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  • tumor cells
  • Whereas such lines would grow indefinitely in concanavalin A-induced mouse spleen cell supernatant, they would only grow for short periods (2 to 3 days) in the IL 2-containing supernatant of phytohemagglutinin-stimulated LBRM-33 tumor cells, or in IL 2 partially purified from spleen cell or LBRM-33 supernatants. (biomedsearch.com)
  • These cells hamper the immune system's ability to clear tumor cells in cancer patients. (dissertations.se)
  • These therapies allow a person's own immune cells, often T cells, to specifically target tumor cells while limiting normal tissue damage. (rupress.org)
  • PNT makes tumor cells resistant to CTL-mediated lysis. (nih.gov)
  • Although cancer cells are less immunogenic than pathogens, the adaptive immune system is able to recognize and eliminate tumor cells. (mcponline.org)
  • Once transferred in the cancer patient, these replicative senescent cells will not be able to eliminate tumor cells and further proliferate, thereby hindering the efficacy of these therapies ( 11 , 12 ). (mcponline.org)
  • molecules
  • Other key reactions move molecules and molecular complexes within the cell, sometimes changing the cell's shape. (thefreedictionary.com)
  • Previously, we showed that with an increasing number of amino acid differences in single HLA class I-mismatched molecules, the probability of T cell alloreactivity decreases. (biomedsearch.com)
  • they use proteins protein, any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. (thefreedictionary.com)
  • Furthermore, we found that impairment of early signaling events following T cell receptor stimulation because of long term culture allows prediction of costimulatory molecules CD28 and CD27 expression levels and the number of population divisions in culture from a limited subset of signaling proteins. (mcponline.org)
  • lymphoma
  • In situ hybridization studies using an EBV-encoded RNA-1 (EBER-1) probe were performed on 12 ALCL to detect EBV in the lymphoma cells. (ovid.com)
  • EBV is often found in the cancer cells suggesting that it may play a role in causing Lymphoma. (clinicaltrials.gov)
  • Purpose The purpose of this study is to find the largest safe dose of EBV specific cytotoxic T cells, to learn what the side effects are and to see whether this therapy might help patients with Hodgkin disease and non-Hodgkin Lymphoma. (clinicaltrials.gov)
  • If after the second infusion there is a reduction in the size of the patient's lymphoma on CT or MRI scan as assessed by a radiologist, the patient can receive up to six additional doses of the T cells. (clinicaltrials.gov)
  • Among those therapies, adoptive transfer of T cells has resulted in encouraging clinical trials for treating metastatic melanoma as well as non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and neuroblastoma ( 3 - 5 ). (mcponline.org)
  • perforin
  • In COPD, these senescent cells expressed increased levels of the cytotoxic mediators, perforin and granzyme b, and the pro-inflammatory cytokines, IFNγ and TNFα. (frontiersin.org)
  • In addition, the CD8αα + T cells exhibit a strong gene expression signature of antiviral activity against HSV-2, including the expression of perforin, a cytolytic protein that punches holes in the membranes of virus-infected host cells. (fredhutch.org)
  • cytomegalovirus
  • Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Würzner R, Schönitzer D, Grubeck-Loebenstein B (2005) Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. (springer.com)
  • Quantitative
  • Quantitative methods for assessing cellular age and responsiveness will facilitate the development of appropriate cell expansion and selection protocols. (mcponline.org)
  • destroy
  • Understanding of the processes by which killer cells select and destroy other cells will aid in an understanding of autoimmune diseases, as well as allow foraiding individuals who are deficient in their immune response. (patentgenius.com)
  • The CD8, in turn, binds to constant portion of the MHC class I. This prompts the cytotoxic T cell to destroy the target cell. (biology-online.org)
  • peripheral
  • Acquisition of CD11b represents an early event in CD8 + T-cell differentiation, which may allow extravasation to peripheral tissues ( 1 , 2 ). (frontiersin.org)
  • Flow cytometric gating technique used to identify CD8 + CD28 null natural killer T-like (NKT-like) cells (and CD8 + CD28 + NKT-like cells) from the peripheral blood of patients with chronic obstructive pulmonary disease. (frontiersin.org)
