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  • CTLs
  • In vitro experiments and studies in mice showed that CTLs are able to specifically target cancerous cells and destroy them by inducing apoptosis ( 12 , 13 , 17 ). (frontiersin.org)
  • Clinical evidence confirmed the importance of CTLs in patients suffering from melanoma and other cancers, as infiltrating CD8 + T cells found in tumor biopsies were strongly associated with improved life expectancy ( 18 - 20 ). (frontiersin.org)
  • vaccine
  • Upcoming treatment paradigms aim to include several primary DC subsets in a single vaccine as pre-clinical studies identified synergistic effects between various antigen-presenting cells. (frontiersin.org)
  • molecules
  • FCs coexpressed the HCC cells-derived WT1 and CEA antigens and DCs-derived MHC class II and costimulatory molecules. (biomedcentral.com)
  • As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. (biomedcentral.com)
  • CD8 + T cells are first activated when their unique T cell receptor (TCR) is triggered by fragments of microbial or tumor antigens in association with MHC I. All nucleated cells express MHC I, however dendritic cells (DCs) also express a range of co-stimulatory molecules, uptake receptors, and other key immune molecules to specifically initiate a cytotoxic CD8 + T cells response. (frontiersin.org)
  • In order to prime the relevant T cells, DCs acquire antigens from infected or cancer cells and process them for presentation on MHC class I molecules (Figure 1). (cam.ac.uk)
  • These signals regulate the efficiency of antigen processing as well as expression of co-stimulatory molecules and, ultimately, determine whether the DC-T cell interaction results in an immunogenic response or, conversely, promotes tolerance. (cam.ac.uk)
  • CD40L
  • Additional CD40L triggering of TSLP-activated DCs induced CD8 + T cells with potent cytolytic activity, producing large amounts of interferon (IFN)-γ, while retaining their capacity to produce IL-5 and IL-13. (rupress.org)
  • vaccines
  • The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma has increased in recent decades, though HPV prevention vaccines may reduce this rise in the future. (sigmaaldrich.com)
  • The bacteria, which is also used in tuberculosis vaccines, attracts immune cells that also attack the bladder cancer. (fool.com)
  • macrophages
  • LL-37 was originally characterized as constitutively expressed in secondary neutrophilic granules ( 12 ), However, LL-37 is produced by many cell types, including macrophages, NK cells, and epithelial cells of the skin, airways, ocular surface, and intestine ( 20 ). (jimmunol.org)
  • secretion
  • Activated NK cells are characterised by the up-regulation of CD69 and MHC class II DR expression, secretion of IFN g and enhanced cytotoxicity. (mdpi.com)
  • Benlahrech A, Donaghy H, Rozis G, Goodier M, Klavinskis L, Gotch F, Patterson S. Human NK Cell Up-regulation of CD69, HLA-DR, Interferon γ Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated through Overlapping but Different Pathways. (mdpi.com)
  • epithelial cells
  • hTSLP is highly expressed by epithelial cells of inflamed tonsils and keratinocytes of atopic dermatitis and its expression is associated with Langerhans cell migration and activation ( 3 ). (rupress.org)
  • cytokine
  • Dendritic cells as most efficient antigen-presenting cells have a role in inducing GVHD.We have isolated dendritic cells from cord blood or cytokine-induced dendritic cells from CD34+ cells in cord blood. (nii.ac.jp)
  • Publications] Chipeta J, Komada Y, Zhang X, Azuma E, Sakurai M :'CD4+ and CD8+ cell cytokine profiles in neonates, older children, and adults :' Cell.Immunol.183. (nii.ac.jp)
  • hTSLP represents the first epithelial cell-derived cytokine that directly triggers DC-mediated TH2 allergic inflammation. (rupress.org)
  • Monocyte-derived DCs from bladder cancer patients were in¬duced to mature in a standard cytokine cocktail (IL-1β, TNF-α, IL-6, and PGE2: standard DCs, sDCs) or anα-type 1-polarized DC (αDC1) cocktail (IL-1β, TNF-α, IFN-α, IFN-γ, and polyinosinic:polycytidylic acid) and loaded with the UVB-irradiated bladder cancer cell line, T24. (intbrazjurol.com.br)
  • immature
  • Human NK cells were analysed after co-culture with immature or CpG-matured blood pDC or with supernatant from these cells. (mdpi.com)
  • peripheral blood mononuclear cells
  • Peripheral blood mononuclear cells were differentiated into phenotypically and functionally confirmed DCs. (aacrjournals.org)
  • Six of 10 patients demonstrated robust systemic cytotoxicity as demonstrated by IFN-γ expression by peripheral blood mononuclear cells in response to tumor lysate after vaccination. (aacrjournals.org)
  • DC presented schizont antigens inducing Peripheral Blood Mononuclear Cells (PBMC) to proliferate and produce Interferon gamma (IFN-y). (cgiar.org)
