• Finally, arginine and ornithine derived from ACs are metabolized into the polyamine putrescine pathway in macrophages via arginase 1 and ornithine decarboxylase to enable actin cytoskeletal rearrangements during efferocytosis 5 . (nature.com)
  • We have found that Arf6 acts through activation of type I phosphatidylinositol 4-phosphate 5-kinases to generate phosphatidylinositol 4,5-bisphosphate and that this activity is instrumental in facilitating the actin cytoskeletal rearrangements and alterations in endosomal membrane trafficking observed with increased Arf6 activation. (portlandpress.com)
  • Numerous proteins regulating the rearrangement of the cytoskeleton are indicative of the functional and structural dynamics of the presynapse. (mdpi.com)
  • These results suggested that the antimetastatic effect of SY is due to its ability to inhibit invadopodia formation, which occurs mainly through Src-dependent cytoskeleton rearrangement. (naturalnews.com)
  • Growth cone turning requires rearrangement of cytoskeleton at the growth cone. (jneurosci.org)
  • The integrity of this monolayer can be disrupted by lipopolysaccharide (LPS), where LPS could increase the permeability of the endothelium via dissociation of cell-to-cell junctions and rearrangement of cytoskeleton. (upm.edu.my)
  • When cytoskeletal proteins like actin undergo mutations and are abnormally expressed, they can contribute to the drug resistance and metastatic ability of cancer cells . (naturalnews.com)
  • Arf1 can also stimulate the activity of phosphatidylinositol kinases and recruit coat proteins and actin cytoskeletal elements to the Golgi complex. (portlandpress.com)
  • Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. (avivasysbio.com)
  • The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling. (embl.de)
  • Thus, Rho GTPases may mediate axon guidance by linking upstream Ca 2+ signals triggered by guidance factors to downstream cytoskeletal rearrangements. (jneurosci.org)
  • Although a report has shown that RhoB, a small GTPase involved in cytoskeletal actin rearrangement, lies downstream of Slug ( 11 ), another member of the Snail super-family, there is no evidence to support a link between Snail and Rho GTPases. (spandidos-publications.com)
  • EMT is characterized by loss of cell-cell adhesion and polarity accompanied by cytoskeletal rearrangements and increased cell motility. (ki.se)
  • Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
  • Her lab also is exploring cellular pathways that mediate cytoskeletal rearrangements associated with adhesion, migration, and phagocytosis of hematopoietic cells involved in inflammation and blood clotting. (harvard.edu)
  • The Rho family of small GTPases may serve as "molecular switches" to regulate the cytoskeletal rearrangements involved in many forms of cell motility ( Etienne-Manneville and Hall, 2002 ). (jneurosci.org)
  • May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. (nih.gov)
  • The researchers reported that SY dose-dependently inhibited EGF-mediated time- and dose-dependent cell responses by inhibiting cytoskeletal rearrangement. (naturalnews.com)
  • From an evolutionary perspective this spatial control is satisfied in that the distant relative S. cerevisiae Cdc24, a GEF for Cdc42, plays a key role in targeting cytoskeletal changes to different spatial domains of the cell in response to different signals O'Shea et al. (justia.com)
  • They are also implicated in cytoskeletal rearrangement, cell differentiation, transformation and proliferation. (umbc.edu)
  • Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. (monash.edu)
  • We found that Wnt5a could activate regulated secretion of IL-6 and VEGF, dependent on cytoskeletal re-arrangements mediated via calcium signaling and Cdc42 activation. (lu.se)
  • Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)
  • A thesis is proposed here, based on rational argument that depletion of the cytoskeletal organizer protein shank3 may result in defective nNOS membrane localization, resulting in defective nitric oxide synthesis. (frontiersin.org)
  • They also participate in cytoskeletal rearrangement, co-regulation of growth factor activities and activation of signal transduction. (go.jp)
  • engagement triggers rapid GTP-loading of the small GTPase Rac as a master regulator of cytoskeletal rearrangements and lamellipodia-driven internalization. (biologists.com)
  • Aside from preventing cytoskeletal arrangement, the researchers also found that SY can significantly inhibit the migration of breast cancer cells in vitro and prevent the pulmonary metastasis of breast cancer cells in vivo. (naturalnews.com)
