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  • lymphoma
  • In situ hybridization studies using an EBV-encoded RNA-1 (EBER-1) probe were performed on 12 ALCL to detect EBV in the lymphoma cells. (ovid.com)
  • Among those therapies, adoptive transfer of T cells has resulted in encouraging clinical trials for treating metastatic melanoma as well as non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and neuroblastoma ( 3 - 5 ). (mcponline.org)
  • EBV is often found in the cancer cells suggesting that it may play a role in causing Lymphoma. (clinicaltrials.gov)
  • Purpose The purpose of this study is to find the largest safe dose of EBV specific cytotoxic T cells, to learn what the side effects are and to see whether this therapy might help patients with Hodgkin disease and non-Hodgkin Lymphoma. (clinicaltrials.gov)
  • If after the second infusion there is a reduction in the size of the patient's lymphoma on CT or MRI scan as assessed by a radiologist, the patient can receive up to six additional doses of the T cells. (clinicaltrials.gov)
  • Prostate Cancer Cells
  • SEAL BEACH, Calif.--( BUSINESS WIRE )--Dendreon Pharmaceuticals LLC, a commercial-stage biopharmaceutical company and pioneer in the development of immunotherapy, today announced publication of new data in Clinical Cancer Research, a journal of the American Association for Cancer Research, showing that treatment with PROVENGE ® (sipuleucel-T) generates killer T cells that target prostatic acid phosphatase (PAP), a protein expressed on the majority of prostate cancer cells. (businesswire.com)
  • cytomegalovirus
  • Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Würzner R, Schönitzer D, Grubeck-Loebenstein B (2005) Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. (springer.com)
  • senescent cells
  • Once transferred in the cancer patient, these replicative senescent cells will not be able to eliminate tumor cells and further proliferate, thereby hindering the efficacy of these therapies ( 11 , 12 ). (mcponline.org)
  • killer T-cel
  • These cells have been trained to attack adenovirus/EBV/CMV- infected cells and are called multivirus-specific cytotoxic (killer) T-cells or 'm-CTL. (clinicaltrials.gov)
  • This research suggests the role of sipuleucel-T in the generation of killer T cells following treatment," said Charles G. Drake, M.D., Ph.D., director of genitourinary oncology at Columbia University Medical Center and senior author. (businesswire.com)
  • lysis
  • Polypeptides released from killer cells and their cytoplasic granules have been implicated in the lytic event of killer cell lysis mechanisms, such polypeptides including serine proteases, toxic lymphokines and pore forming poly-perforins. (patentgenius.com)
  • The inhibition of CTL or NK mediatedtarget cell lysis by low and high molecular weight serine protease inhibitors has been demonstrated. (patentgenius.com)
  • To acquire signaling information with high temporal resolution, we designed a microfluidic chip enabling parallel lysis and fixation of stimulated cell samples on-chip. (mcponline.org)
  • PNT makes tumor cells resistant to CTL-mediated lysis. (nih.gov)
  • destroy
  • The CD8, in turn, binds to constant portion of the MHC class I. This prompts the cytotoxic T cell to destroy the target cell. (biology-online.org)
  • Understanding of the processes by which killer cells select and destroy other cells will aid in an understanding of autoimmune diseases, as well as allow foraiding individuals who are deficient in their immune response. (patentgenius.com)
  • peripheral blood
  • Flow cytometric gating technique used to identify CD8 + CD28 null natural killer T-like (NKT-like) cells (and CD8 + CD28 + NKT-like cells) from the peripheral blood of patients with chronic obstructive pulmonary disease. (frontiersin.org)
  • UCB transplants offer several advantages over adult bone marrow or peripheral blood stem cell transplants, including: 1) rapid availability, 2) absence of donor risk, 3) low risk of transmissible infectious diseases, 4) low risk of acute Graft versus Host Disease (GvHD) in the setting of Human Leukocye Antigen (HLA) mismatch (as compared to recipients of unrelated donor marrow and peripheral blood). (clinicaltrials.gov)
  • Using peripheral blood mononuclear cells (PBMCs) from PBC, we identified an HLA-A2-restricted CTL epitope of the E2 component of pyruvate dehydrogenase (PDC-E2), the immunodominant mitochondrial autoantigen. (rupress.org)
  • naive
  • Sprent J. Life span of naive and memory T cells. (madsci.org)
  • The recirculating pool of mature T cells is formed during young life through gradual release of naive T cells from the thymus. (madsci.org)
  • The resulting high mean velocities allow naive T cells to "scan" high numbers of DCs seeking for their MHC-peptide ligands ( 8 , 9 ). (rupress.org)
  • adoptive
  • The transfer of nonresponsive senescent T cells is a major bottleneck for the success of adoptive T-cell transfer therapy. (mcponline.org)
  • The encouraging results of adoptive transfer therapy could be improved by enhancing the quality of transferred T cells. (mcponline.org)
  • Expression
  • Left: Differentiation of Tc9 cells with low cholesterol decreases the SUMOylation of LXRs, leading to increased production of the cytolytic proteins IFN-γ and Gzmb, increased IL-9 production, possibly increased IL-9R expression, and increased expression of ST2. (rupress.org)
  • They found that Tc9 cells have lower basal expression of cholesterol synthesis genes, such as Hmgcr and Sqle , and high expression of cholesterol efflux genes, such as Abca1 and Abcg1 , than Tc1 cells. (rupress.org)
  • Antigen expression by tumor cells therefore determines both CTL motility within the tumor and profound tumor infiltration. (rupress.org)
  • Boucher N, Dufeu-Duchesne T, Vicaut E, Farge D, Effros RB, Schachter F (1998) CD28 expression in T cell aging and human longevity. (springer.com)
  • autoimmune disease
  • In most situations this is beneficial because an active immune response is only needed for a brief time to eliminate a pathogen, and suppression regulates the cytotoxic response and maintains tolerance, prevents autoimmune disease and limits chronic inflammation. (fredhutch.org)
  • target cells
  • Thus, in the mouse promonocytes have been characterized as NK cells with a defined spectrum of susceptible target cells. (springer.com)
  • Non-specific cytotoxic response against tumor target cells mediated by leucocytes from seawater teleosts, Sparus aurata and Dicentrarchus labrax: an ultrastructural study. (semanticscholar.org)
  • Target cells were mixed at 1:1 ratio and were incubated with OT-1 T cells for 5 hours. (nih.gov)
  • D - F ) Experiments were performed as described in A - C , except that EL-4 target cells were first loaded with SP or CP and then treated with SIN-1 or PNT. (nih.gov)