Cytomegalovirus infection organ recipients organ transplanted. Medical search. Frequent questions

[ 1 ] This condition has been reported in organ transplant patients, those undergoing long-term renal dialysis, patients with human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS), as well as in individuals with other debilitating diseases. (medscape.com)

[ 1 ] One case report has described an elderly diabetic, hypertensive man, who previously underwent renal transplantation and was receiving immunosuppressant agents, with esophageal and gastric ulceration and laboratory confirmation (by polymerase chain reaction) of synchronous CMV, herpes simplex virus, and Epstein-Barr virus infections. (medscape.com)
The average time to the development of CMV esophagitis after solid organ transplantation is 5-7 months. (medscape.com)
CMV esophagitis has been described in only a few patients who have been immunocompromised by conditions other than transplantation, HIV infection, or AIDS. (medscape.com)
It takes advantage of combining data from all transplant programmes in one unique system to perform comprehensive nationwide reporting and to promote translational and clinical post-transplant outcome research in the framework of Swiss transplantation medicine. (bmj.com)
Organ Procurement and Transplantation Network. (cdc.gov)
Cytomegalovirus infection after renal transplantation. (cdc.gov)
Morris MI , Fischer SA , Ison MG . Infections transmitted by transplantation. (cdc.gov)
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. (ersjournals.com)
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have contributed to increase the 1‐yr patient survival after lung transplantation (LTx) to 70-80% 1 . (ersjournals.com)
A shift in the nature of complications from early to late graft dysfunction has been similarly observed after transplantation of other solid organs 2 . (ersjournals.com)
Cytomegalovirus (CMV) infection of the gastrointestinal tract is the most common manifestation of tissue-invasive CMV disease, and is a significant cause of morbidity and mortality in the solid organ transplantation (SOT) recipient. (omeka.net)
1 CMV transmission through blood transfusion or organ transplantation from infected donors can also occur. (contemporarypediatrics.com)
CMV): A member of the herpes virus family which may induce the immune-deficient state or cause active illness, such as pneumonia, in a patient already immune-deficient due to chronic illness, such as cancer or organ transplantation therapy. (digitalnaturopath.com)
OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content. (lidsen.com)
Cytomegalovirus (CMV) is a beta variant of the Herpes Simplex Virus (HSV), a highly prevalent opportunistic pathogen with over 50% of adults infected worldwide by age [ 1. De Matos SB, Meyer R, de Mendonça Lima FW. Cytomegalovirus infection after renal transplantation: Occurrence, clinical features, and the cutoff for antigenemia in a university hospital in Brazil. Infect Chemother. 2017; 49: 255-261. [ CrossRef ] ">1 ]. (lidsen.com)
These are the use of induction immunosuppression, donor seropositivity, old donors, simultaneous kidney-pancreas transplantation, presence of allograft rejection and concurrent infection from other viruses. (nephrologistinagartala.com)
It can happen after transplantation and the cause is sometimes donor-derived infection. (nephrologistinagartala.com)
These include kidney-pancreas transplantation with bladder drainage, deceased-donor transplant, prolonged catheterization, increased immunosuppressed state and the use of ureterovesical stents. (nephrologistinagartala.com)
Donor and recipient CMV serostatus and antigenemia after renal transplantation: an analysis of 486 patients. (ox.ac.uk)
The impact of donor and recipient serostatus on viremia is well recognised, with seronegative recipients at greatest risk after transplantation of an organ from a seropositive donor. (ox.ac.uk)
In 2010, over a 12-month period, more than 3500 new lung transplant procedures were reported to the International Society of Heart and Lung Transplantation (ISHLT) Registry [ 1 ]. (ersjournals.com)
Furthermore, a meticulous approach to post-transplant management in the immediate post-operative period, in the early and long-term has contributed to continually improving long-term survival after lung transplantation. (ersjournals.com)
Whilst quality of life should be considered in all potential recipients, it is currently unlikely that transplantation would be offered solely for this reason due to the shortage of available donor organs. (ersjournals.com)
Canadian Society of Transplantation Consensus Workshop on Cytomegalovirus Management in Solid Organ Transplantation Final Report. (sciendo.com)
8. Lee JJ, Lam MS, Rosenberg A. Role of chemotherapy and rituximab for treatment of posttransplant lymphoproliferative disorder in solid organ transplantation. (sciendo.com)
Registry of the international society for heart and lung transplantation: twenty-second official adult lung and heart-lung transplant report-2005. (medigraphic.com)
CMV can be contracted from the general community, transmitted via solid organ transplantation, or may be a reactivation of latent disease. (cancertherapyadvisor.com)
The primary focus of CMV management post transplantation is prevention of CMV disease (although not necessarily CMV infection). (cancertherapyadvisor.com)
HELANTERÄ I, LAUTENSCHLAGER I, KOSKINEN P. The risk of cytomegalovirus recurrence after kidney transplantation[J]. Transpl Int, 2011, 24(12):1170-1178. (organtranspl.com)
Cytomegalovirus in solid organ transplantation[J]. Am J Transplant, 2013,13(Suppl 4):93-106. (organtranspl.com)
Single test results of CMV IgG are useful in screening organ transplant recipients and donors before transplantation and donors of blood products that are to be administered to premature infants and bone marrow transplant patients. (truemedix.in)
Infection and specially disease due to CMV have determined a rise in morbidity and mortality after transplantation. (ufrgs.br)
Living donor liver transplantation ( LDLT ), which can help to bridge the current organ supply/demand mismatch, accounts for only 3%-4% of adult liver transplants in the United States. (medscape.com)
Goldberg and colleagues [ 2 ] examined national Organ Procurement and Transplantation Network/United Network for Organ Sharing data from 2002 to 2012 to determine whether LDLT (n = 2103) conferred a long-term survival benefit relative to deceased donor liver transplantation (DDLT) (n = 46,674). (medscape.com)

