AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
DyneinsCytoplasmic DyneinsAspergillus nidulansCytoplasmMicrotubulesMolecular Sequence DataAmino Acid SequenceMicrotubule-Associated ProteinsKinesinAxonemal DyneinsMolecular Motor ProteinsFlagellaChlamydomonast-Complex Genome RegionMyosin Heavy ChainsCiliaImmunoglobulin Heavy ChainsCiliary Motility DisordersMicrotubule ProteinsSea UrchinsVanadatesSpindle ApparatusSequence Homology, Amino AcidChlamydomonas reinhardtiiMutation1-Alkyl-2-acetylglycerophosphocholine EsteraseCloning, MolecularBase SequenceSperm TailAdenosine TriphosphatasesProtein BindingAdenosine TriphosphatePhenotypeCell NucleusFungal ProteinsPolymerase Chain ReactionClathrin Heavy ChainsAxonal TransportMolecular WeightBinding SitesMyosinsHeavy Chain DiseaseOrganellesMelanosomesCentrosomeMicrotubule-Organizing CenterMitosisNocodazoleKinetochoresCytoplasmic StreamingGene Rearrangement, B-Lymphocyte, Heavy ChainCells, CulturedAxonemeImmunoglobulin Light ChainsTubulin
Intermediate chainDYNC2H1DYNC1H1FlagellarProteinAxonemal dyneinsMicrotubule motorRetrogradeMicrotubulesMutationAxonemeGenesProteinsDynactinClassificationComplexesChlamydomonasMotilityMolecularUrchinCiliaDimerMutationsRegulationStructuresNeuronalOrganelleLinkerKinesinLightMotorOuter armDihydrolipoamide branched chainComplexStalksAnnotationOrganellesHuman
Intermediate chain3
  • This entry includes the mammalian intermediate chain 1 and 2 (DYNC1I1 and DYNC1I2) and their homologues. (embl.de)
  • Mammalian cytoplasmic dynein-1 complexes contain two copies of the same intermediate chain (typically DYNC1I2 in most cells, DYNC1I1 in neurons) and same light intermediate chain. (embl.de)
  • DYNC1I1 and DYNC1I2 interact with the dynein light chains and the p150 subunit of dynactin at the N terminus and with the heavy chains through WD40 repeats at the intermediate chain C terminus. (embl.de)
DYNC2H14
  • The DYNC2H1 gene provides instructions for making a protein that is part of a group (complex) of proteins called dynein-2. (medlineplus.gov)
  • Cytoplasmic dynein 2 heavy chain 1 is a protein that in humans is encoded by the DYNC2H1 gene. (wikipedia.org)
  • Orthologous to human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1). (zfin.org)
  • 1} Homozygosity or compound heterozygosity for missense or nonsense mutations in the cytoplasmic dynein 2 heavy chain 1 gene {DYNC2H1} are reported in SRPS3. (pediatriconcall.com)
DYNC1H14
  • Analysis revealed a non-sense mutation in cytoplasmic dynein heavy chain 1 (dync1h1), a critical subunit in Dynein1, to underlie the cannonball phenotypes. (nih.gov)
  • The 'Legs at odd angles' (Loa) mouse has a missense 'T' to 'A' point mutation in the cytoplasmic dynein heavy chain gene (Dync1h1), resulting in a phenylalanine to tyrosine substitution at position 580. (figshare.com)
  • Mutations in the cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) gene on chromosome 14 leads to another rare form of SMA known SMA-LED. (chetindia.org)
  • OBJECTIVE To expand the clinical phenotype of autosomal dominant congenital spinal muscular atrophy with lower extremity predominance (SMA-LED) due to mutations in the dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) gene. (figshare.com)
Flagellar7
  • cytoplasmic dyneins and axonemal dyneins , which are also called ciliary or flagellar dyneins. (wikipedia.org)
  • Dynein beta chain, flagellar outer arm OS=Chlamydomonas. (ntu.edu.sg)
  • Dynein-1-beta heavy chain, flagellar inner arm I1. (ntu.edu.sg)
  • Dynein alpha chain, flagellar outer arm OS=Chlamydomonas. (ntu.edu.sg)
  • Dynein heavy chain 5, axonemal: Associated with sperm (flagellar and cillar) motility). (github.io)
  • In the Chlamydomonas reinhardtii flagellar axoneme, at least 11 dynein heavy chains (three outer arm and eight inner arm) exist, and each could play crucial and distinct roles in proper flagellar functions ( Kagami and Kamiya, 1992 ). (rupress.org)
  • Dyneins are large microtubule motor proteins required for mitosis intracellular transport and ciliary and flagellar motility1 2 They generate force through a powerstroke mechanism which is an ATP-consuming cycle of pre- and post-powerstroke conformational changes that cause relative motion between different dynein domains3-5. (researchensemble.com)
Protein6
  • The dynein-2 complex made with the altered protein cannot function normally, which disrupts IFT from the tip of cilia to the base and causes a buildup of materials at the tip. (medlineplus.gov)
