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  • mRNA
  • However, only a year later the first example of RNA editing in a mammal, in a nuclear-encoded mRNA, was reported ( 4 ). (pubmedcentralcanada.ca)
  • mRNA localization is particularly important during early development, when many organisms rely on proteins synthesized from maternal mRNAs to guide development until the onset of zygotic transcription. (biologists.org)
  • Although ascidian and Xenopus eggs provided the first model systems for studying localized transcripts, the Drosophila oocyte has become a major workhorse for both functional and mechanistic analysis of mRNA localization owing to the availability of powerful genetic and transgenic tools. (biologists.org)
  • Intensive analysis of four mRNAs, gurken ( grk ), bicoid ( bcd ), oskar ( osk ) and nanos ( nos ), whose localizations to different regions of the oocyte are essential to specify the anteroposterior (AP) and dorsoventral (DV) body axes of the Drosophila embryo, has provided insight into the role of mRNA localization in setting up developmental asymmetries, as well as into the mechanisms that mediate mRNA localization. (biologists.org)
  • pathway
  • The androgen-signaling pathway plays an important role in the development and hormonal progression of prostate cancer to the castrate-resistant stage (also called androgen-independent or hormone refractory). (aacrjournals.org)
  • The fiber model samples clustered according to the expression profile of androgen-regulated genes to provide genomic evidence for the reactivation of the AR signaling pathway in castrate-resistant prostate cancer. (aacrjournals.org)
  • These studies provide the first in vivo evidence to support aberrant activation of the AR through the Wnt/β-catenin signaling pathway during progression of prostate cancer to the terminal castrate-resistant stage. (aacrjournals.org)
  • Hence, the Akt signaling pathway has become a popular target for therapeutic interventions. (ubc.ca)
  • mRNAs
  • The asymmetric localization of four maternal mRNAs - gurken, bicoid, oskar and nanos - in the Drosophila oocyte is essential for the development of the embryonic body axes. (biologists.org)
  • Fluorescent imaging methods are now being used to visualize these mRNAs in living tissue, allowing dynamic analysis of their behaviors throughout the process of localization. (biologists.org)
  • Cell
  • β-Catenin has dual functions that involve both cell adhesion and signal transduction in response to Wnt ligands ( 6 , 7 ). (aacrjournals.org)
  • Nuclear localization of signal transducer and activator of transcription 3 in head and neck squamous cell carcinoma is associated with a better pro. (nih.gov)
  • A high frequency of head and neck squamous cell cancers (HNSCC) contain constitutively activated signal transducer and activator of transcription 3 (STAT3). (nih.gov)
  • significantly
  • Fourteen days after IT CD exposure and 1 day after the last intraperitoneal BNF injection, AhR immunofluorescence indicated that proportional AhR nuclear expression and the percentage of cells with nuclear AhR were significantly increased in rats receiving IT saline and BNF injections compared to vehicle controls. (biomedcentral.com)
  • Degradation
  • The activating signals are transduced by signaling cascades that converge on the IκB kinases (IKKs) that phosphorylate the NF-κB inhibitory molecules, including members of the IκB family and inhibitory domains of NF-κB precursors, leading to their ubiquitination and subsequent degradation by the proteasome. (biologists.org)
  • interaction
  • Together with the increased expression of AR and β-catenin, there was increased nuclear colocalization and interaction of endogenous AR and β-catenin in castrate-resistant prostate cancer from castrated mice. (aacrjournals.org)
  • addition
  • In addition, co-localization of CYP1A1 and cytokeratin 8/18 expression in alveoli allowed detection of CYP1A1 expression in intact AT-II cells within the lung [ 3 , 4 ], and demonstrated decreased PAH-induced CYP1A1 in AT-II cells. (biomedcentral.com)