These characteristics are caused by altered gene expression, as a result of genetic mutations that inactivate tumour suppressor genes and / or activate oncogenes. (savedelicious.com)
These genes are either tumor suppressors (VHL, TSC) or oncogenes (MET). (medscape.com)
The two main types of genes that are now recognized as playing a role in cancer are oncogenes and tumor suppressor genes. (doctorlib.info)
The results not only help the practitioner and patient choose an effective combination of therapies, but also helps them understand which cancer genes (oncogenes) are blocked by which treatments. (dunphynunley.com)
Chemotherapeutic4
The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
Beyond that, Refametinib now there is normally proof that MMR lacking cells are resistant to methylating realtors and to some antimetabolites intrinsically, including the chemotherapeutic medication 5-Fluorouracil, which is normally regular in adjuvant treatment of intestines carcinoma (CRC) [4]. (immune-source.com)
GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors. (adooq.com)
Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS . (lookformedical.com)
Classic anti-cancer strategies aimed at actively killing cancer cells include alkylating agents that generate crosslinks in DNA and trigger repair mechanisms to induce apoptosis, antimetabolites that severely disrupt nucleic acid synthesis, and alkaloids that interfere with microtubule polymerization/depolymerization and halt mitosis 2 . (cancerbiomed.org)
Replication1
PP2A, a serine/threonine phosphatase composed of 3 distinct subunits-65-kDa PP2A-A (scaffold subunit), 55-kDa PP2A-B (regulatory subunit), and 37-kDa PP2A-C (catalytic subunit)-constitutes 0.2%-1.0% of the total protein content in mammalian cells and has been implicated in the regulation of diverse cellular processes, including signal transduction, cell cycle progression, DNA replication, gene transcription, and protein translation 5 - 8 . (cancerbiomed.org)
Transcription6
The heterodimer binds to vitamin D response element in target genes and leads to gene transcription regulation ( 1 ). (jcancer.org)
In addition, calcitriol has rapid effects that are independent of gene transcription regulation, which are defined as non-genomic effects and not mediated directly through steroid receptor-ligand-DNA interaction. (jcancer.org)
On the other hand, non-genomic actions may indirectly affect gene transcription via the regulation of intracellular signaling pathways that target transcription factors ( 3 ). (jcancer.org)
P53 is a tumor suppressor gene that codes for a transcription factor that regulates the expression of other genes and arrests the cell cycle. (doctorlib.info)
Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. (medindex.am)
Protein6
Despite high protein expression and enzymatic activity of cytochrome P450 1B1 (CYP1B1) in renal cell cancer (RCC), its functional significance has not been elucidated. (oncotarget.com)
An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues. (oncotarget.com)
The SAMHD1 gene was disrupted using CRISPR/Cas9 and SAMHD1 depleted using RNAi, and the viral Vpx protein. (biomedcentral.com)
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. (adooq.com)
Here, Biobran's anti-SARS-CoV-2 activity was assessed using MTT and plaque reduction assays, RT-PCR, ELISA techniques, and measurements of SARS-CoV-2-related gene expression and protein levels. (biobran.org)
Lymphocyte activation gene-3 (LAG-3) is a coinhibitory receptor associated with impaired T-cell function and is frequently coexpressed with programmed cell death protein-1 (PD-1) in the context of human cancers. (aacrjournals.org)
Inhibitor2
More over, since most tumor specimens Decitabine Antimetabolites inhibitor and tumor derived cell lines utilized in these investigations have now been ovarian SACs, the position of mTOR in CCC remains largely as yet not known. (deubiquitinase.com)
CCC may be a good candidate for therapy with a mTOR inhibitor, as it is well known that loss of PTEN expression and consequent activation of AKT signaling end in hypersensitivity to mTOR inhibition. (deubiquitinase.com)
Regulates3
Instead, alteration of CYP1B1 expression regulates the chemosensitivity of RCC cells to docetaxel suggesting its critical contribution to the chemoresistance. (oncotarget.com)
Additionally, miR-200c, which is significantly down-regulated in RCC regulates CYP1B1 expression and activity. (oncotarget.com)
In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
Nonspecific1
Cytotoxicity is cell-cycle nonspecific. (medscape.com)
Tumor supp1
These two important mechanisms of approaching cancer, principally through the clinical application of the P53 tumor suppressor gene and other apoptotic players that for the past 15 years have been included in my cancer strategy as a diagnostic, prognosis, and follow up treatment. (biobran.org)
Compounds3
Specifically, pharmacokinetic genes participate in the inactivation and elimination of active compounds. (wikipedia.org)
Cytochrome P450 (CYP) is a multi-gene family of enzymes implicated in the metabolism of a diverse range of xenobiotics and endogenous compounds. (oncotarget.com)
Moreover, no cytotoxicity towards mammalian and red blood cells at the concentrations tested was observed for any of the compounds under investigation. (ibecbarcelona.eu)
