Cytoplasmic tyrosine protein kinase. Medical search. Frequent questions

SE-induced activation of the BDNF receptor tyrosine kinase, TrkB, is one signaling pathway by which SE induces TLE. (jneurosci.org)
BDNF signaling thru TrkB receptor tyrosine kinase is one molecular mechanism promoting TLE. (jneurosci.org)
Work by multiple investigators including ourselves implicates the receptor tyrosine kinase, TrkB, and its canonical ligand, BDNF, as one signaling pathway by which SE induces development of TLE ( McNamara and Scharfman, 2012 ). (jneurosci.org)
Expression of ALK in malignant T cells is typically due to the t(2;5) translocation resulting in formation of the fusion gene which encodes a 80-kDa hybrid protein that contains portion of the nuclear protein nucleophosmin (NPM) joined to the entire cytoplasmic portion of the receptor tyrosine kinase ALK. (upenn.edu)
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. (joplink.net)

Phosphorylation of proteins by kinases is an important mechanism for communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division. (wikipedia.org)
Tyrosine kinases catalyze the phosphorylation of tyrosine residues in proteins. (wikipedia.org)
The phosphorylation of tyrosine residues in turn causes a change in the function of the protein that they are contained in. (wikipedia.org)
Phosphorylation at tyrosine residues controls a wide range of properties in proteins such as enzyme activity, subcellular localization, and interaction between molecules. (wikipedia.org)
It has also been demonstrated that phosphorylation of a middle-T antigen on tyrosine is also associated with cell transformation, a change that is similar to cellular growth or reproduction. (wikipedia.org)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
The binding of BDNF to the ectodomain of TrkB leads to phosphorylation of tyrosines 515 (Y515) and 816 (Y816) in the cytoplasmic domain of TrkB. (jneurosci.org)
Phosphorylation of residue Y515 promotes association of TrkB with the adaptor protein Shc and activation of PI3-kinase (PI3K)/Akt, MAPK signaling pathways whereas phosphorylation of residue Y816 promotes association of phospholipase Cγ1 (PLCγ1) and signaling mediated by IP3 and DAG ( Reichardt, 2006 ). (jneurosci.org)
Upon immobilization sAxl advertised cell migration and induced the phosphorylation of Axl and phosphatidylinositol 3-kinase. (exposed-skin-care.net)
Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. (genome.jp)
Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. (thermofisher.com)
Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. (thermofisher.com)
In vitro , ritlecitinib inhibits cytokine-induced STAT phosphorylation mediated by JAK3-dependent receptors and the signaling of immune receptors dependent on TEC kinase family members. (drugbank.com)
β1 integrin tyrosine phosphorylation by oncogenic kinases, such as Src, has been predicted to induce tumorigenesis by disrupting adhesion and modifying integrin signaling. (iucc.ac.il)
We conclude that a Src/ FAK signaling unit inhibits differentiation to promote tumorigenesis downstream of β1 integrin and independent of βintegrin tyrosine phosphorylation. (iucc.ac.il)
The exact relationship between these events is likely to be functionally significant, as cytoplasmic-domain serine phosphorylation and internalization have been shown to regulate the function of receptors that possess intrinsic protein-tyrosine kinase activity. (mssm.edu)
Furthermore, disruption of the CD4-p56(lck) complex appears to depend on the integrity of the cytoplasmic-domain serine at position 408, probably due to a requirement for phosphorylation. (mssm.edu)
The binding of extracellular matrix ligands to integrins triggers autophosphorylation at Tyr-397, and activation of FAK through phosphorylation of Tyr residues (Tyr-576 and Tyr577) in the kinase domain activation loop. (fishersci.com)
In addition, phosphorylation of other Tyr residues (Tyr-925, and Tyr-861) creates binding sites for SH2 domains of intracellular signaling molecules such as Src, PI3 kinase, and Grb2. (fishersci.com)
pp60c-src variants containing lesions that affect phosphorylation at tyrosines 416 and 527. (wikidata.org)
Rod cyclic nucleotide-gated (CNG) channels are modulated by changes in tyrosine phosphorylation catalyzed by protein tyrosine kinases (PTKs) and phosphatases (PTPs). (silverchair.com)
Previously, we found that in addition to inhibiting tyrosine phosphorylation of the rod CNG channel α-subunit (RETα), genistein triggers a noncatalytic inhibitory interaction between the PTK and the channel. (silverchair.com)
These studies suggest that PTKs affects RETα channels in two ways: (1) by catalyzing phosphorylation of the channel protein, and (2) by allosterically regulating channel activation. (silverchair.com)
Integrin-FAK signaling has been shown to activate a number of biological mechanisms through phosphorylation and protein-protein interactions promoting tumorigenesis. (aacrjournals.org)
The best characterized FAK phosporylation event is the auto-phosphorylation at the tyrosine397 (Tyr397) which creates a motif that is recognized by various SH2 domain-containing proteins, such as src which phosphorylates FAK on Tyr576. (aacrjournals.org)

