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Phosphoenolpyruvate Carboxykinase (GTP)Phosphoenolpyruvate Carboxykinase (ATP)Phosphoenolpyruvate CarboxylasePhosphoenolpyruvateCytosolGluconeogenesisLiverGlucose-6-PhosphataseMolecular Sequence DataPyruvate KinaseOxaloacetatesProgesterone ReductaseRNA, MessengerBase SequencePhosphoenolpyruvate Sugar Phosphotransferase SystemAmino Acid SequenceKineticsGene Expression Regulation, EnzymologicCarboxy-LyasesPyruvate CarboxylaseBucladesinePicolinic AcidsFructose-BisphosphataseEnzyme InductionGlucoseTriamcinoloneDexamethasoneIsoenzymesPyruvatesCyclic AMPOxaloacetic AcidGuanosine TriphosphateMalate DehydrogenaseMitochondriaTranscription, GeneticCloning, MolecularMalatesSubcellular FractionsInsulinPromoter Regions, GeneticStarvationSequence Homology, Amino AcidGlucagonLiver Neoplasms, ExperimentalCell LineAcidosisInosine DiphosphateManganesePyruvic AcidCitric Acid CycleDNA, ComplementaryAmmonium ChlorideRats, Inbred StrainsPanicumElectrophoresis, Polyacrylamide GelGlucokinaseTriamcinolone AcetonideLactatesQuinolinic AcidsGlucocorticoidsLiver GlycogenCCAAT-Enhancer-Binding ProteinsMitochondria, LiverAminooxyacetic AcidKidneyGlycolysisDeoxyadenosinesDecarboxylationTyrosine TransaminaseCarbohydrate MetabolismGlutaminaseGlycerolAdrenalectomyPhosphotransferases (Nitrogenous Group Acceptor)Inosine TriphosphateCyclic AMP Response Element-Binding ProteinBinding SitesSuccinatesDactinomycinGlucose-6-PhosphateEscherichia coliHepatocytesGene Expression RegulationChickensGlycerol KinaseCarbon DioxideGlycogenPhosphotransferasesTranscription FactorsEnzyme ActivationGenesPhosphotransferases (Paired Acceptors)Phosphofructokinase-1Diabetes Mellitus, ExperimentalCycloheximideProtein BiosynthesisSuccinic AcidPlasmidsChloramphenicol O-AcetyltransferaseCarbon

GenePCK1MitochondrialEnzymeOxaloacetate

Gene2

• The SIRT1 activators isonicotinamide (IsoNAM), resveratrol, fisetin, and butein repressed transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C). An evolutionarily conserved binding site for hepatic nuclear factor (HNF) 4α (-272/ -252) was identified, which was required for transcriptional repression of the PEPCK-C gene promoter caused by these compounds. (elsevierpure.com)
• Methods: To address this question, transgenic Non-Obese Diabetic (NOD) mice which express insulin in the liver were made using the Phosphoenolpyruvate Carboxykinase (PEPCK) promoter to drive the mouse insulin I gene (Ins). (deepdyve.com)

PCK11

• The results of RT-qPCR analysis and gain-of-function experiments confirmed the positive association between the IMF content and phosphoenolpyruvate carboxykinase 1 ( PCK1 ) expression in buffalo. (biomedcentral.com)

Mitochondrial1

• This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). (nih.gov)

Enzyme4

• In glycolysis, PEP is formed by the action of the enzyme enolase on 2-phosphoglycerate. (hmdb.ca)
• This reaction is catalyzed by the enzyme phosphoenolpyruvate carboxykinase (PEPCK). (hmdb.ca)
• A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. (nih.gov)
• Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME. (lookformedical.com)

Oxaloacetate2

• In gluconeogenesis, PEP is formed from the decarboxylation of oxaloacetate and hydrolysis of 1 guanosine triphosphate molecule. (hmdb.ca)
• Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (nih.gov)