• Radiation therapy may be received before, after, or during chemotherapy. (medlineplus.gov)
  • The primary hypothesis was that cytotoxic chemotherapy administered within 35 days of COVID-19 diagnosis would be associated with an increased risk of severe or critical COVID-19. (ascopost.com)
  • On univariate analysis, no increased risk of severe or critical COVID-19 was observed among the 102 patients (33.0%) who received cytotoxic chemotherapy within 35 days of COVID-19 diagnosis (hazard ratio [HR] = 1.10, 95% confidence interval [CI] = 0.73-1.60, P = .74). (ascopost.com)
  • Receipt of cytotoxic chemotherapy within 35 days of COVID-19 diagnosis was not associated with severe or critical COVID-19. (ascopost.com)
  • A total of 314 of patients (34.2%) received cytotoxic chemotherapy within 35 days of testing. (ascopost.com)
  • Subjects must have received no more than 2 lines of prior systemic therapy (including no more than 1 line of systemic cytotoxic chemotherapy) in the locally advanced or metastatic setting. (mayo.edu)
  • 12.No prior chemotherapy or use of systemic cytotoxic therapy agents. (who.int)
  • 3.Breastfeeding or pregnant women are excluded because of potential risks of cytotoxic chemotherapy to an unborn child or infant. (who.int)
  • Tevogen Bio, a clinical stage biotechnology company, announced that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for TVGN-489, Allogeneic COVID-19 Specific Cytotoxic T Lymphocytes (CTLs), allowing Tevogen Bio to initiate clinical trial of its investigational COVID-19 treatment. (medtelligence.net)
  • TVGN-489 is highly purified SARS-CoV-2 specific cytotoxic CD8+ T lymphocytes programmed to detect targets from the entire viral genome. (medtelligence.net)
  • Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy. (ox.ac.uk)
  • Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)
  • We conclude that CR and KDs may act synergistically with radiation therapy for the treatment of cancer patients and provide some guidelines for implementing these dietary interventions into clinical practice. (springer.com)
  • Despite these advancements, several cancer types continue to elude modern treatment techniques with radiation therapy (RT). (springer.com)
  • Similar expansions could also be obtained from the peripheral blood of patients with acute leukemia undergoing therapy ( n = 11). (aacrjournals.org)
  • These patients have an inexplicable failure to respond adequately to FSH therapy during attempts at superovulation. (medscape.com)
  • In this clinical situation, patients also fail to respond adequately to FSH therapy during attempts at superovulation. (medscape.com)
  • CD68 + macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. (ersjournals.com)
  • Our results revealed that 1-deoxysphinganine is a cytotoxic lipid for insulin-producing cells, suggesting that the increased levels of this sphingolipid observed in diabetic patients may contribute to the reduced functionality of pancreatic β-cells. (uzh.ch)
  • Warning: Posttreatment Acute Exacerbation of Hepatitis B (HBV) All patients with HIV-1 should be tested for the presence of HBV before initiating ARV therapy. (natap.org)
  • Patients with ER -negative disease and patients who did not respond to previous tamoxifen therapy rarely responded to ARIMIDEX. (rxlist.com)
  • 4. To prospectively evaluate the IPFSG scoring system as a predictor of outcome to initial salvage therapy in patients with relapsed or refractory GCT. (cincinnatichildrens.org)
  • In this single-arm, open-label, phase II study, 125 patients with indolent non-Hodgkin's lymphomas who had not had a response to rituximab and an alkylating agent or had had a relapse within 6 months after receipt of those therapies were administered idelalisib, until the disease progressed or the patient withdrew from the study. (esmo.org)
  • Patients had received a median of four prior therapy lines (range, 2 to 12). (esmo.org)
  • Purpose: Endocrine therapies, such as tamoxifen, are commonly given to most patients with estrogen receptor (ERa) ^ positive breast carcinoma but are not indicated for persons with ERa-negative cancer. (lu.se)
  • et 20 témoins en bonne santé ne présentant pas d'infection par le virus de l'hépatite C. Une réduction importante de la fréquence des cellules tueuses naturelles totales dans le groupe des patients porteurs d'une infection chronique a été observée par rapport au groupe des témoins ( P = 0,001) ou au groupe des patients dont l'infection a connu une résolution spontanée ( P = 0,01). (who.int)
  • Immunomodulatory and cytotoxic agents that are used in adult MS in the event of suboptimal response to interferon-beta and/or glatiramer acetate have been used in a small number of pediatric patients. (medscape.com)
  • As the major target of 03 inhalation, lung tissue has been reported to sustain both cytotoxic and genotoxic damage as well as cause neo-plastic transformation in vivo and in vitro. (cdc.gov)
