Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. (wikipedia.org)
OX40L binds to OX40 receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. (wikipedia.org)
OX40 binds TRAF2, 3 and 5 as well as PI3K by an unknown mechanism. (wikipedia.org)
OX40 has been implicated in the pathologic cytokine storm associated with certain viral infections, including the H5N1 bird flu. (wikipedia.org)
Experiments in mice have demonstrated that OX40-Ig can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully. (wikipedia.org)
Immobilized OX40 His, human at 2 μg/mL (100 μL/well) can bind Biotin-OX40L His, Human with a linear range of 1.22-19.53 ng/mL. (genscript.com)
Immobilized OX40 His, human at 2.0 μg/ml (100 µl/well) can bind Biotin-OX40L His, Human when detected by Streptavidin-HRP. (genscript.com)
CD1342
The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. (abeomics.com)
CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th)1 and Th2 cells. (abeomics.com)
Subunit3
Ligand binding to either subunit is required for and precedes dimerization and activation of the receptor. (wikidoc.org)
Each subunit of IFNAR contains an N-terminal ligand binding domain (with two or four fibronectin type II-like subdomains, for IFNAR2 and IFNAR1, respectively), a transmembrane (TM) domain, and a cytoplasmic domain. (wikidoc.org)
They are grouped into one family because the receptor complex of each cytokine contains two (IL-6 and IL-11) or one molecule (all others cytokines) of the signaling receptor subunit gp130. (antibodies-online.cn)
Receptors1
However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
Induces1
The name TGF-β derives from the transforming activity of the cytokine, which induces anchorage-independent growth when administered to cells together with EGF or without the need to add EGF, depending on the cell system. (antibodies-online.cn)
Ligand3
[7] Each type I IFN ligand contains a "hotspot", or a sequence of conserved amino acids that are involved in binding to the receptor, specifically the high affinity receptor IFNAR2, which determines the affinity of each ligand for the receptor. (wikidoc.org)
Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)
This protein associates constitutively with Janus kinase 2 ( JAK2 ), and also binds to transcription activator STAT3 in a ligand-dependent manner. (wikidoc.org)
The CD56 bright population produces immunoregulatory cytokines, including interferon-γ (IFN-γ), tumor necrosis factor-beta (TNF-B), tumor necrosis factor-α (TNF-α), granulocyte macrophage-colony stimulating factor (GMCSF), IL-10, and IL-13 ( 4 ). (frontiersin.org)
Cells4
Exosomes are membrane-bound tiny particles that are released by all live cells that contain multiple signal molecules and extensively participate in numerous normal physical activities and pathologies. (bvsalud.org)
CD19+CD24hiCD38hi B cells in IMN patients displayed a skewed pro-inflammatory cytokine profile with a higher level of IL-6 and IL-12, but a lower concentration of IL-10 than their healthy counterparts. (bvsalud.org)
These evolutionarily ancient cytokines are made by and act on innate immune cells to influence their survival and function. (antibodies-online.cn)
IL-6 family cytokines have overlapping but also distinct biologic activities and are involved among others in the regulation of the hepatic acute phase reaction, in B-cell stimulation, in the regulation of the balance between regulatory and effector T cells, in metabolic regulation, and in many neural functions. (antibodies-online.cn)
Human4
Human TNFRSF4 genome location and TNFRSF4 gene details page in the UCSC Genome Browser. (wikipedia.org)
NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Mdm2 p53 Binding Protein Homolog (MDM2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
Description: A sandwich ELISA kit for detection of Mdm2 p53 Binding Protein Homolog from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
Immune1
In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used. (antibodies-online.cn)
Detection2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Mdm2 p53 Binding Protein Homolog (MDM2) in samples from tissue homogenates, cell lysates or other biological fluids. (1elisakits.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Mdm2 p53 Binding Protein Homolog (MDM2) in tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
Production1
Co-stimulates T-cell proliferation and cytokine production. (dimabio.com)
Cell5
