ANCAAntineutrophil cytoplasAntibodiesNuclear and cytoplasmicExamples of cytoplasmicProteinsInclusionsProteinNeutrophilCytoplasmGRANULESMembraneStructuresPhenotypeTyrosineFertilityStrainsExtracellularViralGenesSpeciesCellularKidneyMechanismOuterDescriptorEndoplasmicTissuesInhibitionInfectionSequenceAutoimmuneDecreasePresenceCellsTranscription factorDomainTypeMiceMaleArticleResults

ANCA10

• Perinuclear-ANCA (P-ANCA), cytoplasmic-ANCA (C-ANCA), myeloperoxidase ANCA (MPO-ANCA), and proteinase 3-ANCA (PR3-ANCA) were studied. (hindawi.com)
• It has been demonstrated that antineutrophil cytoplasmic antibody (ANCA) positivity could be detected in many cases of vasculitis associated with viruses. (hindawi.com)
• We aimed in the present study to identify the frequency of perinuclear-ANCA (P-ANCA), cytoplasmic-ANCA (C-ANCA), myeloperoxidase-ANCA (MPO-ANCA), and proteinase 3-ANCA (PR3-ANCA) subgroups of CHB patients in comparison with healthy controls. (hindawi.com)
• This test looks for antineutrophil cytoplasmic antibodies (ANCA) in a sample of your blood. (medlineplus.gov)
• Antineutrophil cytoplasmic antibody (ANCA) tests are used to diagnose and monitor inflammatory activity in the primary systemic small vessel vasculitides. (nih.gov)
• Serum samples containing ANCA, any other cytoplasmic fluorescence, or an antinuclear antibody (ANA) that results in homogeneous or peripheral nuclear fluorescence then should be tested in ELISAs for PR3-ANCA and MPO-ANCA. (nih.gov)
• Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of diseases (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis and microscopic polyangiitis), characterized by destruction and inflammation of small vessels. (nih.gov)
• Antineutrophil cytoplasmic antibodies (ANCA) are found in several vasculitic conditions, including granulomatosis with polyangiitis, microscopic polyangiitis, and Churg-Strauss syndrome. (medscape.com)
• Cytoplasmic ANCA (c-ANCA) represents a subset of these antibodies, in which the primary molecular target is proteinase-3 within the cytoplasm of neutrophils and monocytes. (medscape.com)
• GPA is one of the antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic disorders. (medscape.com)

Antineutrophil cytoplas1

• Antinuclear antibody and antineutrophil cytoplasmic antibody assays were negative. (who.int)

Antibodies7

• Antineutrophil cytoplasmic antibodies (ANCAs) are sensitive and specific markers for vasculitides. (hindawi.com)
• Antineutrophil cytoplasmic antibodies (ANCAs) are autoantibodies, usually of IgG structure, formed against azurophilic granules and lysosomal components in the cytoplasm of neutrophils and monocytes [ 16 ]. (hindawi.com)
• This panel contains qualitative results for neutrophil cytoplasmic antibodies and quantitative results for saccharomyces cerevisiae IgA and IgG antibodies in serum to help distinguish two forms of inflammatory bowel disease (IBD): ulcerative colitis (UC) and Crohn's disease (CD). (loinc.org)
• Using antibodies specific for different forms of ubiquitin, we show that ubiquitinated proteins are present in cytoplasmic bodies, and that this localization is altered after proteasome inhibition. (northwestern.edu)
• Finally, linkage-specific polyubiquitin antibodies revealed that K48-linked ubiquitin chains localize to rhTRIM5α cytoplasmic bodies, implicating these structures in proteasomal degradation. (northwestern.edu)
• Differential staining of cytoplasmic bodies seen with different polyubiquitin antibodies suggests that structural changes occur during proteasome inhibition that alter epitope availability. (northwestern.edu)
• This test detects elevated levels of antineutrophil cytoplasmic antibodies in the blood to diagnose autoimmune disorders such as autoimmune vasculitis. (lotusdiagnostic.com)

Nuclear and cytoplasmic1

• Western blots of nuclear and cytoplasmic fractions of BRCA2 mutant cells. (biomedcentral.com)

Examples of cytoplasmic1

• While considering various examples of cytoplasmic inheritance it has been assumed that the cytoplasm in the sperm cell is present in very minute quantity and mostly it is in larger quantity in the egg. (biologydiscussion.com)

