Cytokines that regulate. Medical search. Frequent questions

Chemokines are secretory cytokines able to attract migratory cells. (europa.eu)
Cytokines and chemokines in cerebrospinal fluid and serum of adult patients with acute disseminated encephalomyelitis. (medscape.com)
Previously, we have shown in a mouse model that exposure to hog dust extract (HDE) collected from a CAFO results in the activation of protein kinase C (PKC), elevated lavage fluid cytokines/chemokines including interleukin-6 (IL-6), and the development of significant lung pathology. (cdc.gov)
Recently, we analyzed serum biomarkers by using samples from the Gulu outbreak and identified associations between cytokines/chemokines, acute-phase reactants, markers of coagulopathy, and markers of endothelial function and patient death, hemorrhage, and viremia. (cdc.gov)

The results from this model of cognate interaction suggest that cytokine-stimulated T cells, interacting with macrophages in the rheumatoid synovial membrane, may contribute to the continuous excessive production of TNF-alpha observed in the RA joint, and to the imbalance of pro-inflammatory cytokines over anti-inflammatory cytokines. (ox.ac.uk)
Were observed significantly elevated levels of pro-inflammatory and anti-inflammatory cytokines in patients with poorly controlled type 2 diabetes and chronic periodontitis, demonstrating that glycemic control may be associated to the immune inflammatory response of sites with chronic periodontitis. (bvsalud.org)
but may also inhibit anti-inflammatory cytokines. (bvsalud.org)

In addition, the cytokine byproduct TGF-β activates macrophages to have an M2-like tumor-associated macrophage (TAM) phenotype. (nature.com)
Together, these observations indicate that in LPS-stimulated murine macrophages LRG47 is induced by IFN-beta and negatively regulates TLR4 signaling to prevent excess proinflammatory cytokine production and shock. (duke.edu)
Glycans are one of the four fundamental macromolecular components of all cells and are highly regulated in immune cells, including macrophages. (frontiersin.org)

BACKGROUND: Main pathological features detected during sepsis and endotoxemia include over-secretion of pro-inflammatory cytokines and multiorgan dysfunction syndrome (MODS). (unab.cl)
RESULTS: Inhibition of TRPM7 with carvacrol and suppression with AdVshTRPM7 were both efficient in inhibiting the over-secretion of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-12, in endotoxemic rats, without inducing downregulation in blood levels of antiinflammatory cytokines IL-10 and IL-4. (unab.cl)
Fixed, cytokine-stimulated T cells induced monocytes to secrete TNF-alpha in a dose-dependent manner, but did not induce secretion of IL-10, a potent endogenous down-regulator of TNF-alpha and other pro-inflammatory cytokines. (ox.ac.uk)
Stimulation of TLRs by PAMPs initiates a signaling cascade leading to the secretion of proinflammatory cytokines following NF-κB activation. (invivogen.com)
Pathophysiologically, asthma exert different effects at different concentrations, can is characterized by constriction of airway smooth synergize or antagonize the effects of other cytokines muscle, hyper secretion of mucus, edema and airway and regulated in a complex manner and function via hyper responsiveness (AHR),[3] mucus secretion and cytokine cascade. (cdc.gov)
Periodontal disease is considered a chronic infectious inflammatory disease characterized by intense leukocyte infiltration in the periodontal tissue resulting in secretion of various cytokines that lead to deleterious inflammatory processes and destruction of the periodontal tissue and alveolar bone 1 . (bvsalud.org)

Socs3(Δ/Δcol2) mice developed exacerbated inflammation and joint damage in response to gp130 cytokine injections, and these histopathologic features were also observed in mice with inflammatory monarthritis. (nih.gov)
Loss of cIAPs and XIAP in the myeloid lineage caused overproduction of many proinflammatory cytokines, resulting in granulocytosis and severe sterile inflammation. (ox.ac.uk)
2012 ). CDK9 regulates inflammation by interacting with p65 and inhibiting the IL-6/STAT3 signaling pathway (Hou et al. (researchsquare.com)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
4] After allergen exposure, that produced exceptionally large quantities of airway inflammation is orchestrated mainly by cytokine IL-9. (cdc.gov)
A member of the S100 PROTEIN FAMILY that regulates INFLAMMATION and the immune response. (bvsalud.org)

