• Therefore, early in the formation of oral lichen planus lesions, CD8 + T cells may recognize an antigen associated with the major histocompatibility complex (MHC) class I on keratinocytes. (medscape.com)
  • Oral lichen planus lesions contain increased levels of the cytokine tumor necrosis factor (TNF)-alpha. (medscape.com)
  • The role of autoimmunity in the pathogenesis is supported by many autoimmune features of oral lichen planus, including its chronicity, onset in adults, predilection for females, association with other autoimmune diseases, occasional tissue-type associations, depressed immune-suppressor activity in patients with oral lichen planus, and the presence of autocytotoxic T-cell clones in lichen planus lesions. (medscape.com)
  • Reported associations between oral lichen planus and systemic diseases may be coincidental, because (1) oral lichen planus is relatively common, (2) oral lichen planus occurs predominantly in older adults, and (3) many drugs used in the treatment of systemic diseases trigger the development of oral lichenoid lesions as an adverse effect. (medscape.com)
  • Moreover, oral lichenoid reactions (OLR) is a term used to describe clinical and histopathological lesions similar to OLP but with an identifiable etiologic factor. (ecancer.org)
  • Lichen planus is a chronic inflammatory disease of unknown origin, which most commonly affects individuals between 30-60 years of age and is characterized by different types of lesions involving the skin and mucosa . (amboss.com)
  • Lichen planus is clinically diagnosed based on the presence of typical skin lesions. (amboss.com)
  • Manifests with diffuse lesions that closely resemble lichen planus but are not histologically identical. (amboss.com)
  • These agents are used to treat painful, erythematous, or erosive oral lichen planus lesions. (medscape.com)
  • Oral ulcers are secondary lesions characterized by loss of mucosal tissue in the oral cavity. (biomedcentral.com)
  • Oral lesions accompanying cutaneous lichen planus or often occurring alone. (ouhsc.edu)
  • Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (ouhsc.edu)
  • All patients with oral lichen planus had their lesions measured and documented using the Escudier scoring system. (bue.edu.eg)
  • Oral lesions have often been seen in the absence of skin lesions. (genomeden.com)
  • The fact that distinguishes the Oral Lichen Planus (OLP) from other variants is that lesions inside the oral cavity rarely undergo spontaneous remission, whereas cutaneous lichen planus lesions are more or less self-limiting. (genomeden.com)
  • In 1937, Guogerot and Burnier described the coexistence of oral, cervical, and stomach LP lesions with no cutaneous involvement as "plurimucosal LP" [ 9 ]. (hindawi.com)
  • In 1982, Pelisse and colleagues reintroduced a similar variant of mucosal LP as the vulvovaginal-gingival syndrome with erosive lesions involving the oral and vulvovaginal mucosa [ 10 ]. (hindawi.com)
  • Dermatomyositis: Oral tofacitinib showed significant improvement of skin lesions in amyopathic anti-MDA5 dermatomyositis and a benefit to the overall 6-month survival in patients with associated interstitial lung disease. (dermnetnz.org)
  • The patient may also experience pruritus and oral lesions that may be asymptomatic, burning or pain (Chuang, 2021). (qualitywriters.org)
  • Ulcers may appear as single or multiple lesions, and they are easily distinguished from primary or secondary viral infections, bacterial infections (eg, necrotizing ulcerative gingivitis), dermatologic conditions (lichen planus, cicatricial pemphigoid, pemphigus), and traumatic injuries (contusions, lacerations, burns) by the healthy appearance of adjacent tissues and the lack of distinguishing systemic features. (medscape.com)
  • Patients with a history of major recurrent aphthous ulcers (canker sores) often have residual scarring in the oral mucosa from previous lesions. (medscape.com)
  • Local (intra-articular or intralesional) injection of [CV004 trade name] may be given as part of the short-term management of inflammatory joint and tendon disorders, and localised inflammatory and hypertrophic skin lesions including those of lichen simplex, lichen planus, granuloma annulare, discoid lupus erythematosus, and keloids. (who.int)
  • Recent data suggest that OLR present a greater percentage of malignant transformation than OLP and, although the association between cancer and OLP has been documented in scientific reports, there is no association between squamous cell carcinoma and cutaneous lichen planus [ 4 - 6 ]. (ecancer.org)
  • Lichen planus is generally a chronic-recurrent condition, except for the cutaneous form, which is usually self-limiting . (amboss.com)
