• Talin, a key intracellular integrin activator, recognizes this site as well as the membrane-proximal helix, thereby promoting cytoplasmic tail separation along the membrane surface. (rcsb.org)
  • To study domains of nectin-1α involved in cell fusion, we measured the ability of nectin-1α/nectin-2α chimeras, nectin-1α/CD4 chimeras, and transmembrane domain and cytoplasmic tail mutants of nectin-1α to promote cell fusion induced by HSV-1 glycoproteins. (umn.edu)
  • The transmembrane domain and cytoplasmic tail of nectin-1 were not required for any viral receptor or cell adhesion function tested. (umn.edu)
  • Cellular cytoplasmic factors that bind to the nectin-1α cytoplasmic tail, therefore, did not influence virus entry or cell fusion. (umn.edu)
  • In this study, we investigate whether binding of the intrinsically disordered T cell receptor zeta cytoplasmic tail to the well-folded simian immunodeficiency virus Nef core domain is accompanied by a disorder-to-order transition. (umassmed.edu)
  • The Epstein-Barr virus (EBV) glycoprotein B cytoplasmic C-terminal tail domain regulates the energy requirement for EBV-induced membrane fusion. (uic.edu)
  • In our current studies, we characterized a gB C-terminal tail domain (CTD) mutant truncated at amino acid 843 (gB843). (uic.edu)
  • To further characterize the function of the EBV gB cytoplasmic C-terminal tail domain (CTD) in fusion, we used a previously constructed CTD truncation mutant and studied its fusion activity in the context of other EBV glycoprotein mutants. (uic.edu)
  • The 140 kDa isoform of NCAM (neural cell adhesion molecule) containing a transmembrane domain and short cytoplasmic tail. (bvsalud.org)
  • The heavy chain consists of 2 peptide-binding domains, an immunoglobulin (Ig)-like domain, and a transmembrane region with a cytoplasmic tail. (msdmanuals.com)
  • each chain has a peptide-binding domain, an Ig-like domain, and a transmembrane region with a cytoplasmic tail. (msdmanuals.com)
  • Analysis of progressive deletions of the transmembrane and cytoplasmic domains of influenza hemagglutinin. (silverchair.com)
  • The injectisome consists of three major components: extracellular needle, basal body, and a cytoplasmic sorting platform. (ku.edu)
  • The dashed lines between the gp41 NHR and CHR domain indicate the interactions between the residues at the e and g positions in NHR and the a and d positions in CHR. (figshare.com)
  • These mutations affect critical residues in the cytoplasmic BTK protein and are highly variable and uniformly dispersed throughout the molecule. (medscape.com)
  • Cytoplasmic dynein, found in all animal cells and possibly plant cells as well, performs functions necessary for cell survival such as organelle transport and centrosome assembly. (wikipedia.org)
  • Cytoplasmic dynein helps to position the Golgi complex and other organelles in the cell. (wikipedia.org)
  • Cytoplasmic dynein positions the spindle at the site of cytokinesis by anchoring to the cell cortex and pulling on astral microtubules emanating from centrosome . (wikipedia.org)
  • Human cytoplasmic dynein 2 domains. (wikipedia.org)
  • Shown is the order of regions of interest for human cytoplasmic dynein 2 motor domains as they occur from the linker to C-terminal. (wikipedia.org)
  • Rabbit polyclonal to SYK.Syk is a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains.Plays a central role in the B cell receptor (BCR) response. (bioskinrevive.com)
  • The cytoplasmic portion contains two phospho-tyrosine-phosphatase domains. (beckman.com)
  • cytoplasmic dyneins and axonemal dyneins , which are also called ciliary or flagellar dyneins. (wikipedia.org)
  • We show here that, whereas membrane-proximal helices of integrin alpha/beta cytoplasmic tails associate in cytoplasm-like aqueous medium, they become partially embedded into membrane-mimetic micelles when unclasped. (rcsb.org)
  • Membrane embedding induces substantial structural changes of the cytoplasmic tails as compared to their aqueous conformations and suggests there may be an upward movement of the membrane-proximal helices into the membrane during their separation. (rcsb.org)
  • Each of the three is composed of two subunits: S1, the membrane distal region, including the receptor-binding and N-terminal domains, and S2, the membrane-proximal protein. (forbes.com)
  • Reverse genetics generation of chimeric infectious Junin/Lassa virus is dependent on interaction of homologous glycoprotein stable signal peptide and G2 cytoplasmic domains. (cdc.gov)
  • It interacts with the cytoplasmic poly(A)-polymerase GLD-2. (nih.gov)
  • FIGURE 1: Schematic of 2019-nCoV S primary structure colored by domain. (forbes.com)
  • Our recent extensive analysis of three cases of subacute sclerosing panencephalitis (SSPE) revealed intriguing genetic defects in the persisting measles virus (MV): the fusion (F) genes encoded truncated cytoplasmic F protein domains (Cattaneo et al. (elsevierpure.com)
  • Autophagy is a cytoplasmic conserved catabolic phenomenon to maintain cellular homeostasis. (nih.gov)
