• Using primary hippocampal neurons from Stat5a/b knock-out mice we have recently shown that the presence of functional Stat5 is required for the trophic but not for the protective effect of EPO against glutamate-induced toxicity [ 9 ]. (biomedcentral.com)
  • EPO acts by binding to its specific transmembrane receptor (EPOR). (biomedcentral.com)
  • This effect was associated with decreased activation of pathways linked to neurotrophin and glutamate receptor signaling. (researchgate.net)
  • Receptor mobility and receptor-cytoplasmic interactions in lymphocytes. (academicinfluence.com)
  • Transcriptional activation of the orphan nuclear receptor Nurr1 by ligands targeting its heterodimer partner retinoid X receptor alpha (RXRα) occurs through a nonclassical pharmacological mechanism involving ligand-binding domain protein-protein interaction inhibition. (elifesciences.org)
  • Two transmembrane EPOR molecules form a homodimer that binds one EPO molecule leading to a conformational change and tight bonding of the two EPOR monomers which in turn activate two Janus family tyrosine kinase 2 (JAK2) molecules which associate with cytoplasmic domain of the EPOR. (biomedcentral.com)
  • The adaptor protein Grb2 is able to enhance the activity of the cytoplasmic tyrosine kinase Btk through a novel mechanism, revealing a new role for Grb2 in B-cell signaling. (elifesciences.org)
  • SynCAM's are localized primarily in the brain at both pre- and postsynaptic sites and their structures consist of intracellular FERM and PDZ binding domains, a single transmembrane domain, and three extracellular Ig-domains. (wikipedia.org)
  • Classical cadherins have five extracellular repeating structures which bind calcium, a single transmembrane domain, and an intracellular tail with a distal cytosolic domain that binds a catenin partner. (wikipedia.org)
  • Components of this complex bind to a number of different scaffolding proteins, phosphotases, kinases, and receptors. (wikipedia.org)
  • Multiple nectins on one cell membrane will bind together at the V-type loop to form a cluster of nectin proteins, a process called cis-clustering. (wikipedia.org)
  • The MSP domain (named after C. elegans MSP) contains a binding site for the FFAT (diphenylalanine [FF] in an acidic tract) that are present in a variety of proteins [ 12 , 13 ]. (biomedcentral.com)
  • Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation. (uiowa.edu)
  • Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. (academicinfluence.com)
  • RBD, Ras-binding domain of Raf-1. (rupress.org)
  • In Drosophila, the Syd-1-PDZ domain binds the Nrx-1 C terminus and couples pre- with postsynaptic maturation at nascent synapses of glutamatergic neuromuscular junctions (NMJs) in Drosophila larvae. (sdbonline.org)
  • This study shows that the conserved scaffold protein spinophilin (Spn) is able to fine-tune Nrx-1 function by binding the Nrx-1 C terminus with micromolar affinity via its PDZ domain. (sdbonline.org)
  • Excitatory synaptic transmission in the brain is predominantly mediated by the neurotransmitter glutamate, while inhibitory transmission is mediated mainly by the neurotransmitter gamma-amino butyric acid (GABA). (frontiersin.org)
  • In the metallothioneins, MT3 is especially enriched while in the brain, Some MT3 zinc binding web sites are redox modulated, making it possible for MT3 to accept and release zinc in response to changes in oxidative standing, Mainly because MT3 can induce or minimize zinc toxicity based on context, it could improve or reduce brain damage, based on the specific state of MT3. (ilreceptor.com)
  • Ras activity relies on proper anchoring to the cytoplasmic leaflet of the plasma membrane (PM) by means of a lipid-based PM targeting motif. (rupress.org)
  • LKB1 itself is a constitutively active kinase, which is regulated by posttranslational modifications and direct binding to phospholipids of the plasma membrane. (sdbonline.org)
  • The constant management constitutively required to bind down the methylmalonic of aberrant plasma. (evakoch.com)
  • Ras is a small GTPase that operates as a binary molecular switch between a GDP-bound inactive and GTP-bound active state. (rupress.org)
  • In Spn mutants, excessive AZs suffered from insufficient evoked release, which may be partly explained by their reduced size, and partly by a genuine functional role of Spn (potentially mediated via Nrx-1 binding). (sdbonline.org)
  • Studies have found that oxidative stress, immune-inflammatory responses,energy metabolism disorders, excitatory glutamate toxicity and calcium homeostasis imbalance are closely related to EP [15]. (termedia.pl)
  • The two major types of excitatory glutamate receptors found at the synapse are AMPA and NMDA, which during over-activation leads to glutamate induced excitotoxicity. (auburn.edu)
  • Components of this complex bind to a number of different scaffolding proteins, phosphotases, kinases, and receptors. (wikipedia.org)
  • N-methyl-D-aspartate receptors (NMDARs) are ion channels gated by glutamate, the major excitatory neurotransmitter in the mammalian central nervous system (CNS). (nih.gov)
  • FMRP responds to signaling from group I metabotropic glutamate receptors (mGluRs)6 7 which mediate its translation-repressing activity8. (biomedigs.org)
  • v DISSERTATION ABSTRACT DIFFERENTIAL MODULATION OF GLUTAMATERGIC SYNAPTIC TRANSMISSION BY POLYSIALIC ACID Catrina Sims-Robinson Doctor of Philosophy, December 17, 2007 (B.S., Auburn University, 2004) 180 Typed Pages Directed by Vishnu Suppiramaniam Controlled modulation and regulation of glutamate receptors are essential for synaptogenesis and synaptic plasticity. (auburn.edu)
  • There are several studies that established a link between PSA-NCAM and glutamate vi receptors. (auburn.edu)
