• The RMT2-26 monoclonal antibody specifically recognizes T cell immunoglobulin and mucin domain-2 (TIM-2) which is also known as T-cell membrane protein 2, TIMD-2, or Tim2. (bdbiosciences.com)
  • Levels of expression of breast epithelial mucin detected by monoclonal antibody BrE-3 in breast-cancer prognosis. (xenbase.org)
  • The crystal structure of the mucin monoclonal antibody SM3 complexed with a 13 amino acid MUC1 mucin peptide was determined. (wisconsin.edu)
  • Mucin glycoprotein expression in IMPN epithelial cells within the cyst lining is routinely used to help characterize these IPMN subtypes by immunohistochemistry [ 12 ]. (gastrores.org)
  • Myristoylated alanine-rich H kinase substrate (MARCKS) health proteins has been named a key regulation molecule managing mucin secretion by simply throat epithelial cells within vitro as well as in vivo. (mdm2signals.com)
  • Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
  • All of them contain a C-type lectin domain, a series of epidermal growth factor like domains (EGF), a highly glycosylated mucin-like domain, a unique transmembrane domain and a short cytoplasmic tail. (absin-reagents.com)
  • Diff-Quik stain highlights cytoplasmic elements such as mucins, fat droplets and neurosecretory granules. (wikipedia.org)
  • Cytoplasmic delivery and cross-presentation of proteins and peptides is necessary for processing and presentation of antigens for the generation of cytotoxic T cells. (edu.au)
  • Genetic studies of osmoregulation in yeast have identified mucin-like proteins as critical regulators of osmosensitive signaling and gene expression. (prolekarniky.cz)
  • Given that mucins and transmembrane proteins play similar roles in yeast osmoregulation, our findings suggest a possible evolutionarily conserved role for the mucin-plasma membrane interface in eukaryotic osmoregulation. (prolekarniky.cz)
  • b) Gastric mucosa showing reduced cytoplasmic mucin (blue arrow), lymphocytes and plasma cells (red arrow). (simonacavalu.ro)
  • That the steroid hormones cannot 2002), c-myc the growth of gastric mucin, cells that produce mucous. (pourchat.com)
  • The healing capacities of the tea extracts could be attributed to their antioxidant activity as well as the ability to protect the mucin content of the gastric tissues. (rsc.org)
  • and 5) the presence of signet ring-shaped cells bearing mucin-containing granules. (wikipedia.org)
  • All these granulomas showed similar, numerous cytoplasmic granules in epithelioid and giant cells with the properties of residual bodies, i.e. , end products of activated lysosomes. (bmj.com)
  • Our studies are the first to show that an extracellular mucin-like protein plays an important role in animal osmoregulation in a manner that requires the activity of a novel transmembrane protein. (prolekarniky.cz)
  • Human TIM-1 is synthesized as a 359 amino acid (aa) precursor that contains a 20 aa signal sequence, a 270 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 48 aa cytoplasmic domain (4-6). (rndsystems.com)
  • We previously described the use of the 16 amino acid peptide penetratin from the Drosophila Antennapedia homeodomain (penetratin, Antp) to transport cytotoxic T lymphocyte epitopes derived from ovalbumin (OVA) or the Mucin-1 tumor-associated antigen into cells. (edu.au)
  • Eosin - a counterstain to haematoxylin, this stain colors red blood cells, cytoplasmic material, cell membranes, and extracellular structures pink or red. (microscopeworld.com)
  • ABPH 2.5 - Stains the acidic mucin present in goblet cells. (pathnostics.com)
  • Cytology - Imparts a characteristic range of coloration to exfoliative cells, allowing critical examination of nuclei and cytoplasmic components. (pathnostics.com)
  • Of note, rhabdoid cells with cytoplasmic inclusion bodies were detected scattered among the tumor cells. (biomedcentral.com)
  • carcinoma contains abundant pools of mucin in which are seen a small number of tumor cells, sometimes having signet-ring appearance. (poznayka.org)
  • We used RNA extracted from PBMCs for real-time reverse transcription PCR and found patient Co45 had the lowest TIGIT mRNA level ( Figure , panel A). Because TIGIT is mainly expressed in T cells, we used flow cytometry to measure the mean fluorescence intensity of TIGIT expressed in the cytoplasmic domain (CD) T cells. (cdc.gov)
