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  • protein
  • Firstly we measured using MCF7 cells growing in estrogen-depleted media the transcriptome changes induced by doxorubicin (doxo) and 5-fluorouracil (5FU), two different drugs both able to stabilize and activate the p53 protein. (omicsdi.org)
  • DDR1 and DDR2 are receptor tyrosine kinases (RTKs) characterized for an extracellular domain of strong homology to the Dictyostelium discoideum protein discoidin that bind to and get activated by collagens in its native triple-helical form. (sciencepublishinggroup.com)
  • site
  • Further studies led us to establish that p53-mediated transcription from the FLT1 half site RE is dependent on ER binding at the EREs and strongly influenced by the level of ER proteins, and the specific nature of the p53-inducing stress as well as ER ligand. (omicsdi.org)