  • Cutaneous lichen planus (CLP) most commonly involves the flexor surfaces of the extremities and presents as small itchy violaceous Papules in middle-aged adults. (hindawi.com)
  • Oral LP (OLP) can be the sole clinical presentation of the disease or accompanied by cutaneous or other mucosal manifestations including the genital area, gastrointestinal tract, and eyes. (hindawi.com)
  • Oral lichen planus (OLP) is a chronic mucocutaneous disorder that presents in a wide range of clinical forms, such as unilateral or bilateral white striations, papules, or plaques on the buccal mucosa, labial mucosa, tongue, and gingiva. (medscape.com)
  • Plaquelike oral lichen planus on the buccal mucosa on the left side. (medscape.com)
  • Oral lichen planus and lichenoid reactions are autoimmune type inflammatory conditions of the oral mucosa with similar clinical and histological characteristics. (ecancer.org)
  • Lichen planus can affect the skin , mucosa , scalp, genitalia, and nails , and manifests with varying symptoms depending on the subtype of the disease. (amboss.com)
  • This study aimed to identify Candida species in the oral mucosa of 59 patients with orogastric cancer (OGC) and to analyze the immunological phenotype of these patients. (biomedcentral.com)
  • When the host immune defenses are impaired or when the normal microbiota is disturbed, C. albicans triggers recurrent infections of the oral mucosa and tongue [ 3 ]. (biomedcentral.com)
  • Oral lichen planus (OLP) is a chronic inflammatory disease that causes bilateral white striations, papules, or plaques on the buccal mucosa, tongue, and gingivae. (medscape.com)
  • Younes F, Quartey EL, Kiguwa S, Partridge M. Expression of TNF and the 55-kDa TNF receptor in epidermis, oral mucosa, lichen planus and squamous cell carcinoma. (medscape.com)
  • It is a chronic immune disorder that can affect the skin, oral mucosa, scalp, genital mucosa, and nails. (genomeden.com)
  • Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? (biomedcentral.com)
  • Patients typically describe a prodromal stage of a burning or pricking sensation of the oral mucosa 1-2 days before the ulcer appears. (medscape.com)
  • It presents in the mouth first before you might see symptoms elsewhere, and the reason for that is because the oral mucosa, so the skin lining the inside of your mouth, it regenerates at a much faster rate than most other parts of your body. (skinterrupt.com)
  • Biopsy also helps detect squamous cell carcinoma , the risk of which is increased in lichen planus. (amboss.com)
  • A Comparison of the Characteristics of Cytokine Storm between Lichen Planus and Oral Squamous Cell Carcinoma. (ouhsc.edu)
  • More than 90% of oral cancers are oral squamous cell carcinoma (OSCC) and the standard method for detection is through a comprehensive clinical examination by oral healthcare professionals. (springeropen.com)
  • More than 90% of the oral cancers are squamous cell carcinomas (OSCC), which arise from the epithelial lining of the oral cavity. (springeropen.com)
  • LP (Greek "Leichen" = tree moss, Latin "planus" = flat, even) [ 2 ] was first explained in 1869 by Dr. Wilson as an inflammatory disorder of the stratified squamous epithelia with an unknown etiology. (hindawi.com)
  • However, Oral Squamous Cell Carcinoma (OSCC) often demonstrates different behaviors in relation to aggressiveness and therapeutic response at the same TNM stage. (ijodontostomatology.com)
  • It was originally named "lichen ruber planus" and "lichen psoriasis" [ 5 ]. (hindawi.com)
  • Psoriasis is a chronic inflammatory disease driven by exaggerated production of pro-inflammatory cytokines and interleukins. (e-ijd.org)
  • Tofacitinib, an oral Janus kinase inhibitor, is being investigated as a treatment for moderate-to-severe chronic plaque psoriasis. (keyopinionleaders.com)
  • OBJECTIVES: To compare plaque psoriasis vs. atopic dermatitis and lichen ruber planus with respect to T-cell subsets, epidermal proliferation and keratinization. (keyopinionleaders.com)
  • Did you know that the inflammation that drives your eczema, psoriasis, rosacea, etc., could be triggered by your oral microbiome ? (skinterrupt.com)
  • [ 19 ] Research published in 2015 also suggests that osteopontin, CD44, and survivin may be involved in the pathogenesis of oral lichen planus. (medscape.com)
  • The pathogenesis of oral lichen planus. (medscape.com)
  • Either cytokine has been reported to be reduced and in some cases elevated and consequently contributed towards disease pathogenesis. (afpm.org.my)
  • The Oral Lichen Planus (OLP) is a chronic inflammatory mucocutaneous disease that clinically presents itself in many ways as reticular, atrophic or erythematous and erosive. (bvsalud.org)