  • TIM-2 contains extracellular IgV and mucin domains and a cytoplasmic region with a conserved tyrosine phosphorylation motif which is involved in transmembrane signaling. (bdbiosciences.com)
  • Current research has demonstrated that the extracellular portions of some receptors act as bait receptors for activating ligands, while in most cases, the phosphorylation of tyrosine residues in their cytoplasmic tails drives critical inhibitory signals. (medicaltrend.org)
  • The cytoplasmic tails of these inhibitory receptors contain tyrosine-based inhibitory motifs (ITIMs) and switch motifs (ITSMs) with common sequence features. (medicaltrend.org)
  • The cytoplasmic tail of PD-1 contains two tyrosine-based motifs, an ITIM (VDY223GEL), and an ITSM (TEY248ATI). (medicaltrend.org)
  • TIM-2 is an ~55 kDa type I transmembrane glycoprotein that is encoded by Timd2 (T cell immunoglobulin and mucin domain containing 2) which belongs to the immunoglobulin gene superfamily. (bdbiosciences.com)
  • However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
  • Mucin 4 (MUC4) is a transmembranous glycoprotein. (chemdict.com)
  • Here, we identified two unknown phosphorylated serine residues, S4428 and S4492, in the cytoplasmic tail of human MUC17. (scilifelab.se)
  • Structurally, PD-1 consists of extracellular immunoglobulin (Ig)-like variable domains, a transmembrane domain, and a cytoplasmic tail responsible for signal transduction and binding to scaffold molecules. (medicaltrend.org)
  • The CXCL16 gene codes for a 273 amino acid polypeptide, which includes a 29 amino acid cytoplasmic domain and transmembrane sequence containing approximately 20 amino acids. (peprotech.com)
  • Transmembrane mucin MUC17 is an integral part of the glycocalyx as it covers the brush border membrane of small intestinal enterocytes and presents an extended O-glycosylated mucin domain to the intestinal lumen. (scilifelab.se)
  • Mucins: structure, function, and associations with malignancy. (xenbase.org)
  • The primary use of Romanowsky-type stains in cytopathology is for cytoplasmic detail, while Papanicolaou stain is used for nuclear detail. (wikipedia.org)
  • The ECD contains oneV-type Ig-like domain and a mucin region characterized by multiple PTTTTL motifs. (rndsystems.com)
  • Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
  • These repeats can be particularly well studied in this gene because the repeats are relatively short and few in number compared to other mucins. (nature.com)
  • Here, we show that mutations in the Caenorhabditis elegans mucin-like gene osm-8 specifically disrupt osmoregulatory physiological processes. (prolekarniky.cz)
  • In this study a large cohort of LGFMS, all with FUS gene rearrangement confirmed by FISH, showed cytoplasmic staining for MUC4, usually in a strong and diffuse manner. (chemdict.com)
  • The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal mucin-like stalk sequence. (peprotech.com)
  • Untreated, it can frequently develops and molecules that are associated with the cytoplasmic domain of the receptor. (pourchat.com)
  • These benefits provide proof a task pertaining to HSP70 inside mediating mucin release through connections with MARCKS and that these kind of interactions tend to be critical for your cytoplasmic translocation of MARCKS after their phosphorylation.The principal (animal-vegetal) (Audio-video) and second (oral-aboral) (OA) axes of marine urchin embryos have established yourself through specific regulation walkways. (mdm2signals.com)
  • MARCKS and also HSP70 friendships get a grip on mucin secretion through man air passage epithelial tissues in Remodelin cost vitro. (mdm2signals.com)
  • The extracellular mucus stained diffusely with Alcian blue staining (Fig. 2c ), mucicarmine staining (Fig. 2d ), and periodic acid-Schiff (PAS) staining, and these findings confirmed the epithelial origin of the mucin. (biomedcentral.com)
  • The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. (scilifelab.se)
  • Transmembrane mucins have previously been shown to play a role in the prevention of bacterial colonization by acting as sheddable decoys for encroaching bacteria. (scilifelab.se)
  • A ubiquitous, cytoplasmic protein found in mature OLFACTORY RECEPTOR NEURONS of all VERTEBRATES. (bvsalud.org)
  • Increased ion accumulation raises cytoplasmic ionic strength, which can disrupt protein structure and function [3] . (prolekarniky.cz)