• Here we show in human cell lines that alternative 3' UTRs differentially regulate the localization of membrane proteins. (nih.gov)
  • 3' UTR-dependent protein localization has the potential to be a widespread trafficking mechanism for membrane proteins because HuR binds to thousands of mRNAs, and we show that the long 3' UTRs of CD44, ITGA1 and TNFRSF13C, which are bound by HuR, increase surface protein expression compared to their corresponding short 3' UTRs. (nih.gov)
  • Conventional antibiotics act on mechanisms by which bacteria carry out their normal metabolic activities: making proteins, manufacturing their cell wall, and undergoing cell division. (databasefootball.com)
  • The ability of ion channels to accomplish these three physiological functions also requires the housekeeping operation of another class of membrane proteins, the transporters and pumps, to set up standing ion concentration gradients across cell membranes. (scholarpedia.org)
  • Ion channels are membrane proteins. (scholarpedia.org)
  • Ion channels have many features of typical membrane proteins. (scholarpedia.org)
  • Landau, E. M. & Rosenbusch, J. P. Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. (nature.com)
  • The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
  • The signal transducing role of receptor related G-binding proteins will be investigated in terms of their potential for stimulating both adenylate cyclase and phospholipase C activities. (grantome.com)
  • RAS family proteins are membrane-associated, small GTPases that have the function of transmitting a multitude of cellular signals [ 7 ] . (encyclopedia.pub)
  • RAS family proteins play a vital role in the modulation of cell survival, proliferation, and differentiation by signaling through a set of molecular pathways [ 10 ] . (encyclopedia.pub)
  • Transporters are essential transmembrane proteins that mediate the selective translocation of solutes, ions or drugs across biological membranes. (uoa.gr)
  • In an in silico search for correlated gene loss with fungal peroxisomal uric acid oxidase (UOX), we identified PMP22-like proteins, some of which function as promiscuous channels in organellar membranes. (uoa.gr)
  • Transport of proteins across membranes is a fundamental process, achieved in every cell by the 'Sec' translocon. (elifesciences.org)
  • The encapsulation and compartmentalisation of cells has necessitated the evolution of machineries that conduct proteins across membranes, including for protein secretion and organellar import. (elifesciences.org)
  • Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
  • Scientists have identified that LEA proteins can be induced to express and function as protectants of proteins and membranes in unique ways when cells are under stress, in particular drought and desiccation. (scoopsicecreamparlour.com.au)
  • Moreover, LEA proteins in every subfamily exhibit different functions, thus these potential functions are additional gaps of knowledge that need to be filled. (scoopsicecreamparlour.com.au)
  • We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
  • These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)
  • This depolarization was thought of as excitation, and if the excitation was large enough, action potentials, or nerve spikes, were generated to transfer signals down the length of the nerve-cell axon. (org.es)
  • Depolarization of presynaptic membranes results in release of the neurotransmitter glutamate (glutamic acid) . (benbest.com)
  • It has recently been reported that mitogen-activated protein (MAP) kinase (also known as extracellular signal reactive kinase [Erk]) might play an important role in linking membrane depolarization to gene expression in the postsynaptic neurons. (asahq.org)
  • Together they identified a novel mechanism by which drugs that block neurotransmission across autonomic ganglia interact with neuronal nicotinic receptors. (wikipedia.org)
  • Membrane Receptors, Channels and Transporters in Pulmonary Circulation. (wikipedia.org)
  • Allosteric conversion of partial to full agonism may be a general mechanism for reversibly scaling the efficacy of GABA A receptors to endogenous partial agonists. (jneurosci.org)
  • It is even more intriguing to consider the potential plasticity of allosteric modulation given the observation of agonist-dependent functional properties of GABA A receptors. (jneurosci.org)