However, even asymptomatic CMV infections may predispose an individual towards an increased risk of atherosclerosis, cancer and immune senescence over the life course, although such associations remain controversial. (viruseradication.com)
Acquired infections are often asymptomatic. (msdmanuals.com)
One of the difficulties with CMV is that many people contracting the virus are asymptomatic and thus remain unaware of their infection. (rainier-research.com)
It was estimated that 75% (attack rate) of the island's inhabitants were infected with ZIKV resulting in 18% symptomatic and 82% asymptomatic infections. (cdc.gov)
Additionally, numerous asymptomatic persons, particularly pregnant women are tested for ZIKV infection and will meet laboratory criteria for infection. (cdc.gov)
Because asymptomatic infection might be epidemiologically significant, revisions to the interim surveillance case definitions are proposed to include ZIKV infections without disease. (cdc.gov)

Iwamoto M , Jernigan DB , Guasch A , Trepka MJ , Blackmore CG , Hellinger WC , Transmission of West Nile virus from an organ donor to four transplant recipients. (cdc.gov)
Srinivasan A , Burton EC , Kuehnert MJ , Rupprecht C , Sutker WL , Ksiazek TG , Transmission of rabies virus from an organ donor to four transplant recipients. (cdc.gov)
When planning blood transfusions or organ transplants, the CMV status of the donor can be checked to avoid passing CMV to a recipient who has not had CMV infection. (medlineplus.gov)
1.6 Consider Valganciclovir prophylaxis for at least 3 months after starting treatment for acute allograft rejection if either donor or recipient are CMV positive (D+/R-, D+/R+ or D-/R+) [2C]. (bts.org.uk)
The new trial compared the efficacy and safety of letermovir to the antiviral valganciclovir for preventing CMV in high-risk CMV-negative kidney transplant recipients who received an organ from a CMV-positive donor. (worldmedicinefoundation.com)
Infection can occur as a result of reactivation of latent virus or new infection from donor tissues. (ox.ac.uk)
We analysed the antigenemia status according to donor and recipient serostatus. (ox.ac.uk)
CONCLUSIONS: In this large study, donor serostatus clearly plays a significant role in determining CMV risk, even in seropositive recipients. (ox.ac.uk)
The risk is greatest when the donor is seropositive (i.e. a carrier) and the recipient is seronegative. (encyclopedia.com)
Risk stratification by serological status of the kidney donor and recipient defines the need and duration of prophylaxis therapy. (cancertherapyadvisor.com)
CMV infection is related to the serologic status of the donor and the recipient, as well as to the type and dosage of immunossupression that the recipient is submitted to. (ufrgs.br)
The improved outcomes have been attributed to a greater appreciation of the technical aspects, advanced perioperative management, and optimal qualities of the donor/recipient dyad. (medscape.com)
this will help to identify optimal donor/recipient matches and counsel wait-listed patients considering LDLT to optimize outcomes and provide objective criteria for donor selection. (medscape.com)

