The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. (blogspot.com)
Protein1
GeneCards Summary for PREP Gene: PREP (Prolyl Endopeptidase) is a Protein Coding gene. (blogspot.com)
Amino1
NS2 is a 217 amino acids (aa) long cysteine-protease composed of a highly hydrophobic N-terminal membrane binding domain (MBD) and a C-terminal globular and cytosolic protease domain. (expasy.org)
Gene2
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. (cancerindex.org)
Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity . (blogspot.com)
Form2
BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. (thermofisher.com)
The propeptide domain contains a cysteine residue that binds zinc in the active site to form the cysteine switch. (periobasics.com)
Domain1
The binding of cysteine in the catalytic domain blocks the active zinc site, maintaining the latent or inactive state 4 . (periobasics.com)
Proteinases1
Calpains are a family of cytosolic cysteine proteinases. (embl.de)
Cytochrome2
Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. (nih.gov)
Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis. (thermofisher.cn)
Degradation3
Using an in vitro ubiquitin conjugating-proteasome degradation system, we show that the cytosolic proteasome can degrade UCP1 at a rate commensurate with the half-life of UCP1 (i.e. 30-72h in brown adipocytes and ~3h, in thymocytes). (ox.ac.uk)
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. (bvsalud.org)
MMPs are Zn 2+ -dependent endopeptidases that cause degradation of different protein substrates in the extracellular matrix (ECM). (oaepublish.com)
Peptides2
They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. (lookformedical.com)
Jasmintides jS1 and jS2 from Jasminum sambac were previously identified as a novel family of cysteine-rich peptides (CRPs) with an unusual disulfide connectivity. (biomedcentral.com)
Mitochondrial1
We conclude that there is a role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial UCP1. (ox.ac.uk)
Digestion1
Peptidomic analysis, using fractionated mixtures of jasmintides and chemical derivatization of cysteine to pseudolysine, trypsin digestion and MS/MS sequencing, revealed an additional 86 jasmintides, some of which were post-translationally modified. (biomedcentral.com)