Proteins5

• Here, we examine the ubiquitination status of cytoplasmic body proteins. (northwestern.edu)
• A decrease in polyubiquitinated proteins localizing to cytoplasmic bodies was apparent after 1 h of proteasome inhibition, and greater differences were seen after extended proteasome inhibition. (northwestern.edu)
• The decrease in polyubiquitin conjugates within cytoplasmic bodies was also observed when deubiquitinating enzymes were inhibited, suggesting that the removal of ubiquitin moieties from polyubiquitinated cytoplasmic body proteins after extended proteasome inhibition is not responsible for this phenomenon. (northwestern.edu)
• In order to explore the factors that regulate the nuclear import of TDP-43, we used a small interfering RNA library to silence 82 proteins involved in nuclear transport and found that knockdowns of karyopherin-beta1 and cellular apoptosis susceptibility protein resulted in marked cytoplasmic accumulation of TDP-43. (crick.ac.uk)
• Cytoplasmic Proteins from different human adult normal tissues are available. (cytomol.com)

Inclusions5

• Glial cytoplasmic inclusions (GCIs) and neuronal multisystem degeneration are the pathologic hallmarks of this clinically variable disorder (see the image below). (medscape.com)
• This particular type of mechanism in which cytoplasmic particles or inclusions take part in transmission of characters from generation to generation constitutes cytoplasmic inheritance. (biologydiscussion.com)
• Cytoplasmic inclusions are diverse structures found within the cytoplasm of cells. (com.ng)
• During viral infections, certain viruses can induce the formation of distinct cytoplasmic inclusions within infected cells. (com.ng)
• In summary, cytoplasmic inclusions encompass a wide range of structures with diverse compositions and functions within the cytoplasm of cells. (com.ng)

Protein6

• Brown GG, Formanova N, Jin H, Wargachuk R, Dendy C, Patil P, Laforest M, Zhang J, Cheung WY, Landry BS (2003) The radish Rfo restorer gene of Ogura cytoplasmic male sterility encodes a protein with multiple pentatricopeptide repeats. (springer.com)
• Taken together, it is likely that rhTRIM5α cytoplasmic bodies are involved in recruiting components of the ubiquitin-proteasome system to coordinate proteasomal destruction of a viral or cellular protein(s) during restriction of HIV-1. (northwestern.edu)
• CSC mice showed decreased GR mRNA and cytoplasmic protein levels compared with single-housed control (SHC) mice. (uni-regensburg.de)
• Basal and acute stress-induced nuclear GR protein expression were comparable between CSC and SHC mice, as were MR and FKBP51 mRNA and/or cytoplasmic protein levels. (uni-regensburg.de)
• In summary, CSC mice show an, if at all, increased hippocampal GC signaling capacity despite lower cytoplasmic GR protein expression, making negative feedback deficits in the hippocampus unlikely to contribute to the increased ACTH drive following CSC. (uni-regensburg.de)
• All cytoplasmic protein products are for research use only. (cytomol.com)

Neutrophil1

• When Do Symptoms of Anti-neutrophil cytoplasmic antibody-associated vasculitis Begin? (nih.gov)

Cytoplasm6

• As the reproductive incompatibility is caused by bacteria that reside in the cytoplasm of the host cells, it is referred to as cytoplasmic incompatibility. (wikipedia.org)
• The relative dispersion of cellular residence times is introduced as a model-independent measure of cytoplasmic equilibration kinetics, which indicates whether diffusion through the cytoplasm is rate limiting. (nih.gov)
• Therefore, the average ribosome density per 0.1 fl cytoplasm was calculated and it was 2840 ± 120 (ranging from 2600 to 2970), which was independent of the whole cytoplasmic volume of each cell and the deviation was very small. (harvard.edu)
• The total self reproducing hereditary material of cytoplasm is termed as Plasmon like the genome (which refers to the total gene complement of an haploid set of chromosomes) of chromosomes and such units of cytoplasmic hereditary material are called cytoplasmic genes or plasma-genes or Plasmon's. (biologydiscussion.com)
• Each set of nuclear genes is sometimes designated as genome and all the hereditary materials transmitted through the cytoplasm is referred to as plasma-genes, cytoplasmic genes, cytogeneses, extra nuclear genes or extra chromosomal genes. (biologydiscussion.com)
• Having got it through the cytoplasm, it may be cited as an example of cytoplasmic inheritance. (biologydiscussion.com)