Gene ontology and upstream regulator pathway analysis showed that WNK1 regulates cell migration, differentiation, and proliferation. (bioone.org)
Yang M, Zhai X, Ge T, Yang C and Lou G: MiR-181a-5p promotes proliferation and invasion, and inhibits apoptosis of cervical cancer cells via regulating inositol polyphosphate-5-phosphatase A (INPP5A). (spandidos-publications.com)

To examine the impact of the gp130 cytokine family on murine articular cartilage and to explore a potential regulatory role of suppressor of cytokine signaling 3 (SOCS-3) in murine chondrocytes. (nih.gov)
Emerging data associates impaired autophagy, increased activity in the endocannabinoid system and upregulation of suppressor of cytokine signaling (SOCS)-3 protein expression during intestinal inflammatory states. (lancs.ac.uk)
Woolson, H. D. , Thomson, V. S. , Rutherford, C. , Yarwood, S. J. and Palmer, T. M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. (gla.ac.uk)
The inhibitory effects of cAMP on sIL-6Ra/IL-6-stimulated phosphorylation of ERK1,2 and STAT3 were abolished by either short interfering (si) RNA-mediated knockdown or genetic ablation of suppressor of cytokine signalling-3 (SOCS-3). (gla.ac.uk)
Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling. (lu.se)
The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family of E3 ubiquitin ligases. (lu.se)
Dive into the research topics of 'Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling. (lu.se)

Scholars@Duke publication: The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. (duke.edu)
In addition, LRG47-deficient mice are highly susceptible to LPS, but not TLR2 ligand-induced shock, an outcome that correlates with enhanced proinflammatory cytokine production in vitro and in vivo. (duke.edu)
Therefore, we proposed a regulatory mechanism of miR-488 and miR-920 in proinflammatory cytokine production in GA. (biomedcentral.com)

Taken together, these results demonstrated that IL-19 up-regulates Th2 cytokines on activated T cells and might play an important role in the pathogenesis of asthma. (nih.gov)
For example, RAD18 plays a vital role in regulating the DNA stability of embryonic stem cells and cellular homeostasis in highly prolific cells [ 6 ]. (nature.com)
In contrast, LPS-induced phosphorylation of IFN regulatory factor-3 and expression of IFN-beta or the type I IFN-regulated genes, CCL5 and CCL10, were unaltered in LRG47(-/-) cells. (duke.edu)
MicroRNAs Regulate Cytokine Responses in Gingival Epithelial Cells. (bvsalud.org)
Our findings indicate that specific miRNAs regulate the expression of inflammatory cytokines in human gingival epithelial cells in response to microbial infection . (bvsalud.org)
Our results demonstrate that cIAPs and XIAP together restrain RIPK1- and RIPK3-dependent cytokine production in myeloid cells to critically regulate myeloid homeostasis. (ox.ac.uk)
Yoshino, T 1998, ' Interleukin-18/interferon-gamma-inducing factor, a novel cytokine, up-regulates ICAM-1(CD54)expression in KG-1 cells ', J Leukoc Biol , vol. 64, pp. 519-527. (elsevierpure.com)
In this report, we investigated further whether T cells activated by cytokines in the absence of T cell receptor stimulation also regulate monocyte cytokine production. (ox.ac.uk)
T cells were activated in an antigen-independent manner using the cytokines interleukin (IL)-15 or IL-2 alone, or in combination with IL-6 and TNF-alpha. (ox.ac.uk)
T cell acquisition of monocyte-activating capacity was shown to be dependent on the period of cytokine stimulation, with T cells activated for 8 days more effective than T cells activated for shorter periods. (ox.ac.uk)
B cells specifically are involved in the humoral immune system and produce antibodies , while T cells are involved in the cell-mediated immune system and destroy virus-infected cells and regulate the activities of other white blood cells (Alberts 1989). (newworldencyclopedia.org)
In response to pathogens, some T cells, called "helper T cells," produce cytokines that direct the immune response while other T cells, called "cytotoxic T cells," produce toxic granules that induce the death of pathogen infected cells. (newworldencyclopedia.org)
Cells that retain IKK activity may produce additional cytokines that trigger apoptosis in neighboring IKK-deficient cells, thus creating an amplification loop that eventually results in the death of all of the IKK-deficient cells. (medscape.com)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)
It produces 2 hormones: vasopressin, which causes blood pressure to rise and regulates the amount of water in the body's cells, and oxytocin, which causes the uterus to contract during childbirth and lactation to begin. (medscape.com)