  • While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)
  • The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. (utsouthwestern.edu)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Dynein Heavy Chain Domain Containing Protein 1 (DNHD1) in samples from Tissue homogenates and other biological fluids. (youngresearch.eu)
  • Description: A sandwich ELISA kit for detection of Dynein Heavy Chain Domain Containing Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (youngresearch.eu)
  • Cytoplasmic dynein is a retrograde motor protein complex that carries cargo such as organelles and growth factors along microtubules from the cell periphery towards the peri-nuclear region. (figshare.com)
Axonemal dyneins2
Microtubule motor1
  • Here we showthat Lis1 is enriched in neurons relative to levels in other cell types,and that Lis1 interacts with the microtubule motor cytoplasmic dynein.Production of more Lis1 in non-neuronal cells increases retrogrademovement of cytoplasmic dynein and leads to peripheral accumulation ofmicrotubules. (embl.de)
Retrograde2
  • Importins associated with dynein are an important component of retrograde injury signalling complexes and enable transport of direct importin cargoes, such as transcription factors, as well as secondary cargoes that bind scaffolding molecules associated with importins. (nature.com)
  • [2] [3] Dynein carries organelles, vesicles and possibly microtubule fragments along the axons of neurons toward the cell body in a process called retrograde axonal transport . (wikipedia.org)
Microtubules8
  • Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells . (wikipedia.org)
  • Axonemal dynein causes sliding of microtubules in the axonemes of cilia and flagella and is found only in cells that have those structures. (wikipedia.org)
  • Cytoplasmic dynein positions the spindle at the site of cytokinesis by anchoring to the cell cortex and pulling on astral microtubules emanating from centrosome . (wikipedia.org)
  • Dynein pulls the microtubules and chromosomes to one end of the cell. (wikipedia.org)
  • When the end of the microtubules become close to the cell membrane, they release a chemical signal that punts the dynein to the other side of the cell. (wikipedia.org)
  • It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly. (embl.de)
  • Microtubules serve as a rail on which motor proteins, such as kinesin and dynein superfamily proteins, convey their cargoes. (embl.de)
  • Coordinated beating and bend propagation of cilia and flagella are generated by active sliding of peripheral doublet microtubules driven by ensembles of various types of dyneins. (rupress.org)
Mutation1
  • Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene. (uchicago.edu)
Axoneme1
  • The differences observed in the post-powerstroke conformations of different dynein isoforms may be due to spatial constraints between the complexes in the axoneme or to intrinsically different functions of the dyneins. (researchensemble.com)
Genes1
  • The light chain (KLC) of dynein's opposing motor - kinesin is one of many genes differentially expressed in Loa compared to wild-type. (figshare.com)
Proteins7
  • Kinesin and dynein superfamily proteins and the mechanism of organelle transport. (embl.de)
  • This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins. (embl.de)
  • 2020). Higher expression of dynein proteins over the course of spermatogeneisis in C. gigas (Dheilly et al. (github.io)
  • Differential abundance of dynein proteins was found in shotgun proteomic characterization of C. gigas ctenidia (Timmins-Schiffman et al. (github.io)
  • 2018). Unfertilized sea urchin eggs contain several dynein proteins (Pratt 1980, Porter 1988). (github.io)
  • KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of LINC complexes that connect nuclei to the cytoskeleton. (ucdavis.edu)
  • In addition to distinct cytoplasmic domains, the luminal KASH domain also varies among KASH domain proteins of distinct functions. (ucdavis.edu)
Dynactin1
  • The nudF gene of the filamentous fungus Aspergillus nidulans acts in the cytoplasmic dynein /dynactin pathway and is required for distribution of nuclei. (xenbase.org)
Classification1
  • Our classification of dyneins from active flagella revealed that this α-ODA was in the pre-I and the β-ODA in the pre-II state in more than 90% of the classified ODA dimers. (researchensemble.com)
Complexes1
