-1 was stereotaxically inoculated into the cortex and ipsilateral striatum posterior of adult male Sprague-Dawley (SD) rats before a 90-min transient middle cerebral artery occlusion (tMCAO) and subsequent reperfusion. (biomedcentral.com)
  • We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
  • Qi et al ( 9 ) reported that GP protected against DNA damage in neurons in I/R-induced cerebral injury. (spandidos-publications.com)
  • Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
  • The effect of moderate whole body hypothermia (300 C) on transient focal cerebral ischemia induced inflammatory injury was investigated. (banglajol.info)
  • Our results indicate that moderate hypothermia has a significant protective effect on the inflammatory injury induced by transient focal cerebral ischemia. (banglajol.info)
  • Burggraf D, Vosko MR, Schubert M, Stassen JM, Hamann GF Different therapy options protecting microvasculature after experimental cerebral ischaemia and reperfusion. (mpg.de)
  • Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. (mpg.de)
  • Vascular Integrin immunoreactivity is selectively lost on capillaries during rat focal cerebral ischemia and reperfusion. (mpg.de)
  • Burk J, Burggraf D, Vosko M, Dichgans M, Hamann G. Effects of hypothermia on focal cerebral ischemia in plasminogen knockout mice. (mpg.de)
  • Burk J, Burggraf D, Vosko M, Dichgans M, Hamann G. Hypothermia strengths inhibitors of matrix degrading proteases following experimental focal cerebral ischemia in mice. (mpg.de)
  • Increasing doses of rt-PA reduce MMP3-activity following experimental focal cerebral ischemia. (mpg.de)
  • Microplasmin reduces dose-dependently microvascular basal lamina damage in experimental focal cerebral ischemia. (mpg.de)
  • rt-PA causes a dose-dependent increase in the extravasation of cellular and non-cellular blood elements after focal cerebral ischemia. (mpg.de)
  • Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. (mpg.de)
  • MB research in ischemic heart stroke While low-dose MB has been shown to lessen neurobehavioral impairment in neurodegenerative illnesses (Parkinson's disease [23 29 Alzheimer disease [30-32]) the neuroprotective ramifications of MB on cerebral ischemia in vivo had been only. (immune-source.com)
  • However, whether NRP-1 can repair mitochondrial structure and promote functional recovery after cerebral ischemia is still unknown. (biomedcentral.com)
  • Both in vitro and in vivo models of cerebral ischemia/reperfusion (I/R) injury presented a sharp increase in NRP-1 expression. (biomedcentral.com)
  • The expression of AAV-NRP-1 markedly ameliorated the cerebral I/R-induced damage to the motor function and restored the mitochondrial morphology. (biomedcentral.com)
  • Therefore, promoting the mitochondrial structural repair and functional recovery is the crucial for the amelioration of the neurological damage after cerebral ischemia. (biomedcentral.com)
  • Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
  • It has been demonstrated that I/R-induced hepatic injury is initially triggered by reactive oxygen species (ROS), which induce oxidative damage and apoptosis, an important mechanism for cell death following hepatic I/R injury ( 2 ). (spandidos-publications.com)
  • Countering NADH production, calcium action on the mitochondrial permeability transition pores increases inner membrane permeability thereby reducing proton potential, causing the matrix to swell and ultimately releasing cytochrome c (an initiator of apoptosis). (benbest.com)
  • Y. Wu and colleagues found that a novel tissue protective peptide, helix B surface peptide (HBSP) derived from erythropoietin, can effectively improve renal function by reducing tissue damage caused by ischemia reperfusion or cyclosporine A. The mechanism might be related to reduced caspase-3 activation, a key trigger in cell apoptosis and inflammation. (hindawi.com)
  • It has also been reported that triiodothyronine (T3) alleviates oxidative stress, inflammation and apoptosis caused by hepatic ischemia-reperfusion injury, and its mechanism of action is associated with negative regulation of the NLRP3 signaling pathway ( 10 ). (spandidos-publications.com)
  • Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
  • Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
  • 11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)
  • Behavioral testing, ischemic damage, blood-brain-barrier disruption, apoptosis, neutrophils infiltration, microglia/macrophage activation, and MPO oxidation were analyzed within a 7-day period after MCAO. (biomedcentral.com)