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell. (wikipedia.org)
Protein kinases are a group of enzymes that possess a catalytic subunit that transfers the gamma (terminal) phosphate from nucleoside triphosphates (often ATP) to one or more amino acid residues in a protein substrate side-chain, resulting in a conformational change affecting protein function. (wikipedia.org)
proteins in the cytosol and proteins in the nucleus are phosphorylated at tyrosine residues during this process. (wikipedia.org)
methylation at certain residues of histones can regulate gene expression [ 4 ], and glycosylation is responsible for targeting substrates and changing protein half-life [ 2 ]. (hindawi.com)
For cytoskeleton-membrane cross-linking, the dormant molecules becomes activated and the FERM domain attaches to the membrane by binding specific membrane proteins, while the last 34 residues of the tail bind actin filaments. (embl.de)
M-CSF binding induces receptor homodimerization, resulting in transphosphorylation of specific cytoplasmic tyrosine residues and signal transduction (6). (rndsystems.com)
EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. (thermofisher.com)
Residues that compose the RNA-binding surface are conserved in a subgroup of SAM domain-containing proteins, suggesting that the function of the domain is conserved from yeast to humans. (embl.de)
SH2 Homology Protein B (SHB) is a cytoplasmic adaptor protein that serves as a link between phosphotyrosine residues on multiple receptor tyrosine kinases and downstream signaling pathways. (rndsystems.com)
Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. (joplink.net)
Upon activation of protein kinase C by phorbol ester, CD4 is phosphorylated on cytoplasmic serine residues and internalized from the cell surface, and disruption of the CD4- p56(lck) complex occurs. (mssm.edu)

Janus tyrosine kinases (JAKs), cytoplasmic tyrosine kinases that are non-covalently associated with the cytoplasmic tails of receptors for cytokines or polypeptidic hormones. (embl.de)
JAKs are intracytoplasmic protein tyrosine kinases that bind to the cytoplasmic region of cytokine transmembrane receptors and mediate signalling via type 1 and type 2 cytokine receptors. (jle.com)
M-CSF receptor, the product of the c - fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. (rndsystems.com)
These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region (1-4). (rndsystems.com)
Ectodomain dropping has emerged as an important posttranslational mechanism to regulate the functions of various integral membrane-bound proteins including adhesion molecules cytokines growth factors and their receptors (57 60 Both. (exposed-skin-care.net)
The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. (genome.jp)
Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. (genome.jp)
Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)
Among these diverse features, it should be acknowledged that auto-antibodies toward glutamate receptors, GABA receptors, and K + channel-related proteins are preferentially found in autoimmune limbic encephalitis but not in IMCAs [ 10 ] (Table 1 ). (springer.com)
Genome-wide association studies have linked the overexpression of UL16-binding protein 3 (ULBP3), a protein that binds to natural killer cell receptors, to the pathogenesis of alopecia areata. (drugbank.com)
SHB is ubiquitously expressed and binds tyrosine kinase receptors such as FGF R1, VEGF R2, and PDGF R following their activation. (rndsystems.com)

The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. (bdbiosciences.com)
The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. (exbio.cz)
It is now recognised that intracellular components of cytokine signalling, in particular the signal transducing Janus kinase (JAK) family, can be targeted to inhibit the effect of a wide range of cytokines. (jle.com)
The intracellular domain of activated M-CSF R binds more than 150 proteins that affect cell proliferation, survival, differentiation and cytoskeletal reorganization. (rndsystems.com)
The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. (genome.jp)
These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase. (genome.jp)

Most tyrosine kinases have an associated protein tyrosine phosphatase, which removes the phosphate group. (wikipedia.org)
STP, serine/threonine protein phosphatase. (rupress.org)
Caenorhabditis elegans protein phosphatase ptp-1. (embl.de)
title{Protein Tyrosine Phosphatase Inhibition Mimics Fc$\varepsilon$RI-induced Anergy and Reveals the Immunomodulatory Role of Hydrogen Peroxide as a Signaling Molecule in Human Basophils\thanksref{grant}} %Really struggling with a title that captures this paper -- probably a bad sign! (openwetware.org)

