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  • secretion
  • This review, however, will present evidence that non-infectious stimuli can induce cytokine secretion from leukocytes and other cells (including muscle cells) following myocellular injury. (springer.com)
  • gene expression
  • QIAGEN provides a broad range of assay technologies for cytokine and chemokine research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • Targets
  • It also provides fascinating case studies of how pharmaceutical and biotechnology companies are researching and developing cytokine-based drugs and identifying new cytokine targets. (smi-online.co.uk)
  • I am therefore inviting you to register for SMi's Cytokines as Drug Targets & Therapeutics. (smi-online.co.uk)
  • The term interleukin was initially used by researchers for those cytokines whose presumed targets are principally leukocytes . (wikipedia.org)
  • inhibitors
  • See 'Cytokine networks in rheumatic diseases: Implications for therapy' and 'Overview of biologic agents and kinase inhibitors in the rheumatic diseases' . (uptodate.com)
  • A body of clinical evidence is emerging that two different approaches to immune-stimulating cytokine therapies could increase efficacy of PD-1 inhibitors in both hot and cold tumors. (biocentury.com)
  • These are indications where checkpoint inhibitors are approved and produce substantial responses, which may make demonstrating an additive effect for the cytokine a high hurdle to clear. (biocentury.com)
  • Posters with early data for Armo Biosciences Inc.'s pegilodecakin (AM0010) showed an alternative cytokine approach could also be effective in augmenting the efficacy of PD-1 inhibitors. (biocentury.com)
  • modulate
  • cytokines modulate the balance between humoral and cell-based immune responses, and they regulate the maturation, growth, and responsiveness of particular cell populations. (wikipedia.org)
  • Search
  • It is a clear sign of how much things have changed that, towards the end of 2011, a PubMed search with the word "cytokines" comes up with about half a million hits and a Google search generates a 4-million-plus list. (hindawi.com)
  • induces
  • Cloning of a new cytokine that induces IFN- γ production by T cells," Nature , vol. 378, no. 6552, pp. 88-91, 1995. (hindawi.com)
  • Discovery
  • Cytokines were measured according to Manufacturer's instructions using the Meso Scale Discovery (MSD) multi-spot assay system with V-plex or ultra-sensitive kits. (dartmouth.edu)
  • antibody
  • The multiplex cytokine assay format differs from conventional ELISA in one significant way- the multiplex capture antibody is attached to a bead whereas the ELISA capture antibody is attached to the microplate well. (dartmouth.edu)
  • necrosis
  • The biological actions and potential adaptive values of these cytokines through the course of muscle necrosis and regeneration will be described. (springer.com)
  • whereas
  • report that T helper (T H ) cell production of granulocyte-macrophage colony-stimulating factor (GM-CSF) may play a pathogenic role in the brains of patients with multiple sclerosis (MS). They found that T H 17-related cytokines-thought from mouse studies to be critical for pathogenesis-actually prevented induction of GM-CSF, whereas T H 1-type cytokines promoted GM-CSF. (sciencemag.org)
  • interrelated regulatory
  • Knowledge that cytokines create regulatory hierarchies and provide independent and/or interrelated regulatory mechanisms that can confer distinct and interactive developmental functions lays a solid, albeit rather complicated foundation, for current and future clinical experiences. (prospecbio.com)
  • leukocyte
  • The presence of human leukocyte antigen (HLA)-DR expression in RA synovium also suggested the presence of IFN-gamma, since this cytokine was the most potent DR inducer known. (uptodate.com)
  • immune responses
  • Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses," Proceedings of the National Academy of Sciences of the United States of America , vol. 111, no. 7, pp. 2650-2655, 2014. (hindawi.com)
  • research
  • A research paper published in 2004 in the 'American Journal of Clinical Nutrition,' discovered that women who ate the most trans fat had the highest levels of pro-inflammatory cytokines in their blood when compared to women who avoided trans fat. (livestrong.com)
  • dendritic
  • High and low spikes (supernatants from stimulated human PBMCs and dendritic cells) were included to determine cytokine recovery. (dartmouth.edu)