• Comprehensive and state-of-the-art, Cytomegalovirus Protocols provides investigators with a powerful collection of the key methods that are illuminating not only the basic biology of this complex and intriguing human herpesvirus, but also its significant role in the pathogenesis of human infectious diseases as well as their emergent therapies. (springer.com)
  • We propose that the cell type in which a human cytomegalovirus particle is produced likely influences its subsequent spread and its contribution to pathogenesis. (pnas.org)
  • Beersma MF, Bijlmakers MJ, Ploegh HL (1993) Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. (springer.com)
  • Cytomegalovirus (CMV) is increasingly recognized as an accomplished modulator of cell-signaling pathways, both directly via interaction between viral and cellular proteins, and indirectly by activating metabolic/energy states of infected cells. (nih.gov)
  • Infection of susceptible mice with murine cytomegalovirus (MCMV) induces persistent inflammation, and the production of autoantibodies reactive with large numbers of proteins from all major organs. (nih.gov)
  • Human cytomegalovirus has a complex double-stranded DNA genome of ≈240,000 bp that contains ≈150 ORFs likely to encode proteins, most of whose functions are not well understood. (pnas.org)
  • Murine cytomegalovirus carries a CC (β) chemokine homolog gene giving rise to two related proteins, murine cytomegalovirus chemokine 1 and 2 (MCK-1 and MCK-2). (pnas.org)
  • The positive and negative cis-acting elements that affect transcription from the human cytomegalovirus major immediate-early (MIE) promoter and the viral and cellular proteins that bind to these elements are discussed. (nih.gov)
  • Beswick M, Pachnio A, Lauder SN, Sweet C, Moss PA (2013) Antiviral therapy can reverse the development of immune senescence in elderly mice with latent cytomegalovirus infection. (springer.com)
  • Cytomegalovirus (CMV) is a globally widespread virus that becomes latent following primary infection but reactivates frequently and, in the setting of immunocompromise, causes disease in solid organ transplant patients, including kidney transplant recipients [ 1 ]. (uptodate.com)
  • cytomegalovirus sī˝təmĕg˝əlōvī´rəs [ key ] , member of the herpesvirus family that can cause serious complications in persons with weakened immune systems. (factmonster.com)
  • As noted, cytomegalovirus (CMV) is a member of a family of 8 human herpesviruses, officially designated as human herpesvirus type 5 (HHV-5). (medscape.com)
  • this genus contains Mouse cytomegalovirus (MCMV) is also known as Murid herpesvirus 1 (MuHV-1) and the closely related Murid herpesvirus 2 (MuHV-2) that is found in rats. (wikipedia.org)
  • Outros dous virus identificados no mono Aotus foron situados provisoriamente no xénero Cytomegalovirus , e denomínanse Herpesvirus aotus 1 e Herpesvirus aotus 3 . (wikipedia.org)
  • In 2013, Astellas Pharma has started on individuals who received a hematopoietic stem cell transplant a Phase III trial with its CMV deoxyribonucleic acid DNA cytomegalovirus vaccine ASP0113. (wikipedia.org)
  • Merck & Co. issued results of a phase III study of letermovir for the prevention of clinically significant cytomegalovirus (CMV) infection in adult (18 years and older) CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT), also known as bone marrow transplant (BMT). (centerwatch.com)
  • Chimerix reported results of a phase II trial CMX001-201 evaluating brincidofovir (CMX001) for the prevention of cytomegalovirus (CMV) infection in hematopoietic cell transplant (HCT) recipients. (centerwatch.com)
  • Cytomegalovirus diseases after hematopoietic stem cell transplantation: a mini-review. (nih.gov)
  • Cytomegalovirus (CMV) infection remains a significant complication after hematopoietic stem cell transplantation (HSCT) and may have a deleterious impact on the overall outcome after transplantation. (nih.gov)
  • Cytomegalovirus (CMV) neurologic disease is an uncommon serious complication of AIDS, which can cause paralysis or rapidly fatal encephalitis. (uptodate.com)
  • Cytomegalovirus (CMV) is a virus found around the world. (medlineplus.gov)
  • A common virus, it is estimated that up to 80% of Americans carry cytomegalovirus by the time they reach adulthood. (factmonster.com)
  • Congenital cytomegalovirus is a condition that can occur when an infant is infected with a virus called cytomegalovirus (CMV) before birth. (medlineplus.gov)
  • Cytomegalovirus (CMV) is a common virus. (thebody.com)
  • Congenital cytomegalovirus is caused when an infected mother passes the virus to the fetus through the placenta. (medlineplus.gov)
  • But cytomegalovirus (site-uh-meg-uh-low-VY-rus) can cause problems for an unborn child whose mother has the virus and for people with weakened immune systems . (kidshealth.org)
  • Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. (uptodate.com)
  • Cytomegalovirus (CMV) is a ubiquitous virus that can have a devastating effect on the fetus. (healio.com)
  • The Bottom Line Introduction Cytomegalovirus (CMV) is a common virus. (thebody.com)
  • Good luck to both you and your dad.Dr. Bob Cytomegalovirus (CMV) October 2007Introduction Cytomegalovirus (CMV) is a common virus. (thebody.com)
  • As the Zika virus continues to spread across the globe, and gain worldwide attention for its' potential birth defects, an NAU researcher is calling for greater public awareness of cytomegalovirus-the most common viral cause of birth defects in the United States. (news-medical.net)
  • This is a urine test for cytomegalovirus (CMV), a common virus that belongs to the herpes family. (rochester.edu)
  • The participation of the cytomegalovirus in the etiopathogenesis of neonatal hepatitis has been already known for some time, but only recently there have been indications that this virus may be one of the possible etiological factors for extrahepatic biliary atresia. (mendeley.com)
  • Cytomegalovirus (CMV) is a virus that spreads through contact with body fluids, such as blood, saliva, urine, and tears. (drugs.com)
  • Exposure to cytomegalovirus, herpes simplex virus type 2, or toxoplasma gondii was associated with cognitive deterioration in older individuals. (greenmedinfo.com)
  • Although there is no definite proof of a causal role of human cytomegalovirus in atherogenesis, a body of knowledge supports the concept that this virus is involved in the development of atherosclerotic lesions. (nih.gov)
  • Cowdry bodies are eosinophilic nuclear inclusions composed of nucleic acid and protein seen in cells infected with Herpes simplex virus, Varicella-zoster virus, and Cytomegalovirus. (wikipedia.org)
  • The cause is still unknown, although it has been associated with several infectious causes, including paratyphoid fever, cytomegalovirus, Mycoplasma pneumoniae and Epstein-Barr virus infection The most common presentation is a single large, deep ulcer (although several smaller ulcers may occur) in the internal surface of one or both labia minora. (wikipedia.org)
  • It can also be caused by Epstein-Barr virus, herpes simplex virus, cytomegalovirus, or HIV. (wikipedia.org)
  • Herpes simplex virus (rare), Adenovirus, Cytomegalovirus[citation needed] Candida Albicans Parasitic causes include Trichomonas vaginalis (rare). (wikipedia.org)
  • It works by targeting the transcribed mRNA of the virus and consequently inhibiting replication of cytomegalovirus. (wikipedia.org)