In patients with HIV infection or AIDS, CMV infection is an opportunistic infection that signals a decline in patient immunity. (medscape.com)
Recommendations for Preventing Transmission of Infections Among Chronic Hemodialysis Patients. (cdc.gov)
Saiman L, Siegel J. Infection control recommendations for patients with cystic fibrosis: microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission. (cdc.gov)
Most patients with CMV infection exhibit few clinical findings on physical examination. (medscape.com)
In patients with HIV infection, CMV involves the entire GI tract. (medscape.com)
The drug of choice for prevention of CMV disease in solid-organ transplant patients is valganciclovir. (medscape.com)
High levels of circulating cytomegalovirus DNA reflect visceral organ disease in viremic immunosuppressed patients other than marrow recipients. (jci.org)
Although viremia is a hallmark of disseminated cytomegalovirus (CMV) infection, not all viremic patients have visceral organ CMV disease. (jci.org)
We used blot hybridization with a cloned subgenomic probe to quantitate viral DNA in blood leukocytes of 60 viremic patients (25 with solid organ transplants, 20 with AIDS, and 15 marrow recipients) who had different clinical manifestations of CMV infection. (jci.org)
Patients with AIDS or with solid organ transplants who had CMV visceral organ disease had the largest amounts of viral DNA in their granulocytes (median 632 and 237 pg, respectively). (jci.org)
The amounts of viral DNA in granulocytes of AIDS and organ transplant patients with CMV retinitis were low (median 22 pg). (jci.org)
Marrow transplant patients were unique in that the amounts of CMV DNA in granulocytes were low whether CMV visceral organ disease was present (17 pg) or absent (14 pg). (jci.org)
We conclude that high levels of circulating CMV DNA in viremic AIDS and solid organ transplant patients reflect viral involvement of visceral organs but not the retina. (jci.org)
BO and its clinical correlate bronchiolitis obliterans syndrome (BOS) affect up to 50-60% of patients who survive 5 yrs after surgery, irrespective of the type of transplant procedure 1 , 4 - 6 . (ersjournals.com)
However, some patients have an acute presentation with an initial episode of acute rejection or infection that doesnot respond to treatment. (ersjournals.com)
Despite the promise of future treatments and vaccines for CMV infection, there is still a need for clinicians to educate patients about congenital CMV so that they will be better equipped to make decisions on diagnosis, treatment and prevention. (contemporarypediatrics.com)
Dr. Dora Ho specializes in infection complications in immunocompromised patients, such as those with bone marrow transplant, solid organ transplant, cancers and other forms of immunodeficiency. (stanford.edu)
Immunodeficient patients ( AIDS patients or who have those who have received transplanted organs), are at high risk of contracting CMV infection. (digitalnaturopath.com)
However, immunodeficient patients and those receiving immunosuppressives may develop pneumonia or other secondary infections. (digitalnaturopath.com)
14 patients with chronic symptoms of disabling fatigue in association with serologic evidence of active Epstein-Barr virus ( EBV ) infection were studied. (digitalnaturopath.com)
Ganciclovir appears promising for treatment of severe CMV infection in patients with kidney or liver transplants. (elsevierpure.com)
The rate of bacterial and viral infections was comparable between patients with and without steroids, although in the former group, cytomegalovirus infection developed earlier ( p = 0.03). (bvsalud.org)
AIMS: Pharmacokinetics of tacrolimus after sublingual administration is not characterized in paediatric liver transplant patients. (bvsalud.org)
Compared to sedated patients, nonsedated status showed an increased first-order absorption rate constant (1.1 vs. 0.1 h-1 ) and a 24% reduction in bioavailability (FNS ) at 14 days post-transplant. (bvsalud.org)
In fact, the survival of these patients is usually lower compared with the patients undergoing a first transplant. (bvsalud.org)
Severe focal disease, including retinitis, can develop in HIV-infected patients and in organ transplant recipients and other immunocompromised patients. (msdmanuals.com)
The study found letermovir was noninferior to valganciclovir through week 52 after a kidney transplant, with 10% of patients in the letermovir group developing CMV disease compared with 12% in the valganciclovir group. (worldmedicinefoundation.com)
The most common adverse effect was diarrhea, which was reported in at least 10% of patients in the letermovir group, as well as tremor and urinary tract infection. (worldmedicinefoundation.com)
Foscarnet is effective in managing HSV infections, including both mucocutaneous and systemic infections, in patients with compromised immune systems. (arkonsolution.com)
Management of Severe Infections: It is beneficial in managing severe cases of viral infections in immunocompromised patients, helping to alleviate symptoms and prevent the progression of the disease. (arkonsolution.com)
For instance, cytomegalovirus (CMV) infection has been associated with colonic inflammation in immunocompromised individuals such as organ transplant recipients or patients who have HIV/AIDS. (healthiersteps.com)
HCMV is the most common opportunistic viral pathogen in transplant recipients leading to significant disease in these patients," explains Chan. (upstate.edu)
Treatment of dermatomal herpes zoster in immunocompromised patients † including transplant recipients and HIV-infected patients. (drugs.com)
1 The positive opinion from the CHMP was based on the SOLSTICE trial, which evaluated the safety and efficacy of maribavir versus conventional antiviral therapies-ganciclovir, valganciclovir, foscarnet or cidofovir-for the treatment of patients with CMV infection refractory, with or without resistance. (newsonfloor.com)
Post-transplant care is critical for transplant recipients, and CMV infection can jeopardize successful outcomes for patients," said Daniel Curran, Head, Rare Diseases Therapeutic Area, Takeda. (newsonfloor.com)
The CHMP positive opinion on the marketing authorization of maribavir is a positive step toward redefining the CMV treatment landscape for transplant patients and their healthcare providers across Europe and toward addressing a great unmet need for this community. (newsonfloor.com)
CMV is one of the most common infections experienced by transplant patients, with a global estimated incidence rate of 16%-56% in SOT recipients and 30%-70% in HSCT recipients. (newsonfloor.com)
Serious disease may occur in individuals with compromised immune systems, which includes patients who receive immunosuppressants associated with various types of transplants including HSCT or SOT. (newsonfloor.com)
In November 2021, maribavir received U.S. Food and Drug Administration (FDA) approval, under the brand name LIVTENCITY TM , for the treatment of adults and pediatric patients (12 years of age or older and weighing at least 35 kg) with post-transplant cytomegalovirus (CMV) infection/disease that is refractory to treatment (with or without genotypic resistance) with ganciclovir, valganciclovir, cidofovir, or foscarnet. (newsonfloor.com)
What does lung transplant offer patients with advanced lung disease? (ersjournals.com)
Identifying those patients with end-stage lung disease who might benefit from lung transplant and referring them promptly for specialist assessment is very important. (ersjournals.com)
Referring clinicians play an essential role in identifying patients who might benefit, but equally need to avoid overwhelming transplant centres with inappropriate referrals which would limit the effectiveness of the centre to assess and list in a timely manner those most likely to benefit. (ersjournals.com)
How should patients with or at risk for cytomegalovirus be managed? (cancertherapyadvisor.com)
What happens to patients with cytomegalovirus? (cancertherapyadvisor.com)
Influence of cytomegalovirus disease in outcome of solid organ transplant patients[J]. Transplant Proc, 2011, 43(6):2145-2148. (organtranspl.com)
This means some patients may have to wait for a long time, sometimes as long as 7 years, to have a transplant. (medicaltourism.com)
These various impediments open the door to transplant tourism, seeing patients from the US and other developed countries travel to countries - mostly China, India, Philippines, and Pakistan - where they can have the procedure done faster and at affordable rates. (medicaltourism.com)
In Taiwan, China, of 118 patients who underwent organ transplants with illegally harvested organs, 69 reported that the procedures were facilitated by doctors. (medicaltourism.com)
Human cytomegalovirus (HCMV) is an important pathogen in transplant patients and in congenital infection. (londonmet.ac.uk)
The objective of this work was to determine the incidence of infection caused by CMV in a cohort of renal transplanted patients, using the antigenemia as a diagnostic tool. (ufrgs.br)
Les résultats sérologiques de 10 560 patients ayant une infection par EBV suspecte ont été évalués. (who.int)

Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. (cdc.gov)
It was approved by the FDA in 2017 for prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant. (worldmedicinefoundation.com)

Organ Procurement Organization Nucleic Acid Testing Yield Project T. Estimated risk of human immunodeficiency virus and hepatitis C virus infection among potential organ donors from 17 organ procurement organizations in the United States. (cdc.gov)
recipients who are seronegative for Herpes Simplex Virus (HSV) receiving an organ from HSV seropositive donors [2D]. (bts.org.uk)
Recipients of blood transfusions from donors with positive CMV antibodies are at some risk. (digitalnaturopath.com)
The widespread prevalence of the virus means there's a risk that organ donors may transmit it when they donate. (worldmedicinefoundation.com)
Illegal organ trafficking has penetrated transplant medicine for more than a decade now, with several individuals and groups illegally harvesting organs from living donors and facilitating such activities. (medicaltourism.com)
While the Chinese authorities maintained that organs for transplant have been provided by voluntary donors or from executed convicts on death rows, there is fresh evidence to the contrary. (medicaltourism.com)
In some instances, live donors are flown from their home countries to the recipient's country and in others, both recipients and donors are transferred to another country to have the transplant surgery done. (medicaltourism.com)
More than 100 illegal kidney transplant surgeries were performed in South Africa between 2001 and 2002, with most of the recipients traveling from Israel and donors coming from Brazil and parts of eastern Europe. (medicaltourism.com)
Factors associated with an increased risk for PSC recurrence include a high Model for End-Stage Liver Disease score, first-degree relative donors, post-transplant cytomegalovirus infection , and early biliary anastomotic complications. (medscape.com)

Cytomegalovirus (CMV) is a serious infection that can cause disease in organ transplant recipients and can raise the risk of organ rejection. (worldmedicinefoundation.com)
HCMV can significantly raise the chance of organ rejection, making its treatment crucial for those needing a life-saving transplant. (upstate.edu)
Mycophenolate mofetil is an antimetabolite immunosuppressant indicated for the prophylaxis of organ rejection in recipients of allogeneic kidney, heart or liver transplants, and should be used in combination with other immunosuppressants. (nih.gov)

Bronchiolitis obliterans (BO) after LTx was first described in 1984 at Stanford University, Stanford, CA, USA, in heart-lung transplant recipients who showed a progressive decline inforced expiratory volume in one second (FEV 1 ) 3 . (ersjournals.com)
In March 2022, a 61-year-old woman in France who had received a heart-lung transplant sought treatment with chronic hepatitis mainly characterized by increased liver enzymes. (cdc.gov)
Clinical and laboratory data over time for a heart-lung transplant patient in France who had cytolytic hepatitis caused by HCirV-1 develop. (cdc.gov)
The patient had received a heart-lung transplant 17 years earlier because of Eisenmenger syndrome related to ventricular septal defect. (cdc.gov)
J Heart Lung Transplant 1998;17:703-709. (medigraphic.com)
J Heart Lung Transplant 2005;24:956-967. (medigraphic.com)

