Cytoskeletal protein actin. Medical search. Frequent questions

It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins. (cshlpress.com)
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). (hmdb.ca)
The Arp2/3 complex generates propulsive forces by nucleating a highly branched network of actin filaments. (columbia.edu)
The cytoskeletal network is composed of three different protein structures named filaments: microtubules, microfilaments (actin), and intermediate filaments. (ptglab.com)
Monomers of the globular actin (G-actin) polymerize to form actin filaments (F-actin), long and thin fibers. (ptglab.com)
Actin filaments are very flexible and show a helical structure. (ptglab.com)
Actin filaments form bands close to the plasma membrane. (ptglab.com)
Many different cellular processes related to cell shape or cell motion depend on actin filaments. (ptglab.com)
Intermediate filaments are polymers of different proteins, depending on the cellular context. (ptglab.com)
Thus, intermediate filaments do not have as rigidly defined a structure as actin filaments or microtubules.Regardless of the composition, intermediate filaments have a diameter of around 10 nm. (ptglab.com)
These filaments are less dynamic and flexible than microtubules and actin filaments. (ptglab.com)
A key factor expressed early in synapse formation is Msp300/Nesprin-1, which organises actin filaments around the new synapse. (ucl.ac.uk)
A family of cytoskeletal proteins that play essential roles in CELL ADHESION at ADHERENS JUNCTIONS by linking CADHERINS to the ACTIN FILAMENTS of the CYTOSKELETON. (bvsalud.org)
Cell-cell and cell-matrix complexes of epithelial cells are interconnected through cytoskeletal filaments and proteins, and they influence the activities and outcome of various cellular processes. (lu.se)
Filamin A binds to another protein called actin, and helps the actin to form the branching network of filaments that make up the cytoskeleton. (medlineplus.gov)

Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. (hmdb.ca)
The neurofilament proteins belong to the intermediate filament family. (ptglab.com)
Neurofilaments usually contain three intermediate filament proteins: L, M, and H that are involved in the maintenance of neuronal caliber. (ptglab.com)

Microtubules form the most rigid part of the cytoskeleton and are responsible for the intracellular movement of organelles or proteins. (ptglab.com)

CUL3 ASD-associated genetic variants are most often de novo missense or loss of function (loF) mutations, dispersed throughout the entire gene and affecting distinct protein domains. (nature.com)
When cytoskeletal proteins like actin undergo mutations and are abnormally expressed, they can contribute to the drug resistance and metastatic ability of cancer cells . (naturalnews.com)
About one-third of dilated cardiomyopathy (DCM) cases are caused by mutations in sarcomere or cytoskeletal proteins. (jci.org)
Mutations in the actin binding protein CAP2 can cause DCM and KO mice, either whole body (CAP2-KO) or cardiomyocyte-specific KOs (CAP2-CKO) develop DCM with cardiac conduction disease. (jci.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Mutations in either alpha- and beta-spectrin are most commonly responsible, but mutations in other cytoskeletal proteins (band 4.1 and glycophorin) are also described. (medscape.com)
These mutations collectively result in defective assembly of the protein scaffolding on the inner aspect of the RBC membrane. (medscape.com)
The most common group of mutations affect alpha- or beta-spectrin and result in defects in the formation of the spectrin heterodimer or in the association of the heterodimer with the lipid anchoring complex (formed by actin, band 3, protein 4.1 and glycophorin C). (medscape.com)

Our unique findings reveal that in intestinal epithelial cells, acute changes in actin dynamics modulate the cell stress response determining which cells survive and which die, influencing signaling that is pivotal to inflammation and Crohn's disease development," said Khurana. (uh.edu)
Under particular scrutiny are villin and gelsolin, two actin-binding cytoskeletal proteins in the intestine that Khurana has already found precipitate changes in actin. (uh.edu)
In airway epithelial cells, altered AQP5 abundance is associated with changes in actin organization and in desmoplakin localization, which could contribute to the changes in paracellular permeability. (plos.org)

