Cytogenetic studies. Medical search. Frequent questions

MDS affects hematopoiesis at the stem cell level, as indicated by cytogenetic abnormalities, molecular mutations, and morphologic and physiologic abnormalities in maturation and differentiation of one or more of the hematopoietic cell lines. (medscape.com)
The study of chromosomes and their abnormalities is known as cytogenetics. (wakehealth.edu)
To identify chromosome abnormalities detectable by routine cytogenetic analysis. (wakehealth.edu)
To identify chromosome abnormalities that can be detected by routine cytogenetic analysis. (wakehealth.edu)
Comparative genomic hybridization (CGH) is now often recommended to identify a greater number of subtle cytogenetic abnormalities in pervasive developmental disorder (PDD). (medscape.com)
Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in different populations and geographic areas. (biomedcentral.com)
A normal karyotype was observed in 59 patients (57.3%), while 44 patients (42.7%) had cytogenetic abnormalities. (biomedcentral.com)
Evaluation of cytogenetic abnormalities is useful in the diagnosis of MDS and crucial in determining the prognosis [ 8 ]. (biomedcentral.com)
However, clinical symptoms, cytogenetic abnormalities, and the disease's pathophysiology are dissimilar in different populations and vary greatly in different geographic areas. (biomedcentral.com)
The cytogenetic abnormalities were described according to the International System for Human Cytogenetic Nomenclature (ISCN). (hindawi.com)
6 In this report an additional cohort of SMS patients was studied more extensively to define the spectrum of sleep abnormalities further. (bmj.com)
Objectives Acute myeloid leukemia (AML) is classified in part by recurrent cytogenetic abnormalities, often detected by both fluorescent in situ hybridization (FISH) and karyotype. (medscape.com)
[ 1-3 ] Several well-known, recurrent cytogenetic abnormalities have prognostic significance. (medscape.com)
It is common practice for laboratories to use interphase fluorescence in situ hybridization (FISH) panels in conjunction with karyotyping for the detection of the most prognostically significant recurrent AML-associated cytogenetic abnormalities, both in diagnostic specimens and during follow-up to monitor response to therapy. (medscape.com)

An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome. (qxmd.com)
Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). (qxmd.com)
Here we have studied the cytogenetics and outcome of 530 iAMP21 patients that highlighted the association of specific secondary chromosomal and genetic changes with iAMP21 to assist in diagnosis, including the gain of chromosome X, loss or deletion of chromosome 7, ETV6 and RB1 deletions. (qxmd.com)
In this study diploid number and chromosome morphology viewed on Giemsa-stained slides for three rodent species trapped in Obafemi Awolowo University Campus are reported. (environtropica.com)
The common inference drawn from such studies is that the sex of the offspring is determined by the Y chromosome. (wikipedia.org)
Several studies concentrated on Silene latifolia have shown a correlation between loci on the Y chromosome and the sex that is expressed phenotypically in the flower. (wikipedia.org)
X-inactivation studies in the proband's blood showed random X-inactivation despite the presence of an abnormal X chromosome. (nih.gov)
This case study reports a rare double minute chromosome via FLT3 amplification in CMML by using array-based comparative genomic hybridization and fluorescence in situ hybridization analyses. (hindawi.com)
The Jackson Laboratory maintains and distributes chromosome-aberration stocks that provide mouse models for Down syndrome, as well as the study of. (jax.org)
In this case, possible clastogenicity is examined in an in vitro and in vivo chromosome aberration study and therefore not considered necessary in the Ames test. (europa.eu)

