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  • toxicity
  • Keywords: Boron, anti-neoplastic, leukemia, topoisomerase 11, RNA polymerase, DNA polymerases, acute toxicity INTRODUCTION There is rapidly growing interest in the biological activity of boron compounds in animals, including humans. (docme.ru)
  • Boron compounds, ranging from analogs of the a-amino-acids, peptides, neurotransmitters (e.g. acetylcholine) to boronated DNA, have been prepared and tested for their biological In view of this promising pharmacological activity, we have been carrying out studies on select compounds to establish further their mode of action and acute toxicity. (docme.ru)
  • present study is an attempt to determine the mode of action as anti-neoplastic agents and to evaluate the agents' acute toxicity in mice. (docme.ru)
  • mice
  • The first, methotrexate, happened to prolong the life of rats and mice with leukemia and was quickly used by Sidney Farber to treat children with leukemia. (swaebr.org)
  • Nowadays, genetically modified mice are the subjects of research on gene therapy and its potential use to fight all leukemia. (swaebr.org)
  • likelihood
  • There is some evidence that the holding of an X-ray during pregnancy increases the likelihood of leukemia in the child as a child. (assuta.clinic)
  • rarely
  • Mitoxantrone therapy is often accompanied by mild to moderate elevations in serum aminotransferase levels, but in typical doses it rarely causes clinically apparent, acute liver injury. (nih.gov)
  • survival
  • Kaplan-Meier estimates will be used to estimate one-year leukemia-free survival. (clinicaltrials.gov)
  • Sadly, the odds of survival for children with leukemia were not always high. (swaebr.org)
  • In conclusion, the use of animals in leukemia research is continuous because even though the survival rates have increased, there is still room for improvement. (swaebr.org)
  • tumors
  • Subsequent to the identification of CSCs in leukemia ( 6 ), CSCs have been reported in various solid tumors, including breast cancer, melanoma and colon cancer ( 7 - 9 ). (spandidos-publications.com)
  • symptoms
  • Symptoms of acute pancreatitis include: (pain in the upper abdomen that worsens with eating, swollen and tender abdomen, nausea, vomiting, fever, and rapid pulse). (chemocare.com)
  • blood
  • The word 'leukemia' means 'white blood,' and is used to indicate the high white blood cell counts of the disease. (medindia.net)
  • liver
  • Idiosyncratic acute liver injury attributed to mitoxantrone is likely due to a hypersensitivity reaction. (nih.gov)
  • instances
  • At each point in the history of leukemia there have been instances of lost time and opportunity because of unreasoned resistance to innovation. (medindia.net)
  • activity
  • The cytotoxic activity requires firm binding of the lymphocyte to the target cell to produce holes in its plasma membrane with loss of its cellular contents and osmotic lysis. (thefreedictionary.com)