• biomarkers
  • Accordingly, the novel clues to DNA methylation fingerprints in blood and tissues with deteriorated metabolic capacity indicate that blood-borne epigenetic biomarkers of T2D progression might become a reality. (frontiersin.org)
  • This review will discuss the potential of identifying DNA methylation biomarkers to predict development of T2D. (frontiersin.org)
  • tissues
  • Recent data demonstrate highly significant correlations between DNA methylation and the most important risk factors of T2D, including age and body mass index, in blood and human tissues relevant to insulin resistance and T2D. (frontiersin.org)
  • This Review will address the most recent associations between DNA methylation and diabetes-related traits in human tissues and blood. (frontiersin.org)
  • Methylation of cytosine residues in DNA (DNA methylation) is the most studied epigenetic trait, and recent data show significant influences of age and lifestyle related risk factors such as overweight and physical activity on site-specific DNA methylation in blood and tissues relevant for T2D ( 11 , 14 , 16 - 20 ). (frontiersin.org)
  • proteins
  • DNA methylation is a robust biomarker, vastly more stable than RNA or proteins, and is therefore a promising target for the development of new approaches for diagnosis and prognosis of breast cancer and other diseases. (biomedcentral.com)