  • LINC complexes interact with lamins in the nucleus and with various cytoplasmic KASH effectors from the surface of nuclei. (ucdavis.edu)
Chlamydomonas1
Motility1
  • 2012). Dynein does not have strict functions relating to sperm motility. (github.io)
Molecular1
  • Dyneins are a group of microtubule-activated ATPases that function as molecular motors. (utsouthwestern.edu)
Urchin1
Cilia5
  • The dynein-2 complex is found in cell structures known as cilia. (medlineplus.gov)
  • Dynein-2 is involved in a process called intraflagellar transport (IFT), by which materials are carried within cilia. (medlineplus.gov)
  • Specifically, dynein-2 is a motor that uses energy from the molecule ATP to power the transport of materials from the tip of cilia to the base. (medlineplus.gov)
  • Like the mutations that cause asphyxiating thoracic dystrophy, these genetic changes impair the function of the dynein-2 complex and disrupt IFT within cilia. (medlineplus.gov)
  • Dynein transports various cellular cargos , provides forces and displacements important in mitosis , and drives the beat of eukaryotic cilia and flagella . (wikipedia.org)
Dimer1
  • The dynein f dimer is located close to the surface of the A-microtubule, whereas the other six heavy chain rings are roughly colinear at a larger distance to form three dyads. (rupress.org)
Mutations1
  • The cytoplasmic dynein complex is centred around two homodimerised heavy chains, within which multiple mutations have been identified in human neurological diseases. (figshare.com)
Regulation2
  • Regulation of cytoplasmic dynein behaviour and microtubule organization bymammalian Lis1. (embl.de)
  • These effects were mediated via the down-regulation of caspase-3, ROCK1 (Rho-associated kinase1) activation and myosin light chain (MLC, Ser-19) phosphorylation. (ijbs.com)
Structures1
  • i.e. the pre-I dyneins were held in place (instead of diffusing in space) by their tails anchoring to the cargo-microtubule and other domains contacting neighbouring axonemal structures. (researchensemble.com)
Neuronal1
  • Lis1 deficiency produces the opposite phenotype.Our results indicate that abundance of Lis1 in neurons may stimulatespecific dynein functions that function in neuronal migration and axongrowth. (embl.de)
Organelle2
  • Cytoplasmic dynein, found in all animal cells and possibly plant cells as well, performs functions necessary for cell survival such as organelle transport and centrosome assembly. (wikipedia.org)
  • Cytoplasmic dynein would be involved in organelle transport. (github.io)
Linker2
  • Shown is the order of regions of interest for human cytoplasmic dynein 2 motor domains as they occur from the linker to C-terminal. (wikipedia.org)
  • Does dynein generate force by the linker swing? (nii.ac.jp)
Kinesin1
  • Dynein and kinesin can both be exploited by viruses to mediate the viral replication process. (wikipedia.org)
Light3
  • These recent findings provide a coherent mechanistic framework for axon-soma communication in the injured nerve and shed light on the integration of cytoplasmic and nuclear transport in all eukaryotic cells. (nature.com)
  • Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. (utsouthwestern.edu)
  • LC, light chain. (rupress.org)
Motor1
  • [1] Additionally, dynein motor is also responsible for the transport of degradative endosomes retrogradely in the dendrites. (wikipedia.org)
Outer arm1
  • To interact with the B-microtubule through stalks, the inner-arm dyneins must have either different handedness or, more probably, the opposite orientation of the AAA rings compared with the outer-arm dyneins. (rupress.org)
Dihydrolipoamide branched chain1
Complex2
  • Cytoplasmic dynein helps to position the Golgi complex and other organelles in the cell. (wikipedia.org)
  • In addition, associations of KLC with the dynein complex is altered in Loa. (figshare.com)
Stalks1
  • that is, one or the other of its stalks is always attached to the microtubule so that the dynein can "walk" a considerable distance along a microtubule without detaching. (wikipedia.org)
Annotation1
  • With new genome, it's possible that this annotation may be a cytoplasmic homologue, as we did not sequence any male DNA. (github.io)
Organelles1
  • The data presented here support a cytoplasmic integrity model where ANC-1 localizes to the ER membrane and extends into the cytoplasm to position nuclei, ER, mitochondria, and likely other organelles in place. (ucdavis.edu)
Human1