Cytotoxic cd8 positive t lymphocytes. Medical search. Frequent questions

The LSM 8.358 antibody reacts with a CD3-like T-cell receptor-associated cell-surface antigen found on thymocytes and peripheral T lymphocytes. (bdbiosciences.com)
Collectively, this study shows that CTLs adapt to persistent infection through a positive feedback pathway (PD-1?FoxO1?PD-1) that functions to both desensitize virus-specific CTLs to antigen and support their survival during chronic viral infection. (nih.gov)
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. (edu.au)
Human leukocyte antigen (HLA)-B27-positive subjects are uncommon in their ability to control infection with human immunodeficiency virus type 1 (HIV-1). (ox.ac.uk)
In some individuals, expansions of antigen-specific CD8+ T lymphocytes bearing specific TCR Vbeta chains were restricted to cells of particular CD45 isoforms. (ox.ac.uk)
CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. (technuc.com)
However, there is no clear evidence that adipocytes interact directly with CD8 + T cells through antigen:MHCI complex. (frontiersin.org)
Activated CD8 lymphocytes were identified by expression of CD69, CD71, and the human leukocyte antigen (HLA) class II, the beta-chain of CD8, and the RO isoform of CD45. (ox.ac.uk)
The QFT Gold Plus system uses specialized blood collection tubes, which are used to collect whole blood via venipuncture, which include a Nil control tube, two TB Antigen tubes and a Mitogen tube (positive control). (cdc.gov)

Furthermore, MP increased WBC and HGB counts and reduced the ratio of G0/G1 phase obviously, increased the proportion of S phase and G2/M phase in peripheral blood lymphocytes, increased the counts of CD4+ T cells and the ratio of CD4+/CD8+, and reduced the inhibition rate of splenic lymphocytes. (hindawi.com)
Peripheral Blood Mononuclear Cells (PBMC) are labeled with BD IMag™ Anti-Human CD8 Magnetic Particles - DM according to the Magnetic Labeling Protocol. (bdbiosciences.com)
The LSM 12.125 antibody reacts with the canine form of the 56 kDa transmembrane glycoprotein, CD4, present on the T-helper/inducer subset of normal canine donor peripheral blood lymphocytes. (bdbiosciences.com)
The cellular immune status includes a large blood profile as well as the determination of the relative and absolute numbers of peripheral lymphocytes: B cells, T cells, total CD4+ (T helper cells) and CD8+ (cytotoxic T cells) cells. (laboklin.com)
The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
This is a normal peripheral blood lymphocyte population with no indication of a neoplastic process. (labce.com)
To determine the immunologic characteristics of tumor infiltrating lymphocytes (TILs) in comparison with the corresponding peripheral blood lymphocytes (PBLs) of patients with ovarian cancer in order to detect specific antitumor-reactive-immunocompetent cells. (nih.gov)
Peripheral blood lymphocytes had a higher proliferative activity and cytotoxicity against natural killer-sensitive tumor cells than the corresponding TILs. (nih.gov)
Peripheral blood lymphocytes showed more potentially valuable behavioral characteristics than TILs. (nih.gov)
This molecule is expressed on the T suppressor/cytotoxic cell population (which comprises about 1/3 of the peripheral blood T lymphocytes total population) and with most of thymocytes, as well as a subset of NK cells. (technuc.com)
Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1. (ox.ac.uk)
To investigate the relationship between CD8 activation and infection by HIV-1 in vivo, activated subsets of CD8 lymphocytes in peripheral blood mononuclear cells (PBMCs) of HIV-seropositive individuals were investigated for CD4 expression and HIV infection. (ox.ac.uk)

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. (thermofisher.com)
A favorable clinical trend is associated with CD8 T-cell immune responses to the human papillomavirus type 16 e6 antigens in women being studied for abnormal pap smear results. (uams.edu)
Fluorescence labelled antibodies that target the immunophenotypical surface antigens (cluster of differentiation, CD) are available for multiple cell types, particularly lymphocytes. (laboklin.com)
The specific targeting of responding CD8 lymphocytes may provide a functional explanation for the previously observed impairment of cytotoxic T-lymphocyte (CTL) function disproportionate to their numerical decline in AIDS and for the deletion of specific clones of CTLs responding to HIV antigens. (ox.ac.uk)
Individuals infected with M. tuberculosis complex organisms (M. tuberculosis, M. bovis, M. africanum, M. microti, M. canetti) usually have lymphocytes in their blood that recognize these and other mycobacterial antigens. (cdc.gov)