  • Our studies show that KYC treatment significantly reduces neurological severity scores, infarct size, IgG extravasation, neutrophil infiltration, loss of neurons, apoptosis, and microglia/macrophage activation in the brains of MCAO mice. (biomedcentral.com)
  • HRS and HBO could all decrease the release of immflammatory cytokines in lung tissue, reduce accumulation of oxidative products and alleviate apoptosis of pulmoanry cells, and could produce good therapeutic effects on ALI induced by LPS. (researchsquare.com)
  • LA can also protect cells from damage by activating antioxidant enzymes, inhibiting apoptosis (cell death), and enhancing cell survival. (geronova.com)
  • Similarly, cardiomyocyte-specific Txnip deletion reduced infarct size after reversible coronary ligation. (jci.org)
  • There is also a small clinical-trial experience of the intervention in patients getting PCI for acute MI, which suggests it may help reduce infarct size in those with anterior infarctions. (medscape.com)
  • Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
  • An IL-36R antagonist (IL-36Ra) decreased neutrophil recruitment, improved blood flow, and reduced infarct size in both adult and aged mice. (jci.org)
  • The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. (uni-wuerzburg.de)
  • Aromatase metabolizes testosterone to 17b- estradiol (E2) and thereby significantly contributes The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. (uni-wuerzburg.de)
  • Anastrozole blocked DES induced preconditioning and increased infarct size compared to DES alone (37.94615.5% vs. 17.163.62%) without affecting area at risk and systemic hemodynamic parameters following ischemia/reperfusion. (uni-wuerzburg.de)
  • Cardiogenic shock in the MI setting was usually fatal until the advent of acute reperfusion therapy with balloon angioplasty, but even today with modern PCI and intra-aortic balloon pumping, mortality is about 50%, note the viewpoint's authors, led by Dr Brian M Stegman (Duke University Medical Center, Durham, NC). (medscape.com)
  • These data indicate that elevated levels of the MPO substrate SCN-, which can be readily modulated by dietary means, can protect against acute ischemia-reperfusion injury. (ku.dk)
  • APC regulates the coagulation system by inactivating the activated form of factors V and VIII in the presence of protein S. Tumor necrosis factor-α(TNF-α) plays critical roles in the development of disseminated intravascular coagulation, acute respiratory distress syndrome and shock in sepsis by inducing endothelial cell damage through activation of neutrophils. (eurekaselect.com)
  • Immediately after acute ischemic stroke, reactive oxygen species (ROS) and reactive nitrogen species (RNS) production increases rapidly, resulting in severe damage to ischemic tissues. (biomedcentral.com)
  • Excess release and over-expression of immflammatory mediators and related immflammatory cytokines could stimulate excess immflammatory reaction, resulting in damage to alvelar-cappilary membrane and increased vascular permeability and ultimately acute lung injury (ALI) [ 5 - 7 ] . (researchsquare.com)
  • The study aims to examine the effects of coenzyme Q10, (a bioenergetic antioxidant), on the indexes of left ventricular remodeling, oxidative damage, and angiotensin-converting enzyme (ACE) level after acute myocardial infarction (AMI) with left ventricular dysfunction. (mdpi.com)
  • We conclude that desflurane efficiently regulates aromatase expression and activity which might lead to increased local estrogen synthesis and thus preserve cellular integrity and reduce cardiac damage in an acute myocardial infarction model. (uni-wuerzburg.de)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • Reperfusion triggers an inflammatory response and often results in oxidative damage. (wikipedia.org)
  • 5 Conversely, p53 induction by oxidative damage may help reduce the development of atherosclerosis, perhaps by suppressing the growth or enhancing the death of cells involved in causing atherosclerotic lesions. (the-scientist.com)
  • This may be mechanistically explained by attenuated endothelial oxidative damage and VCAM-1 expression in IL-36Ra-treated mice. (jci.org)
  • Thus, although Txnip deletion suppresses mitochondrial function, protection from myocardial ischemia is enhanced as a result of a coordinated shift to enhanced anaerobic metabolism, which provides an energy source outside of mitochondria. (jci.org)
  • A major topic of research is the impact of hydrogen sulfide on reducing myocardial ischemia-reperfusion injury. (wikipedia.org)
  • Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ levels. (medscimonit.com)
  • Reperfusion injury and reactive oxygen species: the evolution of a concept. (phypha.ir)