  • However, the mechanisms whereby PSA-NCAM modulates glutamate receptors have not been studied. (auburn.edu)
  • Therefore, this study will investigate the effects of endogenous and soluble PSA-NCAM on synaptic glutamate receptors. (auburn.edu)
  • Elucidating the functional properties of single synaptic glutamate receptors and the modulation of these receptors by PSA will be a step towards understanding many neurodegenerative disorders where PSA expression is altered. (auburn.edu)
  • PSA also inhibited with the binding of glutamate to NR2B subunit- containing NMDA receptors. (auburn.edu)
  • L-glutamate activates several subtypes of receptors leading to an increase in intracellular calcium ion concentration ([Ca 2 +] i ). (silverchair.com)
  • This study was designed to determine whether or not ketamine would prevent NO-dependent cGMP production stimulated by glutamate (GLU) and the GLU analogs NMDA, quisqualate (QUIS), and kainate (KAIN). (silverchair.com)
  • Glutamate (100 microM), NMDA (100 microM), QUIS (300 microM), and KAIN (100 microM) each increased cGMP content of neuronal cultures. (silverchair.com)
  • encodes the Fragile X Mental Retardation Protein (FMRP) a widely indicated Oxaliplatin (Eloxatin) RNA binding protein (RBP) that is found in neuronal soma and synapto-dendrites4. (biomedigs.org)
  • Activity-dependent dendritic growth, which is a critical determinant of neuronal connectivity in the developing brain, is mediated by calcium ion (Ca 2+ )-dependent activation of Ca 2+ /calmodulin kinase-I (CaMKI), which triggers cAMP response element binding protein (CREB)-dependent Wnt2 transcription. (nih.gov)
  • Tau is a protein that binds to and stabilizes microtubules, which is required for maintaining neuronal shape and transport of cellular cargo [ 3 ]. (biomedcentral.com)
  • Pharmacologically, substances that enhance the components of the memory/learning circuits-dopamine, glutamate (neuronal excitation), and/or norepinephrine-stand to improve brain function in healthy individuals beyond their baseline functioning. (frontiersin.org)
  • Classical cadherins have five extracellular repeating structures which bind calcium, a single transmembrane domain, and an intracellular tail with a distal cytosolic domain that binds a catenin partner. (wikipedia.org)
  • Although KO animals displayed a ~15% increase in protein synthesis in acute hippocampal slices the DKO mice were much like WT (Fig. 1b) suggesting that translational homeostasis was restored in these animals. (biomedigs.org)
  • Answers to the comments of A. Lerchl on the paper "No effects of intermittent 50-Hz EMF on cytoplasmic free calcium and on the mitochondrial membrane potential in human diploid fibroblasts" by Pilger et al. (arasysperfector.com)
  • P61959.1 MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY 1367453_at NP_446195 6.64 hsp90 co-chaperone Cdc37 Cdc37 Rattus norvegicus " Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp9N/A complex, resulting in stabilization and promotion of their activity. (nih.gov)
  • The antique Body specifically the binding of PlGF to its receptor VEGFR 1, present on endothelial cells and tumor-associated macrophages. (survivinpathway.com)
  • These tyrosine kinase inhibitors are small molecules, the binding site of the tyrosine kinase Dom ne Occupy of ATP to the intracellular Ren part of the receptor. (survivinpathway.com)
  • The binding of these aggregates also caused functional and structural deficits that were rescued when PrP was either ablated or blocked," they noted. (alzforum.org)
  • There were significantly more TAR DNA-binding protein 43 (TDP43) immunoreactive structures on the BNM-affected side than on the BNM-unaffected side. (biomedcentral.com)
  • First, the pocket, conservation, structural and energy profiles, and physicochemical properties of (non)covalently bound cysteines were collected from both protein sequences and 3D structures of protein-ligand complexes. (uni-freiburg.de)
  • By and large, nearly every previous study has found that certain Aβ assemblies bind to PrP. (alzforum.org)
  • GLUTAMATE (GLU) is the major excitatory neurotransmitter in the vertebrate central nervous system. (silverchair.com)
  • Humans have sought substances to improve our cognitive function for centuries, from ancient civilizations using hallucinogens in an attempt to raise their consciousness to commune with their gods, to the rise of coffee, to the more recent development of drugs such as stimulants and glutamate activators. (frontiersin.org)
  • Altering glutamate function via the use of psychostimulants may impair behavioral flexibility, leading to the development and/or potentiation of addictive behaviors. (frontiersin.org)
  • Caytaxin associates with kinesin heavy chains (KHCs) indirectly by binding to KLCs, suggesting that caytaxin binds to the tetrameric kinesin molecule. (biologists.com)
  • Instead, these interactions are important for stabilizing and/or promoting surface NMDAR expression and linking NMDAR to cytoplasmic signaling pathways. (jneurosci.org)
  • This work clearly suggests that inhibition of oligomer-to-PrPC binding is an important therapeutic target for multiple neurodegenerative diseases," wrote Thomas Wisniewski, New York University School of Medicine. (alzforum.org)
  • Homophillic binding of two synCAM1 molecules on the filopodia of axonal growth cone and dendritic spine allow for initial contact between pre- and postsynaptic cell to be made. (wikipedia.org)
  • Currently, the main classes of drugs used as potential cognitive enhancers include psychostimulants (methylphenidate (MPH), amphetamine), but wakefulness-promoting agents (modafinil) and glutamate activators (ampakine) are also frequently used. (frontiersin.org)
  • All membrane-bound nectins possess an extracellular region with three immunoglobulin-like loops. (wikipedia.org)