Cytogenetic data revealed a same diploid number for all populations (2n = 48), but distinct karyotype formulae (8M+24SM+12ST+4A, FN = 92 in Contas River, 8M+24SM+10ST+6A, FN = 90 in Preto do Costa River, and 8M+18SM+16ST+6A, FN = 90 in Mineiro Stream). (scielo.br)
Among the analyzed specimens, a large degree of cytogenetic variation related to diploid numbers and karyotype structure was observed, with karyotypes showing 2n=42, 44 and 46 chromosomes. (scielo.br)
Routine G-banded karyotype, array-based comparative genomic hybridization, and fluorescence in situ hybridization analyses were used to characterize the cytogenetic abnormality in the patient's bone marrow. (hindawi.com)
Twenty-nine consecutive cases with a t(8;21)(q22;q22) in the bone marrow (BM) karyotype were retrospectively studied concerning clinical, morphological and cytogenetic data. (lu.se)
However, some recent studies have called into question whether FISH actually provides additional diagnostic information compared with karyotype, especially considering its significantly higher cost. (medscape.com)

Finally, the integration of both molecular cytogenetic and phylogenetic approaches allowed the determination of specific chromosomes possibly involved in rearrangements and a better understanding about the evolutionary processes involved in the differentiation of Synbranchus genus. (scielo.br)
Silene recently evolved sex chromosomes 5-10 million years ago and are widely used by geneticists and biologists to study the mechanisms of sex determination since they are one of only 39 species across 14 families of angiosperm that possess sex-determining genes. (wikipedia.org)
The study revealed conserved 23 acrocentric chromosomes (2n = 23) in all 10 male specimens as reported by previous studies. (edu.ng)
The current study attempts to demonstrate the existence of double minute chromosomes via FLT3 gene amplification in a patient diagnosed with chronic myelomonocytic leukemia (CMML). (hindawi.com)
Double minute chromosomes (dmins) are cytogenetic indicators of extrachromosomal gene amplification which usually act as small spherical paired chromatin particles [ 1 ]. (hindawi.com)
Deciphering these relationships entails field work, growing representative populations in a garden or greenhouse, experimental hybridizations among selected populations, and the study of chromosomes in the parental plants and in the artificial hybrids. (scu.edu)
The genetics of the cell, and involves the study of chromosomes and its relationship to disease. (agt-info.org)
Several cytogenetic studies have already been performed in Triatominae, such that different karyotypes could be characterized (ranging from 2n = 21 to 25 chromosomes), being the changes in the number of chromosomes related mainly to fusion and fission events. (bvsalud.org)
Genetic testing encompasses a broad range of laboratory tests performed to analyze DNA, RNA, chromosomes, proteins, and certain metabolites using biochemical, cytogenetic, or molecular methods or a combination of these methods. (cdc.gov)

Cytogenetic and Genome Research , 99(1-4), 194-199. (amphibiaweb.org)

In the present work, morphometric and cytogenetic analyses were carried out in populations of the fish Astyanax fasciatus (Characidae) from Contas and Recôncavo Sul River basins (State of Bahia, Brazil), providing new data on the genetic structure of this species along the region. (scielo.br)
This cytogenetic diversity offers the opportunity to perform cytotaxonomic and phylogenetic studies, as well as structural, evolutionary, and functional analyses of the genome. (karger.com)
Although in Nigeria interesting rodent diversity is currently being uncovered through molecular analyses, the cytogenetic aspects of this diversity are still largely unknown. (environtropica.com)
CHICAGO and RARITAN, NJ, June 4, 2017 - Janssen Research & Development, LLC today announced new data from updated analyses of the pivotal Phase 3 CASTOR and POLLUX clinical studies, demonstrating that DARZALEX ® (daratumumab) in combination with bortezomib and dexamethasone, or lenalidomide and dexamethasone, improved progression-free survival (PFS) and the overall response rate (ORR) for previously-treated patients with multiple myeloma, regardless of cytogenetic risk. (jnj.com)
All research areas are substantiated by analyses (Figure D) monitoring the acute radiation-induced cytogenetic damage and the long-term genetic stability of cells. (gsi.de)

despite this similarity, genetic, morphological, and experimental crossbreeding studies confirmed the specific status of T. petrocchiae. (bvsalud.org)
Participants included geneticists, obstetricians, pediatricians, epidemiologists, teratologists, dysmorphologists, and genetic counselors who had a particular interest in CVS studies or who represented professional organizations and government agencies. (cdc.gov)