Actin-binding proteins (also known as ABPs) are proteins that bind to actin. (wikipedia.org)
This may mean ability to bind actin monomers, or polymers, or both. (wikipedia.org)
GRP78 could also bind to other proteins in the nucleus critical for cancer, opening up a new line of research in cancer biology. (medicalxpress.com)
However, treating the cytoskeleton directly is not possible because drugs that bind to actin are not well tolerated. (jci.org)
The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
At the distal end, they bind to other cytoskeletal proteins, namely actin and protein 4.1. (medscape.com)
Increased adhesion of the cancer cells depended on activation of cyclooxygenase-2, an enzyme that is involved in progression of colon cancers, whereas adhesion of the intestinal epithelial cells was augmented by LTD4-induced translocation of protein kinase C to areas where integrins bind to matrix proteins (focal adhesions). (lu.se)

In 2001, significant advances were made to our understanding of the structure and function of actin monomers. (edu.au)

It is the major component of intranuclear and cytoplasmic actin rods. (aacrjournals.org)
The antibody has been shown to recognize α-skeletal, α-cardiac, α-smooth muscle, β-cytoplasmic, γ-smooth muscle and γ- cytoplasmic actin isotypes (Fig. 1) and has broad species cross-reactivity. (cytoskeleton.com)

We found that LTD4 caused dramatic changes in the actin cytoskeleton in intestinal epithelial cells, and an important factor in this context was the impact of this leukotriene on the actin-binding protein vinculin, which included inducing translocation of vinculin from a cell-cell to a cell-matrix complex. (lu.se)

Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress fibers and lamellipodia, respectively. (nih.gov)
E3 ubiquitin ligases regulate cellular protein composition by providing target recognition and specificity to the ubiquitin-dependent proteasomal degradation pathway 12 . (nature.com)
Arf (ADP-ribosylation factor) GTP-binding proteins function in cells to regulate membrane traffic and structure. (portlandpress.com)
Complexes of Vps34, the sole class III PI3K member, produce PI 3-phosphate (PI(3)P) in the endolysosomal system and during autophagy to regulate vesicle-mediated sorting en route to lysosomes 1 . (nature.com)
The research centers on a cellular chaperone protein known as GRP78, which helps regulate the folding of other proteins inside cells. (medicalxpress.com)
Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway , regulate synaptic development in vertebrates and invertebrates. (sdbonline.org)
Researchers believe that the variants may change the way the filamin A protein helps regulate processes involved in skeletal development, but it is not known how changes in the protein relate to the specific signs and symptoms of Melnick-Needles syndrome. (medlineplus.gov)

Using Xenopus laevis cell-free extracts and mammalian cells, we show that actin nucleation machinery (WASP, Arp2/3, and actin) is recruited to damaged chromatin undergoing HDR. (columbia.edu)
Act in is a major cytoskeletal protein of mammalian muscle and non-muscle cells. (microbiologyresearch.org)
This study shows that Schip1 , a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. (sdbonline.org)

The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. (scriptiebank.be)
This antibody is recommended for detection of actin in a broad spectrum of species such as human, mouse, rat, and bovine. (cytoskeleton.com)
AAN02 is a mouse monoclonal antibody against actin protein. (cytoskeleton.com)
The immunogen used for antibody production was purified actin protein from rabbit skeletal muscle. (cytoskeleton.com)
Western blot of purified actin and cell extracts probed with anti-actin antibody. (cytoskeleton.com)
The blot was probed with a 1:1000 dilution of anti-actin antibody. (cytoskeleton.com)
Immunofluorescence images of mouse Swiss 3T3 cells stained with anti-actin antibody. (cytoskeleton.com)
Immunofluorescence staining using 1:500 dilution of anti-actin antibody in PBS is shown (green). (cytoskeleton.com)

Mechanisms responsible for F-actin stabilization after lysis of polymorphonuclear leukocytes. (microbiologyresearch.org)
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle contractions. (mpg.de)

Many of these are likely to help us understand and distinguish between the structural models of actin microfilaments. (edu.au)
Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)

Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)
Genotoxic agents trigger actin polymerization in the nucleus. (columbia.edu)
Chapter 1 provides context for the rest of the thesis in which I explore the contribution of nuclear actin polymerization to DSB repair. (columbia.edu)
Controls reversibly actin polymerization and depolymerization. (aacrjournals.org)