  • UCB transplants offer several advantages over adult bone marrow or peripheral blood stem cell transplants, including: 1) rapid availability, 2) absence of donor risk, 3) low risk of transmissible infectious diseases, 4) low risk of acute Graft versus Host Disease (GvHD) in the setting of Human Leukocye Antigen (HLA) mismatch (as compared to recipients of unrelated donor marrow and peripheral blood). (clinicaltrials.gov)
  • Studies on T cell turnover indicate that most peripheral T cells can remain in a resting state for long periods (months in rodents and years in humans). (madsci.org)
  • granules
  • Polypeptides released from killer cells and their cytoplasic granules have been implicated in the lytic event of killer cell lysis mechanisms, such polypeptides including serine proteases, toxic lymphokines and pore forming poly-perforins. (patentgenius.com)
  • CD56
  • NKT-like cells co-express T-cell receptors and CD4 or CD8 (or CD4 − /CD8 − ), together with markers associated with NK cells, such as CD56 (Figure 1 C) and/or CD16 or CD161. (frontiersin.org)
  • (C) Identification of NKT-like cells as CD3 + CD56 + events. (frontiersin.org)
  • role
  • And cytotoxic cells are recognized as TC cells once they become activated and are generally classified as having a pre-defined cytotoxic role within the immune system. (biology-online.org)
  • made of DNA (see nucleic acid nucleic acid, any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis. (thefreedictionary.com)
  • Our data suggest that TSLP-activated DCs play an important role in inducing both CD4 + and CD8 + T cell-mediated allergic inflammation. (rupress.org)
  • Expansions of these cells has been shown to be associated with many diseases and seems to have a relevant role in CVD (cardiovascular diseases). (springer.com)
  • Role of T helper cells. (rupress.org)
  • naive
  • Sprent J. Life span of naive and memory T cells. (madsci.org)
  • The recirculating pool of mature T cells is formed during young life through gradual release of naive T cells from the thymus. (madsci.org)
  • autoimmune
  • In most situations this is beneficial because an active immune response is only needed for a brief time to eliminate a pathogen, and suppression regulates the cytotoxic response and maintains tolerance, prevents autoimmune disease and limits chronic inflammation. (fredhutch.org)
  • lysis
  • The inhibition of CTL or NK mediatedtarget cell lysis by low and high molecular weight serine protease inhibitors has been demonstrated. (patentgenius.com)
  • To acquire signaling information with high temporal resolution, we designed a microfluidic chip enabling parallel lysis and fixation of stimulated cell samples on-chip. (mcponline.org)
  • Expression
  • Left: Differentiation of Tc9 cells with low cholesterol decreases the SUMOylation of LXRs, leading to increased production of the cytolytic proteins IFN-γ and Gzmb, increased IL-9 production, possibly increased IL-9R expression, and increased expression of ST2. (rupress.org)
  • They found that Tc9 cells have lower basal expression of cholesterol synthesis genes, such as Hmgcr and Sqle , and high expression of cholesterol efflux genes, such as Abca1 and Abcg1 , than Tc1 cells. (rupress.org)
  • Boucher N, Dufeu-Duchesne T, Vicaut E, Farge D, Effros RB, Schachter F (1998) CD28 expression in T cell aging and human longevity. (springer.com)
  • viral infection
  • If a CD8+ cell recognizes a foreign antigen on a cell's surface, it kills this cells - hence the 'killer cell' name (this is to prevent viral infection or cancer from spreading). (biology-online.org)
  • Some researcher have taken T cells from a person's blood, grown more of them in the laboratory and then given them back to the person during a viral infection after a bone marrow transplant. (clinicaltrials.gov)
  • cytokines
  • Interestingly, hTSLP-activated DCs prime CD4 + T helper cells to produce proallergic cytokines IL-4, IL-5, IL-13, and TNF-α, while down-regulating IL-10 and IFN-γ. (rupress.org)
  • The production of these proallergic TH2 cytokines was initially ascribed to CD4 + T cells ( 6 , 7 ). (rupress.org)
  • CD28 null CD4 T cells are cytotoxic and produce high amounts of pro-inflammatory cytokines. (springer.com)
  • Accumulation
  • Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape. (nih.gov)
  • Accumulation of CD28 null T cells has been traditionally considered a sign of aging, as the percentage of these cells is increased in the elderly. (springer.com)
  • We demonstrate that nonhematopoietic PD-L1 is largely expressed by lymphatic and blood endothelial cells and limits CD8 + T cell accumulation in tumor microenvironments. (rupress.org)