  • Postsynaptic membranes contain several types of glutamate receptors, notably NMDA & AMPA receptors, which allow calcium ion entry. (benbest.com)
  • The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)
  • Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)
  • Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
  • Introduction For some retroviruses, the viral envelope binds to receptors within a pH-independent way, recommending which the virions may fuse towards the cell membrane [1] straight. (angiogenesis-blog.com)
  • As a result, viral receptors over the cell membrane offer binding sites for the trojan and so are also mixed up in structural modulation of viral envelopes, resulting in the fusion Pseudouridimycin from the viral and mobile membranes and virion entrance, the first step in viral an infection of focus on cells [2]. (angiogenesis-blog.com)
  • However, later intracellular marking techniques, in which dyes were injected from the electrode tips into the cytoplasm of the recorded neuron, revealed that horizontal cells, second order neurons postsynaptic to cones, were the source of the S-potentials (3, 4). (org.es)
  • Postsynaptic membranes contain two voltage-gated calcium channels (L-type & T-type) as well as a sodium/calcium exchanger, but the NMDA channel is particularly adept at allowing large amounts of calcium ion to enter the cell. (benbest.com)
  • A distinctive characteristic of transporters is their cotranslational translocation and folding in a membrane bilayer, this being the endoplasmic reticulum (ER) in eukaryotes or the cell membrane in prokaryotes. (uoa.gr)
  • In the former case, transporters exit the ER packed in secretory vesicles and traffic via seemingly unconventional, rather than Golgi-dependent, sorting routes to their final destination, the plasma membrane (PM). Proper folding is a prerequisite for ER exit and further trafficking. (uoa.gr)
  • The function of PM transporters is finely regulated at the cellular level, in response to physiological or stress signals that promote, via α-arrestin-assisted ubiquitination, their endocytosis and vacuolar/lysosomal degradation, and in some cases recycling to the PM. Importantly, transporter oligomerization and specific interactions with membrane lipids are emerging as important players in transporter expression, function and turnover. (uoa.gr)
  • The first intracellular, light-evoked responses recorded in the vertebrate retina were slow, negative going changes in membrane potential that lasted for as long as the light stimulus was present (Fig. 1). (org.es)
  • Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
  • They are derived by a targeted mechanism from the cell endocytic compartment and are formed and stored within the intracellular multivesicular bodies (MVBs). (spandidos-publications.com)
  • Among the obligately intracellular gram-negative bacteria, a genetically related set is classified among the Protobacteria of the subgroup on the basis of sequence analysis of the 16S rRNA gene ( 1 , 2 , 8 , 9 ). (cdc.gov)
  • The Drosophila follicle-cell epithelium provides an appropriate model system for studying the potential role of electrochemical signals, like intracellular pH (pH i ) and membrane potential (V mem ), during development. (biomedcentral.com)
  • 2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
  • Ion channels are ion-permeable pores in the lipid membranes of all cells. (scholarpedia.org)
  • Countering NADH production, calcium action on the mitochondrial permeability transition pores increases inner membrane permeability thereby reducing proton potential, causing the matrix to swell and ultimately releasing cytochrome c (an initiator of apoptosis). (benbest.com)
  • We confirmed that SspA is a peroxisomal membrane protein that co-localizes significantly with PTS1-tagged mRFP, UOX or HexA, the latter considered a protein of Woronin bodies (WB), organelles originating from peroxisomes that dynamically plug septal pores in ascomycetes. (uoa.gr)
  • Finally, peptides disrupt the cell membrane by forming pores (barrel-stave model or toroidal-pore model) or by accumulating on the bilayer surface, covering it, dissolving the membrane in a detergent-like mode (carpet model) (Brogden 2005 ). (springeropen.com)
  • A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. (stanford.edu)