Patterns of CD8 T-cell epitopes within the human papillomavirus type 16 (HPV 16) E6 protein among young women whose HPV 16 infection has become undetectable. (uams.edu)
HLA class I binding promiscuity of the CD8 T-cell epitopes of human papillomavirus type 16 E6 protein. (uams.edu)
However, the extent to which these proteins are targeted in natural HIV-1 infection as well as precise epitopes targeted by human cytotoxic T lymphocytes (CTL) remain to be defined. (ox.ac.uk)
Functional CD8 + T cells recognizing seven epitopes were identified, among them four penton-derived and two hexon-derived peptides. (biomedcentral.com)

Early in the disease process, the epidermis becomes infiltrated with CD8 T lymphocytes and macrophages, whereas the dermis displays a slight influx of CD4 lymphocytes. (medscape.com)
However, due to the release of proinflammatory cytokines and cytotoxic radical species, uncontrolled activity of macrophages may also be detrimental to tissue repair. (hindawi.com)
Starting with colorectal cancer, the researchers relied on multiplex immunohistochemistry to profile immune cells spanning 15 classes, coming up with a tumor microenvironment "signature of immune activation" (SIA) that took anti-tumor CD8-positive lymphocyte and tumor-associated macrophages into account. (genomeweb.com)
Moreover, PCNs altered the immune cell profiles within the tumor by increasing cytotoxic T cells and M1-like macrophages with antitumor activity. (biomedcentral.com)
Another study has show that the fascial inflammatory infiltrate is predominately composed of CD8 + T lymphocytes, macrophages, and fewer eosinophils, suggesting a possible cytotoxic immune reaction in response to possible infectious or environmental agents. (medscape.com)

Blood from patients treated with IVIG is reported to have increased suppressor CD8-positive T-cells. (nursingcenter.com)
The CD8α and β chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and a subpopuplation of mature T-lymphocytes (ie, MHC class I-restricted T cells, including most T suppressor/cytotoxic cells). (bdbiosciences.com)
infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. (lookformedical.com)

The mechanism was perhaps related to inhibiting lymphocyte apoptosis and promoting the balance of Th1/Th2 cell subsets. (hindawi.com)
It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. (researchsquare.com)
This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)
Serum from145 iGCTs patients were collected and lymphocyte subsets were analyzed by flow cytometry. (researchsquare.com)
Dynamic monitoring of serum lymphocyte subsets can be used as an auxiliary indicator for prognosis judgment. (researchsquare.com)
CD4+ T-cells and other lymphocyte subsets in persons infected with human immunodeficiency virus (HIV). (cdc.gov)
The guidelines describe single-platform technology (SPT), a process in which absolute counts of lymphocyte subsets are measured from a single tube by a single instrument. (cdc.gov)
With CD45 gating, the relative numbers of beads and lymphocyte subsets are enumerated, and their absolute numbers and percentage values are calculated. (cdc.gov)
In the current study it is shown that this NKp46 high phenotype was correlated with an increased expression of CD16 and CD27 compared to the CD8α + NKp46 - and NKp46 + NK-cell subsets in spleen and blood. (biomedcentral.com)
In contrast, NKp46 in the pig was shown to divide porcine CD3 - CD8α + NK cells into NKp46 - and NKp46 + subsets in blood and all organs tested [ 20 ]. (biomedcentral.com)
HIV-1 may infect thymic precursor cells destined to become CD4 and CD8 lymphocytes and contribute to the numerical decline in both subsets on disease progression. (ox.ac.uk)

