• Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene. (wikipedia.org)
  • The product of this gene is an epsilon subunit of coatomer protein complex. (wikipedia.org)
  • It has been recently proposed that binding of HIV type 1 Nef to the beta subunit of COPI coatomers participated in the Nef-induced CD4 downregulation through recognition of a novel diacidic motif found in the C-terminal disordered loop of Nef (V. Piguet, F. Gu, M. Foti, N. Demaurex, J. Gruenberg, J. L. Carpentier, and D. Trono, Cell 97:63-73, 1999). (hal.science)
  • Orthologous to human COPB2 (COPI coat complex subunit beta 2). (nih.gov)
  • Violin plots show distribution of expression levels for Coatomer subunit delta (SMED30012276) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of Coatomer subunit delta (SMED30012276) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Violin plots show distribution of expression levels for Coatomer subunit delta (SMED30012276) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (lookformedical.com)
  • Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. (wikipedia.org)
  • The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
  • The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. (lookformedical.com)
  • An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
  • A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)
  • The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
  • Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. (lookformedical.com)
  • A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (lookformedical.com)
  • Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)
  • Based on the type of protein coats, these vesicles can be of three types: coat protein or COP-coated vesicles, COPI and COPII, and clathrin-coated vesicles. (jove.com)
  • COPI vesicles transport molecules between different parts of the Golgi body and from the Golgi back to the rough ER. (jove.com)
  • COPI and COPII vesicles are composed of similar coat protein complexes called coatomers. (jove.com)
  • Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. (jove.com)
  • Coated vesicles are spherical, protein-coated carriers with a 50-100 nm diameter that mediate bidirectional transport between the ER and the Golgi. (jove.com)
  • The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. (jove.com)
  • The coat on the budding vesicle comprises two layers, an inner layer of adaptor proteins (gray ovals) and an outer layer that forms a polyhedral cage. (biologists.com)
  • Coat proteins can help sort the cargo and assemble on the donor membrane to initiate vesicle formation. (jove.com)
  • The COPI and COPII coat proteins share similar structural features with Clathrin but differ in cargo sorting and vesicle formation mechanisms. (jove.com)
  • It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (wikipedia.org)
  • A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)
  • A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)
  • Most plasma membrane proteins are sorted by the trans -Golgi network (TGN) in the conventional secretory pathway. (jneurosci.org)
  • Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)
  • A subclass of clathrin assembly proteins that occur as monomers. (lookformedical.com)
  • Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. (lookformedical.com)
  • A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells. (lookformedical.com)
  • Their formation is driven by the assembly of different classes of coat proteins, namely COPI, COPII, clathrin, or retromer complex. (jove.com)
  • They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2. (lookformedical.com)
  • An adaptor protein complex found primarily on perinuclear compartments. (lookformedical.com)
  • Here, we report that Arl8b binds to the Rab4 and Rab14 interaction partner, RUN and FYVE domain-containing protein (RUFY) 1, a known regulator of cargo sorting from recycling endosomes. (bvsalud.org)
  • Specific coat proteins cover their cytosolic surface. (jove.com)
  • The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
  • Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (lookformedical.com)
  • The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
  • This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
  • Arl8b, an Arf-like GTP-binding protein, regulates cargo trafficking and positioning of lysosomes. (bvsalud.org)
  • Eye proteins are the biological molecules that make up the various structures of the eye and are essential for its proper function. (lookformedical.com)
  • A family of large adaptin protein complex subunits of approximately 90-130 kDa in size. (lookformedical.com)
  • Surprisingly, mutation of the diacidic sequence of Nef did not significantly affect its ability (i) to interact with beta-COP, (ii) to downregulate CD4 cell surface expression, and (iii) to address an integral resident membrane protein containing Nef as the cytoplasmic domain to the endocytic pathway. (hal.science)
  • Arrestin quenches G-protein activation by binding to phosphorylated photolyzed rhodopsin. (lookformedical.com)
  • They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION. (lookformedical.com)
  • Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
  • A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
  • A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
  • A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)
  • Predicted to enable protein kinase C binding activity. (nih.gov)
  • Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response. (lookformedical.com)
  • A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions. (lookformedical.com)
  • Several isoforms of the protein with molecular sizes of 47 kDa and 52 kDa exist due to multiple ALTERNATIVE SPLICING. (lookformedical.com)
  • However, EM methods often lack molecular information, obstructing the correlation of ultrastructural information obtained by EM to fluorescence microscopy-based localization of specific autophagy proteins. (bvsalud.org)
  • Fluorescent biosensors are valuable tools to monitor protein activities and the functional state of organelles in live cells. (bvsalud.org)
  • Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP. (hal.science)
  • For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
  • In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
  • A 48-Kd protein of the outer segment of the retinal rods and a component of the phototransduction cascade. (lookformedical.com)
  • The Nef protein from the human immunodeficiency virus (HIV) induces CD4 cell surface downregulation by interfering with the endocytic machinery. (hal.science)
  • A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis. (nih.gov)
  • protein_coding" "Cz01g27080.t1","No alias","Chromochloris zofingiensis","Solute-binding protein family 5 domain [Interproscan]. (ntu.edu.sg)
  • protein_coding" "Cz03g01030.t1","No alias","Chromochloris zofingiensis","Rieske [2Fe-2S] iron-sulphur domain [Interproscan]. (ntu.edu.sg)
  • They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)
  • Protein activities are confined to organelle zones with a distinct membrane morphology, which can only be seen by electron microscopy (EM). (bvsalud.org)
  • They share a common structure and signal through HETEROTRIMERIC G-PROTEINS. (lookformedical.com)
  • A family of large adaptin protein subunits of approximately 100 kDa in size. (lookformedical.com)
  • A family of medium adaptin protein subunits of approximately 45 KDa in size. (lookformedical.com)
  • Overall, this method presents a valuable tool for ultrastructural localization studies of autophagy proteins and other scarce antigens by bridging light microscopy to EM data. (bvsalud.org)