GRANULES1

• Analysis of centrifuged cells which had been incubated with H 3 -thymidine showed a very high degree of correlation between the location of the nucleic acid-containing granules and that of acid-insoluble, deoxyribonuclease-sensitive labeled molecules and leads to the conclusion that cytoplasmic DNA synthesis in Amoeba proteus occurs in association with these particles. (rupress.org)

Membrane2

• After matching the models for the relative dispersion the remaining differences in relative skewness are predicted, discussing the relative roles of membrane permeability, cellular binding and cytoplasmic transport. (nih.gov)
• Sekler, I , Kobayashi, S & Kopito, RR 1996, ' A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger ', Cell , vol. 86, no. 6, pp. 929-935. (bgu.ac.il)

Structures4

• Two concepts have been proposed for the cytoplasmic distribution process of hydrophobic or amphipathic molecules, (i) slowing of diffusion due to instantaneous binding to immobile cellular structures and (ii) slow binding after instantaneous distribution throughout the cytosol. (nih.gov)
• Characterization of the cytoplasmic SP via cryo-electron tomography allowed us to generate a 3D model of the SP containing six pod-like structures (comprised most prominently of Spa33). (ku.edu)
• Cytoplasmic bodies containing rhTRIM5α have been implicated in the ubiquitin-proteasome pathway, but the specific roles these structures play remain uncharacterized. (northwestern.edu)
• Superresolution structured illumination microscopy revealed finer details of rhTRIM5α cytoplasmic bodies and the polyubiquitin conjugates that localize to these structures. (northwestern.edu)

Phenotype3

• Cytoplasmic male sterility (CMS) is a widespread phenotype in plants, which present a defect in the production of functional pollen. (frontiersin.org)
• Our nuclear transfer experiment showed that the phenotype is attributable to cytoplasmic rather than nuclear defects of the zygotes. (life-science-alliance.org)
• ESE-1 initiates transformation of MCF-12A cells via a non-transcriptional, cytoplasmic process that is mediated by a unique 40-amino acid serine and aspartic acid rich (SAR) subdomain, whereas, ESE-1's nuclear transcriptional property is required to maintain the transformed phenotype of MCF7, ZR-75-1 and T47D breast cancer cells. (biomedcentral.com)

Tyrosine1

• Rabbit polyclonal to SYK.Syk is a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains.Plays a central role in the B cell receptor (BCR) response. (bioskinrevive.com)

Fertility2

• The lack of restorer lines for the newly identified male-sterility led us to predict that it might be a complete cytoplasmic male-sterility without restorer-of-fertility genes in nuclear genomes. (springer.com)
• Bentolila S, Alfonso AA, Hanson MR (2002) A pentatricopeptide repeat-containing gene restores fertility to cytoplasmic male-sterile plants. (springer.com)

Strains1

• How do SHuffle® strains aid in cytoplasmic disulfide bond formation? (neb.com)

Extracellular1

• The injectisome consists of three major components: extracellular needle, basal body, and a cytoplasmic sorting platform. (ku.edu)

Viral1

• DDX58/RIG-I, a sensor of cytoplasmic viral RNA and toll-like receptors (TLR) 3, 7, and 8, which bind RNA in endosomes, are conserved in pangolins. (frontiersin.org)

Genes1

• The cytoplasmic hereditary units are denoted by Greek letters-alpha, beta, gamma, sigma and so on, in contrast to the chromosomal genes which are denoted by Roman letters- a, b, c, d and so on. (biologydiscussion.com)

Species1

• Cytoplasmic male sterility (CMS) has been characterized in over 140 natural species ( Laser and Lersten, 1972 ). (frontiersin.org)

Cellular1

• As a consequence of tissue binding, however, drug distribution cannot be regarded as instantaneous even at the cellular level and the distribution process consists of at least two components: transmembrane exchange and cytoplasmic transport. (nih.gov)

Kidney1

• Kidney, Renal tubule - Cytoplasmic alteration in a male B6C3F1 mouse from a chronic study. (nih.gov)

Mechanism1

• Thus, maternal UHRF1 regulates the proper cytoplasmic architecture and function of oocytes and preimplantation embryos, likely through a mechanism unrelated to DNA methylation. (life-science-alliance.org)

Outer1

• 1998) observed that the outer hair cell cytoplasmic Ca2+ concentration rises following acoustic overstimulation. (cdc.gov)

