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  • aryl hydrocar
  • We found that a major source of IL-17 was CD4 + CD3 − NK1.1 − CD11b − Gr1 − CD11c − B220 − cells, a phenotype that corresponds to lymphoid tissue inducer-like cells (LTi-like cells), which constitutively expressed the IL-23 receptor, aryl hydrocarbon receptor, and CCR6. (rupress.org)
  • We report that splenic lymphoid tissue inducer-like cells (LTi-like cells) constitutively express RORγt, IL-23R, CCR6, and aryl hydrocarbon receptor (AHR) ( 14 ), and produce IL-17 and IL-22. (rupress.org)
  • For ILC 3, the expression of the transcription factor RORγt and partially also the Ahr (aryl hydrocarbon receptor) is typical since interactions of these two transcription factors cause the accumulation of ILC 3 and the production of IL-22 in the intestines. (wikipedia.org)
  • inflammatory
  • Intracellular DNA that is introduced into cells during infection elicits potent inflammatory responses by triggering the induction of antiviral type I IFNs and the maturation and secretion of inflammatory cytokines, such as TNF-α, IL-1β, and IL-18. (jimmunol.org)
  • The novel findings of this study reveal that although PDE inhibitors may not influence RV-induced cytokine production in ASMCs and replication in either ASMCs or HBECs, they have the capacity to be anti-inflammatory during TLR activation by modulating the induction of these chemotactic cytokines. (biomedcentral.com)
  • amino
  • This causes degradation of the mRNA and in turn no translation of the mRNA into amino acids and then proteins. (wikipedia.org)
  • They contain two Immunoreceptor tyrosine-based inhibitory motives (ITIM) in their cytoplasmic tail that are defined by the sequence (I/L/V/S)xYxx(L/V), where "x" means any amino acid at a given position. (wikipedia.org)
  • regulation
  • This entire process is aided by the presence of reactive oxygen species that inhibits protein-tyrosine phosphatases via oxidation, thereby resulting in the up-regulation of the above-mentioned receptors. (wikipedia.org)
  • microbial
  • Recognition of microbial nucleic acids is one strategy by which mammalian hosts respond to infectious agents. (jimmunol.org)
  • subset
  • CD94/NKG2 is a family of C-type lectin receptors which are expressed predominantly on the surface of NK cells and a subset of CD8+ T-lymphocyte. (wikipedia.org)
  • nuclear
  • RORs exhibit a domain structure typical of nuclear receptors and contain an N-terminal domain, the function of which has not yet been clearly defined, a highly conserved DNA-binding domain (DBD) consisting of two zinc finger motifs, a LBD, and a hinge domain spacing the DBD and LBD. (frontiersin.org)
  • keratinocytes
  • Of dermatological interest, these receptors are expressed on several skin cells including keratinocytes, melanocytes, and Langerhans cells. (hindawi.com)
  • IL-17A specifically targets keratinocytes and is the major cytokine causing pathogenesis of skin psoriasis. (wikipedia.org)
  • plasma membrane
  • Unlike most viruses that enter cells by receptor-mediated endocytosis, most paramyxoviruses deliver their genome into the cytoplasm directly by fusion with the plasma membrane ( 6 ). (jimmunol.org)