Autophagy is a catabolic process involved in homeostatic and regulated cellular protein recycling and degradation via the lysosomal degradation pathway. (lancs.ac.uk)
In conclusion, the regulatory protein, SOCS3, is itself regulated by autophagy and cannabinoids play a role in this process, which could be important when considering therapeutic applications for the cannabinoids in inflammatory conditions. (lancs.ac.uk)
Production of inflammatory cytokines, IL-1β, TNFα, and IL-6, was significantly enhanced by exogenous ET-1 treatment, and this effect depended on the mitogen-activated protein kinases via intracellular Ca2+ increase, which resulted from the activation of the phospholipase C/inositol 1,4,5-trisphosphate pathway. (elsevierpure.com)
CONCLUSION: Our results indicate TRPM7 ion channel as a key protein regulating inflammatory responses and MODS during sepsis. (unab.cl)
NF-kB activity is normally regulated via the inhibitor kB protein. (medscape.com)

In summary, ODE-induced NOD2 expression is directly dependent on NF-KB signaling, and NOD2 is a negative regulator of complex, organic dust-induced inflammatory cytokine/chemokine production in mononuclear phagocytes. (cdc.gov)
It recruits LEUKOCYTES, promotes cytokine and chemokine production, and regulates leukocyte adhesion and migration. (bvsalud.org)

Multiple immune biomarkers were tested, including various cytokines and filaggrin degradation products. (medscape.com)

In wild-type (WT) mouse chondrocytes, baseline receptor expression levels and gp130 cytokine-induced JAK/STAT signaling were determined by flow cytometry, and expression of SOCS-3 was assessed by quantitative polymerase chain reaction. (nih.gov)
In addition, it reveals a novel Epac-dependent mechanism by which cAMP can specifically inhibit ERK in response to cytokine receptor activation. (gla.ac.uk)
SOCS2 is known to regulate signal transduction by cytokine receptors and receptor tyrosine kinases. (lu.se)
The cytokine production and consequent cell death caused by IAP depletion was attenuated by loss or inhibition of TNF or TNF receptor 1. (ox.ac.uk)
Interestingly, transient receptor potential (TRP) melastatin 7 (TRPM7) ion channel controlling Ca2+ and Mg2+ permeability is involved in cytokine production and inflammatory response. (unab.cl)
Mechanisms have evolved to fin e-tune and regulate receptor signalling. (europa.eu)

Compared to other gp130 cytokines, OSM was the most potent activator of the JAK/STAT pathway and of SOCS-3 induction. (nih.gov)
The results of this study highlight a key role for SOCS-3 in regulating chondrocyte responses during inflammatory arthritis. (nih.gov)
Together, these observations suggest that while SOCS-3 induction and subsequent inhibition of cytokine-mediated phosphorylation of ERK1,2 and STAT3 in response to cAMP require Epac1 and a transient PKA-independent activation of the ERK pathway, these two events are controlled by distinct mechanisms. (gla.ac.uk)

Therefore, cytokine response is directly related with the influence of treatment in the variation of the immune response. (hindawi.com)
Th1 and Th2 responses are crucial in understanding the role of cytokines in the immune response to infectious agents [ 4 , 5 ]. (hindawi.com)
8 ] speculated that IL-10 is important in regulating the human immune response to Schistosoma mansoni infection and that it is the main cytokine that plays part in the control of morbidity. (hindawi.com)

Within the gp130 cytokine family, OSM is a potent stimulus of chondrocyte responses, while IL-6 probably signals via trans-signaling. (nih.gov)
Summary of the presentations and discussions held at the symposium NF-KB, a Prototypical Cytokine-Regulated Transcription Factor: Implications for Alcohol-Mediated Responses, held during the Joint RSMSBRA meeting in Washington, D.C. in June 1996. (umassmed.edu)
Organic dust augments nucleotide-binding oligomerization domain expression via an NF-kB pathway to negatively regulate inflammatory responses. (cdc.gov)

Recent studies have shown that interleukin (IL)-1β is a key inflammatory mediator in acute gouty arthritis (GA), and its level is regulated by microRNAs (miRNAs). (biomedcentral.com)
Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis. (ox.ac.uk)
Growing evidence suggests that proinflammatory cytokines (PICs), such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNFα), are induced in the spinal cord under various injury conditions and contribute to pain hypersensitivity. (jneurosci.org)
Additionally, alcohol inhibits the lipopolysaccharide (LPS)-induced inflammatory cytokine, interleukin-6 (IL-6), via the p38 ERK1/2 MAPK pathway [ 9 ]. (cdc.gov)