Findings to date Detailed clinical and laboratory data in high granularity as well as patient-reported outcomes from transplant recipients and activities in Switzerland are available in the last decade. (bmj.com)
This is an open label trial to assess the tolerability and clinical effectiveness of letermovir when used in preventing relapsing CMV disease and infection in solid organ transplant recipients. (tuftsmedicalcenter.org)
Cytomegalovirus (CMV) and congenital CMV infection: clinical overview. (medlineplus.gov)
Ten were evaluable (compatible clinical picture, organ involvement shown histopathologically or by culture, viremia, and absence of concomitant infection). (elsevierpure.com)
Solid organ transplant recipients are highly susceptible to infections that sometimes have uncommon clinical manifestations ( 1 - 3 ). (cdc.gov)
Agnostic metagenomic analysis of clinical samples based on next-generation sequencing (NGS) combined with specifically designed PCRs constitute promising tools for diagnosing infection with unforeseen or novel microorganisms ( 8 ). (cdc.gov)
BACKGROUND: Cytomegalovirus infection in renal transplant recipients is a major clinical problem, with both short and long term sequelae. (ox.ac.uk)
Clinical experience shared between transplant centres worldwide has helped refine the assessment process so that those added to a waiting list are those who are most likely to benefit. (ersjournals.com)
Since Nocardia species infections are very often sporadic, information from randomized clinical trials comparing the clinical efficacy of specific antimicrobial agents is lacking. (antimicrobe.org)
The study, which was conducted by Australian researchers led by Wendy Rodgers, Ph.D, a professor of clinical ethics at Macquarie University in Australia, found that 90 percent of these studies did not report how the organs were sourced. (medicaltourism.com)
The most common adverse reactions in clinical trials (20 % or greater) include diarrhea, leukopenia, infection, vomiting, and there is evidence of a higher frequency of certain types of infections e.g., opportunistic infection. (nih.gov)
CMV disease is diagnosed through laboratory evidence of infection associated with a compatible clinical presentation. (ufrgs.br)
Public health jurisdictions are encouraged to evaluate, report, and monitor identified ZIKV infections, particularly in pregnant women, that don't meet the clinical criteria of the confirmed and probable congenital and non-congenital disease case classifications. (cdc.gov)

CMV can be transmitted sexually and via breast milk, and also occurs through receiving transplanted organs or blood transfusions. (wikipedia.org)

The first is primary infection, in which the patient has never been exposed to the pathogen but becomes infected by a patient who is seropositive for the virus. (medscape.com)
In mothers who are seropositive before conception, approximately 1% will transmit CMV infection to the fetus as a result of recurrent maternal infection (ie, reactivation or re-infection with another strain of the virus). (contemporarypediatrics.com)
7 Because many women are seropositive before pregnancy, more congenital infections occur as a result of a recurrent rather than primary maternal infection. (contemporarypediatrics.com)
However, the impact of grafting such organs into seropositive recipients is less clear. (ox.ac.uk)
of these, 86.1% were seropositive with an increasing trend of EBV infection over the study period. (who.int)

Cytomegalovirus (CMV) is a member of the Herpesviridae family, along with herpes simplex viruses (HSVs) 1 and 2, Epstein-Barr virus, varicella-zoster virus, and others. (medscape.com)
CMV shares many attributes with other herpes viruses, including genome, virion structure, and the ability to cause latent and persistent infections. (medscape.com)
Cytomegalovirus (CMV) infection is a disease caused by a type of herpes virus. (medlineplus.gov)
All herpes viruses remain in your body for the rest of your life after infection. (medlineplus.gov)
Cytomegalovirus ( CMV ) is a virus belonging to the herpes family. (digitalnaturopath.com)
One research group reported that lithium inhibits the reproduction of several viruses, including herpes simplex viruses (HSV 1, HSV 2), adenovirus (the "common cold" virus), cytomegalovirus, Epstein-Barr virus (associated with mononucleosis and many cases of chronic fatigue), and the measles virus. (digitalnaturopath.com)
Foscarnet injection is a medication that is primarily used for the treatment of certain viral infections, particularly those caused by the herpes virus. (arkonsolution.com)
Treatment for Resistant Infections: Foscarnet is often used when viral infections, particularly those caused by herpes viruses, develop resistance to standard antiviral therapies. (arkonsolution.com)
TORCH which includes Toxoplasma, Rubella, Cytomegalovirus & Herpes Simplex virus, are some of the most common infections associated with Congenital anomalies. (truemedix.in)
Positive result of HSV (1+2) IgG indicates past infection with Herpes Simplex virus or administration of HSV immunoglobulins. (truemedix.in)
Herpes Simplex virus, are some of the most common infections associated with Congenital anomalies. (truemedix.in)

The approval for CMV disease prophylaxis in adult kidney transplant recipients is based on a phase 3 trial of the drug, published this week in the Journal of the American Medical Association, by Ajit P. Limaye MD, of UW Medicine, Seattle, Washington and colleagues, and simultaneously presented at the American Transplant Congress 2023 in San Diego. (worldmedicinefoundation.com)
Transplant Proc 1992;24:2022-2023. (medigraphic.com)