  • Cytokines produced and released by inflammatory cells present in the OLP are important for the recruitment of lymphocytes to the lesion site and are able to stimulate and inhibit production of new cytokines are essential for the perpetuation and exacerbation of OLP. (bvsalud.org)
  • Oral ulcer diseases are complex inflammatory diseases caused by multi-factors, which severely impact patient quality of life. (biomedcentral.com)
  • Kouyanqing Granule (KYQG) has been used to treat inflammatory diseases of the mouth and throat, including recurrent aphthous stomatitis (RAS), traumatic ulcers, oral leukoplakia and so on. (biomedcentral.com)
  • KYQG is recorded in the Chinese Pharmacopoeia 2015 edition to treat mouth and throat inflammatory diseases, such as RAS, oral leukoplakia, and oral lichen planus [ 5 ]. (biomedcentral.com)
  • reported that KYQG possesses anti-inflammatory activity and promotes the healing of phenol-induced oral ulcers in rats [ 7 ]. (biomedcentral.com)
  • Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil. (cdc.gov)
  • Capparis ovata treatment suppresses inflammatory cytokine expression and ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice. (anticorps-enligne.fr)
  • Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. (hindawi.com)
  • Lichen planus (LP) is a chronic inflammatory and immune mediated disease that affects the skin, nails, hair, and mucous membranes. (hindawi.com)
  • Could the PI3K canonical pathway be a common link between chronic inflammatory conditions and oral carcinogenesis? (pesclinical.com)
  • Abstract The association between chronic inflammatory disorders and oral carcinogenesis has been both a source of interest and contention. (pesclinical.com)
  • Tofacitinib (Xeljanz, Xeljanz XR ®, US) is an oral small- molecule inhibitor of Janus kinase (JAK) 1 and 3 that is used to treat psoriatic arthritis , rheumatoid arthriti s, inflammatory bowel disease , and ankylosing spondylitis. (dermnetnz.org)
  • Topical retinoids also demonstrate inhibition of various immune factors, including the activity of leukocytes, the release of pro-inflammatory cytokines and other mediators, and the expression of transcription factors and toll receptors involved in immunomodulation (Wolf, 2002). (medscape.com)
  • The recently identified cytokines- interleukin (IL)-35 and interleukin (IL)-37-have been described for their anti-inflammatory and immune-modulating actions in numerous inflammatory diseases, auto-immune disorders, malignancies, infectious diseases and sepsis. (afpm.org.my)
  • In view of the recent advances in utilizing cytokine profiles for the development of biological macromolecules, beneficial in the management of certain intractable immune-mediated disorders, these recently characterized cytokines (IL-35 and IL-37) offer potential as reasonable targets for the discovery of novel immune-modulating anti-inflammatory therapies. (afpm.org.my)
  • Vitamin C and quercetin help minimize the release of histamine and pro-inflammatory cytokines or cell signaling proteins present in allergies (6). (rebelherbs.com)
  • Inflammatory cytokines, such as Interferon-gamma, mediate macrophage differentiation. (ijodontostomatology.com)
  • A positive correlation between the pro-inflammatory cytokines and Escherichia/Shigella (pro-inflammatory taxon) and a negative correlation with #Eubacterium rectale (anti-inflammatory taxon). (metabiom.org)
  • KYQG exhibited the therapeutic effects on oral ulcers probably by inhibiting inflammation, regulating immunological response, and suppressing oxidative stress through a complex multi-pathways network. (biomedcentral.com)
  • The reactivation of T cells and local effects of cytokines in the dermis and epidermis lead to inflammation, cell-mediated immune responses, and epidermal hyperproliferation (Lui, 2022). (qualitywriters.org)
  • The resulting immune response from your body can trigger cytokines that then end up elsewhere, increasing inflammation. (skinterrupt.com)
  • My guest today - Dr. Victoria Sampson - is a brilliant dentist who joined me to blow your mind about all of the intricate relationships between inflammation, cytokines, oral microbiome, testing and best dental practices to keep your teeth and gums healthy. (skinterrupt.com)
  • [ 22 ] Oral lichen planus is a common noninfectious oral mucosal disorder among adult patients who attend oral pathology and oral medicine clinics. (medscape.com)
  • The fungus Candida albicans colonizes the oral mucosal surface of 30-70% of healthy individuals. (frontiersin.org)