They were chosen because 1) they represent a family of related proteins, 2) they are widely distributed in nature, 3) an atomic structure (or at least a plausible model) is available for each of them, and 4) each is expressed in significant quantities in cells. (edu.au)
That leaves room for researchers to hone in deeply to where the disease might gain access to the gastrointestinal tract, through the lining of gastrointestinal cells called the actin cytoskeleton. (uh.edu)
Aside from preventing cytoskeletal arrangement, the researchers also found that SY can significantly inhibit the migration of breast cancer cells in vitro and prevent the pulmonary metastasis of breast cancer cells in vivo. (naturalnews.com)
EGF stimulation of breast cancer cells (MBA-MD-231) treated with SY resulted in a decrease in the expression of matrix metallopeptidase 9 (MMP-9) and p-Src proteins and the formation of invadopodia. (naturalnews.com)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with constructs expressing Myc/DDK-tagged full-length human α-actinin proteins (+), using α-Actinin 4 (D7U5A) Rabbit mAb (upper) and Myc-Tag (71D10) Rabbit mAb #2278 (lower). (cellsignal.com)
But when cells are under stress, the chaperone protein migrates to the cell's nucleus, where it alters gene activities and changes the behavior of the cell, allowing the cancer cells to become more mobile and invasive. (medicalxpress.com)
But the chaperone protein was long thought to exist primarily in the endoplasmic reticulum of cells. (medicalxpress.com)
Drosophila melanogaster Kc167 cells were stained for DNA (to label nuclei, red) and actin (a cytoskeletal protein, to show the cell body, green). (cellimagelibrary.org)
Exposure of cells to soluble factors that damage cell membranes results in the release of actin into the extracellular spaces. (microbiologyresearch.org)
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
Mapping cytoskeletal protein function in cells by means of nanobodies. (scriptiebank.be)
Actin is an abundant protein in all eukaryotic cells. (ptglab.com)
Proteins must be folded correctly to fulfill their molecular functions in cells. (mpg.de)
Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. (mpg.de)
Misfolded proteins can aggregate into toxic clumps, which damage cells and contribute to Alzheimer's and Parkinson's disease. (mpg.de)
In comparison with similar proteins that build the cytoskeleton of bacteria, which are evolutionary older and simpler cells, the researchers found fundamental differences in the protein folding. (mpg.de)
In general, cell adhesion favours cell survival signalling, and integrins are the main receptors responsible for mediating the attachment of different types of cells to matrix proteins. (lu.se)

Xie X, Almuzzaini B, Drou N, Kremb S, Yousif A, Farrants AÖ, Gunsalus K, Percipalle P. (2018) 'β-Actin-dependent global chromatin organization and gene expression programs control cellular identity. (nyu.edu)
Chapter 1 provides an overview of these pathways including the key steps of DSB repair, the regulation of actin nucleation, and the proteins involved in chromatin mobility. (columbia.edu)

In particular, 1) the structure of actin was resolved from crystals in the absence of cocrystallized actin binding proteins (ABPs), 2) the prokaryotic ancestral gene of actin was crystallized and its function as a bacterial cytoskeleton was revealed, and 3) the structure of the Arp2/3 complex was described for the first time. (edu.au)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)

Neuronal loss of the serine-threonine protein kinase Tao , a regulator of the Hippo signaling pathway, results in supernumerary boutons, each of which contain a normal number of active zones. (sdbonline.org)
Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)

Memory and learning involve activity-driven expression of proteins and cytoskeletal reorganisation at new synapses, often requiring post-transcriptional regulation a long distance from corresponding nuclei. (ucl.ac.uk)
This thesis is focused primarily on the effect that LTD4 has on reorganisation of the actin cytoskeleton and on cell-cell and cell-matrix adhesion properties. (lu.se)

Furthermore, we found that Pls3 cell-autonomously regulates cell migration by regulating actin cytoskeleton organization, and its levels are inversely proportional to neural migration speed. (nature.com)
Recent studies have proposed roles for cytoskeletal proteins in genome organization and chromosomal dynamics. (columbia.edu)

Xie X, Venit T, Drou N, Percipalle P* (2018) 'In mitochondria β-actin regulates mtDNA transcription and is required for mitochondrial quality control. (nyu.edu)
Xie X, Jankauskas R, Drou N, Percipalle P* (2018) ' β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming . (nyu.edu)

Many actin-binding proteins, including α-actinin, β-spectrin, dystrophin, utrophin and fimbrin, do this through the actin-binding calponin homology domain. (wikipedia.org)
CUL3 is a conserved protein of the Cullin family, comprising eight members, which contain a conserved cullin homology domain, named after its ability to select cellular proteins for degradation. (nature.com)