  • These cells develop into late pro-B cells, in which rearrangement of the heavy chain occurs. (medscape.com)
  • These results indicate that c-Abl kinase is an important determinant of cortical actin-based cytoskeletal rearrangement. (nih.gov)
  • Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. (thermofisher.com)
  • Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. (lsbio.com)
  • Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)
  • Dynamic cytoskeletal rearrangements underlie the changes that occur during cell division in proliferating cells. (bvsalud.org)
  • Their long-range goal is to define in molecular detail the multi-component mechanisms that underlie these critical steps in cytoskeletal remodeling, which govern cell shape, organization, and dynamics. (nih.gov)
  • Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. (monash.edu)
  • Research in the Dr Goode lab focuses on defining the biochemical and cellular mechanisms of actin and microtubule cytoskeleton rearrangements that drive cell morphogenesis, motility, endocytosis, and intracellular transport. (nih.gov)
  • The hair orientation process relies solely on directional cytoskeletal rearrangements without an apparent requirement for a transcriptional response. (reactome.org)
  • In situ immunolocalization of tubulin revealed that important rearrangements occur during all the early symbiotic steps in the Medicago/R. meliloti symbiotic interaction. (biologists.com)
  • A few dozen genes in the actin and tubulin cytoskeletal systems have been characterized thoroughly, including gene families encoding actins, profilins, actin depolymerizing factors, α-tubulins, and β-tubulins. (bioone.org)
  • SH3 domains are involved in a wide-range of important cellular processes including intracellular signaling, cytoskeletal rearrangements and cell movement, cell growth and immune responses. (eu.org)
  • However, the Giniger laboratory has discovered a novel form of growth cone motility in vivo in the TSM1 axon of Drosophila, in which the growth cone is more filamentous (filopodial) in structure and appears to be driven by dynamic rearrangement of actin. (nih.gov)
  • Vav1, PAK1, and WASP may mediate TCR-stimulated actin cytoskeletal rearrangement. (bdbiosciences.com)
  • Thus, Rho GTPases may mediate axon guidance by linking upstream Ca 2+ signals triggered by guidance factors to downstream cytoskeletal rearrangements. (jneurosci.org)
  • MICAL2 has been reported to possess reactive oxygen species- (ROS-) generating properties and act as an important regulator of cytoskeletal dynamics. (bvsalud.org)
  • however, since then they have made a major transition, and about half of the lab currently studies cytoskeletal dynamics in mammalian cells. (nih.gov)
  • It implies that (i) MtC rearrangements occur in pericycle and inner cortex earlier than in the root hair, (ii) the infection process proceeds prior to the formation of the nodule meristem, (iii) the initial primordium prefigures the future zone II of the mature nodule and (iv) the nodule meristem derives from the nodule primordium. (biologists.com)
  • Cytoskeletal protein disruptors led to a decreased stiffness of the lens, and the effects were reversible. (molvis.org)
  • Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. (nih.gov)
  • To understand the innate molecule-cell-tissue relationship across varied length-scales, the functional role of c-Abl kinase in the cytoskeletal nano-biomechanics of ECs in response to barrier-altering agonists was investigated using atomic force microscopy. (nih.gov)
  • Cytoskeletal rearrangements play an important but different role at each stage. (piaolab.org)
  • This study examined whether the highly conserved cytoplasmic tail of podocalyxin also contributes to the unique organization of podocytes by interacting with the cytoskeletal network found in their cell bodies and foot processes. (embl-heidelberg.de)
  • The Significant Role of c-Abl Kinase in Barrier Altering Agonists-mediated Cytoskeletal Biomechanics. (nih.gov)
  • Using two-photon volumetric imaging, we found that during the second postnatal week, Müller glial processes were highly dynamic, with rapid extensions and retractions that were mediated by cytoskeletal rearrangements. (elifesciences.org)
  • This treasure trove of data provides an unprecedented opportunity to make rapid advances in understanding the complex plant cytoskeletal proteome. (bioone.org)