• The phytochemical screening detected the presence of saponins, alkaloids, reducing sugars and coumarins. (researchgate.net)
  • Previous phytochemical studies reveal the presence of coumarins, alkaloids, limonoidal triterpenes as well as phytosterols and their fatty acid estersin this plant [4]. (symbiosisonlinepublishing.com)
  • The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea. (ac.ir)
  • Enzymes such as ammonialyases, methylases and hydroxylases then transform these amino acids to cinnamic acid derivatives which undergo o-hydroxylation yielding coumarins. (wikipedia.org)
  • Coumarin and its derivatives are biologically very active. (biomedcentral.com)
  • Our interest in medicinal chemistry of dicoumarol compounds have been developed by keeping in view the importance of coumarins along with its derivatives in medicinal chemistry. (biomedcentral.com)
  • Coumarin derivatives are widely used in the field of medicines and drugs for many years [ 2 - 7 ] as for example coumarin and its derivatives exhibited pronounced anticancer and antimicrobial activities as revealed from literature. (biomedcentral.com)
  • Two series of novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity. (unboundmedicine.com)
  • ABSTRACT In this study, a total of 12 coumarin-chalcone derivatives, 6 of which are original were synthesized. (biruni.edu.tr)
  • It really is of interest to notice that some synthesized coumarin derivatives possess powerful MAO inhibitions [7, 8]. (abt-888.net)
  • Such distributed general benzopyrone framework between flavonoids and coumarins emphasize a higher potential to inhibit MAO-B. Notably, L. seed products (Computers) (Place common name: bakuchi, family members: Leguminosae) [13] include a selection of benzopyrone buildings such as coumarins and flavonoids derivatives with chromone primary buildings [14]. (abt-888.net)
  • 2. Gas chromatography/mass spectrometry of simple coumarins, 3-phenylpropionic acids and their hydroxy and methoxy derivatives. (tramil.net)
  • It has plenty of bioactive compounds ( flavonoids and coumarins ) as well as antioxidant and pharmacological value that are just now being appreciated. (docshay.com)
  • It has plenty of bioactive compounds ( flavonoids and coumarins ) as well as antioxidant and pharmacological value that are just starting to be appreciated. (drjoannagarvey.com)
  • All the synthesized compounds were fully characterized by spectroscopic and analytical techniques and were screened for antimicrobial and U2OS bone cancer activities. (biomedcentral.com)
  • The compounds with intermolecular H-bonding were found more active revealing a possible relationship among hydrogen bonding, cytotoxicity and antimicrobial activities. (biomedcentral.com)
  • Coumarins are naturally occurring organic compounds [ 1 , 2 ] which belong to benzo-α-pyrones group of compounds. (biomedcentral.com)
  • The two new compounds were tested against Hela, AGS, and MGC-803 human cancer cell lines and exhibited cytotoxic activities with IC50 values between 18.71± 5.23 μM and 36.92± 4.72 μM. (symbiosisonlinepublishing.com)
  • All the synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against seven strains of bacteria and four strains of fungi. (derpharmachemica.com)
  • MIC results of most of the synthesized compounds (14-23, 26-27 and 29) have shown them to possess promising to comparable activities while compounds 15, 19, 21, 26, 27 and 29 were found to be better antifungal agents than the standard drugs in vitro and can serve as lead molecules to discover a new antimicrobial in future to combat the growing drug resistance and infections developed by various microorganisms. (derpharmachemica.com)
  • Among the newly synthesized compounds, compound 4j displayed the best inhibitory activity for SIRT1 (IC50 = 54.21 μM) as well as for SIRT2 (IC50 = 26.85 μM). (unboundmedicine.com)
  • In the last few years, molecules belonging to different classes of compounds have been synthetically combined in order to obtain hybrids with enhanced biological activities. (scielo.org.ar)
  • Ligand-based screening techniques essentially focus on comparative molecular similarity analysis of compounds with known and unknown activity, regardless of the methods or algorithms used. (benthamscience.com)