Tyrosine kinases function in a variety of processes, pathways, and actions, and are responsible for key events in the body. (wikipedia.org)
Lyn and Src family tyrosine kinases in general have been known to function in signal transduction pathways. (wikipedia.org)
Through extensive biochemical and genetic analysis, we now know that pathways are not simply switched on with kinases and off with phosphatases. (rupress.org)
Aside from binding to membranes, the activated FERM domain of ERM proteins can also bind the guanine nucleotide dissociation inhibitor of Rho GTPase (RhoDGI), which suggests that in addition to functioning as a cross-linker, ERM proteins may influence Rho signalling pathways. (embl.de)
CD8+ NKG2D+ T cells promote the inflammation of hair follicles through interferon-γ (IFN-γ) and interleukin-15 (IL-15) signaling pathways, which consequently activate Janus kinase (JAK)/signal transducer and activator of transcription (STAT) molecular pathways. (drugbank.com)
They indicate that pathways involving STAT3, PI3K/AKT and, apparently, STAT5 are constitutively activated by this kinase. (upenn.edu)

Ritlecitinib (PF-06651600) is a highly selective inhibitor of Janus kinase 3 (JAK3) and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family. (drugbank.com)
Ritlecitinib inhibits Janus kinase 3 (JAK3) and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family in an irreversible manner by blocking the adenosine triphosphate (ATP) binding site. (drugbank.com)
The pathway uses a novel mechanism in which cytosolic latent transcription factors, known as signal transducers and activators of transcription (STATs), are tyrosine phosphorylated by Janus family tyrosine kinases (Jaks), allowing STAT protein dimerization and nuclear translocation. (sagepub.com)
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. (sagepub.com)

Genetic disruption of TrkB-Shc signaling had no effect on severity of SE yet partially inhibited activation of the prosurvival adaptor protein Akt. (jneurosci.org)
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. (exbio.cz)
The adaptor protein Grb2 is able to enhance the activity of the cytoplasmic tyrosine kinase Btk through a novel mechanism, revealing a new role for Grb2 in B-cell signaling. (elifesciences.org)

Our studies concentrate on identification of downstream effector molecules triggered by the NPM/ALK kinase. (upenn.edu)
The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. (joplink.net)
Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. (joplink.net)

This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. (cancerindex.org)
Accumulating evidence indicates that expression of anaplastic lymphoma kinase (ALK) defines a distinct type of T-cell lymphoma. (upenn.edu)
Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. (genetex.com)
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in cell differentiation, cell division, cell adhesion, and stress responses. (enzolifesciences.com)

Although the importance of kinases in this process has long been recognized, an appreciation for the complex and fundamental role of phosphatases is more recent. (rupress.org)
Furthermore, kinases and phosphatases may work together to modulate the strength of a signal. (rupress.org)
Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
Protein-tyrosine phosphatases PTPN3 and PTPN4, enzyme that appear to act at junctions between the membrane and the cytoskeleton. (embl.de)
Protein-tyrosine phosphatases PTPN14 and PTP-D1, PTP-RL10 and PTP2E. (embl.de)

In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. (cytekbio.com)

This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. (cancerindex.org)
Filopodin, a slime mold protein that binds actin and which is involved in the control of cell motility and chemotaxis. (embl.de)
ERM proteins are made of three domains, the FERM domain, a central helical domain and a C-terminal tail domain, which binds F-actin. (embl.de)
Smaug, a protein that helps to establish a morphogen gradient in Drosophila embryos by repressing the translation of nanos (nos) mRNA, binds to the 3' untranslated region (UTR) of nos mRNA via two similar hairpin structures. (embl.de)
Anteroposterior patterning in Drosophila melanogaster is dependent on the sequence-specific RNA-binding protein Smaug, which binds to and regulates the translation of nanos (nos) mRNA. (embl.de)
We show here that the SAM domain of Saccharomyces cerevisiae Vts1 binds RNA with the same specificity as Smaug and that Vts1 induces transcript degradation through a mechanism involving the cytoplasmic deadenylase CCR4. (embl.de)

Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)