Treatment of Socs3(Δ/Δcol2) mouse cartilage explants and chondrocytes with gp130 cytokines prolonged JAK/STAT signaling, enhanced cartilage degradation, increased the expression of Adamts4, Adamts5, and RANKL, and elevated the production of IL-6, granulocyte colony-stimulating factor, CXCL1, and CCL2. (nih.gov)
The gp130 cytokine-driven production of RANKL in chondrocytes may link chondrocyte activation and bone remodeling during inflammatory arthritis. (nih.gov)
This study demonstrates the roles of miR-488 and miR-920 in regulating the production of proinflammatory cytokines in the pathogenesis of GA. These findings suggest that miR-488 and miR-920 could serve as potential therapeutic targets in the treatment of GA. (biomedcentral.com)
Moreover, P. gingivalis infection has been shown to induce the production of ET-1 along with other inflammatory cytokines. (elsevierpure.com)
These glycoproteins are widely involved in important biological processes, such as antigen presentation, cytokine production and glycosylation progression. (frontiersin.org)
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. (ox.ac.uk)
OBJECTIVE: To test whether TRPM7 mediates cytokine production and MODS during endotoxemia. (unab.cl)
cIAPs and XIAP negatively regulate cytokine production, including TNF to disrupt myeloid lineage differentiation. (ashpublications.org)
The mechanisms involved in regulating monocyte/macrophage cytokine production are not yet fully understood, but are thought to involve both soluble factors and cell/cell contact with other cell types. (ox.ac.uk)
OBJECTIVE- Chronic activation of the nuclear factor-κB (NF-κB) in white adipose tissue leads to increased production of pro-inflammatory cytokines, which are involved in the development of insulin resistance. (diabetesjournals.org)
RESEARCH DESIGN AND METHODS AND RESULTS- First, we examined whether the PPARβ/δ agonist GW501516 prevents lipopolysaccharide (LPS)-induced cytokine production in differentiated 3T3-L1 adipocytes. (diabetesjournals.org)
Next, it was determined whether NOD2 regulated ODE-induced inflammatory cytokine production. (cdc.gov)
The peripheral eosinophilia seen in the early stages of incontinentia pigmenti may result from the production of eotaxin, an eosinophil-selective cytokine, during the inflammatory cascade that results from a loss of NEMO/IKK -gamma activity. (medscape.com)
To evaluate the association of glycemic control and cytokine production in type 2 diabetic subjects with chronic periodontitis. (bvsalud.org)

Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2. (nih.gov)

SOCS2 negatively regulates FLT3 signaling by blocking activation of Erk 1/2 and STAT5. (lu.se)
Thus, we suggest that SOCS2 associates with activated FLT3 and negatively regulates the FLT3 signaling pathways. (lu.se)

Activation of NF-kB prevents apoptosis in response to the tumor necrosis factor family of cytokines. (medscape.com)

Vitamin D provides antioxidative mechanisms and regulates the immune system by reducing inflammatory cytokines. (yahoo.com)

To assess the immunity within the tumor microenvironment, the level of some cytokines including IFN-, TNF-, IL-12 and IL-4 was analyzed by ELISA. (liveconscience.com)
Previous studies in the laboratory have shown that the pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA). (ox.ac.uk)

However, tryptase was a more selective stimulus than TNF-alpha and did not induce increased expression of mRNA for granulocyte-macrophage CSF or stimulate the release of this cytokine. (eurekamag.com)
Locally Generated Glucocorticoids, Rather Than Pro-Inflammatory Cytokines, Directly Regulate Synovial Dkk-1 Expression in Inflammatory Arthritis. (ox.ac.uk)
Analysis of the WNK1-dependent transcriptome by RNA-Seq demonstrated that WNK1 regulates the expression of 1858 genes during decidualization. (bioone.org)
The expression levels of cytokines were detected by RT-PCR and ELISA. (researchsquare.com)
The analysis indicated a shift in the expression of the cytokines after treatment with all the cytokines being downregulated, except TNF. (hindawi.com)
There was a general trend of decrease in the expression of the cytokines at six and twelve weeks after treatment as compared to the pretreatment levels. (hindawi.com)
These studies provide more evidence that CysLT1R and CysLT2R have opposite functions in colon cancer progression, and we now know how to regulate their expression. (lu.se)