The team found that GRP78 binds to ID2, another cellular protein. (medicalxpress.com)
Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
Here, we show that the local translation of msp300 is promoted during activity-dependent plasticity by the conserved RNA binding protein Syncrip/hnRNP Q, which binds to msp300 transcripts and is essential for plasticity. (ucl.ac.uk)

Actin is the major protein of the microfilament cytoskeletal system and is a key protein in various cell motility processes. (cytoskeleton.com)

In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. (hmdb.ca)

They are responsible for the mechanical strength of the cell and connect cytoplasmic and transmembrane proteins. (ptglab.com)
These proteins, in turn, anchor the scaffold to the lipid bilayer by linking to the transmembrane proteins band 3, glycophorin A, and glycophorin C. (medscape.com)

The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE. (warf.org)
Serum proteins that are categorized loosely by their electrophoretic mobility as alpha globulins that inhibit proteases, beta globulins that exist as various enzymes, and gamma globulins that mainly comprise immunoglobulins (antibodies). (stratech.co.uk)

Intrinsically disordered protein mesophases and their regulation are at the center of cellular nano organisation that guide development and cellular dynamics. (infn.it)
Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)

Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. (hmdb.ca)
Recently Gastroenterology Journal published her findings about how defects in the conversations between actin molecules and the protein EIF2A (that warns of incoming cellular stress) are linked to the development of Crohn's disease. (uh.edu)

[ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)

At the molecular level, Cul3 regulates cytoskeletal and adhesion protein abundance in mouse embryos. (nature.com)

Percipalle P*, Vartiainen, MK (2019) 'Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective. (nyu.edu)
These attachment sites are linked to actin-bundles that surround the nucleus via an Ndj1-Mps3-Csm4 protein bridge that spans the inner and outer nuclear membranes. (biorxiv.org)
The green staining depicts the cytoskeletal protein F-actin which controls cell shape and motility and the blue staining depicts the nucleus. (medicalxpress.com)

Paxillin is a multidomain cytoskeletal protein with a role in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). (biogenex.com)

p58gag" in The Encyclopaedia of Actin-Binding Proteins (and Drugs) Archived February 6, 2007, at the Wayback Machine, op. cit. (wikipedia.org)
The Encyclopaedia of Actin-Binding Proteins (and Drugs)- alphabetical list, sourced profile for each Maciver, Sutherland (ed. (wikipedia.org)
The interaction between drugs and transport proteins is a key factor in drug bioavailability. (mdpi.com)

ILK forms an obligate heterotrimeric complex with particularly interesting Cys-His-rich protein (PINCH) and parvin, which together lend stability to the actin cytoskeleton at focal adhesions ( Brakebusch and Fässler, 2003 ). (jneurosci.org)

Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
Nascent proteins are protected from intermolecular interactions that would hamper their folding by chaperones, molecular folding assistants. (mpg.de)
Typically, proteins spontaneously find their fold - chaperones just assist them by making the process more effective and keeping the protein away from interactions that would hamper folding. (mpg.de)
No yeast two-hybrid interactions found for this protein. (yeastrc.org)

In Saccharomyces cerevisiae , the telomere-associated protein Ndj1 is required for bouquet formation. (biorxiv.org)
Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)

Any material which elicits an immune response (e.g., a bacterial toxin or viral protein). (stratech.co.uk)
Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin. (microbiologyresearch.org)
Actin has many more protein interaction partners than the bacterial cytoskeletal proteins, but it has lost the ability to fold independently. (mpg.de)
Bacterial cytoskeletal proteins also require the help of chaperones to effectively reach a folded state. (mpg.de)

during pachytene, telomeres disperse, yet remain attached to the nuclear envelope and are subject to actin-dependent pulling forces ( Z ickler and K leckner 1998 ). (biorxiv.org)

p-Src proteins, on the other hand, are regulatory proteins that play key roles in cell differentiation , motility, proliferation, and survival. (naturalnews.com)

Invadopodia are actin-rich membrane protrusions that can degrade the extracellular matrix (ECM) and are involved in cell invasion. (naturalnews.com)
These results indicate that extracellular actin enhances haemolysin production by E. coli and may have implications in the pathogenesis of E. coli infections. (microbiologyresearch.org)