Tyrosine kinases belong to a larger class of enzymes known as protein kinases which also attach phosphates to other amino acids such as serine and threonine. (wikipedia.org)
The enzymes fall into two broad classes, characterised with respect to substrate specificity: serine/threonine-specific, and tyrosine-specific (the subject of this article). (wikipedia.org)
Whereas the standard immunosuppressive agents foster development of PTLDs, the impact of novel immunosuppressive agents from the group of selective inhibitors of TOR serine/treonine kinase such as rapamycin and its derivatives including RAD remains undetermined. (upenn.edu)

Transmembrane region forms 25 aa, cytoplasmic tail consists of 38 aa. (exbio.cz)
The amino-acid sequence of the FERM domain is highly conserved among ERM proteins and is responsible for membrane association by direct binding to the cytoplasmic domain or tail of integral membrane proteins. (embl.de)
ERM proteins are regulated by an intramolecular association of the FERM and C-terminal tail domains that masks their binding sites for other molecules. (embl.de)
We directly tested this hypothesis by subjecting mice with "nonphosphorylatable" tyrosine-to- phenylalanine substitutions in the conserved β1 cytoplasmic tail NPxY motifs to a model of cutaneous carcinogenesis in the presence or absence of elevated Src activity. (iucc.ac.il)
We found that hydrophobic phenylalanine substitutions of both tyrosines diminished the binding of tail-interacting proteins, including talins and kindlins, resulting in reduced β1-mediated adhesion, focal adhesion kinase (FAK) signaling, and epidermal progenitor cell-derived skin tumors. (iucc.ac.il)

Focal-adhesion kinases (FAKs), cytoplasmic protein tyrosine kinases involved in signalling through integrins. (embl.de)
Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. (fishersci.com)

KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM) , while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. (caslab.com)

The NPM/ALK kinase is constitutively activated and highly oncogenic. (upenn.edu)
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. (wikidata.org)

These results recommend early and concomitant dysregulation of HNF-1(inhibition of its transcriptional activity without loss of its proteins appearance) and its own focus on genes, aswell as genes involved with mitochondrial function and biogenesis including secreting NKT cells, neutrophils, and monocytes) through regional creation of proinflammatory cytokines, including IFN-and TNF-using IFN-or TNF-stimulation. (bms-911543.com)
However, as opposed to what seen in the AKI model, IFN-treatment induced a moderate but significant reduction in HNF-1protein manifestation (Number 2C), whereas protein levels were drastically decreased (six- to seven-fold) when gene manifestation was inhibited with an siRNA, suggesting that these conditions did not fully recapitulate the condition where HNF-1protein large quantity is probably controlled by multiple cytokines. (bms-911543.com)

and transmembrane receptor protein tyrosine kinase signaling pathway. (zfin.org)

Transcriptional activation of the orphan nuclear receptor Nurr1 by ligands targeting its heterodimer partner retinoid X receptor alpha (RXRα) occurs through a nonclassical pharmacological mechanism involving ligand-binding domain protein-protein interaction inhibition. (elifesciences.org)

A protein tyrosine kinase called pp125, also referred to as focal adhesion kinase (FAK) is likely at hand in the influence of cellular focal adhesions, as indicated by an immunofluorescent localization of FAK. (wikipedia.org)
Focal adhesion kinase (FAK) is a tyrosine kinase localized at the site of focal adhesions (FA). (aacrjournals.org)

FAK seems also to have a role in the proliferation of tumor cells by its biochemical and biological association to cytoplasmic kinases such as src and ERK. (aacrjournals.org)

In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. (embl.de)

Fibroblasts - a type of cell that synthesizes the extracellular matrix and collagen and is involved in wound healing - that have been transformed by the polyomavirus possess higher tyrosine activity in the cellular matrix. (wikipedia.org)
Mouse M-CSF receptor cDNA encodes a 977 amino acid (aa) type I membrane protein with a 19 aa signal peptide, a 492 aa extracellular region containing the ligand-binding domain, a 25 aa transmembrane domain and a 441 aa cytoplasmic domain. (rndsystems.com)
99% aa identity with rat and 60-63% aa identity with corresponding sequences in human, canine, feline and bovine M-CSF R. Activators of protein kinase C induce TACE/ADAM17 cleavage of the M-CSF receptor, releasing the functional ligand-binding extracellular domain (5). (rndsystems.com)
The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. (caslab.com)