  • Thus, FLI1 drives tumor metastasis not only through the canonical oncoprotein pathway, but also by using epigenetic mechanisms mediated by its exonic circular RNA. (biomedcentral.com)
  • The suppression of MAP kinase pathway may thus be a potential target site for the actions of dibucaine and tetracaine, including the modification of the synaptic functions. (asahq.org)
  • In the second part, we will compare the mechanisms that mediate recognition and engulfment and their epigenetic, transcriptional, metabolic, and immunological consequences. (frontiersin.org)
  • Epigenetic mechanisms have been reported to be key to functions of airway smooth muscle (ASM), e.g., aberrant phenotype of ASM lead to the obstruction and inflammation of airway [ 13 ]. (researchsquare.com)
  • Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography. (nature.com)
  • 2008 ). In a brief overview, it is hypothesised that poly(peptides) attach to the bacterial surface and cross the outer membrane of Gram-negative cells, or the thick layer of Gram-positive cells, by a self-promoted uptake to reach the anionic surface of the cytoplasmic membrane (Hancock and Sahl 2006 ). (springeropen.com)
  • Proposed molecular mechanisms of oxidative stress-induced Nrf2 activation. (hindawi.com)
  • The mechanisms of the cytotoxicity, apoptosis, and oxidative stress induced by the 5-15 nm SiNPs still remain unclear. (mdpi.com)
  • Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)
  • Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)
  • Then, we will discuss several principles that govern macrophage phagocytosis of apoptotic cells (efferocytosis), including the existence of redundant recognition mechanisms ("find-me" and "eat-me") that lead to a tight coupling between apoptosis and phagocytosis. (frontiersin.org)
  • In addition to maintenance of membrane integrity, apoptotic cells can be discriminated from viable counterparts based on several morphological hallmarks, including cell contraction, nuclear condensation and fragmentation, and actomyosin contraction-dependent membrane blebbing and apoptotic body formation. (nature.com)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • It is believed that molecular mechanisms of proton movement through different types of proton-conducting molecules have general universal features. (nature.com)
  • A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
  • However, little is known about the molecular mechanisms underlying the aberrant activation of FLI1 in these solid tumors. (biomedcentral.com)
  • Molecular mechanism events in the ovarian microenvironment, such as angiogenesis and apoptosis, are complex. (encyclopedia.pub)
  • The identification of potential inhibitors from natural products, including Traditional Chinese Medicine (TCM), by molecular modeling could expand the arsenal of antiviral chemotherapeutic agents. (bvsalud.org)
  • Molecular dynamics simulations (100 ns) were combined with molecular mechanics Poisson-Boltzmann surface area (MM/PBSA) computations to reveal the binding mechanisms of the complex. (bvsalud.org)
  • A combination of molecular simulation with hydrogendeuterium-exchange mass spectrometry and electron paramagnetic resonance spectroscopy reveal an asymmetry across the membrane: ATP-induced conformational changes in the cytosolic cavity promote unfolded pre-protein structure, while the exterior cavity favours its formation. (elifesciences.org)
  • This facilitates interaction of SET with the newly translated cytoplasmic domains of CD47 and results in subsequent translocation of CD47 to the plasma membrane via activated RAC1 (ref. 5). (nih.gov)
  • At first, the cell type of origin for S-potentials was not really known other than that microelectrode tips were somewhere in the outer retina. (org.es)
  • A lysin-damaged cell wall cannot withstand the cytoplasmic osmotic pressure, leading to bursting of the cell and death of the bacteria. (databasefootball.com)
  • Figure 1: Two ion channels in the lipid bilayer of the cell membrane. (scholarpedia.org)
  • Most of the metabolic energy of neurons is expended on maintaining ion gradients across the cell membrane. (benbest.com)
  • Voltage-gated ion channels and ion-exchangers in the cell membrane also regulate ion concentrations. (benbest.com)