  • Cytoplasmic face-mediated integrin inside-out activation remains a paradigm in transmembrane signal transduction. (rcsb.org)
  • These data provide a structural basis of membrane-mediated changes at the cytoplasmic face in regulating integrin activation and signaling. (rcsb.org)
  • The nucleolus: a nuclear compartment with impact on cytoplasmic mRNA localization. (uni-muenchen.de)
  • Role of nuclear RNP assembly in cytoplasmic mRNA localization. (uni-muenchen.de)
  • The responding samples to H4, displayed increased expression of myeloid markers, a clear decrease in the nuclear-cytoplasmic ratio and the potential of re-activation of the monocytic transcriptional program reducing leukemia propagation in vivo. (lu.se)
  • This results in a differential staining of nuclear DNA in green and of cytoplasmic RNA in red, which allows recognition of the parasites. (cdc.gov)
  • The mAb 1412 recognizes the cytoplasmic domain of the CD20 molecule. (biolegend.com)
  • Our results demonstrate that only chimeras and mutants containing the entire V-like domain and a link to the plasma membrane conferred cell-fusion activity. (umn.edu)
  • Interestingly, the efficiency of cell fusion was reduced when membrane-spanning domains of nectin-1α and gD were replaced by glycosylphosphatidylinositol tethers, indicating that transmembrane domains may play a modulatory role in the gD/nectin-1α interaction in fusion. (umn.edu)
  • Four mutant genes were constructed which express truncated forms of HA that lack the cytoplasmic domain and terminate at amino acids 9, 14, 17, or 27 of the wild-type hydrophobic domain. (silverchair.com)
  • Mutations in each of the 5 domains of BTK can lead to disease. (medscape.com)
  • Characterization of the cytoplasmic SP via cryo-electron tomography allowed us to generate a 3D model of the SP containing six pod-like structures (comprised most prominently of Spa33). (ku.edu)
  • The structure also suggests that the four cyclic nucleotide-binding domains present in each channel form two distinct domains, lending structural weight to the suggestion that the four subunits of the CNG channels are arranged as a pair of dimers. (ox.ac.uk)
  • Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. (nih.gov)
  • The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition. (umassmed.edu)
  • CeGLD-3 contains four K-homology (KH) RNA-binding domains, which are divergent KH domains that lacks the RNA-binding GXXG motif. (nih.gov)
  • WRN is a 1432 amino acid protein consisting of several domains. (nih.gov)
  • Effect of an Inhibitor on the ACE2-Receptor-Binding Domain of SARS-CoV-2. (acs.org)
  • Furthermore, the combinatorial screening identified a bromo- and extra-terminal domain (BET) inhibitor that could further improve H4-dependent leukemic differentiation in FLT3 wild-type monocytic AML. (lu.se)
  • Our data suggest that pore vestibule structure is an important determinant of NaChBac inactivation, whereas the inactivation mechanism is independent of the number of free cytoplasmic N- and C-termini in the functional channel. (nyu.edu)
  • A ) Functional domains of the HIV-1 gp41. (figshare.com)
  • Functional Analysis of the RNA Polymerase II C-terminal Domain Kinase Ctk1 in the Yeast Saccharomyces cerevisiae. (uni-muenchen.de)
  • Finally, the highly accurate models of other ArcB homologs suggest that different experimental approaches are needed to determine signal perception in kinases lacking the PAS domain. (bvsalud.org)
  • It is proposed that alteration of the F protein cytoplasmic domain may play a critical role in the development of SSPE. (elsevierpure.com)
  • Role of SNX16 in the dynamics of tubulo-cisternal membrane domains of late endosomes. (nih.gov)
  • Site-directed oligonucleotide mutagenesis has been used to introduce chain termination codons into the cloned DNA sequences encoding the carboxy-terminal transmembrane (27 amino acids) and cytoplasmic (10 amino acids) domains of influenza virus hemagglutinin (HA). (silverchair.com)
  • AtoS and ArcB homologs were found in meta-genome assemblies along with defined domains for other well-characterized sensor kinases, suggesting the close link between these organisms and bacteria that may have resulted in the metabolic link to the establishment of symbiosis. (bvsalud.org)
  • Furthermore, a PDK1-consensus motif is located within the kinase domain of LKB1 and LKB1 gets phosphorylated by PDK1 in vitro. (sdbonline.org)
  • Spa33 consists minimally of a dimer of C-terminal Spa33 domains (Spa33C) and a full-length copy (Spa33FL). (ku.edu)
  • The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)
  • Molecular architecture of a retinal cGMP-gated channel: the arrangement of the cytoplasmic domains. (ox.ac.uk)
  • This three-dimensional reconstruction provides insight into the architecture of the protein, suggesting that the cyclic nucleotide-binding domains, which initiate the response to ligand, 'hang' below the pore-forming part of the channel, attached by narrow linkers. (ox.ac.uk)