Beghein E, Devriese D, Van Hoey E, Gettemans J (2018) Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function. (springer.com)

Ebola RNA persistence in semen of Ebola virus disease lyzed cytokine levels in serum samples from 6 travelers to survivors--preliminary report. (cdc.gov)
The objective of this study was to evaluate the cytokine profiles of IL-4, IL-2, IL-10, IL-5, IFN- γ, and TNF in serum samples of infected school-aged children by using flow cytometry before and after treatment. (hindawi.com)

Gao YL, Zhao ZS, Zhang MY, Han LJ, Dong YJ and Xu B: Long noncoding RNA PVT1 facilitates cervical cancer progression via negative regulating of miR-424. (spandidos-publications.com)

By controlling the number of activated lymphocytes, these genes help regulate immune system function. (medlineplus.gov)

Substances that have no effect when inhaled precise role of each cytokine remains to be determined. (cdc.gov)

Additionally, RAD18 functions beyond DNA repair and may regulate many other key biological processes, such as chromatin strengthening, cell survival/death, stemness, and differentiation. (nature.com)

Electroporation i.m. of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13. (nih.gov)
However, IL-19 up-regulated IL-13 in asthmatic mice. (nih.gov)
Vessels in Vegfr2(Y949F/Y949F) mice remain sensitive to inflammatory cytokines, and vascular morphology, blood pressure and flow parameters are normal. (lu.se)

Hormones regulate the immune system throughout the female reproductive tract in a way that favors conditions for sperm migration, fertilization, implantation, and pregnancy [ 16 , 17 ]. (hindawi.com)
Hormones are also involved in regulating emotional life. (medscape.com)
These hormones regulate the body's growth, and are involved in cell to cell communication, control metabolic activity, sleep-wake homeostasis, and altered regulation or dysregulation of adaptive response in various physiologic and pathophysiologic states. (medscape.com)

3-MA pretreatment counteracted the cytokine regulation induced by flavopiridol. (researchsquare.com)

The gene mutations that cause familial hemophagocytic lymphohistiocytosis impair the body's ability to regulate the immune system. (medlineplus.gov)

These effects appeared to be regulated by NF-κB, as suggested by altered transcription and/or phosphorylation status of components of the NF-κB system. (bvsalud.org)
Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. (lu.se)

Studies using these samples found associations between fatal outcomes and elevated liver enzyme levels, renal dysfunction, cytokine dysregulation, and genetic factors. (cdc.gov)

Homeostasis is the property of a system that regulates its internal environment to maintain a stable, constant set of properties, such as pH, concentration of specific ions, and the like. (scienceblogs.com)

In addition, this review highlights metabolically active growth factors and cytokines, which may function as important regulators of keto-adaptation in the setting of exercise and the KD. (nutrition.org)

LRG47/Irgm1, a 47-kDa IFN-inducible GTPase, plays a major role in regulating host resistance as well as the hemopoietic response to intracellular pathogens. (duke.edu)
The cellular response pattern is associated with both the acute and chronic phases of the disease, in which cytokines play a critical role. (hindawi.com)
Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. (cdc.gov)

CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis. (medscape.com)

Then, cytokine and MODS levels in the blood were measured. (unab.cl)
The reduction in the cytokine levels can be directly related to the influence of the drug praziquantel, modulating the cytokine response by elimination of adult worms, decline in parasitic load, and reduction of morbidity. (hindawi.com)
The pineal gland is a pea-sized gland that apparently responds to exposure to light and regulates activity levels over the course of the day. (medscape.com)

Excessive amounts of immune system proteins called cytokines are also produced. (medlineplus.gov)

Anatomy44

Organisms10

Diseases15

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes38

Disciplines and Occupations1

Information Science2

Health Care1

Chemokines4

Anti-inflammatory cytokines3

Macrophages3

Secretion6

Inflammation6

Proliferation2

Suppressor of cytokine7

Proinflammatory cytokine production3

Cells17

Protein5

Chemokine production2

Various cytokines1

Receptor6

SOCS3

Immune response3

Responses3

Interleukin4

Production14

Inhibition1

Negatively regulates2

Apoptosis1

Mechanisms1

Tumor2

Expression7

Extracellular1

Serum2

Progression1

Lymphocytes1

Substances1

Differentiation1

Mice3

Hormones3

Pretreatment1

Body's1

Phosphorylation2

Dysfunction1

Homeostasis1

Growth1

Role3

Acute1

Levels3

Proteins1