  • The structural diversity found in this family of compounds led to the division into different categories, from simple coumarins to many other kinds of policyclic coumarins such as furocoumarins and pyranocoumarins. (benthamscience.com)
  • Simple coumarins and analogues are a large class of compounds that have attracted their interest for a long time due to their biological activities: they have shown to be useful as antitumoural, anti-HIV agents and as CNS-active compounds. (benthamscience.com)
  • Some cytochrome P-450 enzymes, such as CYP2C9, and known to metabolize ochratoxin A into more cytotoxic compounds. (selfdecode.com)
  • The present work is to survey the information published from 1990 till 2008, which is mainly related to the occurrence, synthesis and biological importance of simple coumarins and some analogues such as biscoumarins and triscoumarins. (benthamscience.com)
  • thus in the present study, the cytotoxic activity of the extracts and fractions of Ferula szowitsiana , F. hirtella and F. oopoda in MCF-7, HT-29, A-549 and HepG-2 cells have been investigated through MTT assay. (ijpsr.com)
  • The result showed that the n -hexane and chloroform fractions of F. szowitsiana and F. hirtella were the most cytotoxic to all cell lines while F. hirtella extracts/fractions demonstrated little or no cytotoxic activity. (ijpsr.com)
  • The studies on antioxidant activity clearly reveal very high efficiency in reducing free radicals in the tested extracts. (bvsalud.org)
  • TLC-direct bioautography against Bacillus subtilis, showed exceptionally high activity for S. chinensis and S. rubriflora fruit extracts. (bvsalud.org)
  • The leaf extracts showed much stronger antioxidant activity than the fruit ones, which were assessed and compared using both TLC-direct bioautography and spectrophotometric measurements based on ABTS, DPPH and FRAP tests. (bvsalud.org)
  • The disc diffusion method was used to determine the antibacterial activity of the extracts. (biomedcentral.com)
  • The aqueous extracts of T. alternifolia stem bark exhibited antibacterial activity against Gram-positive microorganisms, particularly against clinical isolates of MRSA and vancomycin resistant S. aureus (VRSA). (biomedcentral.com)
  • Petroleum ether and ethyl acetate extracts did not exhibit antibacterial activity. (biomedcentral.com)
  • Leishmanicidal activity of benzophenones and extracts from Garcinia brasiliensis Mart. (ac.ir)
  • 1995). The organic fraction extracts of the plant was shown to possess cytotoxic effects towards human carcinoma cells of the nasopharynx (Seef et al . (eprojecttopics.com)
  • Peel extracts are not cytotoxic or irritating to the skin, making them potentially effective for cosmetic product use. (docshay.com)
  • The negative results for cytotoxic and antimicrobial assays indicated possible low cytotoxicity to the extract. (researchgate.net)
  • Thus, this study aims to evaluate the biological activity of different essential oils (EOs) on Leishmania ( L .) amazonensis promastigotes forms, as well as their cytotoxicity on mammalian cells and chemical composition. (biomedcentral.com)
  • The results suggest that the non-polar/semi polar constituents might be the cause for the cytotoxic behavior of the species. (ijpsr.com)
  • It has been shown that several EOs, or their constituents, have inhibitory activity against protozoa. (biomedcentral.com)
  • We previously reported that Computers ranked one of the most powerful plant ingredients to inhibit recombinant individual (MAO-A and MAO-B. Open up in another screen Fig. 1 The 1234423-95-0 supplier buildings of six seed products (Computers) benzopyrone constituents: Coumarins consist of psoralen (PS), isopsoralen (IPS), and psoralidin (PSD). (abt-888.net)
  • A coumarin derivative namely scopoletin (7-hydroxy-6-methoxychromen-2-one) had been isolated from the methanol extract of unripe noni fruits ( Morinda citrifolia Linn. (unsri.ac.id)
  • K.S. Vidya, U. Raghavendra, A. Muthusamy, S.B. Vidhu, J. Subramani, P.M. Gopinath, and K. Satyamoorthy, Cytotoxic Efficacy of Noni (Morinda citrifolia L.) Fruits Extract and Scopoletin on a Preponredant Panel of Human Tumor Cell Lines, Intl. J. Noni. (unsri.ac.id)