Binds1
An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
Whole-genome2
Strategies for pharmacogenomic discovery using whole-genome sequences include targeting frequently mutated gene stretches (known as hotspots) to identify markers of prognostic and diagnostic significance, or targeting specific genes that are known to be associated with a particular disease. (wikipedia.org)
Machine learning can be used to reduce the complexity of whole genome gene expression patterns to derive manageable signatures of response. (biomedcentral.com)
Multidrug resistance, generally, results from over expression of ATP-dependent efflux pumps [5]. (savedelicious.com)
Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c. (oncotarget.com)
SiRNA2
Previously, siRNAs have been commonly used to suppress gene expressions, but more recently, siRNA have been suggested for use in studying and developing therapeutics. (wikipedia.org)
MVL5 is a new Multivalent Cationic Lipid for siRNA Delivery.Improved total gene silencing and Lower non-specific gene silencing,Lower toxicity. (dcchemicals.com)
Alteration1
Genetic studies of the families at high risk for developing renal cancer led to the cloning of genes whose alteration results in tumor formation. (medscape.com)
Proliferation1
These genes are deleted or inactivated in cancer cells, allowing unregulated proliferation. (doctorlib.info)
Cells5
Cancer is a genetic disease where changes to genes can cause cells to grow and divide out of control. (wikipedia.org)
The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells. (biomedcentral.com)
Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. (biomedcentral.com)
It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. (lookformedical.com)
As a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2) type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked and the expression of signals essential for the activation of inflammatory T-lymphocytes is inhibited. (medindex.am)
Cancer4
Cytochrome P450-based suicide gene therapy for cancer using prodrugs such as cyclophosphamide (CPA) increases anti-tumor activity, both directly and via a bystander killing mechanism. (biomedcentral.com)
It is important to block the activity of multiple genes to successfully regulate cancer expression because single therapies are extremely rare in cancer care, as they often allow the cancer genome to adapt and become more aggressive. (dunphynunley.com)
Treating a cancer without oncogenetic (cancer gene) analysis is like trying to tell where a ship is coming from when it is thirty miles from the shore, without a telescope. (dunphynunley.com)
Cancer is a disease which occurs at the level of the genes. (dunphynunley.com)
Multiple3
We used multiple feature selection layers followed by the XGBoost regression model and reduced the complexity of 20,000 gene expression values to generate a 16-gene signature leading to the identification of a set of predictive candidate biomarkers which form an LP-184 response gene signature. (biomedcentral.com)
The regulatory B subunits are classified into 4 unrelated families, each encoded by multiple genes: B (PR55), B′ (PR56/61), B″ (PR48/59/72/130), and B'″ (PR93/110 or striatin). (cancerbiomed.org)
Viral1
Dr. Ho did her PhD work in herpesvirus pathogenesis and postdoctoral research in CNS gene therapy with viral vectors at Stanford University. (stanford.edu)
Activity1
In one embodiment, substance P analogs are useful for reducing PARP activity or PARP expression. (patentsencyclopedia.com)
Drug2
Classic antimetabolite anticancer drug with chemical structure similar to endogenous intermediates or building blocks of DNA or RNA synthesis. (medscape.com)
Candidate polymorphism search refers to finding polymorphic DNA sequences within specific genes that are candidates for certain traits. (wikipedia.org)
This system can recognize and cleave specific DNA sequences, and thus is a powerful system for gene silencing purposes. (wikipedia.org)
Human1
It is the most frequently mutated gene in human cancers. (doctorlib.info)
Group1
This type of analysis considers a group of related genes, whose altered function may have an effect on therapy, rather than solely focusing on one gene. (wikipedia.org)
Drugs2
Cytotoxicity can occur at any stage of the cell cycle, but cell is most vulnerable to action of these drugs in G1 and S phase. (medscape.com)
Open data on the gene expression of the NCI-60 cell lines, provides a unique opportunity to add another dimension to the preclinical development of such drugs by interrogating correlations with gene expression patterns. (biomedcentral.com)
Loss1
Mutation or loss of this gene can be found in 13% of sporadic pulmonary carcinoids and seem to be associated to shorter survival [ 13 ]. (springeropen.com)
Response1
Therefore, expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response. (oncotarget.com)
Effects1
It can provide insight into additional information such as gene-gene interactions, epistatic effects, or influences from cis-regulatory elements. (wikipedia.org)
Discovery1
We applied our proprietary RADR® platform to an NCI-60 discovery dataset encompassing LP-184 IC50s and publicly available gene expression data. (biomedcentral.com)