Mice with natural immunity against MmuPV1 after colonization and acquired immunity through the transfer of T cells from immune mice or by MmuPV1 vaccination were protected against skin carcinogenesis induced by chemicals or by ultraviolet radiation in a manner dependent on CD8 + T cells. (nature.com)
RNA and DNA in situ hybridization probes for 25 commensal β-HPVs revealed a significant reduction in viral activity and load in human skin cancer compared with the adjacent healthy skin, suggesting a strong immune selection against virus-positive malignant cells. (nature.com)
Consistently, E7 peptides from β-HPVs activated CD8 + T cells from unaffected human skin. (nature.com)
Fig. 3: Reduced β-HPV transcripts in skin cancer cells and presence of β-HPV-specific CD8 + T cells in healthy human skin indicates a selective pressure by antiviral immunity against malignant cells with active HPV. (nature.com)
and the percentage of lymphocytes that are CD4+ T-cells. (cdc.gov)
Labeled cells migrate toward the magnet (positive fraction), leaving the unlabeled cells in suspension so they can be drawn off (negative fraction). (bdbiosciences.com)
The researchers discovered that, among the 22 patients who survived for a shorter period than the average time (a median survival of 313 days), immune cells called IL-10-positive myelomonocytes tended to be located close to a cluster of granzyme B-positive CD8-positive T cells (or cytotoxic T lymphocytes). (ascopost.com)
Among the 23 patients who survived longer than average (a median survival of 832 days), the same myelomonocytes were more grouped near a different type of T cell, known as PD-1-positive CD4-positive T cells (or activated helper T cells). (ascopost.com)
Cytotoxic T lymphocytes produced a toxin capable of killing cancer cells, but the researchers hypothesized that the nearby myelomonocytes blocked that ability in patients who survived shorter than the average. (ascopost.com)
In patients who survived longer than the average, however, researchers proposed that the activated helper T cells switched off the myelomonocytes, which, in turn, let the cytotoxic T lymphocytes more effectively fight the cancer. (ascopost.com)
Median survival was 45.81 months and patients of increased Tc cells, activated T helper cells(CD4 + CD25 + T cells or activated Th cells), activated Tc cells and normal CD4 + /CD8 + ratio presented encouraging outcomes (p = 0.007;0.016;0.028;0.016 respectively). (researchsquare.com)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
The differentiation of naïve CD8(+) T cells into effector and memory CTL thus involves pathways that can be discriminated from each other by their requirement for CD40L-mediated interactions. (ox.ac.uk)
It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells. (lookformedical.com)
Necrotizing vasculitis mediated by cytotoxic T cells, leading to ischaemic changes, appears to be a major cause of Churg-Strauss syndrome-associated neuropathy. (lookformedical.com)
W]e have identified an immune cell signature combining CD8 cytotoxic T-cells and a distinct TAM subset reflecting anti- and pro-tumorigenic immune reactions," they report. (genomeweb.com)
Cytotoxic T cells, for example, are CD3 and CD8 positive and CD21 and CD4 negative. (laboklin.com)
Background Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. (bmj.com)
Methods A wide range of human cancer cell lines derived from solid tumours, keratinocytes and primary embryonic cells were employed, together with helper and cytotoxic T cell lines and human as well as mouse primary T cells. (bmj.com)
Results We discovered that T lymphocytes induce galectin-9 secretion in various types of human cancer cells derived from solid malignant tumors. (bmj.com)
Immunized T-lymphocytes which can directly destroy appropriate target cells. (edu.au)
He cited data from a melanoma study evaluating ipilimumab (Yervoy) plus bevacizumab (Avastin) with on-treatment biopsy showing that, compared with ipilimumab alone, the combination increased CD8 T cells within the tumor and macrophage populations. (targetedonc.com)
The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
Therefore, there is good representation of both T helper and cytotoxic T cells (a neoplastic process could have predominantly one or the other or dual positive CD4 and CD8). (labce.com)
The B cells that are present, though a small percentage of the total lymphocytes, have no abnormal markers. (labce.com)
Most lymphocytes in this sample are T cells, which are also normal. (labce.com)
The CD markers that should be there are present, and there is a good representation of both helper and cytotoxic T cells. (labce.com)
Immunohistochemical examination demonstrated that these accumulated lymphocytes mainly comprised small- to medium-sized T cells expressing CD3, CD4, CD5, CD7, and CD103, but lacking CD8, CD56, and Epstein-Barr virus-encoded small RNAs. (springeropen.com)
More importantly, we found that IPMK interacted with AMPK and functioned as a positive regulator of AMPK protein in osteosarcoma cells. (ijbs.com)
Phenotypical analyses with newly developed monoclonal antibodies (mAbs) against porcine NKp46 recently revealed that in blood NKp46 - and NKp46 + cells with NK phenotype exist with comparable cytotoxic properties. (biomedcentral.com)
Besides their role as cytotoxic cells through the production of perforin and granzymes, NK cells are potent producers of cytokines like Interferon (IFN)-γ and Tumor Necrosis Factor (TNF)-α [ 3 ] and thus play important roles in immunomodulation and the defence against viral, parasitic and bacterial pathogens [ 4 ]. (biomedcentral.com)
CD3 - CD8α + NKp46 - NK cells show phenotypic and functional properties of NK cells although they produce reduced levels of IFN-γ compared to the NKp46 + subset after in vitro stimulation. (biomedcentral.com)
Therefore, in this study we focused on functional and phenotypical properties of CD8α dim/- NKp46 high NK-cells in the spleen. (biomedcentral.com)
CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development. (technuc.com)
CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients. (ox.ac.uk)
In humans, NK receptors are expressed by natural killer cells and some T cells, the latter of which are preferentially alphabetaTCR+ CD8+ cytolytic T lymphocytes (CTL). (ox.ac.uk)
The percentages of NK receptor-positive T cells (NKT cells) varied strongly, and this variation was more important between individual patients than between individual healthy donors. (ox.ac.uk)
CD4(+) and CD4(-) CD8 lymphocytes, CD4 lymphocytes, other T cells, and non-T cells were purified using paramagnetic beads, and proviral sequences were quantified by PCR using primers from the long terminal repeat region. (ox.ac.uk)
Frequencies of activated CD8 lymphocytes were higher in HIV-infected study subjects than in seronegative controls, and they frequently coexpressed CD4 (mean frequencies on CD69(+), CD71(+), and HLA class II(+) cells of 23, 37, and 8%, respectively, compared with 1 to 2% for nonactivated CD8 lymphocytes). (ox.ac.uk)
[ 8 ] Host immunity seems to play a major role because a low CD4 + lymphocyte count (fewer than 100 cells/μL for adults and age-appropriate decreases in children) is associated with an increased frequency of disseminated MAC disease. (medscape.com)
CD4 and CD8 T lymphocytes directly target biliary epithelial cells. (msdmanuals.com)