  • Coumarins with Antiviral and Cytotoxic Activity from Egyptian Ranunculus asiaticus L.' Alex. (edu.sa)
  • with Antiviral and Cytotoxic Activity' Alex. (edu.sa)
  • PTOX structure is closely related to the aryltetralin lactone lignans that have antineoplastic and antiviral activities. (ac.ir)
  • Modern pharmacological studies have established the anti-inflammatory, anti-psychic, and antioxidant activities of this plant [3]. (symbiosisonlinepublishing.com)
  • Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. (tramil.net)
  • Furthermore they have been reported to have multiple biological activities (anticoagulant, anti-inflammatory) although all these properties have not been evaluated systematically. (benthamscience.com)
  • The extract did not induce either lethality in the brine shrimp (Artemia salina Leach) bioassay or antimicrobial activity. (researchgate.net)
  • salina Leach) bioassay or antimicrobial activity. (researchgate.net)
  • Components of essential oil have shown biological properties such as antioxidant and antimicrobial activity (windisch et al. (ac.ir)
  • Some biological studies have shown the antimicrobial activity and the antioxidant properties of the active ingredient in the plant. (ac.ir)
  • These plants have proved to possess biological activity in different studies 4 and some Ferula species have demonstrated cytotoxic activity 5 . (ijpsr.com)
  • Umbelliferone (UMB), a natural coumarin compound, has been reported to possess anti-rheumatic effects on rheumatoid arthritis (RA) experimental models, but its potential role of UMB in regulating migration, invasion and inflammation of RA fibroblast-like synoviocytes (FLS) remain unclear. (harvard.edu)
  • Apiaceae family is one of the most important sources of coumarins. (ac.ir)
  • The isolates showed weak antiprotozoal activity against Leishmania donovani promastigotes, and Trypanosoma brucei brucei blood stream trypomastigotes, and were devoid of interesting activity towards Plasmodium falciparum. (lshtm.ac.uk)
  • The extract did not exhibit cytotoxic activity against Vero cells even at the concentration of 4 mg/ml. (biomedcentral.com)
  • Ochratoxin A is cleaved into phenylalanine and a less toxic iso-coumarin derivative (ochratoxin alpha) by the microbial flora of the colon, and by carboxypeptidase A and alpha-chymotrypsim. (selfdecode.com)
  • Osthol showed a significant antileishmanial effect on promastigotes in early hours of exposure with IC 50 of 14.40 µg/mL but suberosin epoxide showed only a weak antileishmanial activity. (ac.ir)
  • Morales-Yuste M, Morillas-Márquez F, Martín-Sánchez J, Valero-López A, Navarro-Moll M. Activity of (-) α-bisabolol against Leishmania infantum promastigotes. (ac.ir)
  • The EO from F. galbaniflua showed to be effective against L. amazonensis promastigotes forms and presented low cytotoxic activity against L6 cells. (biomedcentral.com)
  • In addition their enzyme inhibition properties, antimicrobial and antioxidant activities are other foremost topics of this field of research. (benthamscience.com)
  • (3) In the family of winter squash, the pumpkin's Cucurbita maxima - with its polysaccharide substance as well as its total phenolic and flavonoid content - has more antidiabetic and antioxidant activities than its related Cucurbita moshata . (docshay.com)
  • Extraordinary levels of minerals, flavonoids, carotenes, phenols, and total antioxidant activity are profuse in the leaves and flowers while the seed is loaded with nutrients and amino acids. (docshay.com)
  • Column chromatography and crystallization process resulted to isolation of three prenylated coumarins. (ac.ir)
  • The extract had marked in vitro ROS scavenging activity and moderate antibacterial activity against gram positive and gram negative bacteria. (biomedcentral.com)
  • 9. Sadooghi SD, Nezhad-Shahrokh-Abadi Kh, Zafar-Balanzhad S, Baharara J. Investigating the cytotoxic effects of ethanolic extract of Ferula assa-foetida resin on HepG2 cancer cell line. (ac.ir)
  • The coumarins can undergo further reactions such as prenylation and oxidation to give multiple furanocoumarins one of which is angelicin. (wikipedia.org)
  • Leishmanicidal activity of isolated coumarins was assessed on Leishmania major strain (MRHO/IR/75/ER) for the first time. (ac.ir)
