Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. (lookformedical.com)
Western blot hybridization studies showed that T2CA downregulates the expression of total gal 3 proteins and extended the survival of AKR/J mice injected with Ehrlich ascites tumor cells in the Kepler-Meier survival curve analysis. (arjournals.org)
Intranasal immunization of mice with Tm-WAP49 formulated with the adjuvant OCH, a truncated analog of alpha-GalCer with adjuvanticity to stimulate natural killer T cells (NKT) and mucosal immunity, induced significantly high levels of IgG and its subclasses (IgG1 and IgG2a) in immunized mice. (bvsalud.org)
Induces2
Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). (lookformedical.com)
Galectin-3 induces endothelial cell morphogenesis and angiogenesis. (arjournals.org)
Proteins3
The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. (lookformedical.com)
Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2 . (lookformedical.com)
T2CA inhibited the expression of phosphorylated galectin-3 expression in human glioblastoma cell line which in turn inhibits the activity of MMP2 and MMP9 proteins in zymography investigations and inhibits migration of cancer cells in in vitro scratch assay. (arjournals.org)
Protein5
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. (lookformedical.com)
Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (lookformedical.com)
Yamaoka K, Ohno S, Kawasaki H, Suzuki K. Overexpression of a beta-galactoside binding protein causes transformation of BALB3T3 fibroblast cells. (arjournals.org)
In summary, intranasal immunization with recombinant Tm-WAP49 protein induced strong protection versus murine trichuriasis. (bvsalud.org)
Significantly2
The T2CA activated T-cytotoxic and NK cells significantly contributing to its immune stimulating effect. (arjournals.org)
Intranasal immunization also induced a significantly higher nasal mucosa-secreted antigen-specific IgA response, as well as higher functional cellular responses including CD4+IL4+ (Th1) and CD8+GnzB+ (Th2) T cells, and antigen-specific INFγ-producing T cells in both spleen and MLNs and antibody-producing B cells (CD19+B220+/B220+GL7+). (bvsalud.org)
Receptors1
NK cell receptors in antiviral immunity. (arjournals.org)
Antigens2
Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. (lookformedical.com)
The N-terminal part of gp41 is thought to be involved in CELL FUSION with the CD4 ANTIGENS of T4 LYMPHOCYTES, leading to syncytial formation. (lookformedical.com)
Functional3
Moreover, T2CA induced the activation of functional NK cells in human lymphocyte cultures that in turn contributed to the death of K562 leukemic cells in a dose-dependent manner in co-culture experiments. (arjournals.org)
Inohara H, Raz A. Functional Evidence That Cell-Surface Galectin-3 mediates homotypic cell-adhesion. (arjournals.org)
It was also associated with the robust cellular responses including functional subsets of CD4 T cells producing IL-4, and cytotoxic CD8 T cells expressing granzyme B. The worm reduction achieved by mucosal immunization was higher than that induced by subcutaneous immunization. (bvsalud.org)
Natural killer T cel1
Ex vivo expansion of CD8+CD56+ and CD8+CD- natural killer T cells specific for MUC1 mucin. (arjournals.org)
Human1
The inhibitory effect of T2CA on phopho-galectin-3 expression and the activation of T-cytotoxic and NK cells suggested its protective effects against pathogenic infections and human malignancies via its immune stimulating mechanisms. (arjournals.org)
Detectable2
Elevated levels of circulating immune complexes in unfractionated serum were directly detectable during early tumour development although, following serum fractionation, immune complexes were identified at both early and late stages of tumour growth. (nih.gov)
It appears to be a polymorphic protein, variant from species to species, barely detectable (if at all) in normal ac cells (except for undifferentiated EC cells), induced by SV4O transformation and, it turns, out , by other forms of oncogeneisis, as well: Jay has found t what is proabaly the a same protein in a host of m neoplastic cells by using antibodies raised against various MCAinduced tumors. (nih.gov)
Malignant1
Oral administration in domestic cats causes malignant hepatomas and tumors of the esophagus and kidney. (nih.gov)
Antibodies2
The present findings suggest that the detection of immune complexes in unfractionated samples of late tumour-bearer serum using a C1q-binding assay is masked by the increasing production of tumour-specific antibodies and by a shift from complement fixing to non-complement-fixing tumour-specific antibodies. (nih.gov)
PMID- 214407 TI - Antibodies to Herpes simplex virus types 1 and 2 in patients with squamous-cell carcinoma of uterine cervix in India. (nih.gov)
Experiments1
T-cell depletion and reconstitution experiments showed that the effect was absolutely dependent upon the presence in the cultures of T cells from these seropositive donors. (nih.gov)
Vitro2
AB - Peripheral blood mononuclear cells from donors of known serological status with respect to EB virus were exposed to the virus in vitro and then cultured at various cell concentrations. (nih.gov)
The results strongly suggest that the regression phenomenon is an in vitro expression of long-term T-cell-mediated immunity to EB virus which the large majority, if not all, infected individuals possess. (nih.gov)
Sera3
Characterization of sera from different stages of tumour growth. (nih.gov)
AB - Antibody activity to Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) was measured by the indirect hemagglutination (IHA) test in sera from 124 women with squamous-cell carcinoma of the uterine cervix, 46 women with non-cervical cancer and 116 matched normal women. (nih.gov)
src These could explain the "perinuclear" location of pp60 claimed by Rohrschnieder, since Kasamatsue found antibodues against the proteins in random tumor antisera, but not in normal sera, THE EARLY REGION OF ADENOVIRUS Presentations foa focused on the transcription, Splicing and regulation of ths region and, in the words of no less than Phil Sharp, "bewildering", and certainly provided no d information beariang directly on the main topic of the meeting. (nih.gov)
Transformation1
I. Complete regression of virus-induced transformation in cultures of seropositive donor leukocytes. (nih.gov)
Growth1
The confusion may arise from the differmt contexts of testing - growth factors, type of cell infected, mkexx animal used. (nih.gov)
Present1
Lyt le T (t) remains in the shadows: it may be required only in certain contexts: it may he mimic cell grwwth factors already present in some cells or some contexts. (nih.gov)
Early2
23¥&# SV49Q transforemd human cells aren't even tumorigenic in nude mice, Efforts to force the SV40 system into a full analogy with Py have failed, to date, Of course, there is a candidate middle T (dubbed mah "phantom Ty by local talent) proposed o by Berg on the basis of a new splice his troops have found in a late version of early message (clear? (nih.gov)
It also appears in normal cells during early G . The protein is phosphorylated and can be precipitated either directly by antisera or by virtue of its apparent ability to bind to T antigen. (nih.gov)
Made1
In contrast, seropositive donor cultures seeded at the higher cell concentrations developed foci of proliferating EBNA-positive cells within the first 1--2 weeks but thereafter regressed completely and subcultures made after 4 weeks never gave rise to cell lines. (nih.gov)
Surface1
Isolated fractions were examined for their capacity to bind [125I]C1q as a measure of immune complex levels, and for their ability to bind soluble tumour-specific antigen as well as to react with antigens expressed at the surface of viable hepatoma cells. (nih.gov)