  • Thus, diverse biotrophic pathogens have evolved many mechanisms to suppress programmed cell death, and mutualistic and commensal microbes may employ similar mechanisms. (biomedcentral.com)
  • The aim of the study was to evaluate the anti-cancer effect and mechanism of action of SiNPs in breast cancer cell lines. (mdpi.com)
  • These findings identify emperipolesis as a new cell-in-cell interaction that enables neutrophils and potentially other cells passing through the megakaryocyte cytoplasm to modulate the production and membrane content of platelets. (elifesciences.org)
  • Thus, poly(oxazoline)s are thought to present selectivity to negatively charged microbial cell envelopes relatively to the neutral mammalian cytoplasmic membranes, as occurs in poly(peptides) (Hancock and Sahl 2006 ). (springeropen.com)
  • Endocrinology, by definition, focuses on homeostatic, and cell‑to‑cell and tissue‑to‑tissue communication mechanisms. (spandidos-publications.com)
  • Microvesicles have a diameter ranging from 100 nm to 1 µm and are released by cell membrane budding. (spandidos-publications.com)
  • Our data show that in the Drosophila follicle-cell epithelium stage-specific pH i - and V mem -gradients develop which result from the activity of several ion-transport mechanisms. (biomedcentral.com)
  • Isolated Listeria cell walls were exposed to various antimicrobials, and the solubilized material was analyzed by MALDI-TOF MS. The differences in the MS spectra in Fig. 3 indicate that individual antimicrobials had specific mechanisms of action and suggest that Listeria cell walls were broken down by sakacin A into fragments in the 1000-2500 Da range. (cdk-receptor.com)
  • In separate set of experiments, isolated Listeria cell walls were treated for 24 h at 30 °C with increasing amounts of sakacin A, and the released fragments (Fig. 4) were sequenced by MS/MS. No fragments were released in the absence of sakacin A or with sakacin A concentrations lower than 0.1 mg mL−1. (cdk-receptor.com)
  • Mammalian CDs are surrounded by a cell membrane and contain cytoplasm that houses the cytosol and cytoskeletal network [ 7 ]. (biomedcentral.com)
  • Finally, the important interaction of C-kinase with the tyrosine kinase, pp56 Tck, will be studied with a view to understanding the possible link between membrane phospholipid metabolism and mitogenic events. (grantome.com)
  • A host of second messengers are required to set the stage for subsequent autocrine proliferation through secretion of IL-2 and expression of its receptor. (grantome.com)
  • PCR using primers specific for 20beta-hydroxysteroid dehydrogenase (20beta-HSD) which is involved in DHP production, follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), the two forms of membrane progestin receptor: mPR-alpha and mPR-beta, as well as GAPDH (control), were performed. (biomedcentral.com)
  • The bulk of protein secretion and membrane protein insertion is conducted by the ubiquitous Sec translocon. (elifesciences.org)
  • We provide a comprehensive overview of the proteases acting on the platelet membrane. (frontiersin.org)
  • Also, DM induced histopathological alterations such as cytoplasmic vacuolization and degeneration in nuclei, congestion, an enlargement of the blood vessels and lymphocytes infiltration in the liver. (scialert.net)
  • The exact mechanism by which alterations in fractional magnesium absorption occur has yet to be determined. (medscape.com)
  • They regulate the excitability of cells and contribute to their resting membrane potential [ 1 , 2 ]. (ersjournals.com)
  • Therefore, we analysed stage-specific gradients of pH i and V mem as well as their dependence on specific ion-transport mechanisms. (biomedcentral.com)
  • While there she identified a positive feedback effect of cytoplasmic Ca2+ on cardiac calcium channels, a role for ATP-sensitive potassium channels in regulating the membrane potential of artery smooth muscle cells and the main features of the ion channels that set the resting potential of pulmonary artery smooth muscle cells. (wikipedia.org)
  • Thus, when open, potassium ion-selective channels and anion channels hyperpolarize cells (cause the membrane potential to become more negative), whereas sodium- or calcium-selective channels and non-selective cation channels depolarize cells (cause the membrane potential to become more positive). (scholarpedia.org)