CMV also causes serious disease in solid organ (SOT) and haematopoietic stem cell transplant (HSCT) recipients. (viruseradication.com)
Alternative to varicella-zoster immune globulin (VZIG) for postexposure prophylaxis of VZV infection † in HSCT recipients. (drugs.com)
Although long-term prophylaxis not routinely recommended for prevention of recurrent VZV infections in HSCT recipients, such prophylaxis may be considered in those with severe, long-term immunodeficiency. (drugs.com)
5 Out of the estimated 200,000 adult transplants per year globally, CMV is one of the most common viral infections experienced by transplant recipients, with an estimated incidence rate between 16-56% in SOT recipients and 30-70% in HSCT recipients. (newsonfloor.com)

Foscarnet is known for its potent antiviral properties , making it a crucial treatment option for viral infections that do not respond to other medications. (arkonsolution.com)
While less common than bacterial or viral infections, certain fungal species can also contribute to colon inflammation. (healthiersteps.com)

ABSTRACT In Bahrain, adequate epidemiological information is lacking concerning the rate of EBV infection, which could be helpful in order to develop measures to protect against EBV infections. (who.int)

Currently there are no licensed CMV vaccines, but there is increased interest in developing and testing potential candidates, driven by the demonstration that a recombinant CMV glycoprotein B (gB) vaccine has some efficacy in prevention of infection in young women and adolescents, and in CMV-seronegative SOT recipients. (viruseradication.com)

In developing countries, most infections are acquired during childhood, whereas in developed countries, up to 50% of young adults are CMV seronegative. (medscape.com)
Primary CMV infections occur in 1% to 4% of seronegative pregnant women. (contemporarypediatrics.com)
Additionally, sera from seronegative vaccine recipients had minimal effect on the replication of a strain of HCMV engineered to be cell-associated in a viral spread assay. (londonmet.ac.uk)
Furthermore, although natural infection can induce antibody-dependent cellular cytotoxicity (ADCC) responses, serological analysis of seronegative vaccinees again presented no evidence of a substantial ADCC-promoting antibody response being generated de novo. (londonmet.ac.uk)

Many complications normally follow these, which are postoperative infections, pneumonia and septicemia. (nephrologistinagartala.com)
Moreover, in these tough times, when Corona cases have spread all over the world, post-COVID-19 pneumonia can lead to serious complications in kidney transplant recipients. (nephrologistinagartala.com)
So, if you need to undergo a kidney transplant, consult your doctor and take the necessary precautions to avoid complications after the surgery. (nephrologistinagartala.com)

Participants Over 5500 solid organ transplant recipients have been enrolled in all six Swiss transplant centres by end of 2019, around three-quarter of them for kidney and liver transplants. (bmj.com)

To highlight common problems encountered in lung transplant recipients and explain how they are managed. (ersjournals.com)

Outcomes of SOT Recipients With COVID-19 in Different Eras of COVID-19 Therapeutics. (nih.gov)
Outcomes of transplant recipients treated with cidofovir for resistant or refractory cytomegalovirus infection. (nih.gov)
Researchers across disciplines are striving to better understand the epidemiology of congenital CMV, improve diagnostic tools, develop new treatments, and explore interventions for preventing infection and improving outcomes for infected infants. (contemporarypediatrics.com)
Increased susceptibility to infections, including opportunistic infections and severe infections with fatal outcomes [see Warnings and Precautions (5.3) ]. (nih.gov)
Although early national data demonstrated inferior outcomes in LDLT recipients, recent data reveal excellent outcomes when the procedure is performed at an experienced center. (medscape.com)

From November 2007 through April 2012, adult renal transplant recipients were randomized, in an open-label, single-center study, at a 1:1 ratio to 3-month prophylaxis with valganciclovir ( n = 60) or valacyclovir ( n = 59). (biomedcentral.com)
Intravenous ganciclovir, or its oral prodrug valganciclovir, are the antivirals generally used for the prevention and treatment of CMV infection, according to Zoe Raglow, MD, and Daniel Kaul, MD, from the University of Michigan Medical School, who co-authored an accompanying editorial about the study, also published in JAMA . (worldmedicinefoundation.com)
In the week following their kidney transplant, one group received letermovir 480 mg once-daily with 400 mg acyclovir twice daily (n = 292), and a valganciclovir placebo. (worldmedicinefoundation.com)

Overall unadjusted graft and patient post-transplant survival was significantly higher for LDLT recipients, although the benefit was restricted to centers that had performed more than 15 LDLT procedures. (medscape.com)

In transplant recipients, reactivation of CMV can lead to serious consequences including loss of the transplanted organ and, in extreme cases, can be fatal. (newsonfloor.com)
Most primary infections occur between 1 and 5 years while most reactivation infections occur after the age of 25 years. (who.int)

It helps to prevent the progression of CMV-related diseases, such as retinitis and gastrointestinal infections. (arkonsolution.com)
However, immunocompromised individuals, such as those with HIV/AIDS, organ transplant recipients, or those undergoing chemotherapy, are susceptible to developing illnesses such as pneumonitis or retinitis. (rainier-research.com)