  • Given the central role that mitochondria play during hypoxia, we hypothesized that Txnip deletion would enhance ischemia-reperfusion damage. (jci.org)
  • In vitro, HL-1 cells (mouse cardiomyocytes) received chamber hypoxia-oxygenation reperfusion (H/R) for 24H4R with/without DLC1β plasmid, before collection for protein/mRNA analyses. (uwo.ca)
  • Hypoxia and ischemia of the brain are key pathophysiological mechanisms of ischemic stroke ( 5 , 6 ). (frontiersin.org)
  • Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
  • Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
  • Barring complications, the liver can repair itself completely and, within a month, the patient will show no signs of damage. (jonbarron.org)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • While we could also describe a sophisticated success of isolated mouse ventricular myocytes (VMs) in ConT, the framework of the anti-apoptotic system during I/R damage remained to become established. (mycareerpeer.com)
  • Various pharmacologic studies have indicated that morroniside has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption [ 1 - 4 ]. (ijpsonline.com)
  • Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
  • Accordingly, reducing oxidative stress has been proposed as a therapeutic strategy for limiting damage in the brain after stroke. (biomedcentral.com)
  • SCN- supplementation did not modulate serum markers of damage/inflammation (ANP, BNP, galectin-3, CRP), but returned metabolomic abnormalities (reductions in histidine, creatine and leucine by 0.83-, 0.84- and 0.89-fold, respectively), determined by NMR, to control levels. (ku.dk)
  • Mechanical damage during flap preparation and positioning, bending and torquation of pedicle's vessels, thrombosis, edema, inflammation, all may lead to complication, resulting in flap necrosis 5 5. (scielo.br)
  • Both offer a variety of potential health benefits, from supporting heart health to reducing inflammation. (cibdol.com)
  • ALA can prevent I/R injury by reducing the production of free radicals, scavenging free radicals, and reducing inflammation. (geronova.com)
  • The most relevant goal, they write, would be to "improve cardiac function and hemodynamics and reduce end-organ damage from prolonged hypoperfusion. (medscape.com)
  • Composite flaps used in reconstructive surgery may intra- and postoperatively suffer from hypoperfusion and/or ischemia-reperfusion influencing wound healing. (scielo.br)
  • Methylene blue provides been shown to boost blood circulation pressure and myocardial function by inhibiting nitric oxide activities in individual septic surprise disease [41 47 50 52 These research Zotarolimus showed that methylene blue provides vascular results and causes vasoconstriction transiently thus improving blood circulation pressure that could help to reduce the chances of hypoperfusion during heart stroke. (immune-source.com)
  • At the LMU, she engaged in postdoctoral research in neurology leading the junior research group "Vascular Damage in Stroke" for several years. (mpg.de)
  • This article reviews the specific links between HHcy and endothelial dysfunction, and highlights recent evidence that endothelial mesenchymal transition contributes to HHcy-induced vascular damage, with a hope to provide new ideas for the clinical treatment of HHcy-related vascular diseases. (bvsalud.org)
  • In stroke, the ischemic crisis activates a series of events, including the inflammatory reactions that are potentiated by reperfusion, eventually leading to neuronal damage. (banglajol.info)
  • Therefore, it is of great significance finding an effective target to offset the I/R-induced neuronal damage. (biomedcentral.com)
  • INTRODUCTION: Testicular torsion, migration of neutrophils to the ischemic region and the formation of free oxygen radicals are important factors in the occurrence of ischemia-reperfusion damage in testes. (hnhtipdergisi.com)
  • In our study, we evaluated the prophylactic effects of the Verapamil in testicular ischemia-reperfusion damage. (hnhtipdergisi.com)
  • Intravaginal testicular torsion with ischemia in adolescent boy. (medscape.com)
  • Others reported that berberine reduced ETEC-induced diarrhea in humans, castor oil-induced diarrhea in mice, and irritable bowel syndrome-induced diarrhea in humans. (usda.gov)
  • Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
  • CaMKIV knockout mice experience significantly worse organ damage after I/R and are deficient in hepatocyte autophagic signaling. (usuhs.edu)
  • Restoration of autophagic signaling with rapamycin reduces organ damage in CaMKIV knockout mice to wild-type levels. (usuhs.edu)
