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  • granulocyte-macrop
  • Interleukin (IL)-3/granulocyte macrophage-colony stimulating factor/IL-5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS-related tyrosine kinase 3 receptor. (semanticscholar.org)
  • Modulates granulocyte-macrophage colony-stimulating factor-deprivation-induced apoptosis possibly via a novel mechanism involving interaction with an unliganded cytokine receptor common beta subunit molecule. (nih.gov)
  • The objectives of the study were to characterize the expression of the α- and β-subunits of granulocyte-macrophage colony stimulating factor (GM-CSF) receptor in bovine cumulus cells and oocytes and to determine the effect of exogenous GM-CSF on cumulus cells expansion, oocyte maturation, IGF-2 transcript expression and subsequent competence for embryonic development. (biomedcentral.com)
  • kinase
  • The GM-CSF receptor (GMR) shares a signaling subunit, beta(c), with interleukin-3 and interleukin-5 receptors and has recently been shown to induce activation of Janus kinase 2 (JAK2) and downstream signaling via formation of a unique dodecameric receptor complex. (semanticscholar.org)
  • The N-terminal region of JAKs contains a FERM domain, which is critical for their association with the receptor and for kinase function. (guwsmedical.info)
  • Interestingly, these mutations not only disrupted kinase-receptor association, but also abrogated adenosine triphosphate (ATP) binding to the kinase domain, thereby destroying kinase activity. (guwsmedical.info)
  • proliferation
  • Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. (wikipathways.org)
  • chemokine
  • Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. (springer.com)
  • Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. (springer.com)
  • Sallusto F, Lenig D, Mackay CR, Lanzavecchia A: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. (springer.com)
  • IL-36α, β, and γ are known to promote proinflammatory cytokine/chemokine production (CXCL8). (biolegend.com)
  • It can induce chemokine and cytokine (e.g. (biolegend.com)
  • Antibody
  • Immunohistochemistry analysis of paraffin-embedded human brain, using IL-3R beta (Phospho-Tyr593) Antibody. (acris-antibodies.com)
  • Western blot analysis of extracts from RAW264.7 cells treated with G-CSF 25ng/ml 15', using IL-3R beta (Phospho-Tyr593) Antibody. (acris-antibodies.com)
  • downstream
  • Hence, the major aim of this project is to study the influence of IL-31 on DCs activation and furthermore the modulatory capacities of this cytokine in terms of downstream T cell activation and T cell polarization. (uni-salzburg.at)
  • consists
  • Group 1 receptor chains have an extracellular domain that consists solely of a CHD. (biomedcentral.com)
  • Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. (embl.de)
  • Human
  • Through screening of TRIF-interacting 'autophagy receptors' in human cells, we identified that NDP52 mediated the selective autophagic degradation of TRIF and TRAF6 but not TRAF3. (springer.com)
  • Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells. (wikipathways.org)
  • We treated human CD8+ T cells with the cytokines IL-2, IL-7 or IL-15 either at rest or after stimulation with anti-CD3 and anti-CD28. (biomedcentral.com)
  • CR3 is a human cell surface receptor, found on polymorphonuclear leukocytes (mostly neutrophils), NK cells, and mononuclear phagocytes like macrophages, which is capable of recognizing and binding to many molecules found on the surfaces of invading bacteria. (advancedcancerresearchinstitute.com)
  • Carballido JM, Faith A, Carballido-Perrig N, Blaser K: The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells. (springer.com)
  • motif
  • Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch. (semanticscholar.org)
  • The Class I receptor CHD contains two pairs of conserved cysteines linked via disulfide bonds and arranged in a CX- (9-10) -CXWX- (26-32) -CX- (10-15) -C motif within the first FBN fold. (biomedcentral.com)
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. (abcam.com)
  • analyze
  • To address this we have used bioinformatics to analyze the Class I receptor repertoire in sea squirt ( Ciona intestinalis ) and zebrafish ( Danio rerio ). (biomedcentral.com)
  • interleukins
  • Cytokines are a class of proteins that includes interleukins (ILs), interferons (IFNs), colony-stimulating factors (CSFs), and tumor necrosis factors (TNFs). (biomedcentral.com)
  • This page only covers receptors for Interleukins, not chemokines, interferons, or other growth factors. (biolegend.com)
  • family
  • New insights into the regulation of T cells by gamma(c) family cytokines. (wikipathways.org)
  • This study suggests that the majority of diversification of this receptor family occurred after the divergence of urochordates and vertebrates approximately 794 million years ago (MYA), but before the divergence of ray-finned from lobe-finned fishes around 476 MYA. (biomedcentral.com)
  • It has been concluded that the renal cell carcinoma risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family. (nih.gov)
  • Interleukin-31 (IL-31) is a recently discovered four-helix bundle cytokine closely related to the IL-6 cytokine family. (uni-salzburg.at)