Synergy among thymocytes and peripheral lymph node cells in the in vitro generation of lymphocytes cytotoxic to alloantigens. (ox.ac.uk)
Antibodies3
This application covers novel compositions and uses of cytotoxic radioisotopes attached to antibodies that bind to uPAR, thereby creating precision targeted radiotherapeutics for the treatment of severe COVID-19 and other respiratory diseases. (stockwinners.com)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Targeted Alpha Therapy works by combining alpha-particle emitting radioisotopes with tumor-specific carrier molecules such as Monoclonal Antibodies or Peptides. (medsurgeindia.com)
Molecules1
PET and SPECT are whole body imaging techniques that use trace quantities of radioisotope-tagged bioactive molecules to probe biological function. (nottingham.ac.uk)
Radionuclide2
An emerging approach is targeted radiotherapy, a strategy that utilizes a molecular vehicle (antibody or peptide) to selectively deliver cytotoxic radiation emitted by a radionuclide to malignant cell populations. (unife.it)
This evidence, following the clinical experience with peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors, has suggested that somatostatin analogs, coupled with appropriate radioisotopes, might also be of value in the treatment of brain tumors. (unife.it)
Somatostatin1
These results suggest that sst 2 may be a unique target for antiangiogenic therapy with sst 2 preferring somatostatin analogues conjugated to radioisotopes or cytotoxic agents. (beatingcancercenter.com)
Therapy2
Targeted Radioisotope Therapy (TRT) is known as a radiotherapy using cytotoxic radioisotopes which are administered orally or intravenously in a patient and accumulate in a targeted organ or a tumor. (edu.kz)
Alpha PSMA Therapy, which incorporates alpha-emitting radioisotopes such as Actinium 225 , is a safe and effective procedure with no or small adverse effects. (medsurgeindia.com)
Cells7
Endogenous biomolecules (such as lactate dehydrogenase) or previously added exogenous labels (such as the radioisotope 51Cr) that leak into the media are then measured as an indirect readout of the damage caused by effector cells. (technologynetworks.com)
This is due to its useful characteristics: in its decay, it kills cancer cells, having high cytotoxic potency within a very short range (limited to few cancerous cells while sparing surrounding healthy tissues). (iba-radiopharmasolutions.com)
During a viral infection, non-customized (naïve) CD8+ T cells become activated and cytotoxic, seeking out and killing infected cells. (nootropicsnewshubb.com)
As these drugs cause damage to cells they are termed cytotoxic . (wikidoc.org)
We have synthesized a series of DNJ analogues to study the contribution of N-alk(en)yl side chains (C4, C9 or C18) to the behaviour of these analogues in cultured HL60 cells. (ox.ac.uk)
When cells were treated for 16 h at non-cytotoxic concentrations of inhibitor, a 40-50% decrease in GSL levels was measured by HPLC analysis of GSL-derived oligosaccharides following ceramide glycanase digestion of GSL and 2-aminobenzamide labelling of the released oligosaccharides. (ox.ac.uk)
The present study further characterizes the properties of N-alk(en)ylated DNJs, and demonstrates that increasing the length of the side chain is a simple way of improving imino sugar retention and therefore inhibitory efficacy for CGT in cultured cells. (ox.ac.uk)
Drugs2
Treatment options may include passive immunotherapy with both mAbs, mixed passive supplement to active specific immunotherapy with Avicine and conjugation of the mAbs with radioisotopes or cytotoxic drugs. (oregonstate.edu)
Many chemotherapy drugs used to treat cancer are cytotoxic at very low doses. (cdc.gov)
Effects1
The beta radiation of iodine 131 exerts cytotoxic effects on the salivary glands because these organs are highly radiosensitive 5 . (bvsalud.org)
Action1
In the case of carbon disulphide, gastrointestinal involvement is attributed to the specific neurotropic action of this substance on the intramural plexus whilst liver damage seems to be more due to the solvent's cytotoxic action, which produces changes in lipoprotein metabolism. (cloudaccess.net)
Treatment1
Monopar Therapeutics ( MNPR ) and NorthStar Medical Radioisotopes announced that a provisional patent application entitled "Precision Radioimmunotherapeutic Targeting of the Urokinase Plasminogen Activator Receptor for Treatment of Severe COVID-19 Disease" has been filed with the U.S. Patent and Trademark Office. (stockwinners.com)
Patient1
Dynamic total-body PET involves injecting a very small amount of a radioisotope tracer into the patient, followed by continuous imaging over a period of time, which creates a movie showing the tracer's kinetics (distribution over time) within the body. (nootropicsnewshubb.com)