The two peaks for primary CMV infection occur in preschool children and young adults. (medscape.com)
Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infection in infants and children and the second most common viral cause of pneumonia in adults. (medscape.com)
In otherwise healthy children and adults, primary CMV infection rarely causes illness. (viruseradication.com)
60 to 90% of adults have CMV infection (resulting in lifelong latent infection). (msdmanuals.com)
Chronic suppressive or maintenance therapy (secondary prophylaxis) of recurrent HSV infections † [off-label] in immunocompromised adults, adolescents, and children, including HIV-infected individuals who have frequent or severe recurrences. (drugs.com)

Primary infection in immunocompetent hosts causes few or no symptoms. (medscape.com)
Symptoms, when apparent, develop 9-60 days after primary infection. (medscape.com)
Contact your provider for an appointment if you have symptoms of CMV infection. (medlineplus.gov)
Individuals with normal immune systems usually do not experience symptoms from a primary CMV infection. (contemporarypediatrics.com)
CMV infection can cause more severe symptoms, however, in fetuses, in HIV-infected individuals, and in organ transplant recipients who are on immunosuppressive therapies. (contemporarypediatrics.com)
Our latest blog delves into cytomegalovirus(CMV), exploring symptoms and risks associated with healthy and immunocompromised individuals. (rainier-research.com)

Twelve liver and 5 kidney transplant recipients with severe cytomegalovirus infection were treated with Ganciclovir (7.5 mg/kg/day, intravenously). (elsevierpure.com)

Bone marrow transplant. (bvsalud.org)

The US Food and Drug Administration (FDA) has approved letermovir (Prevymis) for the additional indication of prevention of cytomegalovirus in high-risk adult kidney transplant recipients. (worldmedicinefoundation.com)
serologic evidence of prior infection can be found in 40%-100% of various adult populations. (newsonfloor.com)
The number of adult lung transplants reported to the ISHLT each year since 1985. (ersjournals.com)

Human Cytomegalovirus (CMV) is a member of the family Herpesviridae, also known as Human Herpesvirus 5 (HHV-5). (medscape.com)
Human betaherpesvirus 5, also called human cytomegalovirus (HCMV), is species of virus in the genus Cytomegalovirus, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. (wikipedia.org)
Chan, an associate professor of microbiology and immunology at SUNY Upstate Medical University, said his lab is focused on studying host-pathogen interactions involving human cytomegalovirus (HCMV) and understanding how HCMV-mediated alterations to cellular function lead to human disease. (upstate.edu)

According to the World Health Organization (WHO), about 100,800 solid organ transplants are done every year, most of which are liver and kidney transplants. (medicaltourism.com)

Who should be referred for lung transplant assessment and when? (ersjournals.com)
The first lung transplant in man (1963) and the first Heart transplant in man (1964). (medigraphic.com)
The Toronto lung transplant group. (medigraphic.com)
International guidelines for selection of lung transplant candidates. (medigraphic.com)

Obliteration of small airways by these lesions produces progressive airflow obstruction, often accompanied by recurrent lower respiratory tract infection. (ersjournals.com)

Primary CMV infection may be a cause of fever of unknown origin. (medscape.com)
5,6 Each year in the United States, an estimated 27,000 pregnant women experience primary CMV infection and are thus at high risk of giving birth to a child with congenital CMV. (contemporarypediatrics.com)

eCollection 2022 Jan. Transplant Direct. (nih.gov)

With the advent of immunosuppressive medications and the increased incidence of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) in the early 1980s, a new class of CMV infection was described. (medscape.com)
Human immunodeficiency virus infection in transplant recipients. (cdc.gov)
A third category of CMV infection can occur as a complication of AIDS ( acquired immunodeficiency syndrome ). (encyclopedia.com)

However, chronic allograft dysfunction in the form of bronchiolitis obliterans remains a major hurdle that threatens both the quality of life and long-term survival of the recipients. (ersjournals.com)
After single LTx, survival after BOS onset is longer in recipients with emphysema compared with recipients with idiopathic pulmonary fibrosis 8 . (ersjournals.com)
There is a decreased survival rate among kidney transplant recipients with HCV infection. (nephrologistinagartala.com)
In experienced centres, specific patient groups, such as those with cystic fibrosis (CF), can expect a median survival of well over 10 years with some recipients functioning well more than 20 years after their transplant. (ersjournals.com)
based on the severity and nature of illness of the prospective recipient, the chances of survival of the patient without a timely transplant, and the availability of the organs. (medicaltourism.com)

9 Such disability can result from maternal infection during any point in the pregnancy, but more severe disabilities are usually associated with maternal infection during the first trimester. (contemporarypediatrics.com)
Typically, a healthy person isn't aware of the infection, but HCMV can cause severe and sometimes fatal disease in immunocompromised individuals and newborns. (upstate.edu)
The spectrum of the disease ranges from completely assymptomatic all the way up to a severe systemic disease with multiple organ compromise. (ufrgs.br)

As with the other members of this family, CMV has the ability to produce a latent infection. (medscape.com)
Studies with in-situ hybridization have shown that CMV DNA can persist in a latent form in most organs of the body. (medscape.com)
After infection, HCMV remains latent within the body throughout life and can be reactivated at any time. (wikipedia.org)
After initial infection, all herpesviruses remain latent within specific host cells and may subsequently. (msdmanuals.com)