Therefore, the cytoskeleton interacts with several cytoplasmic proteins or organelles. (ptglab.com)

We show that this united ExM (uniExM) protocol can be used to preserve and visualize RNA transcripts, proteins in biologically relevant ultrastructures, and sets of RNA transcripts in patient-derived xenograft (PDX) cancer tissues and may support the visualization of other kinds of biomolecular species as well. (plos.org)

It mainly forms the catalytic subunits of two protein complexes, including mTOR complex 1 (mTOR complex1, mTORC1) and mTOR complex 2 (mTOR complex2, mTORC2). (hindawi.com)
These subunits form a cavity inside which actin gets folded. (mpg.de)

We have found that Arf6 acts through activation of type I phosphatidylinositol 4-phosphate 5-kinases to generate phosphatidylinositol 4,5-bisphosphate and that this activity is instrumental in facilitating the actin cytoskeletal rearrangements and alterations in endosomal membrane trafficking observed with increased Arf6 activation. (portlandpress.com)

Visa N, Percipalle P. (2010) 'Nuclear functions of actin. (nyu.edu)
Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)

Arf1 can also stimulate the activity of phosphatidylinositol kinases and recruit coat proteins and actin cytoskeletal elements to the Golgi complex. (portlandpress.com)

The actin cytoskeleton is a complex structure that performs a wide range of cellular functions. (edu.au)
Together, our work demonstrates ILK as necessary for normal oligodendrocyte development, reinforces its role as a bridge between the actin cytoskeleton and cell membrane, and highlights the overarching compensatory capacity of oligodendrocytes in response to cellular milieu. (jneurosci.org)
Autophagy is the "self-eating" process of degrading damaged proteins and organelles, as well as recycling intracellular energy to maintain cellular homeostasis under stress conditions. (hindawi.com)
Researchers from the department "Cellular Biochemistry" of MPIB director F.-Ulrich Hartl have now revealed the unique non-folding properties of the universal protein actin. (mpg.de)
Therefore, even though proteins can also fold in their absence, chaperones contribute to cellular health by improving the folding efficiency. (mpg.de)

Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. (mpg.de)
Newly-synthesized proteins at the ribosomes are not yet able to fulfill their molecular functions in the cell. (mpg.de)
But actin is different because it absolutely requires the molecular folding help of TRiC. (mpg.de)
It seems like this molecular trade-off made the versatility of actin possible", comments Balchin. (mpg.de)
Molecular function GO terms and their p-values for co-expressed proteins. (lu.se)

Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)

Despite the well-understood process of CUL3-mediated protein ubiquitination and degradation 12 , its target proteins in the developing central nervous system and its role in brain development remain utterly understudied. (nature.com)

find that Syncrip (hnRNPQ RNA binding protein) acts directly on msp300 to modulate activity-dependent synaptic plasticity. (ucl.ac.uk)

Domain commonly found in eukaryotic signalling proteins. (embl.de)

Arf1 and Arf6 are the most divergent and most studied human Arf proteins that localize predominantly to the Golgi complex and plasma membrane respectively. (portlandpress.com)

May act as a scaffolding protein within caveolar membranes. (aacrjournals.org)

C. elegans hypothetical proteins C04D8.1, K06H7.4 and ZK632.12. (embl.de)
S. cerevisiae hypothetical proteins YBR129c and YHR155w. (embl.de)

Anatomy7

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes5

Information Science2

Filaments15

Filament3

Microtubules1

Mutations8

Changes in actin3

Bind7

Monomers1

Cytoplasmic actin2

Intestinal epithelial cells1

Regulate7

Mammalian3

Antibody8

Stabilization2

Structural2

Polymerization4

Cells18

Chromatin2

Gene3

Kinase2

Reorganisation2

Organization2

20182

Homology domain2

Binds3

Microfilament1

ATPase1

Transmembrane2

Antibodies2

Regulation2

Molecules2

Cytokines1

Regulates1

Nucleus3

Paxillin1

Drugs3

Focal1

Interactions4

Saccharomyces2

Bacterial4

19981

Motility1

Extracellular2

Interacts1

Tissues1

Subunits2

Alterations1

Nuclear2

Phosphatidylinositol1

Cellular5

Molecular5

Tyrosine1

Degradation1

Modulate1

Eukaryotic1

Plasma membrane1

Membranes1

Hypothetical2