Monoclonal antibody3
When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues. (medicalterminologydb.com)
A variety of ADCs has also been developed that link a monoclonal antibody to a potent cytotoxin or radioisotope, knows as payloads. (biomedcentral.com)
A monoclonal antibody linked to the radioisotope Yttrium-90, Zevalin targets the CD20 antigen on the surface of mature B cells and B-cell tumors, inducing cellular damage in the target and neighboring cells. (idecpharm.com)
Payloads1
These advances have provided newly designed antibody-based therapeutics that have multi-specific binding properties and functions, novel linkers, and carry that cytotoxic payloads (antibody-drug conjugates). (drugtargetreview.com)
Clearly this is important in order to predict organ distribution prior to any treatment with particles carrying cytotoxic radioisotopes or toxins. (biomedcentral.com)
These antibodies can also be used to deliver drugs, radioisotopes, or toxins to the antigen-expressing cells. (basicmedicalkey.com)
Chemotherapy2
Many chemotherapy drugs used to treat cancer are cytotoxic at very low doses. (cdc.gov)
In Group 1 patients, compare toxicity as defined by grade 3 or greater adverse events during the first cycle of blinatumomab or blinatumomab/nivolumab to similar patients treated with block 1 of cytotoxic chemotherapy on the predecessor trial AALL1331. (iu.edu)
Tumor1
Based on promising preclinical imaging results with MNPR-101-Zr showing high uptake across multiple tumor types, and with preclinical therapeutic efficacy and biodistribution studies utilizing the radioisotopes Ac-225 and Lu-177, Monopar and its collaborator, NorthStar Medical Radioisotopes, committed to additional funding with the aim of initiating a first-in-human (FIH) imaging study with MNPR-101-Zr as early as end of this year. (monopartx.com)
Therapeutic1
ITM-11 consists of two molecular components - firstly, Edotreotide (DOTATOC), an octreotide-derived somatostatin analog, and secondly, EndolucinBeta ® (no-carrier-added (n.c.a.) lutetium-177 chloride) a synthetic, low-energy beta-emitting therapeutic radioisotope. (itm-radiopharma.com)
Radioactive3
To achieve the cytotoxic effect necessary to destroy tumour cells, radioactive dose administered is higher compared to diagnostic imaging. (qtinstruments.com)
However, workers who handle radioactive materials, such as radioisotopes in health care and laboratories, or radioactive waste, need to take precautions to reduce exposure. (cdc.gov)
Co-60, a commercially important radioisotope, is useful as a radioactive tracer and gamma ray source. (americanelements.com)
Preclinical1
Although there are multiple methods for analysing the biodistribution of labelled biotherapeutics in vivo , the two most commonly used preclinical methods employ radioisotope labelling with PET and near-infrared fluorescence labelling with optical imaging. (drugtargetreview.com)
Dose1
Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. (hemonc.org)
Antineoplastic1
A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope lutetium Lu 177 with potential antineoplastic activities. (hemonc.org)
DOTA1
The targeting molecule Edotreotide contains DOTA, which functions as a chelator for radioisotopes, and TOC, a synthetic somatostatin receptor ligand. (itm-radiopharma.com)
Agents1
In addition, sharps containers (scalpels, razor blades, Pasteur pipettes, pipette tips, needles, and syringes), animal bedding contaminated with pathogenic agents which cannot be decontaminated through autoclaving, and other material potentially contaminated with cytotoxic or cytostatic drug. (nih.gov)
Waste2
The hazards of exposure to waste, anesthetic gases, cytotoxic drugs, and blood-borne diseases such as hepatitis and HIV/AIDS are the subject of NIOSH criteria documents and OSHA policy statements. (osha.gov)
10. We kee p Medical Pathological Waste (MPW) free of radioisotopes or hazardous chemicals. (nih.gov)
Results1
The combos of gemcitabine and various other cytotoxic agencies also afforded unsatisfactory results. (technuc.com)
Potential1
Compound 1 showed significant potential cytotoxic ability in the bioassay. (researchgate.net)
High1
The Gelman Synerflow Radioisotope Fume Hoods are designed to provide a high degree of personnel and environment protection from applications requiring the use of radio-chemicals in the laboratories, hospitals and industries. (gelmansingapore.com)
Play2
CD8+ cytotoxic T lymphocytes (CTLs) play an important role in containment of virus replication in primary human immunodeficiency virus (HIV) infection. (ox.ac.uk)
Although, cytotoxic T-cells and complement may also play a role [ 17 - 19 ]. (scientificarchives.com)
Activities1
Cytotoxic, anti-HIV-1, and antioxidant activities have been previously reported for this class of natural products [12, 20, 21]. (researchgate.net)