Within Herpesviridae, HCMV belongs to the Betaherpesvirinae subfamily, which also includes cytomegaloviruses from other mammals. (wikipedia.org)
Although they may be found throughout the body, HCMV infections are frequently associated with the salivary glands. (wikipedia.org)
HCMV infection is typically unnoticed in healthy people, but can be life-threatening for the immunocompromised, such as HIV-infected persons, organ transplant recipients, or newborn infants. (wikipedia.org)
HCMV infection is more widespread in developing countries and in communities with lower socioeconomic status and represents the most significant viral cause of birth defects in industrialized countries. (wikipedia.org)

Cytomegalovirus (CMV) is the most common source of congenital infection in newborns and is a leading cause of hearing loss and intellectual disability in the United States. (contemporarypediatrics.com)
Due to the rapidly evolving epidemic of Zika virus infection, the Council of State and Territorial Epidemiologists (CSTE) Executive Board developed an interim position statement to establish standardized case definitions for Zika virus disease and ZIKV congenital infection dated February 26, 2016, and to add these conditions to the Nationally Notifiable Diseases List. (cdc.gov)

But usually, it's people with a weakened immune system, such as those with HIV/AIDS, who become ill from CMV infection. (medlineplus.gov)
Foscarnet is also used in the treatment of CMV infections, particularly in immunocompromised individuals, such as those with HIV/AIDS or organ transplant recipients. (arkonsolution.com)

Cytomegalovirus (CMV) is a major infectious agent in renal allograft recipients. (ufrgs.br)

Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America. (cdc.gov)
Management of infectious diseases is a critical component of care of solid organ transplant recipients. (biomedcentral.com)
Herpesviruses: Cytomegalovirus A number of infectious diseases cause uveitis (see table Infectious Causes of Uveitis). (msdmanuals.com)
Gary Chan, PhD has been awarded a five-year $3.2 million grant National Institute of Allergies and Infectious Diseases to find a treatment for one of the most dangerous infections for transplant recipients. (upstate.edu)

Eighty-six percent had serologic evidence of cytomegalovirus ( CMV ) infection. (digitalnaturopath.com)

Some otherwise healthy people with CMV infection develop a mononucleosis-like syndrome. (medlineplus.gov)

After colitis, esophagitis is the most common gastrointestinal (GI) manifestation of cytomegalovirus (CMV) infection. (medscape.com)
Infection with CMV is very common. (medlineplus.gov)
Throat infection is the most common complication. (medlineplus.gov)
Congenital cytomegalovirus (CMV) infection is the most common infectious cause of disability in newborn infants. (viruseradication.com)
Congenital and Perinatal Cytomegalovirus Infection (CMV) Cytomegalovirus infection may be acquired prenatally or perinatally and is the most common congenital viral infection. (msdmanuals.com)
The most common bacterial infections, from which kidney transplant recipients suffer, are urinary tract infections (UTIs). (nephrologistinagartala.com)
It's the most common viral infection infants can acquire while still in the uterus, affecting about one in every 200 newborns. (rainier-research.com)
EBV is a common viral infection in Bahrain. (who.int)
Control measures for outbreaks of viral gastroenteritis should focus on the removal of an ongoing common source of infection (e.g., an ill food handler or the contamination of a water supply) and on the interruption of person-to-person transmission that can perpetuate an outbreak in a population after the common source has been removed. (cdc.gov)

Another antiviral maribavir (Livtencity), which inhibits the activity of a viral protein kinase, was approved in November 2021 for the treatment of post-transplant CMV that is resistant to other drugs in transplant recipients aged 12 years or older who weigh at least 35 kg (77 pounds). (worldmedicinefoundation.com)

Among the kidney transplant recipients, there are cases of morbidity and mortality due to infections. (nephrologistinagartala.com)
A major cause of morbidity and mortality after kidney transplant is infection from Epstein-Barr virus (EBV) as it has a connection with PTLD development. (nephrologistinagartala.com)
There are morbidity and mortality from HCV in kidney transplant recipients. (nephrologistinagartala.com)

Anatomy25

Organisms13

Diseases34

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Psychiatry and Psychology1

Phenomena and Processes35

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science5

Named Groups4

Health Care14

Geographicals1

Undergoing long-1

Transplantation34

Asymptomatic6

Donor13

Patients51

Hematopoietic2

Donors9

Rejection3

Heart-lung trans6

Clinical13

Blood transfusions1

Seropositive5

Herpes11

20232

HSCT4

Viral infections2

Abstract1

Efficacy1

Seronegative4

Complications3

Kidney and liver transplants1

Encountered in lung transplant recipients1

Outcomes5

Valganciclovir3

Graft1

Reactivation2

Retinitis2

Adults5

Symptoms6

Ganciclovir1

Bone marrow tra1

Adult3

Human cytomegalovirus3

Solid organ transplants1

Lung transplant4

Recurrent1

Primary CMV infection2

20221

Immunodeficiency3

Survival5

Severe3

Latent4

HCMV4

Congenital infection2

AIDS2

Renal allograft1

Infectious diseases4

Serologic evidence1

Mononucleosis1

Common9

Least 35 kg1

Morbidity and morta3