Cytogenetic analysis of Hematology-Oncology specimens for leukemia and solid tumors is available. (wakehealth.edu)
We have applied comparative genomic hybridization to routinely processed, paraffin-embedded radical prostatectomy specimens derived from patients who participated in the European Randomized Study of Screening for Prostate Cancer. (amsterdamumc.org)
In Uruguay, the first evidence of the circulation of these viruses came from a study of serum specimens collected from blood donors between 1985 and 1987 that showed a seroprevalence of 1%, as measured by indirect fluorescent antibody (IFA) test using Hantaan and Seoul antigens ( 11 ). (cdc.gov)

2004) Leiomyosarcoma of the breast: A pathologic and comparative genomic hybridization study of two cases. (scirp.org)

The clinical records of pediatric patients diagnosed with de novo Acute Myeloid Leukemia admitted to the National Institute of Neoplastic Diseases, between 2001 and 2011, with cytogenetic analysis in bone marrow were included. (edu.pe)
A statistical study on clinical cases of pesticide poisoning in rural districts for eight years. (cdc.gov)

Trisomy 8 (+ 8) was the most common cytogenetic abnormality (n = 14) followed by del 17p (n = 9) and monosomy 7 (− 7) (n = 7). (biomedcentral.com)
Our data betokened that among our MDS patients, Trisomy 8 is the predominant cytogenetic abnormality, and MDS-MLD and MDS-SLD are the most common of subtypes. (biomedcentral.com)

The Cytogenetic Laboratory has two Directors who are board-certified Cytogeneticists and 15 certified Cytogenetic Technologists [CLSp(CG)] with an average of 14 years experience. (wakehealth.edu)
Cytogenetic technologists are accorded the same level of responsibility in the laboratory as that of their counterparts in medical technology. (agt-info.org)

No specific biochemical test exists for the presence of medulloblastoma, although several molecular studies have revealed that histologically identical medulloblastomas are composed of distinct subgroups with different prognosis. (medscape.com)

These iAMP21 patients when treated as high risk showed the same improved outcome as those in trial-based studies regardless of the backbone chemotherapy regimen given. (qxmd.com)
This study reinforces the importance of intensified treatment to reduce the risk of relapse in iAMP21 patients. (qxmd.com)
The workup in patients with possible MDS includes a complete blood count with differential, peripheral blood smear, and bone marrow studies (see Workup). (medscape.com)
Objective: To determine cytogenetic risk groups in pediatric Acute Myeloid Leukemia patients according to overall survival. (edu.pe)
Additionally, data from the Phase 1b MMY1001 study will show the potential of daratumumab in combination with carfilzomib, lenalidomide and dexamethasone (KRd) for newly diagnosed patients with multiple myeloma. (jnj.com)
These compelling findings from the Phase 3 CASTOR and POLLUX trials show daratumumab delivered deep and durable responses for previously-treated patients, regardless of cytogenetic risk," said Dr. Katja Weisel, Associate Professor, Department of Hematology and Oncology, University Hospital of Tuebingen, Tuebingen, Germany. (jnj.com)
Herein, we determined the cytogenetic spectrum and clinico-hematological features of Iranian MDS patients for the first time. (biomedcentral.com)
This prospective cross-sectional study was conducted on 103 patients with MDS in Ahvaz, southwest of Iran, from 2014 to 2018. (biomedcentral.com)
There are many reports from western countries in terms of cytogenetic profiles of MDS patients. (biomedcentral.com)
Physical mapping studies indicate that all patients with the common deletion are haploinsufficient for subunit 3 of the COP9 signalosome ( COPS3 ), which is conserved from plants to humans, and in the plant Arabidopis thaliana regulates gene transcription in response to light. (bmj.com)
METHODS Urinary excretion of 6-sulphatoxymelatonin (aMT6s), the major hepatic metabolite of melatonin, in 19 SMS patients were measured in conjunction with 24 hour sleep studies in 28 SMS patients. (bmj.com)
All patients studied, including the one patient with a normal melatonin rhythm, were haploinsufficient for COPS3 . (bmj.com)
Finally, using primary lung stem cells or lymphocytes from different donors, we study the effects of radon on patients, who are treated in radon spas or baths to alleviate rheumatic diseases. (gsi.de)
An international phase 2 study treated 75 patients with relapsed or refractory B-cell ALL with Kymriah. (childrensmercy.org)
In a hospital-based, retrospective, case-control study in 20112012, adult cases of lymphoproliferative disorders (n = 130) were recruited from outpatient clinics in Menoufia, Egypt, while controls (n = 130) were age- and sex-matched fracture patients. (who.int)
Auditory and olfactory findings in patients with USH2A-related retinal degeneration-Findings at baseline from the rate of progression in USH2A-related retinal degeneration natural history study (RUSH2A). (cdc.gov)
In addition to cytogenetic analysis, testing for common single-gene mutations ( FLT3 , NPM1 , KIT , and CEBPA ) is recommended to aid in stratification of patients with newly diagnosed AML. (medscape.com)

