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  • dsDNA
  • Prior to the discovery of cGAS, it was known that interferon beta was produced in the presence of cytosolic dsDNA and that STING-deficient cells were unable to produce interferon in the presence of dsDNA. (wikipedia.org)
  • receptor
  • From these the a-subtype of cytosolic phospholipases A2 (cPLA2α) appears to be the most likely candidate to catalyze this hydrolysis, since the enzyme is highly selective for arachidonoyl-containing phospholipids and is tightly regulated by receptor-stimulated mechanisms (calcium influx and phosphorylation). (ingentaconnect.com)
  • activates
  • DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. (genome.jp)
  • Sperm
  • These observations indicate that cytosolic pH plays a role in the regulation of motility and metabolism of mammalian sperm that is not mediated by cyclic AMP but that may be under control of a plasma membrane voltage-dependent proton channel. (pnas.org)
  • mitochondria
  • On the other hand, however, the proteomes of mitochondria and chloroplasts include translation products from both cytosolic 80S and organellar 70S ribosomes. (plantphysiol.org)
  • Primary
  • Cytosolic ciliogenesis is divided into three types: Primary cytosolic cilia are formed by exposing the axoneme of compartmentalized cilium (formed initially by compartmentalized ciliogenesis) to the cytoplasm. (wikipedia.org)
  • Cell
  • Cytosolic pH (pHc) is a crucial parameter in the cell because it is highly dynamic and it changes affect the function of all biomolecules containing weakly acidic or basic groups. (uva.nl)
  • Its cytosolic localization was demonstrated by cell fractionation experiments. (wikipedia.org)