  • Studies of various medicinal plants and other natural products from nature have shown the anti-proliferative, cytostatic and cytotoxic activities of various phytochemicals against different cancer cells [ 3 ]. (biomedcentral.com)
  • We reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy. (mdpi.com)
  • ARIMIDEX is indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy. (rxlist.com)
  • Quality of life is assessed at baseline, every 4 weeks while on therapy, and then every 8 weeks until disease progression. (knowcancer.com)
  • It is concluded that thymidine phosphorylase is associated with angiogenesis, with resistance to radiotherapy and cytotoxic therapy, and with poorer survival in squamous cell head and neck cancer. (ox.ac.uk)
  • The Warburg phenotype provides tumors an enhanced resistance against cytotoxic insults. (springer.com)
  • Natural killer (NK) cells can kill cancer cells in the absence of prior stimulation and hold considerable potential for cell-based therapies targeting human malignancies ( 1 - 4 ). (aacrjournals.org)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/434284/all/Immunosuppressive_and_cytotoxic_therapy_for_pulmonary_sarcoidosis. (unboundmedicine.com)
  • The ophthalmologist can work with other physicians involved in the patient's care to monitor therapy with systemic corticosteroids and immunosuppressive agents. (aao.org)
  • The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
  • Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
  • These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
  • However, cellular immune reconstitution of CMV-specific cytotoxic T-cells (CMV-CTL) is generally considered to be necessary for the long-term control of CMV reactivation after allo-HCT. (nature.com)
  • A better and deeper understanding of immune reconstitution following allo-HCT is required for further clinical application of these adoptive T-cell therapies. (nature.com)
  • In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
  • Here the authors describe the design of a flex-patch loaded with anti-PD-1 antibodies and immuno-adjuvant nanosheets, layered double hydroxide, to fuel anti-tumor immune response in the SLN for postsurgical breast cancer adjuvant therapy. (nature.com)
  • Anti-inflammatory, antioxidant, and cytotoxic properties have yet to be fully explored. (drugs.com)
  • Using cytotoxic and antioxidant studies, the study attempted to assess some of the commonly used medicinal plants used to cure cancer among Yoruba people in Ogun, Oyo, Osun, and Lagos (South-West, Nigeria). (who.int)
  • Study Design: Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)
  • The results that we report here provide rationale and practical platform for clinical testing of expanded and activated NK cells for cell therapy of cancer. (aacrjournals.org)
  • Cytotoxic and anti-angiogenic properties of n-hexane extract of Sandoricum koetjape stem bark were investigated in vitro . (scialert.net)
  • There are few reports on the bioactivity and pharmacological properties of S. koetjape with fewer reports on cytotoxic activity and no reports could be found about anti-angiogenic activity of S. koetjape , thus this research was done in order to study the in vitro cytotoxic and anti-angiogenic properties of the stem bark extract of S. koetjape . (scialert.net)
  • This study reported both in vitro cytotoxic and anti-angiogenic properties of S. koetjape indicating that S. koetjape is a good candidate for further in vivo studies targeting colorectal carcinoma. (scialert.net)
  • In vitro antibacterial and cytotoxic activity of leaf extracts of Centella asiatica (L.) Urb, Warburgia salutaris (Bertol. (biomedcentral.com)
  • Exclusion criteria: 1.Current acute, chronic, or recurrent infections that are serious, in the opinion of the site investigator, for which the participant has not completed at least 14 days of therapy before study entry and/or is not clinically stable. (who.int)
  • Ex vivo models for the noninvasive study of myelin-related diseases represent an essential tool to understand the mechanisms of diseases and develop therapies against them. (researchgate.net)
  • However, the precise molecular determinants involved in the cytotoxic autophagy caused by ABTL0812 remained unclear. (nih.gov)
  • topical NSAIDs and cytotoxic agents may be used to supplement treatment. (aao.org)
  • This article must therefore be hereby marked advertisement in accordance benefit from tamoxifen therapy, although a fraction of ERa- with 18 U.S.C. Section 1734solely to indicate this fact. (lu.se)
  • To evaluate the bovine pulp tissue dissolution ability of photodynamic therapy. (bvsalud.org)
  • Twenty pieces of bovine pulp tissue were weighed and divided randomly into four groups (n=5), according to the cleaning protocol: G1 distilled water (negative control), G2 sodium hypochlorite 1% (positive control), G3 photodynamic therapy, G4 sodium hypochlorite 1% + photodynamic therapy. (bvsalud.org)
  • Only the sodium hypochlorite was able to dissolve the fragments of bovine pulp tissue and photodynamic therapy does not show ability to dissolve tissue. (bvsalud.org)