  • Under the principle of abductive reasoning through successive approximation on sporadic set of observations, roles of self gravity on identical astrophysical principles of larger mass have been conceptualized on some evidences detailed in Part I and II of the article. (webmedcentral.com)
  • To inform both prevention and intervention measures, more research is warranted to determine if and how adenovirus might contribute to hepatitis risk and the potential roles of other pathogens and host factors. (cdc.gov)
  • We focus on the Rab GTPases that are master regulators of membrane trafficking. (stanford.edu)
  • Tethered neutrophils enter in membrane-bound vesicles before penetrating into the megakaryocyte cytoplasm. (elifesciences.org)
  • The cytoplasmic droplet then becomes known as excess residual cytoplasm, which can impair overall sperm function and produce higher levels of reactive oxygen species, potentially leading to male infertility. (biomedcentral.com)
  • Though the distinction between cytoplasmic droplets and excess residual cytoplasm has been made, some studies fail to recognize the difference and incorrectly label the latter as a cytoplasmic droplet. (biomedcentral.com)
  • One known cause is the retention of excess cytoplasm around the midpiece due to an arrest in spermiogenesis and incomplete cytoplasmic extrusion [ 1 ]. (biomedcentral.com)
  • Illustration comparing ( A ) spermatozoa with typical cytoplasmic droplets (CD) and ( B ) spermatozoa presenting with excess residual cytoplasm (ERC). (biomedcentral.com)
  • Ion channels set up the resting membrane potentials of all cells. (scholarpedia.org)
  • However, one set of channels (ClC chloride channels) has two homologous subunits forming one pore in each of the subunits. (scholarpedia.org)
  • Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. (ersjournals.com)
  • While the inhibition of Na + /H + -exchangers (NHE) and amiloride-sensitive Na + -channels or of V-ATPases resulted in relative acidification, inhibiting the other ion-transport mechanisms led to relative alkalisation. (biomedcentral.com)
  • V mem was most efficiently hyperpolarised by inhibiting voltage-dependent L-type Ca 2+ -channels or ATP-sensitive K + -channels, whereas the impact of the other ion-transport mechanisms was smaller. (biomedcentral.com)
  • Consequently, poly(oxazoline)s are believed to be less susceptible to microbial resistance when compared to conventional antibiotics because it would imply a complete remodelling of the structure of the cellular membrane (Zasloff 2007 ). (springeropen.com)
  • Therefore, diverse cellular compartments orchestrated by multiple environment-driving factors make the mechanisms underlying asthma extraordinary complex and unclear, particularly with respect to long noncoding RNAs (lncRNAs). (researchsquare.com)
  • Lysosomes are membrane-bound compartments that degrade macromolecules and clear damaged organelles to enable cellular adaptation to various metabolic states. (stanford.edu)
  • This phenomenon occurs in otherwise unmanipulated murine marrow in vivo, resulting in circulating platelets that bear membrane from non-megakaryocytic hematopoietic donors. (elifesciences.org)
  • Moreover, we identify a distinct, N-terminal, higher affinity interaction interface between LRRK2 phosphorylated Rab8 and Rab10 termed 'Site #2', that can retain LRRK2 on membranes in cells to catalyze multiple, subsequent phosphorylation events. (stanford.edu)
  • In order to perform these studies, the following methodology has been developed: protein phosphorylation studies, immunoprecipitation of specific phosphorylated substrates, SDS- PAGE and autoradiography, phospho-amino acid analysis, TLC of phospholipid extracts, ion exchange chromatography to measure IP3 release and cytoplasmic dot-blot analysis for mRNA. (grantome.com)
  • MIH activates the cytoplasmic maturation promoting factor (MPF), which is made up of two subunits: cyclin B (a regulatory subunit) and cdc2 (a catalytic subunit). (biomedcentral.com)
  • To determine the effect of TGF-beta1 on mRNA levels of several key effectors of oocyte maturation, three sets of experiments were performed. (biomedcentral.com)
  • These data demonstrate a direct RLN3/RXFP3 action in the PVN of male and female rats, identify the associated ionic mechanisms, and reveal that hypothalamic RLN3/RXFP3 signaling regulates binge-eating behavior. (jneurosci.org)