Descriptor1

• Receptors, Cytoplasmic and Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)

Endoplasmic1

• Intriguingly, cytoplasmic lattices were disorganized, and mitochondria, endoplasmic reticulum, and components of the subcortical maternal complex were mislocalized. (life-science-alliance.org)

Tissues1

• Complexity of cytoplasmic RNA in different mouse tissues measured by hybridization of polyadenylated RNA to complementary DNA. (harvard.edu)

Inhibition1

• Analysis of deletion mutants demonstrated that the RRFSALE motif in the cytoplasmic tail of LAG3 was necessary and sufficient for LAG3-mediated inhibition. (bvsalud.org)

Infection1

• In 1971, Janice Yen and A. Ralph Barr of UCLA demonstrated the etiologic relationship of Wolbachia infection and cytoplasmic incompatibility in Culex mosquitos when they found that eggs were killed when the sperm of Wolbachia-infected males fertilized infection-free eggs. (wikipedia.org)

Sequence1

• The data in this paper identify a histidine-rich sequence within the cytoplasmic domain of the nonerythroid anion exchanger, AE2, that serves as an intracellular pH 'sensor' that modulates anion exchange activity within the physiological range of cytoplasmic pH. (bgu.ac.il)

Autoimmune1

• Lymphocyte activation gene 3 (LAG3) is an inhibitory immune checkpoint receptor that restrains autoimmune and antitumor responses, but its evolutionarily conserved cytoplasmic tail lacks classical inhibitory motifs. (bvsalud.org)

Decrease2

• If a decrease in cytoplasmic vacuoles is seen following treatment in male mice (compared with controls), then this finding should be diagnosed as "cytoplasmic alteration" and given a severity grade. (nih.gov)
• A decrease in the normal cytoplasmic vacuoles is evident in this treated male mouse. (nih.gov)

Presence1

• The presence of cortical Lewy bodies is confirmed by the finding of alpha synuclein positive rounded cytoplasmic inclusion in neurons. (medscape.com)

Cells3

• Numerous clear cytoplasmic vacuoles are present in renal tubule cells. (nih.gov)
• Based on TPS, the nuclear/cytoplasmic ratio (N/C ratio) of the observed urothelial cells is a crucial criterion and the cutoff values of 0.5 and 0.7 are used for the diagnosis of Atypical Urothelial Cells (AUC) and High-Grade Urothelial Carcinoma (HGUC)/Suspicious for HGUC respectively. (aacrjournals.org)
• In certain cells, particularly melanocytes, melanin is stored in specialized cytoplasmic organelles called melanosomes. (com.ng)

Transcription factor1

• BACKGROUND: Oestrogen receptor alpha (ER) is involved in cell growth and proliferation and functions as a transcription factor, a transcriptional coregulator, and in cytoplasmic signalling. (lu.se)

Domain2

• The mAb 1412 recognizes the cytoplasmic domain of the CD20 molecule. (biolegend.com)
• Furthermore, we show that exclusive cytoplasmic targeting of the SAR domain is sufficient to initiate transformation, and we report that an intact SAR domain is required, since block mutagenesis reveals that an intact SAR domain is necessary to maintain its full transforming potency. (biomedcentral.com)

Type1

• Selection of nuclear genotypes associated with the thermo-sensitivity of Owen-type cytoplasmic male sterility in sugar beet (Beta vulgaris L. (springer.com)

Mice1

• Cytoplasmic vacuolation that is present as a normal background finding in male mice does not have to be diagnosed. (nih.gov)

Male3

• Discovery of a novel cytoplasmic male-sterility and its restorer lines in radish (Raphanus sativus L. (springer.com)
• Bannerot H, Loulidard L, Cauderon MY, Tempe J (1974) Transfer of cytoplasmic male sterility from Raphanus sativus to Brassica oleracea . (springer.com)
• Bonhomme S, Budar F, Ferault M, Pelletier G (1991) A 2.5 kb Nco I fragment of Ogura radish mitochondrial DNA is correlated with cytoplasmic male-sterility in Brassica cybrids. (springer.com)

Article1

• In this article we will discuss about the meaning of cytoplasmic inheritance. (biologydiscussion.com)

Results1

• Cytoplasmic incompatibility (CI) is a phenomenon that results in sperm and eggs being unable to form viable offspring. (wikipedia.org)