This first Scandinavian study of AML with t(8;21) corroborates the previous findings that these AMLs are characterized by distinct morphological features, a high frequency of CR and a striking tendency to develop extramedullary leukaemic manifestations. (lu.se)
Therefore, we performed morphological, cytological and molecular studies and characterized the feeding and defecation pattern of hybrids from crosses between T. sordida and T. rosai. (bvsalud.org)

Cytogenetic analysis has revealed the presence of chromosomal aberrations of importance in the patient prognosis. (edu.pe)
Interestingly, chromosomal alterations that were found in previous studies to be potential biomarkers for tumor aggressiveness, ie, gain of 7pq and/or 8q, were already distinguished in the small and intermediate cancers. (amsterdamumc.org)
Moreover, a reliable in vitro study (Murie and Innes, 1997 K3 CSR) is available in which the potential of LAS Na to cause chromosomal aberrations in mammalian cells was examined. (europa.eu)

Cytogenetic analysis is one major tool useful for unravelling rodent diversity. (environtropica.com)
According to the global survival analysis, two cytogenetic risk groups were observed: favorable and unfavorable. (edu.pe)
The Statements of Competence is a thoughtful, comprehensive analysis of all the knowledge and skills necessary to be a successful and competent cytogenetic technologist. (agt-info.org)

Fluoride and endosulfan together potentiate cytogenetic effects in Swiss albino mice bone marrow cells. (fluoridealert.org)

Cancer Genetics and Cytogenetic, 149, 53-57. (scirp.org)

The diploid numbers detected in this study for Cricetomys gambianus (2n=64) differ from diploid numbers published for these species from other locations in previous studies and this raises a possibility of yet to be identified rodent diversity in the present area of study. (environtropica.com)

A public meeting was convened on March 11, 1994, to discuss the results of studies of CVS-associated limb deficiencies and preliminary counseling recommendations that had been drafted at CDC (3). (cdc.gov)

Cytogenetic studies are an important tool in the classification and risk stratification of AML into favorable, intermediate, and unfavorable risk groups. (medscape.com)

The goal of this work was to use cytogenetic and molecular methods to determine the species delimitations and understand the karyoevolution of S . marmoratus using samples collected from distinct Brazilian localities. (scielo.br)
I study the distribution of western North American plant species and plant communities. (scu.edu)
Within that, I focus on the comparative study of populations of widely distributed species complexes. (scu.edu)

A 52-week chronic toxicity study on DDUP in dogs. (cdc.gov)

Cytogenetic data combined with other lines of scientific evidence will help us appreciate and understand more the bountiful diversity of small mammals across Nigeria. (environtropica.com)
Despite the diversity and cytotaxonomic value of this family, however there are only a few studies on their karyology. (edu.ng)
In South America, studies of the correlation between rodent hosts and indigenous hantaviruses are complicated by the great diversity of sigmodontine rodents in this area. (cdc.gov)

Cytogenetic testing in this area is used for diagnosis, classification of disease, determining treatment regimens, and to monitor disease status and recovery. (wakehealth.edu)
The goal of this study was to assess the utility of FISH and karyotyping at diagnosis and follow-up. (medscape.com)