  • assay
  • We have found that dendritic cells express TPO receptor c-Mpl and its messenger RNA by flow cytometry, immunohistochemistry, and RNase protection assay. (nii.ac.jp)
  • Antigen-loaded αDC1s were evaluated by morphological and functional assays, and the bladder cancer-specific CTL response was analyzed by cytotoxic assay. (intbrazjurol.com.br)
  • transgenic
  • Here we use adoptive transfer of TCR transgenic T cells and DC immunization to show that specific CTL significantly inhibited CD4+ T cell proliferation induced by DC loaded with peptide or low concentrations of protein antigen. (duhnnae.com)
  • activity
  • While the paper demonstrates that inducing REHA CTL is dependent at least in part on the production of IL-12, the neutralization of IL-12 did not affect the cytotoxic activity of REHA CTL. (drugs.com)
  • generate
  • We believe that the results seen in this publication suggest that Argos' proprietary dendritic cells are uniquely capable of delivering the complex array of signals needed to generate stable and potent REHA CTL, which may confer significant immunologic benefit to dendritic cell-based immunotherapies for infectious disease and cancer," said Charles Nicolette, Ph.D., Chief Scientific Officer of Argos. (drugs.com)
  • Cancer
  • This advance may potentially improve the clinical benefit of dendritic cell-based immunotherapies for the treatment of infectious disease and cancer. (drugs.com)
  • Arcelis is Argos' proprietary technology for personalizing RNA-loaded dendritic cell immunotherapies for HIV, other infectious diseases, and cancer. (drugs.com)
  • We have previously reported that the expression of MUC1 was observed in all cancer cells from all 55 pancreatic ductal adenocarcinomas as well as 2 liver metastases by immunohistochemistry. (biomedcentral.com)
  • Dendritic cells (DCs) are promising antigen presenting cells for cancer treatment. (nih.gov)
  • In this review, we will focus on the CD8 + T cells that are key in the elimination of infected or cancer cells. (frontiersin.org)
  • Technically, Bristol-Myers Squibb 's ( NYSE:BMY ) melanoma treatment Yervoy helps the patient by stimulating the immune system, but the stimulation isn't specific to skin-cancer cells. (fool.com)
  • Oncothyreon 's ( NASDAQ:ONTY ) Stimuvax, for example, used a lipid to help train the immune system to recognize tumor cells expressing the cancer-associated marker MUC-1, but the drug failed to show an effect on lung cancer patients in a phase 3 trial reported last year. (fool.com)
  • mice
  • Here, we document that the MuTuDC line was rejected in C57BL-6 mice by a CD4 T cell help-independent, perforin-mediated CD8 T cell response to the SV40LgT without pre-activation or co-injection of adjuvants. (duhnnae.com)
  • Our model reflects experimental results both for dendritic cell trafficking and for immune suppression of tumor growth in mice. (frontiersin.org)
  • efficiently
  • In contrast, CTL had little effect on CD4+ T cell proliferation induced by DC loaded with high protein concentrations or expressing antigen endogenously, even if these DC were efficiently killed and failed to accumulate in the lymph node LN. Residual CD4+ T cell proliferation was due to the transfer of antigen from carrier DC to host APC, and predominantly involved skin DC populations. (duhnnae.com)
  • lysate
  • The primary goal of this Phase I study was to assess the safety and bioactivity of tumor lysate-pulsed dendritic cell (DC) vaccination to treat patients with glioblastoma multiforme and anaplastic astrocytoma. (aacrjournals.org)
  • proliferation
  • Thus, CTL-mediated DC killing can inhibit CD4+ T cell proliferation, with the extent of inhibition being determined by the form and amount of antigen used to load DC. (duhnnae.com)
  • Such inflammation may contribute to HIV persistence by potentiating T cell proliferation and thereby clonal expansion of infected cells, by exacerbating CD8+ T cell exhaustion and potentially by promoting viral replication despite ART. (clinicaltrials.gov)
  • regional tissue inflammation is associated with invasion, activation, and proliferation of immune-competent cells. (physiology.org)
  • biology
  • The Company has generated multiple platform technologies and a diverse pipeline of products based on its expertise in the biology of dendritic cells - the master switch that turns the immune system on or off. (drugs.com)
  • The cell biology of cross-presentation is clearly different from the classical MHC I antigen presentation. (frontiersin.org)
  • role
  • Our data suggest that TSLP-activated DCs play an important role in inducing both CD4 + and CD8 + T cell-mediated allergic inflammation. (rupress.org)
  • However, little is known about the role of different subsets of Foxp3 + T cells in malignant or tuberculous hydrothorax. (biomedcentral.com)