  • Photodynamic therapy (PDT) or photoactivated disinfection uses light of a specific wavelength to activate a non-toxic photoactive dye, known as the photosensitizer in the presence of oxygen (9). (bvsalud.org)
  • For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. (rxlist.com)
  • The purpse of this study is to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for Telisotuzumab Vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate effectiveness in the selected population(s) (Stage 2). (mayo.edu)
  • In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. (mayo.edu)
  • Fingolimod and teriflunomide are the newest disease-modifying therapies to achieve FDA approval for treatment of relapsing and remitting MS in adults. (medscape.com)
  • The prevalence of 03 as the dominant oxidant of world-wide photochemical smog, its occupational utilization and its application as a direct or adjunct therapy for treatment of various diseases make it a global human health concern. (cdc.gov)
  • We consolidated current studies exploring intrathecal therapies for LM treatment. (bvsalud.org)
  • Antibiotic therapy with intravenous although Miller reported necrotizing the right lateral malleolus. (cdc.gov)
  • In addition, therapies such as rituximab, daclizumab, and cyclophosphamide have been evaluated in phase II trials in adults with breakthrough disease, as have add-on therapies such as monthly steroids and intravenous immunoglobulin (IVIG). (medscape.com)
  • Because of its bifunctional role, TP may have interactions with cytotoxic drugs or radiation via pathways requiring thymidine or prodrug activation. (ox.ac.uk)
  • A highly efficient non-viral process for programming mesenchymal stem cells for gene directed enzyme prodrug cancer therapy. (invivogen.com)
  • Aims: Medicinal plants used by traditional medical practitioners (TMP) to treat cancers are considered safe when used alone or combined with conventional therapy to ensure their effectiveness and eliminate the toxic effects of orthodox medicines. (who.int)
  • The survival advantage conferred by islet macrophage infiltration may be related to their cytotoxic antitumour activity. (ersjournals.com)
  • Dr. Marlana Orloff gives an update on targeted therapies currently being studied in clinical trials. (slideshare.net)
  • Chronic or recurrent uveitis and the corticosteroid therapy used to manage it contribute to cataract formation. (aao.org)
  • Dosage and duration of calcium folinate rescue primarily depend on the type and dosage of methotrexate therapy, the occurrence of toxicity symptoms, and the individual excretion capacity for methotrexate. (janusinfo.se)
  • We therefore adapted the K562-mb15-41BBL stimulation method to large-scale clinical-grade conditions, generating large numbers of highly cytotoxic NK cells. (aacrjournals.org)
  • Using a wide range of biochemical and lipidomic analyses, we demonstrated that ABTL0812 increases cellular long-chain dihydroceramides by impairing DEGS1 (delta 4-desaturase, sphingolipid 1) activity, which resulted in sustained ER stress and activated unfolded protein response (UPR) via ATF4-DDIT3-TRIB3 that ultimately promotes cytotoxic autophagy in cancer cells. (nih.gov)
  • Here we show the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T-cells in actual recipients according to the cytomegalovirus reactivation pattern. (nature.com)
  • Single-cell RNA-sequence analyses demonstrate the homogenous distribution of the gene expression profile in individual cytomegalovirus-specific cytotoxic T-cells within each recipient. (nature.com)
  • However, it has been shown a cytotoxic effect on vital tissues, causing severe inflammatory reactions to the periapex, with the concentration of 5.25% producing more toxic and caustic solutions than 0.5 and 1% (7). (bvsalud.org)
  • In a sensitivity analysis, receipt of targeted therapy alone (n = 49) within 35 days of diagnosis was associated with a trend toward an increased risk of intensive care unit stay or death after diagnosis (HR = 2.2, 95% CI = 1.1-4, P = .02). (ascopost.com)
  • 10.Corticosteroid use at doses above those given for replacement therapy for adrenal insufficiency within the last 30 days prior to study entry. (who.int)
  • Ogundare O. C., Adedosu O. T., Afolabi O. K., Adeleke G. E., Akinboro T., Daniel A. A., Akoro S. M., Oludare V. I.. Ethnobotanical Survey, Physiochemical Composition and Preliminary Cytotoxic Evaluation of some Medicinal Plants with Anticancer Potential from Certain Areas in South-West Nigeria. (who.int)
  • Identification of miRNAs panel can be thus considered an upcoming and potentially useful strategy in PCa diagnosis, given that radioresistance biomarkers, in both prognosis and therapy still remains a challenge. (frontiersin.org)
  • have reported anti-carcinogenic activity of both koetjapic acid and 3-oxo-olean-12-en-29-oic acid. (scialert.net)
  • The results of these studies suggest that although these therapies show promise for the future, they currently do not clearly and consistently report a benefit. (bvsalud.org)