  • Immunofluorescence studies show that KYC treatment reduces the formation of chlorotyrosine (ClTyr), a fingerprint biomarker of MPO oxidation, nitrotyrosine (NO 2 Tyr), and 4-hydroxynonenal (4HNE) in MCAO mice. (biomedcentral.com)
  • Ischemia-reperfusion (I/R) injury is a common complication of surgery, and a major cause of organ dysfunction, especially in the liver. (geronova.com)
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • On average, ocular blood flow (OBF) is reduced in glaucoma patients in various tissues of the eye. (molvis.org)
  • The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)
  • HBOT could obviously enhance aterial oxygen level, increase partial pressure of oxygen and improve ischemia in various organs or tissues, decrease acid metabolites and hasten functional recovery of various organs. (researchsquare.com)
  • abstract = "Sterile inflammatory insults, such as ischemia-reperfusion (I/R) injury, result from pathogenic factors, including damage-associated molecular pattern signaling, activation of innate immunity, and upregulation of proinflammatory cytokines. (usuhs.edu)
  • 8. Eltzschig H, Eckle T. Ischemia and reperfusion - from mechanism to translation. (scielo.br)
  • Nevertheless, the reduced retention price of MSCs after transplantation and their low propensity to differentiate right into a cardiac phenotype [4] make it improbable that cell alternative is the major mechanism of great benefit. (mycareerpeer.com)
  • Combination Of Hypothermia With Thrombolysis With Rt-PA Reduces Haemorrhages In A Rat Model Of Experimental Stroke. (mpg.de)
  • An important role of this protein was also demonstrated in different experimental studies on heart damage. (springer.com)
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • Neutrophil infiltration and activation contributes to tissue damage, via the release of myeloperoxidase (MPO) and formation of the damaging oxidant hypochlorous acid. (ku.dk)
  • We hypothesized that elevation of thiocyanate ions (SCN-), a competitive MPO substrate, would modulate tissue damage. (ku.dk)
  • Nacetylcysteine prevents kidney and lung disturbances in renal ischemia/reperfusion injury in rat. (phypha.ir)
  • moreover, in vivo grafts demonstrated reduced neutrophilic infiltrate/fibrosis/overall injury. (uwo.ca)
  • A similar problem may occur in ischemia-reperfusion injuries, such as those that occur in heart attack and stroke. (the-scientist.com)
  • In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
  • Persons with SCD produce abnormal hemoglobin that causes erythrocytes to become rigid and deform under low oxygen conditions, leading to ischemia-reperfusion injury in the microvasculature with subsequent organ damage and pain. (cdc.gov)
  • In fact, this description represents a reperfused instead of a nonreperfused ischemic bowel because there should not be a lot of erythrocytes or plasma extravasating through the damaged and ruptured microvascular wall into the mucosa, submucosa, or bowel lumen if the arterial supply is severely reduced, either occlusively or nonocclusively, without a subsequent reperfusion taking place. (ajronline.org)
  • Intra- and postoperative monitoring of flap microcirculation may provide useful information for better understanding and following-up the ischemia-reperfusion-related alterations in tissue perfusion 6 6. (scielo.br)
  • Agents from sunlight to chemicals, ionizing radiation, and oxygen radicals can either directly damage bases or break the phosphodiester backbone on which the bases reside. (the-scientist.com)
  • Surprisingly, Txnip-KO hearts had greater recovery of cardiac function after an ischemia-reperfusion insult. (jci.org)
  • The damage starts with the mucosa, which is most vulnerable to the ischemic insult, extends outward through the submucosa and the proper muscular layer, and ends at the serosa. (ajronline.org)
  • The severity of IRI induced- lung insult can be affected by gender and reperfusion time alteration. (phypha.ir)
  • Ischemia/reperfusion (I/R) is a predominant cause of hepatic injury, which is of clinical significance following liver surgery, hemorrhagic shock and liver transplantation ( 1 ). (spandidos-publications.com)
  • The liver is one of the only organs in the body that is able to replace damaged tissue with new cells rather than scar tissue. (jonbarron.org)
  • The incidence of ALD has steadily increased in the last 10 years and it is now the second major cause of liver damage, secondary only to viral hepatitis ( 2 ). (spandidos-publications.com)
  • Furthermore, Lycium barbarum has been reported to inhibit the NLRP3 inflammasome signaling pathway, thereby reducing alcohol-induced liver cell damage ( 11 ). (spandidos-publications.com)