These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. (edu.au)

Tumor infiltrating lymphocytes and PBLs were phenotyped by their surface markers, cytokine pattern, proliferation rate, and cytotoxic ability. (nih.gov)
CD25 plays a role in lymphocyte differentiating and activation/proliferation. (thermofisher.com)
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. (thermofisher.com)
IL-2 enhances lymphocyte proliferation and cytotoxic activity and upregulates production of IFN-gamma. (medscape.com)

Incorporation of a combination of cytotoxic chemotherapy plus anti-PD–L1 can increase the percentage of tumor-infiltrating lymphocytes that are CD8-positive. (targetedonc.com)

the TB2 tube contains an additional set of peptides targeted to the induction of CMI responses from CD8+ cytotoxic T lymphocytes. (cdc.gov)

Simultaneously, adipocytes secrete various cytokines including leptin, resistin, TNF-α and IL-6 to regulate the differentiation and function of T and B lymphocytes. (frontiersin.org)

Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8+ T lymphocytes. (ox.ac.uk)
Immunity against CMV comprises a large population of CD8+ T lymphocytes with heterogeneous potential, a spectrum in which CD45 isoform expression may play a central role. (ox.ac.uk)

CD25 is expressed by early progenitors of T and B lineage as well as by activated mature T and B lymphocytes. (thermofisher.com)