  • As part of the human mycobiome the polymorphic fungus Candida albicans colonizes the oral mucosal surface of up to 70% of healthy individuals ( 4 ). (frontiersin.org)
  • Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. (biomedcentral.com)
  • Oral lichen planus predominantly occurs in adults older than 40 years, although younger adults and children can be affected. (medscape.com)
  • Abstract Introduction: Oral mucositis (OM) is a common toxicity of cytotoxic cancer regimens and remains one of the most painful, injurious, and treatment-disrupting side effects of radiation and ablative therapy. (pesclinical.com)
  • Abstract Low level laser therapy (LLLT) has been noted to be effective in mitigating the development of oral mucositis among patients being treated with chemoradiation for cancers of the head and neck. (pesclinical.com)
  • ABSTRACT Introduction: Oral mucositis is a frequent and devastating toxicity secondary to cancer treatment, which may affect 20-40% of patients receiving conventional chemotherapy and 60-85% of patients undergoing hematopoietic stem cell transplantation. (pesclinical.com)
  • Candida albicans is a dimorphic fungus that is part of the commensal microbiota of the oral cavity. (biomedcentral.com)
  • Therefore, we utilized C. albicans clinical isolates which are able to persist in the oral cavity without causing disease to analyze adaptive responses to oral fungal commensalism. (frontiersin.org)
  • Thus, in the oral cavity B lymphocytes contribute to control commensal C. albicans carriage by secreting IgA at foci of colonization thereby preventing fungal dysbiosis. (frontiersin.org)
  • Indeed, the oral cavity hosts various commensal fungal species ( 3 ). (frontiersin.org)
  • Over the past two decades, using salivary biomarkers specifically for early cancer detection has attracted much research interest, especially for cancers occurring in the oral cavity and oropharynx, for which the five-year survival rate (62%) is still one of the lowest among all major human cancers. (springeropen.com)
  • Despite the fact that the oral cavity is easily accessible, most OSCCs are not diagnosed until an advanced stage, which is believed to be the major reason for the low survival rate, and points to the urgent need for clinical diagnostic aids for early detection of OSCC. (springeropen.com)
  • Even though the oral cavity is easily accessible for direct visual examination, most OSCCs are not diagnosed until an advanced stage, which is believed to be the major reason for the low survival rate. (springeropen.com)
  • The specific antigen that triggers lichen planus is unknown, although it may be a self-peptide (or altered self-peptide), in which case lichen planus would be a true autoimmune disease. (medscape.com)
  • The expression or unmasking of the lichen planus antigen may be induced by drugs (lichenoid drug reaction), contact allergens in dental restorative materials or toothpastes (contact hypersensitivity reaction), mechanical trauma (Koebner phenomenon), viral infection, or other unidentified agents. (medscape.com)
  • The T-cells are then activated and cytokines are released resulting in co-stimulatory signals from the T-cell CD2 and LFA-1 receptors that interact with adhesion molecules of lymphocyte function-associated antigen (LFA)-3 and intercellular adhesion molecule-1 (Lui, 2022). (qualitywriters.org)
  • Erosive oral lichen planus that is recalcitrant to topical corticosteroids may respond to topical tacrolimus. (medscape.com)
  • These agents are used for painful, erythematous, or erosive oral lichen planus that is recalcitrant to topical corticosteroids. (medscape.com)
  • Recent data suggest that oral lichenoid reactions (OLR) present a greater percentage of malignant transformation than oral lichen planus (OLP). (ecancer.org)
  • Predicting malignant transformation in potentially malignant oral illnesses would allow for focused treatment, prognosis, and secondary prevention. (biomedcentral.com)
  • Presently, the likelihood of an oral potentially malignant disorder (OPMD) progressing to oral cancer is determined according to histopathological findings, which are susceptible to inadequate and/or subjective qualitative interpretations [ 5 ]. (biomedcentral.com)
  • SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes. (famri.org)
  • [ 9 ] Serum and salivary TNF levels are elevated in oral lichen planus patients. (medscape.com)
  • Of possible significance, elevated concentrations of interleukin-6 (IL-6) and neopterin in saliva and serum of patients with the erosive-atrophic form of oral lichen planus suggest they may be involved in the etiology of this disease variation. (medscape.com)