TRAF2 is required for survival via NF-κB and memory cell generation whereas TRAF5 seems to have a more negative or modulatory role, as knockouts have higher levels of cytokines and are more susceptible to Th2-mediated inflammation. (wikipedia.org)
Cytokines, cancer vaccines, adoptive cell transfers, and especially checkpoint inhibitors constitute valuable elements in the immunotherapeutic armamentarium. (frontiersin.org)
Molecules in the IgSF are further classified as members of the B7/CD28 family, T cell immunoglobulin and mucin (TIM) family, signaling lymphocyte activation molecule (SLAM) family, butyrophilin family, and nectin and nectin-like binding receptor family. (rndsystems.com)
The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. (cromauv.org)
Domain1
ScFv is the antigen-binding domain of CAR structure, which is composed of a single heavy and light chain of monoclonal antibody connected by a linker. (biomedcentral.com)
Important2
[8] Mutagenesis studies of type I IFNs, IFNAR1 and IFNAR2 demonstrated important binding residues, i.e. "hotspots", on the type I IFN subtypes which influenced its ability to bind to IFNAR2. (wikidoc.org)
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin 1 (CT-1), cardiotrophin-like cytokine (CLC), and IL-27. (antibodies-online.cn)
Type5
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
[7] [8] Upon binding of type I interferons, IFNAR activates the JAK-STAT signalling pathway , along with MAPK , PI3K , and Akt signaling pathways. (wikidoc.org)
Type I IFN binding to IFNAR1 was less strongly impacted by mutating single amino acids to alanine. (wikidoc.org)
[8] The evolutionary conservation of type I IFN subtypes binding the same IFNAR receptor at the same site with differing affinities suggests that type I IFNs are nonredundant and potentially regulate different cellular responses. (wikidoc.org)
Interleukin-23 receptor is a type I cytokine receptor . (wikidoc.org)
CD402
Upon intravenous administration, cifurtilimab binds to CD40 on a variety of immune cell types, triggering both cellular proliferation and activation of antigen-presenting cells (APCs), which activates B-cells and T-cells, and enhances the immune response against tumor cells. (nih.gov)
In addition, this agent binds to the CD40 antigen present on the surfaces of tumor cells, which induces antibody-dependent cytotoxicity (ADCC), and eventually inhibits the proliferation of CD40-expressing tumor cells. (nih.gov)
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. (nih.gov)
Upon oral administration, ibcasertib binds to and inhibits the activity of aurora B, VEGFRs, c-kit and PDGFRs, which may result in a decrease in the proliferation of tumor cells that overexpress these kinases. (nih.gov)
Upon administration of anvatabart opadotin, the antibody moiety targets and binds to HER2 on tumor cells. (nih.gov)
Upon antibody/antigen binding and internalization, opadotin binds to and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor cell apoptosis. (nih.gov)
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. (wikipedia.org)
Inflammation1
TRAF2 is required for survival via NF-κB and memory cell generation whereas TRAF5 seems to have a more negative or modulatory role, as knockouts have higher levels of cytokines and are more susceptible to Th2-mediated inflammation. (wikipedia.org)
Gene1
Human TNFRSF4 genome location and TNFRSF4 gene details page in the UCSC Genome Browser. (wikipedia.org)
Antibody2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fatty Acid Binding Protein 4, Adipocyte (FABP4) in serum, plasma, tissue homogenates and other biological fluids. (lotuskringpoeldijk.nl)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Fatty Acid Binding Protein 4, Adipocyte (FABP4) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (lotuskringpoeldijk.nl)
Protein1
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Fatty Acid Binding Protein 4, Adipocyte (FABP4) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. (lotuskringpoeldijk.nl)
Cancer1
Following this step, the transduced cells are selected, expanded, activated, and reinfused back into the patient (A). Upon encountering target cancer cells, CAR T cells become activated: they secrete cytokines, proliferate, and destroy cancer cells (B). The outline of CAR T-cell therapy is shown in Fig. 1. (actanaturae.ru)
Activity2
Upon administration, luvixasertib selectively binds to and inhibits the activity of Mps1. (nih.gov)
Multiple subtypes of T-cells and the phenotypic changes that accompany them can be distinguished via the cytokines and pathways that maintain, promote, and modulate their activity. (canopybiosciences.com)