These results show that A. fasciatus populations from northeastern river basins are well differentiated and present peculiar cytogenetic features when compared to populations from other regions. (scielo.br)

Systematics of Mepraia (Hemiptera-Reduviidae): cytogenetic and molecular variation. (karger.com)

Mutagenicity studies with 5-thio-d-glucose. (jax.org)
A bacterial mutagenicity study (Ames test) was conducted on LAS and was found to be negative for mutagenicity. (europa.eu)

However, some studies about systematic distribution, reproduction, and cytogenetic aspects have been published ( 13 - 17 ). (cdc.gov)

The cytogenetic evaluation was performed using the conventional G banding method on the BM. (biomedcentral.com)

Cytogenetic investigation" by S K. Majumdar, B Buchanan et al. (jax.org)
Cytogenetic investigation in mice, and the sex-linked recessive lethal gene test in drosophila. (jax.org)

The Cytogenetic Laboratory of the Wake Forest School of Medicine is one of the largest university-based laboratories in the Southeast. (wakehealth.edu)
This laboratory is a nationally approved cytogenetic laboratory for CALGB and COG studies. (wakehealth.edu)

Studies of the occupational exposure of field workers to insecticides. (cdc.gov)

The purpose of this study was to identify the carrier rodents of hantavirus in Uruguay and their potential association with HPS cases, to determine the prevalence of infection in different habitats, and to begin to genetically characterize the hantaviruses recovered from these rodents. (cdc.gov)

The study also proposed another possible mechanism of FLT3 genes in leukemogenesis. (hindawi.com)

Hospitalizations in long-term survivors of childhood AML treated with allogeneic HCT-An Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study. (cancercentrum.se)
Study protocol for the Fex-Can Childhood project: An observational study and a randomized controlled trial focusing on sexual dysfunction and fertility-related distress in young adult survivors of childhood cancer. (cancercentrum.se)

The heterogeneity of MDS reflects the fact that its course involves a series of cytogenetic events. (medscape.com)

Cytogenetic risk groups were established according to the criteria of the Medical Research Council. (edu.pe)
Conclusion: Two cytogenetic risk groups were determined: high and standard. (edu.pe)
This report describes CVS and amniocentesis, provides information on indications for their use, reviews studies about the safety of the procedures, compares the benefits and risks of the two procedures (focusing particularly on the risk for limb deficiency after CVS), and provides recommendations for counseling about these issues. (cdc.gov)

PA, according to the classification criteria established by the studies by Matutes et al. (bvsalud.org)

Whole-Exome Sequencing Targeting a Gene Panel for Sensorineural Hearing Loss: The First Portuguese Cohort Study. (cdc.gov)

Overall, results from these studies indicate no evidence of genotoxic potential of the tested substance. (europa.eu)

Among this group of chemicals, tected in epidemiological studies of IARC evaluations of the carcinogen- there is remarkable concordance in exposed workers. (who.int)
epidemiological studies that reduce Table 1.2 . (who.int)
In the face of climate and environmental changes, the study of hybrids of triatomines has evolutionary and epidemiological implications. (bvsalud.org)

In vitro and in vivo genotoxicity studies were conducted with the test substance C10-13 LAS. (europa.eu)
Three in vitro genotoxicity studies are available, all providing evidence that LAS Na is negative for in vitro genotoxicity. (europa.eu)
Dose-response relationships for different radiation types (neutrons, radon, alpha particles, HZE-particles, X-rays) over a wide range of LETs/energies (in vitro studies). (gsi.de)

No other imaging studies other than chest radiography to evaluate for a mediastinal mass are routinely required in pediatric ALL. (medscape.com)

Materials y methods: Observational cross-sectional study. (edu.pe)

Conclusions: The present study shows that CD276 can be used to discriminate ECs from malignant tissue from ECs from normal tissue. (researchgate.net)

Subsequent studies support the hypothesis that CVS can cause transverse limb deficiencies. (cdc.gov)

Anatomy37

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19941

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