  • [ 20 ] Additionally, microRNA 4484 (miR-4484) has been found to be significantly up-regulated in the salivary exosomes of patients with oral lichen planus. (medscape.com)
  • Shan J, Ma JM, Wang R, Liu QL, Fan Y. Proliferation and Apoptosis of Peripheral Blood Mononuclear Cells in Patients with Oral Lichen Planus. (medscape.com)
  • Based on the current literature, it is evident that oral health is not prioritized by the majority of diabetic patients in Saudi Arabia. (com.sa)
  • Saudi diabetic patients with lesser education demonstrate lower awareness levels about oral health issues in general. (com.sa)
  • Similarly, more older patients have been seen to possess less oral health awareness relative to their younger counterparts. (com.sa)
  • It is vital to reinforce the need for routinely visits to dentists for education on oral health when patients visit their diabetic clinic. (com.sa)
  • 60 subjects were equally divided into patients with and without oral lichen planus. (bue.edu.eg)
  • Results: Disease activity was significantly higher in the "oral lichen planus/hepatitis C virus-positive" patients than in the "oral lichen planus/hepatitis C virus-negative" patients (P=0.003). (bue.edu.eg)
  • T were significantly more prevalent in the patients with oral lichen planus than in those without. (bue.edu.eg)
  • One such breakthrough research has been recently done on the relationship between our oral hygiene and severity of COVID-19 by a team of researchers in London, claiming that the bacteria within the mouth may have a role to play in the increased complications and fatality of the patients. (genomeden.com)
  • International Academy of Oral Medicine and Toxicology (IAOMT) Position Statement against Dental Mercury Amalgam Fillings for Medical and Dental Practitioners, Dental Students, Dental Patients, and Policy Makers. (evolvedental.com.au)
  • Alopecia areata: A meta-analysis of 30 studies including 289 patients with extensive alopecia areata showed that oral tofacitinib had a 72% response rate (partial in 21%) with a time to complete hair growth in 6 months. (dermnetnz.org)
  • Do cytokines affect development of fatigue in rheumatoid arthritis patients? (rsu.lv)
  • For patients where oral therapy is desired (or injectable biologics contraindicated), tofacitinib may be a good option. (aad.org)
  • The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. (hindawi.com)
  • Current data suggest that oral lichen planus (OLP) is a T-cell-mediated autoimmune disease in which autocytotoxic CD8 + T cells trigger the apoptosis of oral epithelial cells. (medscape.com)
  • Objectives: This study aimed to determine the association of rs2430561 and rs4073 polymorphisms in the Interferon gamma (IFN-ɤ) and Interleukin 8 (IL-8) genes, respectively, with hepatitis C virus-related oral lichen planus and disease severity. (bue.edu.eg)
  • In FAM-FLICA caspase assay, III remarkably induced caspase-3/7 in HCT-116 cells most probably by tumor necrosis factor-alpha (TNF-α) independent intrinsic pathway and significantly inhibited in vitro synthesis of cytokines, interleukin - 1 (IL- 1 ) and TNF-α in human macrophages (U937 cells). (afpm.org.my)
  • 1 . Free radicals generated by ferric nitrilotriacetate (FeNTA) can activate osteoclastic activity and this is associated with elevation of the bone resorbing cytokines interleukin (IL)- 1 and IL-6. (afpm.org.my)
  • BACKGROUND: Ixekizumab is a humanised monoclonal antibody against the proinflammatory cytokine interleukin 17A. (keyopinionleaders.com)
  • Monocytes and macrophages in diabetic individuals are often hyper-responsive to bacterial antigens.65 This up-regulation results in a significantly increased production of proinflammatory cytokines and mediators. (health.am)
  • DM can cause various oral complications such as salivary gland dysfunction, infections including candidiasis, delayed wound healing, increased caries susceptibility, gingival and periodontal diseases, lichen planus and burning mouth disorders. (com.sa)
  • It is also vital that individuals are provided with the latest recommendations on methods to practice oral health related self-care techniques in order to minimize the risk of periodontal destruction and tooth loss, thereby reducing the burden of dental illnesses on the Saudi health infrastructure. (com.sa)
  • The microbial shift in the periodontal milieu causes a dominance of gram-negative aerobic bacteria which along with increased cytokine activity accelerates destruction (6). (com.sa)
  • Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
  • The term is itself inspired by the lichen plant that usually covers rocks and trees in a mossy, web-like fashion, similar to the disorder's clinical appearance. (genomeden.com)