  • To confirm this popular use, ethanol extract from leaves of G. globosa L. was prepared by maceration and analyzed by some phytochemical and biological assays, including cardiovascular activity. (researchgate.net)
  • Two New Coumarins from the Leaves of Phellodendronamurense . (symbiosisonlinepublishing.com)
  • Two new coumarins, PhellodenolsI (1) and J (2), were isolated from the leaves of Phellodendronamurense. (symbiosisonlinepublishing.com)
  • In our study, two new coumarins, phellodenolsI (1) and J (2), were isolated from the leaves of P.amurense (Figure 1). (symbiosisonlinepublishing.com)
  • An aqueous crude extract from Solanum nigrum lyophilized leaves was evaluated for its phytochemical composition and antifungal activity against Penicillium digitatum , the causative agent of green mold of citrus fruit. (ac.be)
  • In view of above, both 2H-benzopyran-2-one especially 7-hydroxy-4-methyl-2H-benzopyran-2-ones and 1,2,4-triazole individually act as an important pharmacophore and exhibit promising biological activities. (derpharmachemica.com)
  • Another substance named "isocoumarin glucoside", has also been extracted from Patrinia heterophylla, which may exhibit cytotoxic activities. (med-pro.org)
  • There are clues of antileishmanial effects of prenylated coumarins. (ac.ir)
  • Storage of the extract at 4 °C for 60 days had no effect on its in vitro antifungal activity. (ac.be)
  • Further, the extract was tested for its in vivo (preventive- and curative treatments) antifungal activity on lemons wound-inoculated with P. digitatum . (ac.be)
  • A slight curative antifungal activity was observed only after 7 days of storage (14.29% of inhibition). (ac.be)
  • E type has weak estrogenic activity, Z type having the effect of anti-estrogen. (lookchem.com)
  • Cell proliferation assay showed that compound 4j possessed good antitumor activity against three different types of cancer cells derived from colon (HCT-116), breast (MDA-MB-468) and blood-leukemia (CCRF-CEM) with cell viability of 40.0%, 53.2% and 27.2% respectively at 50 μM. (unboundmedicine.com)
  • The present study aims to evaluate the plant rhizome for chemical composition and in vitro antioxidant, antibacterial and cytotoxic bioactivities. (biomedcentral.com)
  • In view of these considerations, this study was designed to evaluate the cytotoxic and genotoxic potential of geraniol, in an in vitro protocol, using two types of human cells: one without the ability to metabolize (peripheral blood mononuclear cells - PBMC), and the other with this capability (human hepatoma cell line - HepG2) through the comet assay and the micronucleus test. (geneticsmr.org)
  • No fluorouracil dose has been proven safe in patients with absent DPD activity. (nih.gov)
  • For C2, the usual V. condensate dose, results indicate that care is needed when consuming the plant, since it was cytotoxic. (scielo.org.ar)
  • Cytotoxic effect of the extract in cancer and normal cell lines was determined by MTT assay. (biomedcentral.com)
  • An important preventive antifungal effect was observed after 7 days of storage (100% of inhibition), although this activity decreased after 14 and 21 days (85.71 and 57.14% of inhibition, respectively). (ac.be)
  • F. szowitsiana DC, F. hirtella Boiss and F. oopoda Boiss are three species with little or no history of previous cytotoxic investigations. (ijpsr.com)
  • This information and website content is not intended to diagnose, guarantee results, or recommend specific treatment or activity. (docshay.com)
  • Results of ELISA, western blot and gelatin zymography indicated that UMB decreased the productions of pro-inflammatory factors, including IL-1[Formula: see text], IL-6, IL-8, MMP-2 and MMP-9, and inhibited MMP-2 activity in TNF-[Formula: see text]-stimulated MH7A cells. (harvard.edu)
  • In other hand, it promoted a hypotensive activity by significant reduction in arterial blood pressure without change heart rate, confirming the therapeutic use as antihypertensive for this plant. (researchgate.net)
  • Folk Indian medicine refers to the use of leaf and stem bark powder of Tabernaemontana alternifolia (Roxb) in treatment of skin infections, but no scientific report establishes its antibacterial activity. (biomedcentral.com)