Kinase is a large family of enzymes that are responsible for catalyzing the transfer of a phosphoryl group from a nucleoside triphosphate donor, such as ATP, to an acceptor molecule. (wikipedia.org)
To be specific, Lyn, a type of kinase in the Src family that was identified in the nuclear matrix, appears to control the cell cycle. (wikipedia.org)
Src family tyrosine kinases are closely related but demonstrate a wide variety of functionality. (wikipedia.org)
Roles or expressions of Src family tyrosine kinases vary significantly according to cell type, as well as during cell growth and differentiation. (wikipedia.org)
As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. (thermofisher.com)
Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is found do not share any region of similarity outside of this domain. (embl.de)
A common heterophilic ligand for these RTK family members is definitely Gas6 a vitamin K-dependent protein that is widely secreted by most cells including the lungs intestine Serping1 and vascular endothelium (43). (exposed-skin-care.net)
EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. (thermofisher.com)
It has been suggested that the dual activity of ritlecitinib toward JAK3 and the TEC kinase family block cytokine signaling as well as the cytolytic activity of T cells, both implicated in the pathogenesis of alopecia areata. (drugbank.com)
This represents a new function for the SAM domain family, which is well characterized for mediating protein-protein interactions. (embl.de)
Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
CD4 is noncovalently associated via the cytoplasmic domain with the protein-tyrosine kinase p56(lck), a member of the src protein-tyrosine kinase family. (mssm.edu)
Notch2 encodes a protein member of your Notch family that plays a part in a range of developmental processes. (bcrablinhibitor.com)

The protein also contains an AAA domain, which is associated with ATPase activity. (cancerindex.org)
Taxonomic distribution of proteins containing FERM_C domain. (embl.de)
The complete taxonomic breakdown of all proteins with FERM_C domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing FERM_C domain in the selected taxonomic class. (embl.de)
The c-Abl protein is inhibited by its SH3 domain, and deletion of this domain turns ABL1 into an oncogene. (enzolifesciences.com)
Widespread domain in signalling and nuclear proteins. (embl.de)
The sterile alpha motif (SAM) domain is a putative protein interaction module present in a wide variety of proteins [ ( PUBMED:9007998 ) ] involved in many biological processes. (embl.de)
Taxonomic distribution of proteins containing SAM domain. (embl.de)
These mutations scattered throughout the BTK gene and mostly affected the kinase domain. (bvsalud.org)

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. (thermofisher.com)
Ezr encodes ezrin, a cytoplasmic peripheral membrane protein that functions as a protein-tyrosine kinase substrate in microvilli. (bcrablinhibitor.com)

Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. (joplink.net)

Ritlecitinib is a kinase inhibitor used to treat severe alopecia areata in adults and adolescents 12 years and older. (drugbank.com)
Ritlecitinib is a kinase inhibitor that promotes the decrease of absolute lymphocyte levels, T lymphocytes (CD3) and T lymphocyte subsets (CD4 and CD8) in a dose-dependent manner. (drugbank.com)
A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes. (elifesciences.org)

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation. (sagepub.com)

FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. (embl.de)

The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. (genetex.com)

pp60c-src has less affinity for the detergent-insoluble cellular matrix than do pp60v-src and other viral protein-tyrosine kinases. (wikidata.org)

The LINE-1 retrotransposon protein, ORF1p, forms a condensate on RNA that is essential for retrotransposition, and may explain cis -preference through a co-translational assembly mechanism. (elifesciences.org)
Whereas the G s /G i -protein-dependent tuning of striatal neurons is fairly well known, the precise impact and underlying mechanism of G q -protein-dependent signals remain poorly understood. (jneurosci.org)
Here, using different experimental approaches, especially designer receptor exclusively activated by designer drug (DREADD) chemogenetic technology, we found that sustained activation of G q -protein signaling impairs the functionality of striatal neurons and we unveil the precise molecular mechanism underlying this process: a phospholipase C/Ca 2+ /proline-rich tyrosine kinase 2/cJun N -terminal kinase pathway. (jneurosci.org)

Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. (genome.jp)

Finally mutations can cause some tyrosine kinases to become constitutively active, a nonstop functional state that may contribute to initiation or progression of cancer. (wikipedia.org)
Either at genomic or at proteomic level, mutations have significant impact on normal gene or protein function, and human diseases could be associated with mutations like nonsynonymous single-nucleotide variations (nsSNVs) on amino acids. (hindawi.com)
Yet how gene mutations affect protein activities through posttranslational modification sites have not been widely studied. (hindawi.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. (thermofisher.com)

FAK's ability to bind numerous structural and signaling proteins via a variety of interactions is important for FAK activation level, and for FAK interaction with a variety of substrates localized to sites of cell adhesion. (fishersci.com)