  • Sklavounou A, Chrysomali E, Scorilas A, Karameris A. TNF-alpha expression and apoptosis-regulating proteins in oral lichen planus: a comparative immunohistochemical evaluation. (medscape.com)
  • The objective of this study was to investigate the expression of Toll-like receptors (TLR) and TLR-associated signalling pathway genes in oral lichen planus (OLP). (afpm.org.my)
  • Receptor-mediated tobacco toxicity: alterations of the NF-kappaB expression and activity downstream of alpha7 nicotinic receptor in oral keratinocytes. (famri.org)
  • The dense subepithelial mononuclear infiltrate in oral lichen planus is composed of T cells and macrophages, and there are increased numbers of intraepithelial T cells. (medscape.com)
  • However, this condition is rarely if ever symptomatic, and it generally does not complicate healing of the erosions related to oral lichen planus. (medscape.com)
  • Activated CD8 + T cells (and possibly keratinocytes) may release cytokines that attract additional lymphocytes into the developing lesion. (medscape.com)
  • Besides CD19 + CD138 − B cells, plasmablasts, and plasma cells were enriched in the tongue of mice colonized with C. albicans suggesting a potential role of B lymphocytes during oral fungal colonization. (frontiersin.org)
  • Because of my own journey overcoming gingivitis (which I firmly believe was due to both poor habits and a dysbiotic oral microbiome), I'm fascinated by this information. (skinterrupt.com)
  • Lichen Planus, Oral" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • Thus, oral fungal challenge generates an acute immune response in a naive host. (frontiersin.org)
  • Thus, oral fungal challenge with the commonly used laboratory C. albicans strain SC5314 generates an acute immune response in a naive host ( 13 ). (frontiersin.org)
  • Lichen planus is a cell-mediated immune response of unknown origin (Chuang, 2021). (qualitywriters.org)
  • This work not only offers a method for understanding the functional mechanisms of KYQG for treating oral ulcer diseases from a multi-scale perspective but also may provide an efficient way for research and development of complex composition formula. (biomedcentral.com)
  • First, multiple targets of both active components and oral ulcer diseases were searched and fished by a comprehensive method. (biomedcentral.com)
  • Association of polymorphisms in the human IFN-gamma and IL-4 gene with oral lichen planus: a study in an ethnic Chinese cohort. (cdc.gov)
  • Conclusion: Hepatitis C virus infection is associated with the development of erosive oral lichen planus. (bue.edu.eg)
  • As 2020 unfolded, never did I, a practicing periodontist and a passionate researcher in oral-systemic health, think that all my scientific interest would be redirected to this miniscule living being, the SARS-CoV 2! (genomeden.com)
  • The results of the experimental verification indicated that KYQG significantly inhibited the serum levels of cyclooxygenase-2 (COX2), matrix metalloproteinase 9 (MMP9) and tumor necrosis factor-alpha (TNF-α) in rats with oral ulcer. (biomedcentral.com)
  • Although the incidence of oral and pharyngeal cancers is not considered high in the US (it accounts for approximately 3% of all malignancies in men and 2% of those in women) [ 1 ]-- its five-year survival rate has remained around 62%-- in contrast to the five-year survival rates for breast cancer (89%) and prostate cancer (99%) [ 2 ]. (springeropen.com)
  • Could there be a link between oral hygiene and the severity of SARS-CoV-2 infections? (skinterrupt.com)
  • Due to local or systemic immunosuppression, this commensal fungus is able to proliferate resulting in oral disease, called oropharyngeal candidiasis (OPC). (frontiersin.org)
  • [ 8 ] T cells in oral lichen planus contain mRNA for TNF and secrete TNF in vitro. (medscape.com)
  • The yeasts were identified by MALDI-TOF mass spectrometry (MS). For all isolates, we performed phospholipases and proteinases assays, in vitro adherence to buccal epithelial cells (BEC), minimum inhibitory concentration of antifungal drugs and determined the cytokine profile by Cytometric Bead Array flow citometry assay. (biomedcentral.com)
  • Treatment primarily consists of high-dose topical steroids but may also include oral steroids and phototherapy in cases of extensive or steroid -refractory disease. (amboss.com)
  • Topical corticosteroids are the mainstay of medical treatment of oral lichen planus, although rarely, corticosteroids may be administered intralesionally or systemically. (medscape.com)
  • Some topical corticosteroid therapies may predispose the patient to oral pseudomembranous candidosis. (medscape.com)
  • A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus. (ouhsc.edu)