The phenotypes of both lymphocyte populations were very heterogeneous. (nih.gov)
Change in immunological status (CD4 and CD8 lymphocyte populations) compared with baseline values (before therapy). (who.int)

We have therefore investigated the CD8+ T-lymphocyte response against CMV directly ex vivo using Class I tetramers combined with stains for a range of phenotypic markers followed by four-colour flow cytometric analysis. (ox.ac.uk)
There is increasing evidence that CD8 lymphocytes may represent targets for infection by human immunodeficiency virus type 1 (HIV-1) in vivo whose destruction may contribute to the loss of immune function underlying AIDS. (ox.ac.uk)
Combined, these findings provide evidence that antigenic stimulation of CD8 lymphocytes in vivo induces CD4 expression that renders them susceptible to HIV infection and destruction. (ox.ac.uk)

Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. (lookformedical.com)

For flow cytometric analysis, fresh PBMC (left panel), the negative fraction (middle panel) and the positive fraction (right panel) were stained with PE Mouse Anti-Human CD8 (Cat. (bdbiosciences.com)
The Dog T Lymphocyte Cocktail is a three-color reagent cocktail designed to identify dog T lymphocytes by direct immunofluorescence staining with flow cytometric analysis. (bdbiosciences.com)

Implement of comprehensive treatments led to positive responses. (researchsquare.com)
CD8(+) cytotoxic T lymphocytes (CTL) play a key role in the control of many virus infections, and the need for vaccines to elicit strong CD8(+) T-cell responses in order to provide optimal protection in such infections is increasingly apparent. (ox.ac.uk)
Rapid characterization of HIV clade C-specific cytotoxic T lymphocyte responses in infected African children and adults. (ox.ac.uk)

The distribution on lymphocytes for canine is similar to that found for both human and monkey, with the majority of CD4-positive lymphocytes being CD8-negative and lacking reactivity with antibodies to B- or NK-cell markers. (bdbiosciences.com)

In addition, a deeper characterization of immune infiltrates, including the presence of a high number of cytotoxic (CD8 + ) TILs or a high CD8 + /FOXP3 + ratio, is able to define TNBC patients with a better prognosis following neoadjuvant chemotherapy [ 6 ]. (biomedcentral.com)

Mouse monoclonal to CD8.COV8 reacts with the 32 kDa a chain of CD8. (technuc.com)

This may develop into systemic EBV-positive T cell lymphoma. (wikipedia.org)
Macrophage activation has been described as a dynamic process: the same cell may initially induce proinflammatory and cytotoxic reactions and later may take part in the resolution of inflammation and wound healing [ 9 ]. (hindawi.com)
Recognition of a cervical cancer derived tumor cell line by a human papillomavirus type 16 E6 52-61-specific CD8 T cell clone. (uams.edu)
The positive predictive value for recovery of virus in cell culture was 56.7% for BinaxNOW-positive and 35.4% for rRT-PCR-positive specimens. (cdc.gov)

11 ] demonstrated a substantial overall survival (OS) benefit in patients with PD-L1-positive (PD-L1 + ) metastatic or inoperable locally advanced TNBC through the addition of the anti-PD-L1 agent atezolizumab to first-line chemotherapy with nab-paclitaxel. (biomedcentral.com)
Oncological diseases (cytotoxic chemotherapy, current or received within the last 3 months before the start of treatment). (who.int)

The process of measuring the percentage of CD4+ T-lymphocytes in the whole blood sample is referred to as ``immunophenotyping by flow cytometry'' (9-14). (cdc.gov)
Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)

The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. (ox.ac.uk)

The LSM 1.140 antibody reacts with a CD8-like 32-35 kDa heterodimer. (bdbiosciences.com)
CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). (technuc.com)

CD4+ T-lymphocyte levels are also used as prognostic indicators in patients with human immunodeficiency virus (HIV) disease (8). (cdc.gov)
A positive overall survival outcome was achieved only in PD-L1 + TNBC patients, suggesting a need to enrich the patient population more likely to benefit from an immunotherapeutic approach. (biomedcentral.com)
[ 16 ] In one series of adult patients infected with HIV with positive respiratory or stool isolates, 75% developed mycobacteremia within a year (mean 6 mo) after the isolation. (medscape.com)
A preceding stool culture positive for isolates was present in 25-36% of the patients. (medscape.com)