  • Previous studies have confirmed that changes in thyroxine levels are associated with the severity of liver damage ( 10 , 12 ). (spandidos-publications.com)
  • In animal studies, LA has been found to be effective in reducing I/R injury in the liver, kidneys, and heart. (geronova.com)
  • Thus, we must rely on the elegant mechanisms our cells have developed to repair damage. (the-scientist.com)
  • Predictably, different mechanisms are needed to repair these broadly differing types of damage. (the-scientist.com)
  • Although these cellular-suicide mechanisms may protect the organism in some physiologic settings, such as by preventing cancer, the double-edged sword is that these same DNA-damage response pathways that help prevent cancer can also contribute to debilitating disease processes. (the-scientist.com)
  • 15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
  • Coordinated with reduced mitochondrial function, deletion of Txnip enhanced anaerobic glycolysis. (jci.org)
  • Whereas mitochondrial ATP synthesis was minimally decreased by Txnip deletion, cellular ATP content and lactate formation were higher in Txnip-KO hearts after ischemia-reperfusion injury. (jci.org)
  • As part of the mitochondrial electron transport chain , coenzyme Q 10 accepts electrons from reducing equivalents generated during fatty acid and glucose metabolism and then transfers them to electron acceptors. (oregonstate.edu)
  • In its reduced form (CoQ 10 H 2 ), coenzyme Q 10 is an effective fat-soluble antioxidant that protects cell membranes and lipoproteins from oxidation . (oregonstate.edu)
  • Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes and release of damage-associated molecular patterns [ 16 ]. (springer.com)
  • Potential systems of MSC-mediated safety from ischemic damage will be the differentiation of MSCs into cardiomyocytes, the excitement of cardiac stem cell proliferation, and/or cells that enhance vascularization [3]. (mycareerpeer.com)
  • Reperfusion injury is a significant threat to myocardial function that arises with the reintroduction of blood flow to the heart following an ischemic episode. (wikipedia.org)
  • citation needed] Large blood clots can also cause ischemia by blocking blood flow. (wikipedia.org)
  • The "ischemia" phase of cardiac IRI occurs when the donor heart is being collected and blood/oxygen is not going to the heart. (uwo.ca)
  • The surgery connects the recipients blood supply back to the heart, however, the rush of blood back to the heart can result in further damage. (uwo.ca)
  • Taking N-acetyl cysteine by mouth seems to reduce levels of a blood fat called lipoprotein(a) in people with high levels of this blood fat. (medlineplus.gov)
  • Bowel ischemia represents a process of insufficient blood supply of the small or large bowel with the consequences ranging from a transient, totally reversible attack to a lethally catastrophic event. (ajronline.org)
  • These periods of surging blood pressure inflict massive arterial damage and are the main reason why at-home and at-office blood pressure testing are so important. (lifeextension.com)
  • Early studies revealed that animals deprived of PQQ exhibit signs of accelerated aging in the form of elevated plasma glucose concentrations, impaired oxygen metabolism, stunted growth, compromised immunity, impaired reproductive capability, reduced numbers and survival rate of offspring, and a decrease in energy-producing mitochondria in their tissue. (lifeextension.com)
  • Sometimes, the ischemic event persists long enough without reperfusion and becomes destined to its final outcome: necrosis of the whole bowel wall. (ajronline.org)
  • I also attempt to assess what can be done to minimize such damage. (benbest.com)
  • The chief aim in this study was to investigate whether changing temperature during and after ischemia could minimize this damage by reducing the inflammatory injury. (banglajol.info)
  • Abnormal and uncontrolled activation of these enzymes lead to cellular damage after CPB. (medscape.com)
  • 1 Thus, a broad range of physiologic processes depends on cellular responses to DNA damage. (the-scientist.com)
  • Cellular DNA can be damaged in several ways: Bases can be covalently altered, the phosphodiester backbone can break on one or both strands, or chemical interstrand cross-links can be introduced. (the-scientist.com)
  • A critical coenzyme known as PQQ activates vital cell-signaling pathways involved in creating new mitochondria, improving cellular metabolism, protecting neurons, and repairing DNA damage. (lifeextension.com)