What does this gene/protein do? (cancerindex.org)
Gas6 is the product of growth arrest-specific gene 6 which was in the beginning cloned from serum-starved fibroblasts and shares about CUDC-305 (DEBIO-0932 ) 44% sequence identity and related website organization with protein S a negative regulator of blood coagulation (48). (exposed-skin-care.net)

Tyrosine kinase activity in the nucleus involves cell-cycle control and properties of transcription factors. (wikipedia.org)
Acute G q -protein activation in direct-pathway or indirect-pathway neurons produced an enhancement or a decrease, respectively, of activity-dependent parameters. (jneurosci.org)
In contrast, sustained G q -protein activation impaired the functionality of direct-pathway and indirect-pathway neurons and disrupted the behavioral performance and electroencephalography-related activity tasks controlled by either anatomical framework. (jneurosci.org)
Little is known about how the kinase activity-deficient RYKs transduce Wnt signals. (biologists.com)
Derailed and SRC64B form a complex, which contains catalytically active SRC64B, the formation or stability of which requires SRC64B kinase activity. (biologists.com)

Several studies shown that Axl could mediate cell adhesion and aggregation through homotypic ectodomain associations (9 23 Both CUDC-305 (DEBIO-0932 ) murine and human being Axl proteins undergo proteolytic processing to yield a soluble form of this molecule. (exposed-skin-care.net)

Protein kinases can become mutated, stuck in the "on" position, and cause unregulated growth of the cell, which is a necessary step for the development of cancer. (wikipedia.org)
The receptor tyrosine kinases function in transmembrane signaling, whereas tyrosine kinases within the cell function in signal transduction to the nucleus. (wikipedia.org)
Immunoprecipitation of Syk protein from SR cell extracts, using Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900 (lane 2) or Syk(D3Z1E) XP ® Rabbit mAb (lane 3). (cellsignal.com)
This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. (thermofisher.com)
We studied measures of molecular signaling and cell death in a model of SE in mice of both sexes, including wild-type and TrkB Shc/Shc mutant mice in which a point mutation (Y515F) of TrkB prevents the binding of Shc to activated TrkB kinase. (jneurosci.org)
Talin, a cytoskeletal protein concentrated in regions of cell-substratum contact and, in lymphocytes, of cell-cell contacts. (embl.de)
FAK (phospho Tyr576) antibody detects FAK (phospho Tyr576) protein at cell membrane by immunohistochemical analysis. (genetex.com)
ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. (frontiersin.org)
A Disintegrin and Metalloproteases (ADAM), originally named metalloproteinases disintegrin cystein-rich (MDC), are membrane-anchored cell surface proteins containing both disintegrin and metalloproteinase domains. (frontiersin.org)
It is estimated that as much as 10% of the cell surface proteins undergo ectodomain shedding. (frontiersin.org)
Bruton's tyrosine kinase (BTK) is a cytoplasmic protein tyrosine kinase, which plays an essential role in B cell receptor (BCR) signaling (Brunner C et al. (reactome.org)
3. Mechanisms of malignant cell transformation by the chimeric NPM/ALK kinase. (upenn.edu)
Background: Bruton's tyrosine kinase (BTK) is a cytoplasmic protein involved in the B cell development. (bvsalud.org)
This protein promotes stem cell properties (37), plays a key function in cell surface structure adhesion, migration, and organization, and has been implicated in colon cancer initiation (38). (bcrablinhibitor.com)

Anatomy19

Organisms7

Diseases4

Chemicals and Drugs173

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes38

Technology, Industry, Agriculture1

Information Science3

Receptor tyrosi5

Phosphorylation28

Residues11

Receptors11

Intracellular6

Phosphatase4

Pathways6

Janus4

Adaptor protein3

Downstream3

Anaplastic lympho3

Encodes a cytoplasmic2

Phosphatases6

P56Lck1

Binds6

RTKs1

Serine3

Tail5

Integrins2

Short cytoplasmic1

Oncogenic2

Cytokines2

Transmembrane receptor1

Ligands1

Focal2

Biochemical and biological1

Signal transduction via1

Extracellular4

Family13

Domain9

Peripheral membran2

Phosphorylates1

Inhibitor3

Regulates1

Plasma membrane1

Subfamily1

Pp60c-src1

Mechanism3

Phosphatidylinositol1

Mutations5

Interactions1

Gene2

Activity5

Mediate1

Cell14