It neutralizes pathogenic cytokines such as tumor necrosis factor and interleukin-1 as well as superantigens that prevent activation of classes of T lymphocytes. (nursingcenter.com)
Here, we show that during chronic murine lymphocytic choriomeningitis virus infection, activation of AKT and mTOR are impaired in antiviral cytotoxic T lymphocytes (CTLs), resulting in enhanced activity of the transcription factor FoxO1. (nih.gov)

NPS was calculated from four parameters, including serum albumin level, serum total cholesterol (TC), lymphocyte-to-monocyte ratio (LMR), and neutrophil-to-lymphocyte ratio (NLR). (biomedcentral.com)

The pathogenesis of acquired immunodeficiency syndrome (AIDS) is largely attributable to the decrease in T-lymphocytes bearing the CD4 receptor (CD4+) (1-5). (cdc.gov)
Triple-negative breast cancer (TNBC) accounts for approximately 15-20% of all breast carcinomas and is associated with earlier age of onset, aggressive clinical course, and dismal prognosis compared to hormone receptor- and HER2-positive breast carcinomas [ 1 ]. (biomedcentral.com)

CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection. (ox.ac.uk)
There is also evidence for the induction of CD4 expression and susceptibility to infection by HIV-1 of CD8 lymphocytes activated in vitro. (ox.ac.uk)
The conclusion was that positive serology alone for Borrelia does not implicate Borrelia infection in the pathogenesis of eosinophilic fasciitis in the absence of the positive demonstration of Borrelia by histochemical stains, immunohistochemical stains, or polymerase chain reaction amplification in tissue samples. (medscape.com)

The maintenance of memory CD8(+) CTL precursors (CTLp) at stable frequencies over time was not impaired in CD40L-deficient mice. (ox.ac.uk)

This document has been developed by CDC to give guidance to laboratories performing lymphocyte immunophenotyping assays in human immunodeficiency virus-infected persons. (cdc.gov)

Positive selection of human CD8+ T lymphocytes from PBMC. (bdbiosciences.com)
Leukocytes were labeled with BD IMag™ Anti-Human CD8 Magnetic Particles - DM (Cat. (bdbiosciences.com)
Detection of human papillomavirus type 16-specific T lymphocytes by a recombinant vaccinia virus-based enzyme-linked immunospot assay. (uams.edu)
Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. (ox.ac.uk)

These antimitochondrial antibody (AMA), the serologic hallmarks of PBC, are not cytotoxic and are not involved in bile duct damage. (msdmanuals.com)

Another typical finding is increased blood lymphocytes of which more than 10% are atypical. (wikipedia.org)

CD40L-deficient mice produced lower levels of CD8(+) CTLp during the primary immune response to LCMV than did wild-type controls, despite the fact that the LCMV-specific effector CTL response of CD40L-deficient mice was indistinguishable from that of control animals. (ox.ac.uk)
However, late viral escape from a narrowly directed immunodominant Gag-specific CD8(+) T-lymphocyte (CTL) response has been linked to AIDS progression in these individuals. (ox.ac.uk)

Anatomy39

Organisms12

Diseases13

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes39

Disciplines and Occupations1

Information Science3

Health Care1

Antigen9

Peripheral12

Antigens5

Epitopes4

Macrophages5

Suppressor3

Subsets11

Cells41

Generated in vitro1

Proliferation4

Tumor-Infiltrating1

Peptides1

Differentiation1

CD452

CD251

Populations2

Vivo3

Eosinophils1

Flow cytometric2

Responses3

Antibodies1

TILs1

Monoclonal1

Cell4

Chemotherapy2

Percentage2

Regulatory1

Heterodimer2

Patients4

Activation2

Ratio1

Receptor2

Infection3

Frequencies1

Assays1

Human4

Antibody1

Atypical1

Response2