  • 2.4 S-Potentials and Horizontal cells. (org.es)
  • Since being first described in fish retinas, S-potentials have been recorded from retinal horizontal cells in all vertebrate classes. (org.es)
  • Research in this laboratory focuses on gaining a better understanding of the mechanisms which underlie these signaling patterns with a primary goal of relating this knowledge to the physiology and pathophysiology of exocrine cells. (rochester.edu)
  • This gene subfamily is constitutively active at physiological resting membrane potentials in excitable cells, including smooth muscle cells, and has been particularly linked to the human pulmonary circulation. (ersjournals.com)
  • Here we demonstrate that a likely mechanism underlying the orexigenic action of RLN3 is RXFP3-mediated inhibition of oxytocin- and arginine-vasopressin-synthesizing paraventricular nucleus (PVN) magnocellular neurosecretory cells. (jneurosci.org)
  • 7 The goal of these processes is detection and removal of dead cells and associated debris to limit potential further damage. (nature.com)
  • Membrane enriched extracts (40 µg lysate) of Caco-2 (Lane 1), Caco-2 treated with IFN Gamma (50 ng/mL for 24hrs) (Lane 2), A-431 (Lane 3), HEL 92.1.7 (Lane 4) and Jurkat (Lane 5). (thermofisher.com)
  • However, the underlying mechanisms linking surface topography to the inhibition of microbial attachment and growth still remain unclear. (rsc.org)
  • This is reinforced by their well described biocompatibility with human tissues and by their proposed mechanism of action which difficult the development of microbial resistance to these compounds. (springeropen.com)
  • Apoptosis is a fundamental homeostatic mechanism essential for the normal growth, development and maintenance of every tissue and organ. (nature.com)
  • Notably, FECR1 utilizes a positive feedback mechanism to activate FLI1 by inducing DNA hypomethylation in CpG islands of the promoter. (biomedcentral.com)
  • One of the potential confounding factors associated with investigating subunit-specific pharmacology is that "functional" differences among isoforms, as opposed to simply the presence or absence of modulator binding sites, may play a significant role in determining pharmacological profiles. (jneurosci.org)
  • The idea that allosterism could also depend on functional differences would offer yet another mechanism for specificity among isoforms, even if the binding site and coupling machinery of the modulator (the often sited basis for subunit specificity) were present in every isoform. (jneurosci.org)
  • At that time, neurons were thought only to be depolarized by synaptic inputs (inside becoming more positive relative to outside), thus having their inside-negative resting membrane potentials become reduced. (org.es)
  • Ethylene dibromide is a liquid at ambient temperatures that can cause skin, eye, mucous membrane, and respiratory tract irritation. (cdc.gov)
  • Before the morphological source of these responses became clear, they were called simply S-potentials (1). (org.es)
  • For long stimuli, the S-potential only changes in duration but the amplitude remains constant (2 leftmost responses in Fig. 1B). (org.es)
  • The aim of the present study was to investigate the mechanisms underlying this action. (biomedcentral.com)
  • Phosphatidylserine-exposing platelets, usually located around a thrombus, provide a negatively charged membrane surface, which supports coagulation factor binding and the formation of tenase and prothrombinase complexes ( 6 , 7 ). (frontiersin.org)
  • ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)
  • S-potentials, however, were not depolarized by light, but rather hyperpolarized, and did not fire action potentials, even with the brightest light stimuli. (org.es)
  • Sensors: detectors of stimuli that respond to electrical potential changes or chemical signals. (scholarpedia.org)
  • It is likely that S-potentials were named in honor of their discoverer, Gunnar Svaetichin, although 'slow potential' is another common interpretation. (org.es)
  • INTERPRETATION: Adenovirus, alone or in combination with other factors, might play a potential role in acute hepatitis among immunocompetent children identified in this investigation, but the pathophysiologic mechanism of liver injury is unclear. (cdc.gov)