Peptidomic studies have determined hundreds of intracellular peptides derived from cytosolic mitochondrial and nuclear proteins in mammalian cells [1]-[6]. (health-ground.com)
The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling. (embl.de)
Serine1
Recent studies have shown that the cytosolic serine dipeptidyl peptidases DPP8 and DPP9 suppress inflammasome activation upstream of NLRP1 and CARD8 in human keratinocytes and peripheral blood mononuclear cells. (inra.fr)
CCP21
Based on sequence similarities, CCP1 was proposed to be involved in tubulin processing along with five other carboxypeptidases, designated CCP2 to CCP6. (wikipedia.org)
Protein4
ATP/GTP binding protein 1 is gene that encodes the protein known as cytosolic carboxypeptidase 1 (CCP1), originally named NNA1. (wikipedia.org)
The autosomal recessive Purkinje cell degeneration mutation affects Agtpbp1 located on mouse chromosome 13, with alleles containing a zinc carboxypeptidase domain and an ATP/GTP binding motif, a protein first identified in alpha-motoneurons during axonal regeneration. (wikipedia.org)
Thus an emerging concept is that peptides produced from cytosolic mitochondrial and/or nuclear proteins have functional roles in cellular processes and are not merely intermediates in the protein degradation pathway [13]. (health-ground.com)
This diploma thesis revolves around the preparation of biocompatible polymeric conjugates called "iBodies" that will be used to induce targeted lysosomal degradation of two model enzymes - Fibroblast activation protein α, and Glutamate carboxypeptidase II. (nusl.cz)
NNA11
NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse. (nih.gov)
Tyrosine1
Important for the sorting of lysosomal membrane proteins to lysosomes are the tyrosine and dileucine-based consensus motifs within their cytosolic tails. (healthcarecoremeasures.com)
Gene2
In HCC cells, cytosolic CPE-ΔN was translocated to the nucleus and interacted with histone deacetylase 1/2 to upregulate expression of the gene encoding neural precursor cell expressed, developmentally downregulated gene 9 (Nedd9) - which has been shown to promote melanoma metastasis. (jci.org)
This group of sequences contain a diverse range of gene families, which include metallopeptidases belonging to MEROPS peptidase family M14 (carboxypeptidase A, clan MC), subfamilies M14A and M14B. (embl.de)
Pathway1
In the absence of Wnt pathway activation cytosolic β-catenin is definitely phosphorylated and targeted for degradation. (ecologicalsgardens.com)
Enzyme2
Members of the carboxypeptidase A family are synthesised as inactive molecules with propeptides that must be cleaved to activate the enzyme. (embl.de)
The leading and most diverse group of GSTs are the cytosolic enzyme spresent in humans. (medchemexpress.com)
Proteins1
Interestingly, sortilin, with SorLA and SorCS1C3 collectively, forms a proteins family posting homology towards the lumenal site from the candida vacuolar sorting proteins Vps10p, which directs carboxypeptidase Y towards the vacuole (Marcusson et al. (healthcarecoremeasures.com)
Digestive1
In the small intestine, the pH is in the range of between 5.5 to 7 and several digestive enzymes such as trypsin, chymotrypsin, carboxypeptidase, amylase, lactase and lipase, as well as bile salts, are present. (medscape.com)
Domain1
Physique 1 Structure and topology of mouse SCD1 Physique 2 Architecture of the acyl-CoA binding site Vigabatrin The cytosolic domain name contains a substantial nonprotein density consistent with an 18-carbon acyl-CoA molecule (Physique 2a Extended Data Physique 5a). (tam-receptor.com)